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*  Chromothripsis
42 chromosomal rearrangements were found in the long arm of chromosome 4 and a significant number of rearrangements were found ... Mutations in FANCM gene cause increased micronucleus formation and hence extreme chromothripsis. As well as cells encompassing ... Mutations in the TP53 gene are important for the maintenance of genome stability has been seen to be a predisposing mutation ... Poor clinical outcome in neuroblastomas (such as those caused by deletion of the FANC gene in Fanconi Anaemia) has been linked ...
*  Junctional diversity
However, the rearrangement of several lambda variable subgenes can activate expression of an overlapping miRNA gene, which has ... The immunoglobulin lambda light chain locus contains protein-coding genes that can be lost with its rearrangement. This is ... CS1 maint: Multiple names: authors list (link) Krangel, M.S. (2009). "Mechanics of T cell receptor gene rearrangement". Current ... "MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic ...
*  Ancestral reconstruction
BADGER uses a Bayesian approach to examining the history of gene rearrangement. Count reconstructs the evolution of the size of ... duplication or horizontal gene transfer. The "genome rearrangement problem", first posed by Watterson and colleagues, asks: ... Genome rearrangements provide valuable information in comparative genomics between species. ANGES compares extant related ... Shapiro, B. (2006). "A Phylogenetic Method for Detecting Positive Epistasis in Gene Sequences and Its Application to RNA Virus ...
*  Antineoplastic resistance
Chromosomal rearrangement due to genome instability can cause gene amplification and deletion. Gene amplification is the ... "Gene rearrangement: a novel mechanism for MDR-1 gene activation". Journal of Clinical Investigation. 99 (8): 1947-1957. doi: ... Gene deletion is the opposite of gene amplification, where a region of a chromosome is lost an drug resistance occurs by losing ... Experiments in different drug resistant cell lines and patient DNA revealed gene rearrangements which had initiated the ...
*  Nodular lymphocyte predominant Hodgkin's lymphoma
BCL6 gene rearrangements have been frequently observed. The characteristics of NLPHL differ from classical Hodgkin lymphoma ( ... After transformation, neoplastic cells carry monoclonal immunoglobulin gene rearrangements. Histological transformation may ... Wlodarska I, Stul M, De Wolf-Peeters C, Hagemeijer A (August 2004). "Heterogeneity of BCL6 rearrangements in nodular lymphocyte ... January 2003). "Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in ...
*  Entrectinib
... or chromosomal rearrangements. Gene rearrangements, leading to the expression of constitutively activated fusion tyrosine ... Shaw, Alice (17 October 2013). "Tyrosine kinase gene rearrangements in epithelial malignancies". Nature Reviews Cancer. 13: 772 ... phase II basket study to examine the use of entrectinib in patients having tumors with these gene rearrangements. The study ... and success has been demonstrated using these rearrangements as targets for drug development. The expression of such gene ...
*  Antibody
Hozumi N, Tonegawa S (1976). "Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant ... Combining these genes with an array of genes for other domains of the antibody generates a large cavalry of antibodies with a ... one D and one J gene segment (or one V and one J segment in the light chain). As there are multiple copies of each type of gene ... "MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic ...
*  ROS1
... are positive for a ROS1 gene rearrangement, and these rearrangements are mutually exclusive of ALK rearrangement.[unreliable ... Gene rearrangements involving the ROS1 gene were first detected in glioblastoma tumors and cell lines. In 2007 a ROS1 ... Nonetheless, as gene rearrangement events involving ROS1 have been described in lung and other cancers, and since such tumors ... Birchmeier C, Sharma S, Wigler M (December 1987). "Expression and rearrangement of the ROS1 gene in human glioblastoma cells". ...
*  Enoplea
2011). "Rampant gene rearrangement and haplotype hypervariation among nematode mitochondrial genomes". Genetica. 139 (5): 611- ...
*  Hypoxanthine-guanine phosphoribosyltransferase
"Spontaneous reversion of novel Lesch-Nyhan mutation by HPRT gene rearrangement". Somatic Cell and Molecular Genetics. 14 (3): ... Mutations in the gene lead to hyperuricemia: Some men have partial (up to 20% less activity of the enzyme) HGPRT deficiency ... Yamada Y, Goto H, Ogasawara N (1992). "Identification of two independent Japanese mutant HPRT genes using the PCR technique". ... Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) is an enzyme encoded in humans by the HPRT1 gene. HGPRT is a transferase ...
