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*  ERRFI1
ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is a Cytoplasmic protein ... "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking ... "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 ... Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O (Sep 2002). "Expression of RALT, a feedback inhibitor of ErbB ...
*  ERBB4
Receptor tyrosine-protein kinase erbB-4 is an enzyme that in humans is encoded by the ERBB4 gene. Alternatively spliced ... ErbB-2, ErbB-3 and ErbB-4". Oncogene. 15 (23): 2841-8. doi:10.1038/sj.onc.1201458. PMID 9419975. Check date values in: ,year ... "Localization of the human HER4/erbB-4 gene to chromosome 2". Oncogene. 10 (6): 1235-7. PMID 7700649. Sardi SP, Murtie J, ... "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0. PMID ...
*  Plakoglobin
Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S (Mar 1995). "c-erbB-2 gene product directly ... The JUP gene contains 13 exons spanning 17 kb on chromosome 17q21. Plakoglobin is a member of the catenin family, since it ... Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. ... Arnemann J, Spurr NK, Wheeler GN, Parker AE, Buxton RS (Jul 1991). "Chromosomal assignment of the human genes coding for the ...
*  HER2/neu
Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. ERBB2, a known proto- ... Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S (March 1995). "c-erbB-2 gene product directly ... ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. ... Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE (September 1998). "ErbB-1 and ErbB-2 acquire distinct ...
*  Beta-catenin
Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S (March 1995). "c-erbB-2 gene product directly ... gene 1) gene transcription is regulated by wnt4 in the female developing gonad". Molecular Endocrinology. 17 (4): 507-19. doi: ... encoded by the tumour-suppressing APC gene. Therefore, genetic mutation of the APC gene is also strongly linked to cancers, and ... Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene. β-catenin is a dual ...
*  Tumour heterogeneity
Sauter, G; Moch, H; Gasser, T. C.; Mihatsch, M. J.; Waldman, F. M. (1995). "Heterogeneity of chromosome 17 and erbB-2 gene copy ... Allows for the analysis of specific genes (i.e. driver genes, tumour suppressors). The process is simple with straightforward ... Similarly, MTOR, a gene encoding a cell regulatory kinase, has shown to be constitutively active, thereby increasing S6 ... It is important to avoid contamination of non-malignant cells to ensure an accurate representation of gene expression and ...
*  Neuregulin 3
2007). "Interactions among genes in the ErbB-Neuregulin signalling network are associated with increased susceptibility to ... Neuregulin 3 also known as NRG3 is a member of the neuregulin protein family which in humans is encoded by the NRG3 gene. NRG3 ... 2008). "ErbB/HER ligands in human breast cancer, and relationships with their receptors, the bio-pathological features and ... 2000). "Human NRG3 gene Map position 10q22-q23". Chromosome Res. 8 (6): 560. doi:10.1023/A:1009232025144. PMID 11032326. ...
*  List of MeSH codes (G14)
... genes, erbb MeSH G14.340.024.340.383.500.791.295.300 --- genes, erbb-1 MeSH G14.340.024.340.383.500.791.295.305 --- genes, erbb ... genes, nef MeSH G14.340.400.500.667 --- genes, pol MeSH G14.340.400.500.735 --- genes, px MeSH G14.340.400.500.775 --- genes, ... genes, viral MeSH G14.340.400.500.172 --- genes, env MeSH G14.340.400.500.258 --- genes, gag MeSH G14.340.400.500.345 --- genes ... genes, helminth MeSH G14.340.357.500 --- genes, insect MeSH G14.340.365.500 --- genes, plant MeSH G14.340.375.500 --- genes, ...
*  ERBB3
1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0 ... Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene. 229 (1-2): 215-21. doi:10.1016/S0378-1119 ... 1996). "Expression of c-erbB family gene products in adenoid cystic carcinoma of salivary glands: an immunohistochemical study ... Citri A, Skaria KB, Yarden Y (2003). "The deaf and the dumb: the biology of ErbB-2 and ErbB-3". Exp. Cell Res. 284 (1): 54-65. ...
