This may weaken the effects of gene silencing mechanisms that occur prior to methylation. Certain methylations are believed to ... and therefore demethylation may reduce the stability of silencing signals and confer relative gene activation. Azacitidine ...

"The silencing of the SWI/SNF subunit and anticancer gene BRM in Rhabdoid tumors". Oncotarget. 5 (10): 3316-32. doi:10.18632/ ... The SMARCB1 gene (also termed BAF47, INI1, or hSNF5) is located on chromosome 22q11.2 and codes for a member of the SWI/SNF ... For tumor suppressor genes to carry out their normal function (appropriately initiating apoptosis), they must be located in the ... A common characteristic of epithelioid sarcoma (observed in 80% of all cases) is the loss of function of the SMARCB1 gene (also ...

"Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs". Cell. 136 (3): 496-507. doi:10.1016/j ... "Entrez Gene: Importin 8". Görlich D, Dabrowski M, Bischoff FR, Kutay U, Bork P, Hartmann E, Prehn S, Izaurralde E (July 1997 ... Importin 8 is a protein that in humans is encoded by the IPO8 gene. The importin-alpha/beta complex and the GTPase Ran mediate ... The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif ...

"G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition". Nature Neuroscience. 18 (12 ... This gene is found near this cluster; it was mapped near the gene for C2 within a 120-kb region that included a HSP70 gene pair ... This gene was thought to be two different genes, NG36 and G9a, adjacent to each other but a recent publication shows that there ... A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. ...

Xi LC, Ji YX, Yin D, Zhao ZX, Huang SC, Yu SL, Liu BY, Li HY (January 2018). "Effects of Dermatopontin gene silencing on ... In the osteosarcoma MG-63 cell line, silencing the DPT gene decreased the proliferation of the MG-63 cells.[unreliable medical ... Dermatopontin also known as tyrosine-rich acidic matrix protein (TRAMP) is a protein that in humans is encoded by the DPT gene ... "Entrez Gene: DPT dermatopontin". Krishnaswamy VR, Korrapati PS (December 2014). "Role of dermatopontin in re-epithelialization ...

... or silence, reporter genes when fused to DNA-binding domains of heterologous transcription factors, suggesting that specific ... silencing transcription of the target gene. Other histone modifications have similar or opposite effects on transcription. The ... The acetylation state of nucleosomes on a promoter is related to the rate of transcription of the gene. Histone acetylase ... Using sequences from cloned coregulator genes, laboratories such as those led by Bert O'Malley (SRC-1), Bob Roeder (TRAP220), ...

2011). "miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA". EMBO J. 30 (21): 4414-22 ... MicroRNAs function to regulate the expression levels of other genes by several mechanisms. miR-671 expression levels have been ... miR-671 has been seen to negatively regulate the CDR1 (Cerebellar Degeneration-Related protein 1) gene, through the targeting ...

2003). "Methylation of TFPI-2 gene is not the sole cause of its silencing". Int. J. Oncol. 22 (4): 843-8. doi:10.3892/ijo.22.4. ... "Entrez Gene: TFPI2 tissue factor pathway inhibitor 2". Bützow R, Huhtala ML, Bohn H, et al. (1988). "Purification and ... 1996). "Assignment of the human PP5/TFPI-2 gene to 7q22 by FISH and PCR-based human/rodent cell hybrid mapping panel analysis ... Tissue factor pathway inhibitor 2 is a protein that in humans is encoded by the TFPI2 gene. GRCh38: Ensembl release 89: ...

... also intervene in the control of flowering by silencing the Flowering Locus C gene. This gene is a ... Polycomb Gene complexes or PcG silencing consist of at least three kinds of multiprotein complex Polycomb Repressive Complex 1 ... Golbabapour S, Majid NA, Hassandarvish P, Hajrezaie M, Abdulla MA, Hadi AH (2013). "Gene silencing and Polycomb group proteins ... Polycomb-group proteins are well known for silencing Hox genes through modulation of chromatin structure during embryonic ...

