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*  Gene silencing
... is the regulation of gene expression in a cell to prevent the expression of a certain gene. Gene silencing can ... Gene silencing is considered a gene knockdown mechanism since the methods used to silence genes, such as RNAi, CRISPR, or siRNA ... Gene silencing is often considered the same as gene knockdown. When genes are silenced, their expression is reduced. In ... Researchers have been looking to gene silencing as a potential therapeutic for HD. Gene silencing can be used to treat HD by ...
*  Gene silencing pesticide
... s are pesticides that use gene silencing, and RNA interference (RNAi) in particular to target ... Gene silencing pesticide description[dead link] Silencing the pests EOS magazine, June 2010. ... Equally surprising was that the genes were also silenced when the worms ingested the dsRNA. Steven Whyard, working for CSIRO ... Monsanto and Devgen developed a gene silencing pesticide against Diabrotica virgifera A team, led by Xiao-Ya Chen fed gossypol ...
*  Piwi like rna-mediated gene silencing 4
... is a protein that in humans is encoded by the PIWIL4 gene. PIWIL4 belongs to the ... "Entrez Gene: Piwi like RNA-mediated gene silencing 4". Retrieved 2017-02-11. Sugimoto K, Kage H, Aki N, Sano A, Kitagawa H, ... Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X (2010). "Genetic variants in Piwi-interacting RNA pathway genes confer ... Gu A, Ji G, Shi X, Long Y, Xia Y, Song L, Wang S, Wang X (2010). "Genetic variants in Piwi-interacting RNA pathway genes confer ...
*  MiRGator
MiRNA Gene silencing Nam, Seungyoon; Kim Bumjin; Shin Seokmin; Lee Sanghyuk (Jan 2008). "miRGator: an integrated system for ...
*  Karolin Luger
"Seeing the Shape of Gene Silencing". Howard Hughes Medical Institute - Research News. 14 September 2008. Retrieved 10 January ... Another related research interest for Luger's research group is the genetic cause of Rett syndrome, the gene MECP2. The gene ... Histones are important in the process of gene expression, and their positioning as determined by chaperone proteins is ... are important because of their role in activating and deactivating genes. In 2008, Luger published a study that showed that ...
*  History of genetic engineering
... has been used to silence an organism's genes. By modifying an organism to express microRNA targeted to its endogenous genes, ... By removing the genes in the plasmid that caused the tumor and adding in novel genes researchers were able to infect plants ... Schwab, Rebecca; Ossowski, Stephan; Warthmann, Norman; Weigel, Detlef (2010-01-01). "Directed Gene Silencing with Artificial ... The ability to partially reduce gene function has allowed the study of genes that are lethal when completely knocked out. Other ...
*  Epigenetics and melanoma
This can result in gene silencing. This silencing of genes can be dangerous to cells, especially when the genes silenced are ... 2012). An overproduction of MiRNAs can cause the epigenetic silencing of many important genes such as MITF, FOXO3, TFAP2C, ... It is a gene that, when hypermethylated, loses function (Muthusamy et al., 2006). This gene is found in 30- 89% of melanoma ... TABLE 1. Various genes targeted by promoter hypermethylation in malignant melanoma Some of the genes affected by cytosine ...
*  RNA
The discovery of gene regulatory RNAs has led to attempts to develop drugs made of RNA, such as siRNA, to silence genes. In ... In 1990, it was found in Petunia that introduced genes can silence similar genes of the plant's own, now known to be a result ... Doran G (2007). "RNAi - Is one suffix sufficient?". Journal of RNAi and Gene Silencing. 3 (1): 217-19. Archived from the ... Several types of RNA can downregulate gene expression by being complementary to a part of an mRNA or a gene's DNA. MicroRNAs ( ...
*  Bromo adjacent homology domain containing 1
"Human BAHD1 promotes heterochromatic gene silencing". Proc. Natl. Acad. Sci. U.S.A. 106 (33): 13826-31. doi:10.1073/pnas. ... acts as an inhibitor of BAHD1 and activates interferon-stimulated genes . The BAHD1 gene is downregulated in the colon tissue ... Bromo adjacent homology domain containing 1 (BAHD1) is a protein that in humans is encoded by the BAHD1 gene. BAHD1 is involved ... "Entrez Gene: BAHD1". Retrieved 2016-10-22. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H ...
*  DNA-directed RNA interference
... gene. Silencing the mutant gene using ddRNAi offers a potential therapeutic approach. Besides the ex vivo approach by the City ... that once processed bring about silencing of a target gene or genes. Any RNA, including endogenous mRNAs or viral RNAs, can be ... The shRNA molecules are then processed by endogenous systems and enter the RNAi pathway and silence the desired genes. Unlike ... DNA-directed RNA interference (ddRNAi) is a gene-silencing technique that utilizes DNA constructs to activate an animal cell's ...
*  Histone H2A
Other functions of H2A have been seen in the histone variant H2A.Z. This variant is associated with gene activation, silencing ... H2A.Z gene is an essential gene in yeast and it is denoted as Htz1. Comparatively, vertebrates have two H2A.Z genes. These ... H2AZ is a variant that exchanges with conventional H2A core protein; this variant is important for gene silencing. Physically, ... Variability in gene sequence was seen in bacterial, fungi, plant, and mammalian genes. One variant of H2A protein is H2ABbd ( ...
*  Derepression
McManus, Michael T.; Petersen, Christian P.; Haines, Brian B.; Chen, Jianzhu; Sharp, Phillip A. (June 2002). "Gene silencing ... If the repressor is bound upstream of a gene, such as in an operator sequence, then it would be repressing the gene's ... One common cause of familial Alzheimer's is mutation in the PSEN1 gene. This gene encodes a protein that cleaves certain ... which derepresses enhancer activity on the maternal Igf2 gene. This abnormal derepression and increase in gene expression can ...