*  ErbB
In humans, the family includes Her1 (EGFR, ErbB1), Her2 (Neu, ErbB2), Her3 (ErbB3), and Her4 (ErbB4). The gene symbol, ErbB, is ... ErbB-1), 1S78 (ErbB-2), 1M6B (ErbB-3) and 2AHX (ErbB-4): The four members of the ErbB protein family are capable of forming ... Excessive ErbB signaling is associated with the development of a wide variety of types of solid tumor. ErbB-1 and ErbB-2 are ... The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named ...
*  ETV4
"The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for ... "Entrez Gene: ETV4 Ets variant gene 4 (E1A enhancer binding protein, E1AF)". Friedman LS, Ostermeyer EA, Lynch ED, Welcsh P, ... Urano F, Umezawa A, Hong W, Kikuchi H, Hata J (Feb 1996). "A novel chimera gene between EWS and E1A-F, encoding the adenovirus ... Coutte L, Monté D, Baert J, de Launoit Y (Nov 1999). "Genomic organization of the human e1af gene,a member of Ets transcription ...
*  Neuregulin 2
1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. doi:10.1038/387509a0 ... 2000). "Characterization of the human NTAK gene structure and distribution of the isoforms for rat NTAK mRNA". Gene. 255 (1): ... "Entrez Gene: NRG2 neuregulin 2". Chang H, Riese DJ, Gilbert W, Stern DF, McMahan UJ (May 1997). "Ligands for ErbB-family ... The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the ...
*  CIC (gene)
Lee CJ, Chan WI, Scotting PJ (Jun 2005). "CIC, a gene involved in cerebellar development and ErbB signaling, is significantly ... "Entrez Gene: CIC capicua transcriptional repressor [ Homo sapiens (human) ]". Human CIC genome location and CIC gene details ... Protein capicua homolog is a protein that in humans is encoded by the CIC gene. GRCh38: Ensembl release 89: ENSG00000079432 - ... 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from ...
*  Stuart A. Aaronson
His discovery of erbB2 as a v-erbB-related gene amplified in a human breast carcinoma and the demonstration of its transforming ... The New York Times, September 28, 1983 Cancer Gene Linked to Flaws in Growth of an Ordinary Cell. The New York Times, February ... 2007). "CDIP, a novel pro-apoptotic gene, regulates TNFalpha-mediated apoptosis in a p53-dependent manner". The EMBO Journal. ... Current research includes investigations into the mechanisms by which tumor suppressor genes induce permanent growth arrest/ ...
*  PSMC3
"Induction of the Tat-binding protein 1 gene accompanies the disabling of oncogenic erbB receptor tyrosine kinases". Proc. Natl ... a BRCA1 locus-related gene". Gene. 248 (1-2): 99-107. doi:10.1016/S0378-1119(00)00141-4. PMID 10806355. ... The gene PSMC3 encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity ... "Entrez Gene: PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3". "Uniprot: P17980 - PRS6A_HUMAN". Le Tallec B, ...
*  Cyclin D1
"ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo". Cancer Research. 67 (9): 4364-72. doi: ... The CCND1 gene encodes the cyclin D1 protein. The human CCNDI gene is located on the long arm of chromosome 11 (band 11q13). It ... "Entrez Gene: CCND1 cyclin D1". He Y, Liu Z, Qiao C, Xu M, Yu J, Li G (Jan 2014). "Expression and significance of Wnt signaling ... "CCND1" Gene". GeneCards. "Weizmann Institute of Science". 2013. Retrieved May 6, 2015. Withers DA, Harvey RC, Faust JB, Melnyk ...
