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*  TOB1
Protein Tob1 is a protein that in humans is encoded by the TOB1 gene. This gene encodes a member of the tob/btg1 family of anti ... Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO (May 2001). "Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 ... TOB1 human gene location in the UCSC Genome Browser. TOB1 human gene details in the UCSC Genome Browser.. ... Yoshida Y, Matsuda S, Yamamoto T (May 1997). "Cloning and characterization of the mouse tob gene". Gene. 191 (1): 109-13. doi: ...
*  Epiregulin
"Entrez Gene: epiregulin". Sato K, Nakamura T, Mizuguchi M, Miura K, Tada M, Aizawa T, Gomi T, Miyamoto K, Kawano K (October ... Révillion F, Lhotellier V, Hornez L, Bonneterre J, Peyrat JP (January 2008). "ErbB/HER ligands in human breast cancer, and ... Epiregulin (EPR) is a protein that in humans is encoded by the EREG gene. Epiregulin consists of 46 amino acid residues. Its ... 2003). "Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression ...
*  TMF1
"Entrez Gene: TMF1 TATA element modulatory factor 1". Schwartz, Y; Ben-Dor I; Navon A; Motro B; Nir U (Sep 1998). "Tyrosine ... 2002). "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609-18 ... TATA element modulatory factor is a protein that in humans is encoded by the TMF1 gene. TMF1 has been shown to interact with ... Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome ...
*  Laboratory Syrian hamster
As the tumor develops in the hamster, they also have increased gene expression in p53 and c-myc which is similar to human ... 877-878 cites Werkmeister, R; Brandt, B; Joos, U (January 2000). "Clinical relevance of erbB-1 and -2 oncogenes in oral ... The gene responsible for hamster cardiomyopathy in a widely studied inbred hamster strain, BIO14.6, has been identified as ... Cardiomyopathy in hamsters is an inherited condition and there are genetic lines of hamsters which are bred to retain this gene ...
*  Stuart A. Aaronson
His discovery of erbB2 as a v-erbB-related gene amplified in a human breast carcinoma and the demonstration of its transforming ... The New York Times, September 28, 1983 Cancer Gene Linked to Flaws in Growth of an Ordinary Cell. The New York Times, February ... 2007). "CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner". The EMBO Journal. ... Current research includes investigations into the mechanisms by which tumor suppressor genes induce permanent growth arrest/ ...
*  GRB2
This gene is similar to the sem-5 gene of Caenorhabditis elegans, which is involved in the signal transduction pathway. Two ... Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE (Sep 1998). "ErbB-1 and ErbB-2 acquire distinct signaling ... In humans, the GRB2 protein is encoded by the GRB2 gene. The protein encoded by this gene binds receptors such as the epidermal ... Abl gene, Arachidonate 5-lipoxygenase, B-cell linker, BCAR1, BCR gene, Beta-2 adrenergic receptor, C-Met, CBLB, CD117, CD22, ...
*  DLG2
"Entrez Gene: DLG2 discs, large homolog 2, chapsyn-110 (Drosophila)". "Body weight data for Dlg2". Wellcome Trust Sanger ... Garcia RA, Vasudevan K, Buonanno A (2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal ... is a protein that in humans is encoded by the DLG2 gene. Chapsyn-110/PSD-93 a member of the membrane-associated guanylate ... Genes Cells. 5 (11): 905-911. doi:10.1046/j.1365-2443.2000.00374.x. PMID 11122378. DeMarco SJ, Strehler EE (2001). "Plasma ...
*  Ras subfamily
The three human ras genes encode extremely similar proteins made up of chains of 188 to 189 amino acids. Their gene symbols are ... Oncogenes such as p210BCR-ABL or the growth receptor erbB are upstream of Ras, so if they are constitutively activated their ... "Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on ... "Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses". Proc. Natl. ...
*  STAT1
Database, GeneCards Human Gene. "IRF9 Gene - GeneCards , IRF9 Protein , IRF9 Antibody". www.genecards.org. Retrieved 2017-06-01 ... Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE (June 1999). "ErbB receptor-induced activation of stat transcription ... STAT1 has a key role in many gene expressions that cause survival of the cell, viability or pathogen response. There are two ... STAT molecules form dimers and bind to ISGF3G/IRF-9, which is Interferon stimulated gene factor 3 complex with Interferon ...
