Leaf spot disease is usually caused by a fungus, but can also be caused by bacteria (e.g. S. proteamaculans). Leaf spot disease ... Serratia utilizes a metabolic enzyme, ADP glucose pyrophosphorylase, with distinct kinetic properties from those found in ... Joshi, Sadhna; Kozlowski, Maya (1987), "Cloning of Serratia Liquefaciens Chitinase Gene(s)", Molecular genetics of plant- ... and skin and soft tissues and other ailments that are commonly caused by other bacteria. Outbreaks of S. marcescens meningitis ...
Research into neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and ... All non-spherical bacteria have genes encoding actin-like proteins, and these proteins form a helical network beneath the cell ... Keratin intermediate filaments in epithelial cells provide protection for different mechanical stresses the skin may endure. ... They also provide protection for organs against metabolic, oxidative, and chemical stresses. Strengthening of epithelial cells ...
Patients with autoimmune diseases also often have a unique gene signature and certain environmental risk factors that ... for more information, see Immune tolerance in pregnancy). The skin and digestive tract of humans and many other organisms is ... There is an accumulation of metabolic enzymes that suppress T cell proliferation and activation, including IDO and arginase, ... Break in this tolerance is thought to underlie the pathogenesis of inflammatory bowel diseases like Crohn's disease and ...
... as it led to the discovery of skin sensors for temperature and touch, and identification of the single gene causing sensitivity ... First, capsaicin inhibits the metabolic rate of the cells that make up the fungal biofilm. This inhibits the area and growth ... May 2017). "Fungal Biofilms and Polymicrobial Diseases". Journal of Fungi. 3 (2): 22. doi:10.3390/jof3020022. PMC 5715925. PMID ... They cause burning or stinging pain to the skin and, if ingested in large amounts by adults or small amounts by children, can ...
The immediate metabolic precursor to 5(S)-HETE, 5(S)-hydroperoxy-6S,8Z,11Z,14Z-eicosatetraenoic acid 5(S)-HpETE, can be ... Furthermore, 5-oxo-ETE appears to be involved in various animal and human reactions: injected into the skin of rabbits, it ... Studies therefore suggest that 5-HEDH contributes to the development and progression of these reactions and diseases by being ... for its gene, of in pure form; furthermore, most studies on it have been conducted in human tissues. The substrate specificity ...
"Age-related transcriptional changes in gene expression in different organs of mice support the metabolic stability theory of ... Aging And Disease. 2010;1(2) 75-88. Pérez VI, Bokov A, Van Remmen H, Mele J, Ran Q, Ikeno Y, et al. (2009). "Is the oxidative ... Herrling T, Jung K, Fuchs J (2008). "The role of melanin as protector against free radicals in skin and its role as free ... The metabolic stability theory of aging suggests it is the cells ability to maintain stable concentration of ROS which is the ...
Vynohradova SV (2005). "[The role of angiotensin-converting enzyme gene I/D polymorphism in development of metabolic disorders ... Serum levels are decreased in renal disease, obstructive pulmonary disease, and hypothyroidism. The angiotensin converting ... processing of the proopiomelanocortin peptides adrenocorticotropin and alpha-melanocyte-stimulating hormone in the skin". ... Role of angiotensin-converting enzyme gene polymorphism in the development of metabolic syndrome]. Terapevticheskii Arkhiv (in ...
Ustic acid, a metabolic product of Aspergillus ustus (Bainier) Thom & Church". Biochemical Journal. 48 (1): 53-66. doi:10.1042/ ... Although disseminated infection carries a high mortality rate, the response of skin to treatment varies depending on the degree ... It only rarely found to cause serious infection (e.g., endocarditis, pneumonia, disseminated disease), typically as an ... A phylogenetic study of Aspergillus section Usti using morphology, secondary metabolite chemistry and gene sequencing (beta- ...
The extra oxalate can also build up, and damage other parts of the body, including eyes, heart, skin, and bone. This is called ... This results in reduction of urinary and plasma oxalate levels, the underlying cause of disease manifestations in people with ... "FDA Approves First Drug to Treat Rare Metabolic Disorder". U.S. Food and Drug Administration (FDA) (Press release). 23 November ... the mechanism of action of lumasiran is independent of the underlying AGXT gene mutation. Lumasiran was approved for medical ...
"ATP7A gene addition to the choroid plexus results in long-term rescue of the lethal copper transport defect in a Menkes disease ... high forehead Looseness of skin and "double jointed" Inguinal hernias Twisting of blood vessels Bladder diverticula ... clinical features and treatments of congenital copper metabolic disorders--focus on neurologic aspects". Brain & Development. ... the other 1/3 do not have the disease in their family history. Since the disorder is X-linked recessive the disease affects ...
