Loading...
*  Breast cancer classification
These co-expressing clusters have included hormone receptor-related genes, HER2-related genes, a group of basal-like genes, and ... BRCA1 and BRCA2 polymorphic variants can increase the risk of breast cancer, and these cancers tend to express a pr ofile of ... The MammaPrint gene pattern is a commercial-stage 70-gene panel marketed by Agendia, that was developed in patients under age ... Although these gene-expression profiles look at different individual genes, they seem to classify a given tumor into similar ...
*  Male breast cancer
In familial cases, male BRCA2 carriers are at higher risk, rather than BRCA1 carriers. With the relative infrequency of male ... Estrogen receptor and progesterone receptor status and HER2/neu (Human Epidermal Growth Factor Receptor 2) gene amplification ... and BRCA1 mutation being in the minority. "Male Breast Cancer Treatment". National Cancer Institute. 2006. Retrieved 2010-05-14 ...
*  RAD52
Of 21 genes in the homologous recombinational repair pathway and 7 genes in the non-homologous end joining pathway examined, ... Chun J, Buechelmaier ES, Powell SN (2013). "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2- ... "Cloning of human and mouse genes homologous to RAD52, a yeast gene involved in DNA repair and recombination". Mutation Research ... This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing ...
*  Biological patent
Corderoy, Amy (March 4, 2013). "BRCA1 gene patent ruling to be appealed". Sydney Morning Herald. Retrieved June 14, 2013. ... Corderoy, Amy (February 15, 2013). "Landmark patent ruling over breast cancer gene BRCA1". Sydney Morning Herald. Retrieved ... ruled in the Federal Court of Australia in favour of a Myriad Genetics patent on the BRCA1 gene. This was a landmark ruling, ... making it unlikely that many countries will prohibit patents on genes altogether. Some[who?] say that patenting genes only ...
*  BRCA2
... invalidating Myriad's patents on the BRCA1 and BRCA2 genes. However, the Court also held that manipulation of a gene to create ... "Pathology and gene expression of hereditary breast tumors associated with BRCA1, BRCA2 and CHEK2 gene mutations". Oncogene. 25 ... BRCA1 and BRCA2 have been described as "breast cancer susceptibility genes" and "breast cancer susceptibility proteins". The ... Chan KY, Ozçelik H, Cheung AN, Ngan HY, Khoo US (2002). "Epigenetic factors controlling the BRCA1 and BRCA2 genes in sporadic ...
*  Cancer biomarkers
... mutations of genes BRCA1 and BRCA2 for breast and ovarian cancer; abnormal methylation of tumor suppressor genes p16, CDKN2B, ... When these two chromosomes combine they create a cancer-causing gene known as BCR-ABL. In such patients, this gene acts as the ... An example is the gene encoding the enzyme thiopurine methyl-transferase (TPMPT). Individuals with mutations in the TPMT gene ... Oncotype DX looks at a panel of 21 genes in cells taken during tumor biopsy. The results of the test are given in the form of a ...
*  Association for Molecular Pathology v. Myriad Genetics, Inc.
Had Myriad created an innovative method of manipulating genes while searching for the BRCA1 and BRCA2 genes, it could possibly ... The same issue, namely the patentability of the DNA sequence in the BRCA1 gene, was considered in a February 2013 case in the ... Similarly, this case does not involve patents on new applications of knowledge about the BRCA1 and BRCA2 genes. Judge Bryson ... In 1996, Myriad launched their BRACAnalysis product, which detects certain mutations in the BRCA1 and BRCA2 genes that put ...
*  ARL4D
"Comparison of the positional cloning methods used to isolate the BRCA1 gene". Human Molecular Genetics. 4 (8): 1259-66. doi: ... Human ARL4D genome location and ARL4D gene details page in the UCSC Genome Browser. Human ARL6 genome location and ARL6 gene ... "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi:10.1126/ ... Mutations in this gene have been associated with Bardet-Biedl syndrome (BBS). Model organisms have been used in the study of ...
