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*  ERRFI1
"Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking ... "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 ... ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is a Cytoplasmic protein ... Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O (Sep 2002). "Expression of RALT, a feedback inhibitor of ErbB ...
*  List of MeSH codes (G14)
... genes, erba MeSH G14.340.024.340.383.500.791.295 --- genes, erbb MeSH G14.340.024.340.383.500.791.295.300 --- genes, erbb-1 ... genes, nef MeSH G14.340.400.500.667 --- genes, pol MeSH G14.340.400.500.735 --- genes, px MeSH G14.340.400.500.775 --- genes, ... genes, viral MeSH G14.340.400.500.172 --- genes, env MeSH G14.340.400.500.258 --- genes, gag MeSH G14.340.400.500.345 --- genes ... genes, helminth MeSH G14.340.357.500 --- genes, insect MeSH G14.340.365.500 --- genes, plant MeSH G14.340.375.500 --- genes, ...
*  PSMC3
... a BRCA1 locus-related gene". Gene. 248 (1-2): 99-107. doi:10.1016/S0378-1119(00)00141-4. PMID 10806355. ... The gene PSMC3 encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity ... "Entrez Gene: PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3". "Uniprot: P17980 - PRS6A_HUMAN". Le Tallec B, ... A pseudogene has been identified on chromosome 9. The human PSMC3 gene has 12 exons and locates at chromosome band 11p11.2. The ...
*  Cyclin D1
"ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo". Cancer Research. 67 (9): 4364-72. doi: ... The CCND1 gene encodes the cyclin D1 protein. The human CCNDI gene is located on the long arm of chromosome 11 (band 11q13). It ... "Entrez Gene: CCND1 cyclin D1". He Y, Liu Z, Qiao C, Xu M, Yu J, Li G (Jan 2014). "Expression and significance of Wnt signaling ... "CCND1" Gene". GeneCards. "Weizmann Institute of Science". 2013. Retrieved May 6, 2015. Withers DA, Harvey RC, Faust JB, Melnyk ...
*  PTGES3
Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene. 229 (1-2): 215-221. doi:10.1016/S0378- ... The protein encoded by this gene is also known as p23 which functions as a chaperone which is required for proper functioning ... Prostaglandin E synthase 3 (cytosolic) is an enzyme that in humans is encoded by the PTGES3 gene. ... Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome ...
*  ERBB3
1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0 ... Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene. 229 (1-2): 215-21. doi:10.1016/S0378-1119 ... 1996). "Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study ... Citri A, Skaria KB, Yarden Y (2003). "The deaf and the dumb: the biology of ErbB-2 and ErbB-3". Exp. Cell Res. 284 (1): 54-65. ...
*  NDRG1
Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene. This gene is a member of the N-myc downregulated gene ... Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways". J. Biol. Chem. 291 (3): 1029- ... doi:10.1016/j.gene.2008.03.002. PMID 18455888. "Entrez Gene: NDRG1 N-myc downstream regulated gene 1". Kachhap SK, Faith D, ... 2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol ...
*  Tumour heterogeneity
Sauter, G; Moch, H; Gasser, T. C.; Mihatsch, M. J.; Waldman, F. M. (1995). "Heterogeneity of chromosome 17 and erbB-2 gene copy ... Allows for the analysis of specific genes (i.e. driver genes, tumour suppressors). The process is simple with straightforward ... Similarly, MTOR, a gene encoding a cell regulatory kinase, has shown to be constitutively active, thereby increasing S6 ... It is important to avoid contamination of non-malignant cells to ensure an accurate representation of gene expression and ...
*  Neuregulin 3
2007). "Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to ... Neuregulin 3 also known as NRG3 is a member of the neuregulin protein family which in humans is encoded by the NRG3 gene. NRG3 ... 2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and ... 2000). "Human NRG3 gene Map position 10q22-q23". Chromosome Res. 8 (6): 560. doi:10.1023/A:1009232025144. PMID 11032326. ...
*  List of intestinal stem cell marker genes
"The Pan-ErbB Negative Regulator Lrig1 is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor". Cell. 149 (1): ... "PW1 gene/paternally expressed gene 3 (PW1/Peg3) identifies multiple adult stem and progenitor cell populations". Proceedings of ... Below, a table of intestinal stem cell "marker" genes is given, along with a notation if this marks active of CBC stem cells, ... The following is a list of intestinal stem cell marker genes, including their name and known function. In the adult intestine, ...
*  Ki-67 (protein)
Bánkfalvi A (November 2000). "Comparative methodological analysis of erbB-2/HER-2 gene dosage, chromosomal copy number and ... Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by ... "Entrez Gene: Antigen identified by monoclonal antibody Ki-67". Schonk DM, Kuijpers HJ, van Drunen E, van Dalen CH, Geurts van ... Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 7 (12): 1231-42. doi:10.1046/j.1365-2443.2002.00596.x. PMID ...
*  Zinc finger transcription factor
Beerli RR, Segal DJ, Dreier B, Barbas CF (1998). "Toward controlling gene expression at will: specific regulation of the erbB-2 ... Zinc finger protein transcription factors can be encoded by genes small enough to fit a number of such genes into a single ... engineered ZF-TFs have enormous therapeutic potential including correction of abnormal gene expression profiles (e.g., erbB-2 ... genes in order to control the transcription of all these genes with a single transcription factor. Also, it is possible to ...
*  ETV4
"The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for ... "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)". Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, ... Urano F, Umezawa A, Hong W, Kikuchi H, Hata J (Feb 1996). "A novel chimera gene between EWS and E1A-F, encoding the adenovirus ... Coutte L, Monté D, Baert J, de Launoit Y (Nov 1999). "Genomic organization of the human e1af gene,a member of Ets transcription ...