Ler positively regulates the LEE genes by competition with its homolog, H-NS. H-NS silences LEE genes via rigid filament ... "Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing". Scientific Reports. 2: 509 ... pathogenicity island genes, which are responsible for creating intestinal attachment and effacing lesions and subsequent ... transcriptionally regulates Ler from an upstream position where it also regulates other genes. The Ler protein also represses ...

Orii KE, Fukao T, Song XQ, Mitchell GA, Kondo N (July 2008). "Liver-specific silencing of the human gene encoding succinyl-CoA ... This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial ... The OXCT1 gene resides on chromosome 5 at the band 5p13. OXCT1 spans a length of over 100 kb and includes 17 exons. The crystal ... "Entrez Gene: OXCT1 3-oxoacid CoA transferase 1". Fukao T, Mitchell G, Sass JO, Hori T, Orii K, Aoyama Y (July 2014). "Ketone ...

At the silent mating type loci and at the telomeres, SIR proteins participate in transcriptional silencing of genes within ... These mutants, they reasoned, were specifically defective in silencing the cryptic mating type genes. Eventually, all of the ... Smith JS, Boeke JD (January 1997). "An unusual form of transcriptional silencing in yeast ribosomal DNA". Genes & Development. ... Norris A, Boeke JD (January 2010). "Silent information regulator 3: the Goldilocks of the silencing complex". Genes & ...

miRNA: Micro RNA are small (approximately 24 nucleotides) that are used in gene silencing. snoRNA: Small nucleolar RNA are used ... and there are even some cases of small genes residing completely within the intron of a large gene. For some genes (such as the ... Gene family Genetic marker G banding Genome Regulator gene Satellite DNA Pryde FE, Gorham HC, Louis EJ (1997) Chromosome ends: ... act as barriers against transcriptional silencing; provide a location for the adaptive amplification of genes; and be involved ...

This pathway allowed for a better understanding of different post translational gene silencing pathways. Since then, many other ... LncRNA has been established to play a role in gene regulation by influencing the ability of specific regions of the gene to ... The study was one of its kind as no other studies have been able to incorporate the XIST gene into a chromosome due to its ... It was derived from gene lin-4 and was identified as a small RNA molecule (as compared to longer mRNA molecules) forming stem- ...

... or may induce gene silencing as a result of gene disruption. For allopolyploid genomes chromosomal rearrangements may result ... in addition to altering gene products if inserted into a gene, also alter promoter activity for genes if inserted upstream of ... July 2009). "Gene loss and silencing in Tragopogon miscellus (Asteraceae): comparison of natural and synthetic allotetraploids ... Therefore, discordant gene trees are only evidence of introgression if a gene tree produced by excess allele sharing between ...

Fabian MR, Sonenberg N (Jun 2012). "The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC". Nature ... Protective roles of miR-155 may arise in response to its action on silencing genes thereby regulating their expression time, ... "Entrez Gene: MIR155HG". Faraoni I, Antonetti FR, Cardone J, Bonmassar E (Jun 2009). "miR-155 gene: a typical multifunctional ... mutations in miR-155 target site deny it the optimal access necessary to bring about gene silencing, leading to over abundance ...

... involvement of methylation-mediated gene silencing". World J Surg Oncol. 11: 57. doi:10.1186/1477-7819-11-57. PMC 3605395. PMID ... "Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas". ... "Entrez Gene: Dishevelled binding antagonist of beta catenin 2". Retrieved 2017-09-10. Koga Y, Yao T, Hirahashi M, Kumashiro Y, ... Dishevelled binding antagonist of beta catenin 2 is a protein that in humans is encoded by the DACT2 gene. GRCh38: Ensembl ...

Lou, Y; Baldwin, I. T. (2006-03-01). "Silencing of a germin-like gene in Nicotiana attenuata improves performance of native ... and patterns of gene expression of (−)-germacrene D synthase, PtdTPS1". The Plant Journal. 37 (4): 603-616. doi:10.1111/j.1365- ...

The silencing of genes along the Xi occurs soon after coating by Xist RNA. Like Xist, the Tsix gene encodes a large RNA which ... in females that are heterozygous at the involved gene or genes than in females that are homozygous at that gene or those genes ... and silences most of the genes on the extra copy of chromosome 21. In these modified stem cells, the Xist-mediated gene ... meaning that the Tsix gene overlaps the Xist gene and is transcribed on the opposite strand of DNA from the Xist gene. Tsix is ...