*  YAP1
Gene. 509 (2): 215-22. doi:10.1016/j.gene.2012.08.025. PMC 3455135 . PMID 22939869. Vassilev A, Kaneko KJ, Shu H, Zhao Y, ... Komuro A, Nagai M, Navin NE, Sudol M (August 2003). "WW domain-containing protein YAP associates with ErbB-4 and acts as a co- ... When the Hippo pathway is not activated, YAP1/TAZ enter the nucleus and regulate gene expression. It is reported that several ... Two splice isoforms of the YAP1 gene product were initially identified, named YAP1-1 and YAP1-2, which differed by the presence ...
*  SNTB2
This gene is a member of the syntrophin gene family, which contains at least two other structurally related genes. SNTB2 has ... Garcia RA, Vasudevan K, Buonanno A (2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal ... "Entrez Gene: SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)". Buechler C, Boettcher A, ... Beta-2-syntrophin is a protein that in humans is encoded by the SNTB2 gene. Dystrophin is a large, rod-like cytoskeletal ...
*  DLG3
"Entrez Gene: DLG3 Discs, large homolog 3 (neuroendocrine-dlg, Drosophila)". Makino K, Kuwahara H, Masuko N, Nishiyama Y, ... Garcia RA, Vasudevan K, Buonanno A (2000). "The neuregulin receptor ErbB-4 interacts with PDZ-containing proteins at neuronal ... 2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from ... the gene encoding human neuroendocrine Dlg (NE-Dlg), is located within the 1.8-Mb dystonia-parkinsonism region at Xq13.1". ...
*  Mothers against decapentaplegic homolog 7
... or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. SMAD7 is a protein ... Recent insights into the activation of EGF/ErbB receptors". Mol. Cell. 12 (3): 541-52. doi:10.1016/S1097-2765(03)00350-2. PMID ... A mutation located in SMAD7 gene is a cause of susceptibility to colorectal cancer (CRC) type 3. Perturbation of Smad7 and ... Röijer E, Morén A, ten Dijke P, Stenman G (1998). "Assignment1 of the Smad7 gene (MADH7) to human chromosome 18q21.1 by ...
*  IFNA2
The gene encoding IFNα2, the IFNA2 gene, is clustered with all other type I IFN genes on chromosome 9 and as all type I IFN ... Stagg J, Loi S, Divisekera U, Ngiow SF, Duret H, Yagita H, Teng MW, Smyth MJ (Apr 2011). "Anti-ErbB-2 mAb therapy requires type ... Paul F, Pellegrini S, Uzé G (2015). "IFNA2: The prototypic human alpha interferon". Gene. 567 (2): 132-7. doi:10.1016/j.gene. ... Interferon alpha-2 is a protein that in humans is encoded by the IFNA2 gene. Human interferon alpha-2 (IFNα2) is a cytokine ...
*  STAT3
... synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene". Genes & Development. 17 (20): 2564-77. ... Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE (June 1999). "ErbB receptor-induced activation of stat transcription ... STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular ... Gain-of-function mutations in the STAT3 gene have been reported to cause multi-organ early onset auto-immune diseases; such as ...
*  SH3BGRL
"Entrez Gene: SH3BGRL SH3 domain binding glutamic acid-rich protein like". Dawson SJ, White LA (1992). "Treatment of Haemophilus ... Schulze WX, Deng L, Mann M (2006). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1): ... SH3 domain-binding glutamic acid-rich-like protein is a protein that in humans is encoded by the SH3BGRL gene. GRCh38: Ensembl ... characterization of a new human gene encoding a small protein with high homology to the proline-rich region of the SH3BGR gene ...
*  Pediatric ependymoma
However, gene mutations linked to the familial syndromes are rarely found in sporadic cases of ependymoma. For example, NF2 ... 2002). "ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for ... A gene expression profiling experiment has shown that three members of the SOX family of transcription factors also possessed ... Loss of 22q has been found in both sporadic and familial cases, supporting the presence of a tumor suppressor gene at this ...
*  PLXNB1
"Entrez Gene: PLXNB1 plexin B1". Driessens MH, Olivo C, Nagata K, Inagaki M, Collard JG (Oct 9, 2002). "B plexins activate Rho ... "Plexin-B1/RhoGEF-mediated RhoA activation involves the receptor tyrosine kinase ErbB-2". J. Cell Biol. 165 (6): 869-80. doi: ... Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene. Within neural tissues, the plexin ... Genes Dev. 16 (7): 836-45. doi:10.1101/gad.966402. PMC 186329 . PMID 11937491. Swiercz JM, Kuner R, Behrens J, Offermanns S ( ...