A 2006 study showed other mutations found in the MMP2 gene. This has led to the belief that there are many similar diseases ... Many individuals experience leathery skin where the skin appears dark and thick. Excessive hair growth is known to be found in ... Articles with short description, Short description is different from Wikidata, Inborn errors of metabolism, Metabolic disorders ... Increased uronic acid is demonstrated in cultured fibroblasts from the skin and to a lesser degree in both parents. Despite ...
Stiehm ER (January 2006). "Disease versus disease: how one disease may ameliorate another". Pediatrics. 117 (1): 184-91. doi: ... Running efficiency in women, and birth canal size Encephalization, and gut size Skin pigmentation protection from UV, and the ... Howard RS, Lively CM (November 2004). "Good vs complementary genes for parasite resistance and the evolution of mate choice". ... so a modern sedentary lifestyle may continuously cue the body to trigger life preserving metabolic and stress-related responses ...
... deficiency is associated with an increased risk of metabolic syndrome, cardiovascular disease and mortality, which ... It can be administered as a cream or transdermal patch that is applied to the skin, by injection into a muscle, as a tablet ... It activates genes in Sertoli cells, which promote differentiation of spermatogonia. It regulates acute HPA (hypothalamic- ... Goldman D, Lappalainen J, Ozaki N. Direct analysis of candidate genes in impulsive disorders. In: Bock G, Goode J, eds. ...
This work is the first in silico report of an integrative model that comprises the QS gene regulatory network and the metabolic ... With bacterial vascular diseases, the infection is spread within the plants through the xylem. Once within the plant, the ... skin (Staphylococcus) or the urinary tract (Escherichia and Pseudomonas). Such bacteria may colonise wounds (Vibrio and ... To carry out this study, a metabolic network model of P. aeruginosa was built based on the iMO1056 model, the genomic ...
Implications for Animal Models and Human Gene Therapy". Human Gene Therapy. 6 (3): 317-323. doi:10.1089/hum.1995.6.3-317. PMID ... The skin can show the effects of vascular damage often coupled with depletion of coagulation factors in the form of petechiae, ... Gomes, Júnia Maria Geraldo; Costa, Jorge de Assis; Alfenas, Rita de Cássia Gonçalves (March 2017). "Metabolic endotoxemia and ... Endotoxemia is associated with obesity, diet, cardiovascular diseases, and diabetes, while also host genetics might have an ...
Diabetes mellitus type 1 Cushing's disease Fahr's syndrome Coeliac disease India portal Medicine portal Long link - please ... His research revealed that vitamin D deficiency among Indian population is due to their dark skin (which prevented formation of ... Ravinder Goswami (2013). "Endocrine and Metabolic Aspects of OSA". Article (full text). Ann Natl Acad Med Sci (India). (Use dmy ... vitamin D by blocking ultra violet rays) as well as inhibition of over-expression of Calcitriol receptor gene, resulting in ...
Gene expression is imperfectly controlled, and it is possible that random fluctuations in the expression levels of many genes ... and increased risk of aging-associated diseases including cancer and heart disease. Aging has been defined as "a progressive ... However, graying of hair, face aging, skin wrinkles and other common changes seen with aging are not better indicators of ... metabolic rate is a poor predictor of lifespan for birds, bats and other species that, it is presumed, have reduced mortality ...
"Prolidase Deficiency" (PDF). Climb National Information Centre for Metabolic Diseases. Retrieved 2012-11-30. Viglio S, ... Rare diseases, Skin conditions resulting from errors in metabolism). ... Each of the parents of the person who suffers from an autosomal recessive disorder possesses one copy of the mutant gene, but ... Collagen is a structural protein found i.a. in bone, skin and connective tissues that is broken down into iminodipeptides at ...
Of the two common gene variants known to be associated with pale human skin, Mc1r does not appear to have undergone positive ... "Lewy Body Disease". Archived from the original on 21 July 2009. Meyskens FL, Farmer P, Fruehauf JP (June 2001). "Redox ... "pheomelanin". MetaCyc Metabolic Pathway Database. 2010.[full citation needed] Thody, A. J.; Higgins, E. M.; Wakamatsu, K.; Ito ... Dark skin is a complicating factor in the laser removal of port-wine stains. Effective in treating white skin, in general, ...
The SLC39A4 gene encodes a transmembrane protein that serves as a zinc uptake protein. The features of the disease usually ... Individuals with acrodermatitis enteropathica may present with the following: Blistering of skin Dry skin Emotional lability ... Acrodermatitis enteropathica is an autosomal recessive metabolic disorder affecting the uptake of zinc through the inner lining ... Skin lesions may be secondarily infected by bacteria such as Staphylococcus aureus or fungi such as Candida albicans. These ...