*  Polypurine reverse-Hoogsteen hairpin
PPRHs are gene silencing tools acting by different mechanisms than triplex forming oligonucleotides (TFOs), antisense ... "Improved Design of PPRHs for Gene Silencing". Molecular Pharmaceutics. 25: 198-208. doi:10.1089/nat.2015.0531. PMID 26042602. ... "Stability and Immunogenicity Properties of the Gene-Silencing Polypurine Reverse Hoogsteen Hairpins". Molecular Pharmaceutics. ... Upon binding to their targets, PPRHs can decrease the mRNA and protein levels of the selected genes. Their action has been ...
*  Heterochromatin
Gene silencing at this location depends on components of the RNAi pathway. Double-stranded RNA is believed to result in ... Facultative heterochromatin is the result of genes that are silenced through a mechanism such as histone deacetylation or Piwi- ... December 2002). "The insulation of genes from external enhancers and silencing chromatin". Proc. Natl. Acad. Sci. USA. 9 (Suppl ... Both RNAi and an exosome-dependent RNA degradation process contribute to heterochromatic gene silencing. These mechanisms of ...
*  Opal (apple)
The "Gene Silenced" Apple Is Coming". Mother Jones. Retrieved 3 January 2018. Opal Brand Page Opal Information Page Institute ...
*  Phaeodactylum tricornutum
De Riso, V; Raniello, R.; Maumus, F.; Rogato, A.; Bowler, C.; Falciatore, A. (2009). "Gene silencing in the marine diatom ... prokaryote-like genes, an unusually large proportion. Over 30000 expressed sequence tags (ESTs) have been organized into the ...
*  Sense (molecular biology)
Gene silencing can be achieved by introducing into cells a short "antisense oligonucleotide" that is complementary to an RNA ... Watts, J.K.; Corey, D.R. (2012). "Silencing Disease Genes in the Laboratory and in the Clinic". J. Pathol. 226 (2): 365-379. ... This makes the mechanism of gene silencing catalytic. Double-stranded RNA can also act as a catalytic, enzyme-dependent ... For example, YEL021W, an alias of URA3 gene used in NCBI database, defines that this gene is located on the 21st open reading ...
*  Manel Esteller
Staff (March 2007). "Gene Silencing 2006 - Interview with Dr. Manel Esteller". esi-topics.com. Retrieved 8 May 2011. Staff. " ...
*  HLTF
2002). "HLTF gene silencing in human colon cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4562-7. doi:10.1073/pnas.062459899. ... Helicase-like transcription factor is an enzyme that in humans is encoded by the HLTF gene. This gene encodes a member of the ... "Entrez Gene: HLTF helicase-like transcription factor". Unk I, Hajdú I, Blastyák A, Haracska L (Jan 2010). "Role of yeast Rad5 ... Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by ...
*  Agroinfiltration
"Retraction: 'An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of ... Hammond, Scott M.; Caudy, Amy A.; Hannon, Gregory J. (Feb 2001). "Post-transcriptional gene silencing by double-stranded RNA". ... Johansen, Lisa K.; Carrington, James C. (2001-07-01). "Silencing on the Spot. Induction and Suppression of RNA Silencing in the ... An enhanced transient expression system in plants based on suppression of gene silencing by the p19 protein of tomato bushy ...
*  Peter Waterhouse (scientist)
In the late 1990s, Waterhouse led the CSIRO group which discovered that gene silencing and transgene-mediated virus resistance ... Waterhouse, P. M.; Wang, M. B.; Lough, T. (2001). "Gene silencing as an adaptive defence against viruses". Nature. 411 (6839): ... Waterhouse, P. M.; Helliwell, C. A. (2003). "Exploring plant genomes by RNA-induced gene silencing". Nature Reviews Genetics. 4 ... "Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA". ...
*  Methylated DNA immunoprecipitation
For example, silencing of tumour-suppressor genes in cancer can be attributed to DNA methylation. By identifying mutational ... Esteller M (April 2007). "Epigenetic gene silencing in cancer: the DNA hypermethylome". Hum. Mol. Genet. 16 (Spec No 1): R50-9 ... Gene-set analysis (for example using tools like DAVID and GoSeq) has been shown to be severely biased when applied to high- ... The genes contained in these regions are of functional interest as they may offer a mechanistic explanation to the underlying ...
*  Onion
In 2008, the New Zealand Institute for Crop and Food Research created "no tears" onions by using gene-silencing biotechnology ... "Tearless Onion Created In Lab Using Gene Silencing". ScienceDaily. 5 February 2008. Retrieved 23 November 2016. Boyhan, George ...
*  Timeline of Australian inventions
"Gene technology: gene silencing. The inventors and patents". CSIRO. Nicholson, Brendan (7 January 2006). "Australia's Key Role ... 1995 - Gene silencing - A CSIRO team led by Dr Peter Waterhouse discovered that double-stranded RNA was the trigger for RNA ... 1986 - Gene shears - The discovery of gene shears was made by CSIRO scientists, Wayne Gerlach and Jim Haseloff. So-called ... "Gene Shears - Australian scientists are using Gene Shears to fight disease". Questacon National Science and Technology Centre, ...
*  MiR-338
Barik S (Sep 2008). "An intronic microRNA silences genes that are functionally antagonistic to its host gene". Nucleic Acids ... "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing". Cell. 123 (4): 631-40. doi:10.1016/j.cell. ... miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). It has been predicted ... that it may downregulate genes which have a downstream negative effect on AATK expression. miR-338 is a brain-specific miRNA ...