*  CIC (gene)
Lee CJ, Chan WI, Scotting PJ (Jun 2005). "CIC, a gene involved in cerebellar development and ErbB signaling, is significantly ... "Entrez Gene: CIC capicua transcriptional repressor [ Homo sapiens (human) ]". Human CIC genome location and CIC gene details ... Protein capicua homolog is a protein that in humans is encoded by the CIC gene. GRCh38: Ensembl release 89: ENSG00000079432 - ... 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from ...
*  ERBB4
Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced ... ErbB-2, ErbB-3 and ErbB-4". Oncogene. 15 (23): 2841-8. doi:10.1038/sj.onc.1201458. PMID 9419975. Check date values in: ,year ... "Localization of the human HER4/erbB-4 gene to chromosome 2". Oncogene. 10 (6): 1235-7. PMID 7700649. Sardi SP, Murtie J, ... "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0. PMID ...
*  Neuregulin 2
1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0 ... 2000). "Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA". Gene. 255 (1): ... "Entrez Gene: NRG2 neuregulin 2". Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family ... The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the ...
*  GRB7
These two genes are commonly co-amplified (present in excess copies) in breast cancers. GRB7 thought to be involved in ... "Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer". Biochemical and Biophysical ... The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor ... This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ...
*  60S ribosomal protein L19
Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the ... "High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2". Cancer Res. 53 (6): 1403-8 ... As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through ... Davies B, Fried M (1995). "The L19 ribosomal protein gene (RPL19): gene organization, chromosomal mapping, and novel promoter ...
*  CBLB (gene)
Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1: ... CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family. ... "Entrez Gene: CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b". Wallner S, Gruber T, Baier G, Wolf D (2012 ... Human CBLB genome location and CBLB gene details page in the UCSC Genome Browser. Fang N, Fang D, Wang HY, et al. (2002). " ...
*  Neuregulin 1
... gene with schizophrenia". Hum. Mol. Genet. 15 (12): 1995-2002. doi:10.1093/hmg/ddl122. PMID 16687441. Gene Overview of All ... Britsch S (2007). "The neuregulin-I/ErbB signaling system in development and disease". Adv Anat Embryol Cell Biol. Advances in ... doi:10.1016/j.gene.2004.07.029. PMID 15527969. Liu X, Bates R, Yin DM, Shen C, Wang F, Su N, Kirov SA, Luo Y, Wang JZ, Xiong WC ... "Entrez Gene: NRG1 Neuregulin 1". Agarwal A, Zhang M, Trembak-Duff I, Unterbarnscheidt T, Radyushkin K, Dibaj P, Martins de ...
*  TMEFF2
"Entrez Gene: TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2". Maruyama K, Sugano S (January 1994 ... "A novel epidermal growth factor-like molecule containing two follistatin modules stimulates tyrosine phosphorylation of erbB-4 ... Liang G, Robertson KD, Talmadge C, Sumegi J, Jones PA (September 2000). "The gene for a novel transmembrane protein containing ... Tomoregulin-2 is a protein that in humans is encoded by the TMEFF2 gene. GRCh38: Ensembl release 89: ENSG00000144339 - Ensembl ...
*  Akt/PKB signaling pathway
Studies have identified gene amplification of the Akt isoforms in many types of cancer, including glioblastoma, ovarian, ... Toulany M, Rodemann HP (2013). "Potential of Akt mediated DNA repair in radioresistance of solid tumors overexpressing erbB- ... HIF promotes gene expression of VEGF and glycolytic enzymes, allowing metabolism in oxygen-depleted environments. In cancer ... Liu W, Shen SM, Zhao XY, Chen GQ (2012). "Targeted genes and interacting proteins of hypoxia inducible factor-1". Int J Biochem ...
*  Thomas Graf (biologist)
Graf, Thomas; Beug, Hartmut (1983-08-01). "Role of the v-erbA and v-erbB oncogenes of avian erythroblastosis virus in erythroid ... Genes & Development. 9 (10): 1250-1262. ISSN 0890-9369. PMID 7758949. Xie, Huafeng; Ye, Min; Feng, Ru; Graf, Thomas (2004-05-28 ... Genes & Development. 1 (3): 277-286. ISSN 0890-9369. PMID 2824281. Graf, Thomas (2011-12-02). "Historical Origins of ... Feng, R.; Desbordes, S. C.; Xie, H.; Tillo, E. S.; Pixley, F.; Stanley, E. R.; Graf, T. "PU.1 and C/EBP / convert fibroblasts ...
*  Neuregulin
The NRG1 gene has been identified as a potential gene determining susceptibility to schizophrenia by a combination of genetic ... In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4 ... doi:10.1016/j.gene.2004.07.029. PMID 15527969. Lemke G, Zhou M, Ghosh S, Harvey RP, Gulcher JR, Stefansson K, Gurney ME, ... ARIA plays a role in synapse development, influencing the upregulation of acetylcholine receptor genes beneath the endplate ...
*  Receptor tyrosine kinase
Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are ... A gene for a fifth FGFR protein, FGFR5, has also been identified. In contrast to FGFRs 1-4, it lacks a cytoplasmic tyrosine ... The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor ... In mice, loss of signaling by any member of the ErbB family results in embryonic lethality with defects in organs including the ...
*  Afatinib
It is mainly used to treat cases of NSCLC that harbour mutations in the epidermal growth factor receptor (EGFR) gene. It has ... an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab". ... In May 2012, the Phase IIb/III trial Lux-Lung 1 came to the same conclusion. In January 2015 a Phase III trial in people with ... doi:10.1007/s10549-012-2126-1. PMC 3409367 . PMID 22763464. Cite error: A list-defined reference named "cancergrace" is not ...