*  PSME3
"A physical map and candidate genes in the BRCA1 region on chromosome 17q12-21". Nat Genet. 7 (4): 472-9. doi:10.1038/ng0894-472 ... PSME3 human gene location in the UCSC Genome Browser. PSME3 human gene details in the UCSC Genome Browser.. ... "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259-66. doi:10.1093/hmg/ ... "Molecular cloning and expression pattern of genes from a 470 Kb region near BRCA1 locus on chromosome 17q21". Oncogene. 11 (5 ...
*  Neutrophil cytosolic factor 1
"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi:10.1126/ ... Mutations in this gene have been associated with chronic granulomatous disease. Genetic variability in the NCF1 gene has been ... Neutrophil cytosol factor 1, also known as p47phox, is a protein that in humans is encoded by the NCF1 gene. The protein ... Gene. 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Izuhara K, Arinobu Y, Sumimoto H, Nunoi H, Takeya R, ...
*  Myriad Genetics
... invalidating Myriad's patents on the BRCA1 and BRCA2 genes. However, the Court also held that manipulation of a gene to create ... Two of the company's patents on the BRCA1 and BRCA2 genes were ruled invalid on March 29, 2010 by Judge Robert W. Sweet in the ... In 2013, the actress Angelina Jolie had her ovaries removed because she tested positive for a mutation in the BRCA1 gene. This ... Myriad's discovery of the breast cancer gene, BRCA1 was universally acclaimed as a monumental achievement: "There is no more ...
*  NBR1
Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene. The protein encoded by this gene was ... This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three ... "Entrez Gene: NBR1 neighbor of BRCA1 gene 1". Kirkin, Vladimir (2009). "A Role for Ubiquitin in Selective Autophagy". Molecular ... "Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes". Gene. 262 (1-2): 89-98. doi: ...
*  VAT1
1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259-66. doi: ... 1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi: ... 1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2 ... "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1". Genome Res. 6 (11): 1029-49. doi: ...
*  60S ribosomal protein L27
1995). "Comparison of the positional cloning methods used to isolate the BRCA1 gene". Hum. Mol. Genet. 4 (8): 1259-66. doi: ... 1994). "A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1". Science. 266 (5182): 66-71. doi: ... Uechi T, Tanaka T, Kenmochi N (2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the ... As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through ...
*  IFI35
... and identification of genes within a 500-kb region containing BRCA1". Proceedings of the National Academy of Sciences of the ... "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1". Genome Research. 6 (11): 1029-49. doi ... Interferon-induced 35 kDa protein is a protein that in humans is encoded by the IFI35 gene. IFI35 has been shown to interact ... "Entrez Gene: IFI35 interferon-induced protein 35". Chen J, Shpall RL, Meyerdierks A, Hagemeier M, Böttger EC, Naumovski L ( ...
*  BRCA1P1
BRCA1 pseudogene 1 is a protein that in humans is encoded by the BRCA1P1 gene. "Human PubMed Reference:". "Entrez Gene: BRCA1 ...
*  Rnd2
The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. ... "Entrez Gene: RND2 Rho family GTPase 2". "Entrez Gene: RND1 Rho family GTPase 1". Wennerberg K, Forget MA, Ellerbroek SM, Arthur ... "Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1". Genome Res. 6 (11): 1029-49. doi: ... It is encoded by the gene RND2. It contributes to regulating the organization of the actin cytoskeleton in response to ...
*  NBR2
... is a gene best known for its location near the breast cancer associated gene BRCA1. Like BRCA1, NBR2 has been a subject of ... "Isolation and characterisation of the NBR2 gene which lies head to head with the human BRCA1 gene". Hum. Mol. Genet. 6 (7): ... NBR2 human gene location in the UCSC Genome Browser. NBR2 human gene details in the UCSC Genome Browser.. ... Xiao, Zhen-Dong; Liu, Xiaowen; Zhuang, Li; Gan, Boyi (2016-07-03). "NBR2: A former junk gene emerges as a key player in tumor ...
*  Ovarian cancer
BRCA1 and BRCA2 are essential for homologous recombination DNA repair, and germline mutations in these genes are found in about ... The major genetic risk factor for ovarian cancer is a mutation in BRCA1 or BRCA2 DNA mismatch repair genes, which is present in ... About 10% of cases are related to inherited genetic risk; women with mutations in the genes BRCA1 or BRCA2 have about a 50% ... Overall, the most common gene mutations in ovarian cancer occur in NF1, BRCA1, BRCA2, and CDK12. Type I ovarian cancers, which ...