2007). "Antisense RNA Stabilization Induces Transcriptional Gene Silencing via Histone Deacetylation in S. cerevisiae". Cell. ... CUTs have a relatively uncharacterized function but have been implicated in a number of putative gene regulation and silencing ... which serve to recruit the Hda1/2/3 histone deacetylase complex to the PHO84 gene, effectively silencing transcription and ... One class of SUTs has been found to participate in the trans-silencing of a retrotransposon. Within yeast models, it has been ...

It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple ... However, quite many genes are known to be methylated in tumor cell genomes, and the majority of these genes are not expressed ... Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene. This gene encodes a member of the ... "Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer". Biochemical and ...

Sun, FL; Cuaycong, MH; Elgin, SCR (April 2001). "Long-Range Nucleosome Ordering Is Associated with Gene Silencing in Drosophila ... her lab developed a P element construct with a copy of the white gene driven by the hsp70 promoter. When this reporter gene is ... Wu, C; Bingham, PM; Livak, KJ; Holmgren, R; Elgin, SCR (April 1979). "The chromatin structure of specific genes: I. Evidence ... Louis, and is noted for her work in epigenetics, gene regulation, and heterochromatin, and for her contributions to science ...

Through gene silencing, H-NS acts as a global repressor preferentially inhibiting transcription of horizontally transferred ... Consequently, many genes were repressed, and many quiescent genes were expressed. Besides, there are many specific cases in ... A null strain of topA, the gene encoding Topo I, survives only because of the presence of suppressor mutations in the genes ... inhibits transcription of horizontally transferred genes and it is the rigid filament that leads to gene silencing. Taken ...

... a novel transient gene silencing system for gene function discovery and validation in tobacco plants". The Plant Journal. 32 (5 ... expression of the foreign gene was enhanced or overexpressed. In the case of gene silencing, various satellite RNA-based ... The vector system could be applied for the overexpression and silencing of foreign genes. The unique example of a foreign ... They are thus similar to viroids in their means of replication (rolling circle replication) and in their lack of genes, but ...

"An analysis of repressor element 1- silencing transcription factor interactions with its target genes , WorldCat.org". www. ... of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in ... She completed her doctoral research on the transcriptional repressor REST (Repressor Element 1-Silencing Transcription factor) ...

The virus codes for RNA silencing genes, which turn off the host plant's defenses. Its genome also codes for a movement protein ...

2006). "Regulatory factor interactions and somatic silencing of the germ cell-specific ALF gene". J. Biol. Chem. 281 (45): ... Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion ... "Entrez Gene: ALF TFIIA-alpha/beta-like factor". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap ... This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that ...

"American golfers silence Scotland". Eugene Register-Guard. Eugene, Oregon. AP. 17 October 1993. p. 11G. Retrieved 19 December ...

"DNMT1 and DNMT3b cooperate to silence genes in human cancer cells". Nature. 416 (6880): 552-6. doi:10.1038/416552a. PMID ... DNA (cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. Mutation in this gene are ... expression and chromosome locations of the human DNMT3 gene family". Gene. 236 (1): 87-95. doi:10.1016/S0378-1119(99)00252-8. ... Variants of the gene can also contribute to nicotine dependency. DNMT3B has been shown to interact with: CBX5, DNMT1, DNMT3A, ...

June 1997). "Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila ... June 1997). "Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila ... EZH2 is a gene suppressor, so when it becomes overexpressed, many tumor suppressor genes that are normally turned on, are ... Methylation activity of EZH2 facilitates heterochromatin formation thereby silences gene function. Remodeling of chromosomal ...

The H3K27me3 mark silences the gene while the H3K4me3 mark allows the gene to not be permanently silenced, and activated when ... H3K4me3 and H3K27me3 marks are used on the paternal allele of the gene to keep it silenced in all tissues except the brain. The ... These regulators work to enhance or silence the expression of genes. Since these regulators work in opposition to each other, ... When keeping an ES cell in its undifferentiated state, bivalent domains of DNA are used to silence developmental genes that ...