*  Cancer systems biology
"Gene Expression Omnibus: NCBI gene expression and hybridization array data repository". Nucleic Acids Research. 30 (1): 207-10 ... identified a previously unknown, complementary and potentially superior mechanism of inhibiting the ErbB receptor signaling ... "Gene Expression Omnibus: NCBI gene expression and hybridization array data repository". Nucleic Acids Research. 30 (1): 207-10 ... Pinpointing the genes involved in cancer will help chart a new course across the complex landscape of human malignancies". Sci ...
*  Retinoblastoma protein
This states that only one working allele of a tumour suppressor gene is necessary for its function (the mutated gene is ... Xia X, Cheng A, Lessor T, Zhang Y, Hamburger AW (May 2001). "Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb ... Some genes activated during the G1/S transition such as cyclin E are repressed by HDAC during early to mid-G1 phase. This ... The RB gene may have been responsible for the evolution of multicellularity in several lineages of life including animals. In ...
*  GATA3
Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. GATA-3 is one of the ... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... "Entrez Gene: GATA3 GATA binding protein 3". Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z (Dec 2006). "GATA-3 maintains the ... Transcription factor GATA-3 is a protein that in humans is encoded by the GATA3 gene. GATA-3 belongs to the GATA family of ...
*  Index of biochemistry articles
... erbA gene - erbB gene - erbB-2 gene - erbB-2 receptor - erythropoietin - erythropoietin receptor - Essential amino acid - Ester ... gene - gene expression - gene pool - gene regulatory network - genetic carrier - genetic code - genetic drift - Genetic ... fms gene - Formaldehyde - fos gene - free energy - freezing point - FSH receptor - functional group - fungal protein - fungi - ... end ABC-Transporter Genes - abl gene - acetic acid - acetyl CoA - acetylcholine - acetylcysteine - acid - acidic fibroblast ...
*  Julian Downward
Castellano, E.; Downward, J. (2011). "RAS Interaction with PI3K: More Than Just Another Effector Pathway". Genes & Cancer. 2 (3 ... v-erbB. This work led to the identification of the closely related cellular oncogene ErbB2/HER2, which is over-expressed in a ... ISBN 978-1-621820-77-2. "Julian Downward". rnaiglobal.org. Archived from the original on 2016-03-04. J. Downward; J. de ...
*  Epidermal growth factor
... and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell ... "Role of the N-terminus of epidermal growth factor in ErbB-2/ErbB-3 binding studied by phage display". Biochemistry. 41 (27): ... Howell WM (2004). "Epidermal growth factor gene polymorphism and development of cutaneous melanoma". J. Invest. Dermatol. 123 ( ... 284 (1): 2-13. doi:10.1016/S0014-4827(02)00105-2. PMID 12648462. Stortelers C, Souriau C, van Liempt E, van de Poll ML, van ...
*  Gamma secretase
Presenilin, an aspartyl protease, is the catalytic subunit; mutations in the presenilin gene have been shown to be a major ... Ni CY, Murphy MP, Golde TE, Carpenter G (2001). "gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine ... APH-1, which is required for proteolytic activity, binds to the complex via a conserved alpha helix interaction motif and aids ... In humans, two forms of presenilin and two forms of APH-1 have been identified in the genome; one of the APH homologs can also ...
*  Alzheimer's disease research
doi:10.1016/j.gene.2004.04.024. Washizuka, S; et al. (2009). "Expression of mitochondrial complex I subunit gene NDUFV2 in the ... EGFR is a transmembrane protein and a member of the HER/ErbB receptor family that share a common pathway with insulin receptors ... reveals gene expression distribution difference between AD and normal aging brains. That is, expressed genes that are ... SV2B is another gene that is downregulated in AD and has been shown to be related to neurodegeneration, particularly synaptic ...
*  Androgen receptor
Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. In some cell types, ... "Repression of androgen receptor mediated transcription by the ErbB-3 binding protein, Ebp1". Oncogene. 21 (36): 5609-18. doi: ... The AR gene contains CAG repeats which affect receptor function, where fewer repeats leads to increased receptor sensitivity to ... In humans, the androgen receptor is encoded by the AR gene located on the X chromosome at Xq11-12. The androgen insensitivity ...