*  RNA splicing
For instance, DNA damages modulate the alternative splicing of the DNA repair genes Brca1 and Ercc1. Splicing events can be ... Introns are found in the genes of most organisms and many viruses. They can be located in a wide range of genes, including ... between two exons of a gene. The term intron refers to both the DNA sequence within a gene and the corresponding sequence in ... A quantifiable method for gene knockdown". Genesis. 30 (3): 154-6. doi:10.1002/gene.1053. PMID 11477696. Sazani, Peter; Kang, ...
*  IP Australia
The patent claims the human BRCA1 gene. This patent provided the opportunity to test the legal validity of gene patents in the ... "The Gene Patents Case". Institute for Ethics and Emerging Technologies. Retrieved 13 April 2010. John Michael Keogh (2 August ... "In vivo mutations and polymorphisms in the 17q-linked breast and ovarian cancer susceptibility gene" (PDF). IP Australia. ... "In vivo mutations and polymorphisms in the 17q-linked breast and ovarian cancer susceptibility gene", invented by Donna M ...
*  BRAT1
"Entrez Gene: BRCA1-associated ATM activator 1". Human BRAT1 genome location and BRAT1 gene details page in the UCSC Genome ... BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene. The protein encoded by this ... The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. GRCh38: ... ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia ...
*  Loss of heterozygosity
The genes BRCA1 and BRCA2 show loss of heterozygosity in samplings of tumors from patients who have germline mutations. BRCA1/2 ... The remaining copy of the tumor suppressor gene can be inactivated by a point mutation, leaving no tumor suppressor gene to ... When allelic gene conversion removes the major allele at these sites organisms are likely to experience a mild decline in ... Genes Chromosomes Cancer. 2008 Mar;47(3):221-37. Tucker AE, Ackerman MA, Eads BD, Xu S, Lynch M. Population-genomic insights ...
*  Genetic testing
Hereditary breast cancer along with ovarian cancer syndrome are caused by gene alterations in the genes BRCA1 and BRCA2. Major ... Li-Fraumeni syndrome is caused by a gene alteration on the gene TP53. Cancer types associated with a mutation on this gene ... Research testing includes finding unknown genes, learning how genes work and advancing our understanding of genetic conditions ... Mutations in the BCHE gene lead to deficiency in the amount or function of the protein, which in turn results in a delay in the ...
*  DNA damage theory of aging
also showed that expression of four key DNA repair genes that are necessary for homologous recombinational repair (BRCA1, MRE11 ... Women with an inherited mutation in the DNA repair gene BRCA1 undergo menopause prematurely, suggesting that naturally ... This led to the identification of a set of genes whose expression was altered after age 40. These genes play central roles in ... The longer-lived species, humans and naked mole rats expressed DNA repair genes, including core genes in several DNA repair ...
*  ABL (gene)
Abl gene has been shown to interact with: ABI1, ABI2, ABL2, ATM, BCAR1, BCR, BRCA1, CAT, CBL, CRKL, DOK1, EPHB2, GPX1, GRB10, ... This gene is a partner in a fusion gene with the BCR gene in the Philadelphia chromosome, a characteristic abnormality in ... The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes, leading to a fusion gene present in ... Mutations in the ABL1 gene are associated with chronic myelogenous leukemia (CML). In CML, the gene is activated by being ...
*  Premature ovarian failure
"Premature menopause in patients with BRCA1 gene mutation". Breast Cancer Res. Treat. 100 (1): 59-63. doi:10.1007/s10549-006- ... In addition to BRCA1, the MCM8-MCM9 protein complex also plays a crucial role in the recombinational repair of DNA double- ... BRCA1 protein plays an essential role in the repair of DNA double-strand breaks by homologous recombination. Women with a ... BRCA1 mutations are associated with occult primary ovarian insufficiency. Impairment of the repair of DNA double-strand breaks ...