Addison's disease can present with tanning of the skin that may be patchy or even all over the body. Characteristic sites of ... congenital adrenal hypoplasia due to DAX-1 gene mutations and mutations to the ACTH receptor gene (or related genes, such as in ... ". "Secondary Adrenal Insufficiency - Endocrine and Metabolic Disorders". Merck Manuals Professional Edition. Sklar, CA; Antal ... Other diseases that are more common in people with autoimmune adrenalitis include premature ovarian failure, celiac disease, ...
The forcing of vomiting may result in thickened skin on the knuckles, breakdown of the teeth, and effects on metabolic rate and ... In addition, gene knockout studies in mice have shown that mice that have the gene encoding estrogen receptors have decreased ... The percentage risk that is estimated to be due to genetics is between 30% and 80%. Other risk factors for the disease include ... This practice stemmed from the belief that human diseases were caused by the food itself. In ancient Rome, elite society ...
Psoriasis, another inflammatory skin disease, causes epidermal thickening, forming plaques which are mainly populated with T ... are therefore a potential therapeutic target for treating people with liver disease or metabolic syndrome. ILC2s have also been ... The circadian clock and ILC interactions have been demonstrated by studying the regulation of the master gene clock Arntl. Its ... The expression of TNF also plays a role in wound healing as it directs localization of ILC3s to the damaged skin epidermis. In ...
Lam WK, Cleary MA, Wraith JE, Walter JH (1996). "Histidinemia: a benign metabolic disorder". Archives of Disease in Childhood. ... The gene that encodes for HAL spans a roughly 25 kb and consists of 21 exons located at the 12q22-q24.1 position of human ... This also results in decreased levels of the metabolite urocanic acid in blood, urine, and skin cells. In Japan, neonatal ... Suchi M, Sano H, Mizuno H, Wada Y (1995). "Molecular cloning and structural characterization of the human histidase gene (HAL ...
Viruses causing disease in humans often enter through the mouth, nose, genital tract, or through damaged areas of skin, so ... Staeheli P, Grob R, Meier E, Sutcliffe JG, Haller O (October 1988). "Influenza virus-susceptible mice carry Mx genes with a ... This could be through releasing enzymes to degrade host metabolic precursors, or releasing proteins that inhibit the synthesis ... A viral infection does not always cause disease. A viral infection simply involves viral replication in the host, but disease ...
Nonalcoholic steatohepatitis (NASH) is a disease that has progressed from nonalcoholic fatty liver disease (NAFLD) and is ... Human IL-19 is encoded by the IL-19 gene which codes for 9 exons and is located on chromosome 1. The IL-19 protein is composed ... 2021). "Interleukin-17A Drives IL-19 and IL-24 Expression in Skin Stromal Cells Regulating Keratinocyte Proliferation". ... Cardiovascular and Metabolic Implications". Frontiers in Immunology. 10: 3096. doi:10.3389/fimmu.2019.03096. PMC 6974482. PMID ...
The metabolic & molecular bases of inherited disease. New York: McGraw-Hill. pp. 2326-2356. ISBN 978-0-07-913035-8. Hillman RE ... Yang SY, Yang XY, Healy-Louie G, Schulz H, Elzinga M (June 1990). "Nucleotide sequence of the fadA gene. Primary structure of 3 ... deficiency is easily diagnosed by urinary organic acid analysis and can be confirmed by enzymatic analysis of cultured skin ... evidence for a gene fusion in SCPx". DNA Cell Biol. 10 (9): 695-8. doi:10.1089/dna.1991.10.695. PMID 1755959. ...
The company develops anti-aging therapeutics that leverage gene therapies to modulate gene signaling pathways. Its technology ... Zhavoronkov, Alex (31 October 2022). "This Harvard Female Scientist Wants To Use Genetics To Reverse The Age Of Your Skin". ... Kumar, Akash (2022). "Whole-genome risk prediction of common diseases in human preimplantation embryos". Nature Medicine. ... metabolic, and cognitive conditions. MyOme has combined clinical data with whole-genome genetic models that work across diverse ...
Davis is a senior scientist in the Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch at the National Human ... This research identifies the types of genes that are subject to social-environmental regulations, the neural and molecular ... lab is also assessing the association of ancestry on sub-clinical cardiovascular risk factors among African-Americans and skin ... The study is designed to test the hypothesis that race-ancestry differences in the burden of cardiovascular disease in African- ...
... chromatin structure and gene expression. Mutations in this gene can lead to several diseases besides Malouf syndrome, such as ... skin lesions, and skeletal abnormalities are used as a reference to diagnosis this rare disease, and genetic testing of the ... hypogonadism cardiomyopathy dilated cardiomyopathy blepharoptosis broad nasal base mild intellectual deficit metabolic ... It is caused by a heterozygous missense mutation in the LMNA gene located on chromosome 1 (1q22). LMNA gene encodes for lamin A ...