*  Ki-67 (protein)
Bánkfalvi A (November 2000). "Comparative methodological analysis of erbB-2/HER-2 gene dosage, chromosomal copy number and ... Antigen KI-67 also known as Ki-67 or MKI67 is a protein that in humans is encoded by the MKI67 gene (antigen identified by ... "Entrez Gene: Antigen identified by monoclonal antibody Ki-67". Schonk DM, Kuijpers HJ, van Drunen E, van Dalen CH, Geurts van ... Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 7 (12): 1231-42. doi:10.1046/j.1365-2443.2002.00596.x. PMID ...
*  PTGES3
Yoo JY, Hamburger AW (1999). "Interaction of the p23/p198 protein with ErbB-3". Gene. 229 (1-2): 215-221. doi:10.1016/S0378- ... The protein encoded by this gene is also known as p23 which functions as a chaperone which is required for proper functioning ... Prostaglandin E synthase 3 (cytosolic) is an enzyme that in humans is encoded by the PTGES3 gene. ... Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome ...
*  CBLB (gene)
Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1: ... CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family. ... "Entrez Gene: CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence b". Wallner S, Gruber T, Baier G, Wolf D (2012 ... Human CBLB genome location and CBLB gene details page in the UCSC Genome Browser. Fang N, Fang D, Wang HY, et al. (2002). " ...
*  Zinc finger transcription factor
Beerli RR, Segal DJ, Dreier B, Barbas CF (1998). "Toward controlling gene expression at will: specific regulation of the erbB-2 ... Zinc finger protein transcription factors can be encoded by genes small enough to fit a number of such genes into a single ... engineered ZF-TFs have enormous therapeutic potential including correction of abnormal gene expression profiles (e.g., erbB-2 ... genes in order to control the transcription of all these genes with a single transcription factor. Also, it is possible to ...
*  NDRG1
N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic ... Gene. 417 (1-2): 5-12. doi:10.1016/j.gene.2008.03.002. PMID 18455888. "Entrez Gene: NDRG1 N-myc downstream regulated gene 1". ... Protein NDRG1 is a protein that in humans is encoded by the NDRG1 gene. This gene is a member of the N-myc downregulated gene ... 2002). "Characterization and expression of three novel differentiation-related genes belong to the human NDRG gene family". Mol ...
*  GATA3
Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. GATA-3 is one of the ... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... "Entrez Gene: GATA3 GATA binding protein 3". Kouros-Mehr H, Slorach EM, Sternlicht MD, Werb Z (Dec 2006). "GATA-3 maintains the ... Transcription factor GATA-3 is a protein that in humans is encoded by the GATA3 gene. GATA-3 belongs to the GATA family of ...
*  FOXA1
Mutations in this gene have been recurrently seen in instances of prostate cancer. GRCh38: Ensembl release 89: ENSG00000129514 ... supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB ... Mincheva A, Lichter P, Schütz G, Kaestner KH (1997). "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, - ... 2009). "Role of FOXA in mitochondrial citrate carrier gene expression and insulin secretion". Biochem. Biophys. Res. Commun. ...
*  Ras subfamily
The three human ras genes encode extremely similar proteins made up of chains of 188 to 189 amino acids. Their gene symbols are ... Oncogenes such as p210BCR-ABL or the growth receptor erbB are upstream of Ras, so if they are constitutively activated their ... "Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on ... "Human genome contains four genes homologous to transforming genes of Harvey and Kirsten murine sarcoma viruses". Proc. Natl. ...
*  Index of biochemistry articles
... erbA gene - erbB gene - erbB-2 gene - erbB-2 receptor - erythropoietin - erythropoietin receptor - Essential amino acid - Ester ... gene - gene expression - gene pool - gene regulatory network - genetic carrier - genetic code - genetic drift - Genetic ... fms gene - Formaldehyde - fos gene - free energy - freezing point - FSH receptor - functional group - fungal protein - fungi - ... end ABC-Transporter Genes - abl gene - acetic acid - acetyl CoA - acetylcholine - acetylcysteine - acid - acidic fibroblast ...
*  Afatinib
It is mainly used to treat cases of NSCLC that harbour mutations in the epidermal growth factor receptor (EGFR) gene. It has ... an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab". ...