*  Epstein-Barr virus-positive DLBCL of the elderly
It is usually CD20 positive, and has clonal immunoglobulin gene rearrangement. This type of lymphoma is not associated with ...
*  Interleukin-7 receptor-α
Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR (1998). "Impaired immunoglobulin gene rearrangement in mice lacking the IL ... 1992). "c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid- ... 1992). "The interleukin-7 receptor gene is at 5p13". Hum. Genet. 89 (5): 566-8. doi:10.1007/BF00219186. PMID 1634235. Pleiman ... 1991). "Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and ...
*  Alpha-galactosidase
... six gene rearrangements and an exonic point mutation in the alpha-galactosidase gene". The Journal of Clinical Investigation. ... Kornreich R, Bishop DF, Desnick RJ (1990). "Alpha-galactosidase A gene rearrangements causing Fabry disease. Identification of ... "Entrez Gene: GLA galactosidase, alpha". Fervenza FC, Torra R, Warnock DG (December 2008). "Safety and efficacy of enzyme ... Ishii S, Sakuraba H, Suzuki Y (1992). "Point mutations in the upstream region of the alpha-galactosidase A gene exon 6 in an ...
*  Natural computing
The latter process is called gene assembly, or gene re-arrangement. It involves re-ordering some fragments of DNA (permutations ... Gene regulatory networks comprise gene-gene interactions, as well as interactions between genes and other substances in the ... which can regulate gene transcription, or through small RNA species that can directly regulate genes. These gene-gene ... Genes are transcribed into messenger RNA (mRNA), and then translated into proteins according to the genetic code. Each gene is ...
*  Lutzner cells
This mutation is a clonal gene rearrangement at the TCR-γ gene. Clonal gene rearrangements create novel or new surface ... Lutzner cells develop because of clonal gene rearrangements in the T-cell receptor or antibody. This rearrangement occurs early ... Skin biopsy Checks for signs of cancer Immunophenotyping Flow cytometry T-cell receptor gene rearrangement test Liver Function ... Skin biopsy Checks for signs of cancer Immunophenotyping Flow cytometry T-cell receptor gene rearrangement test Liver Function ...
*  Chromoplexy
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements. Nature Genetics, 42(8), 668-75. ... rapid genome evolution from complex chromosomal rearrangements. Genes & Development, 27(23), 2513-30. doi:10.1101/gad. ... such as disruption of the tumor suppressor gene PTEN or creation of the TMPRSS2-ERG fusion gene. Chromplexy was originally ... It also may explain how DNA from multiple chromosomes may be involved in a single complex rearrangement due to the nuclear co- ...
*  Cyclin D1
Seto M, Yamamoto K, Iida S, Akao Y, Utsumi KR, Kubonishi I, Miyoshi I, Ohtsuki T, Yawata Y, Namba M (1992). "Gene rearrangement ... The CCND1 gene encodes the cyclin D1 protein. The human CCNDI gene is located on the long arm of chromosome 11 (band 11q13). It ... and sequence of a tumor-specific rearrangement breakpoint". Genes Chromosomes Cancer. 7 (2): 89-95. doi:10.1002/gcc.2870070205 ... "Entrez Gene: CCND1 cyclin D1". He Y, Liu Z, Qiao C, Xu M, Yu J, Li G (Jan 2014). "Expression and significance of Wnt signaling ...
*  Roughneck monitor lizard
Timing of a mtDNA gene rearrangement and intercontinental dispersal of varanid lizards. Genes Genet. Syst. 83: 275-280 Auliya, ...
*  BRD4
"BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19)". The American Journal of Pathology. ... This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines the NUT midline ... "Entrez Gene: BRD4 bromodomain containing 4". Zeng L, Zhou MM (Feb 2002). "Bromodomain: an acetyl-lysine binding domain". FEBS ... Bromodomain-containing protein 4 is a protein that in humans is encoded by the BRD4 gene. BRD4 is a member of the BET ( ...
*  Acute lymphoblastic leukemia
KMT2A (formerly MLL) gene rearrangements are most common and occur in the embryo or fetus before birth. These rearrangements ... In childhood ALL, this process begins at conception with the inheritance of some of these genes. These genes, in turn, increase ... The gene-modified effector cells are then transplanted back into the patient. Typically this process is done in conjunction ... This move can result in placing a gene from one chromosome that promotes cell division to a more actively transcribed area on ...
*  Acute biphenotypic leukaemia
... and MLL gene rearrangement at 11q23. T(9;22) affect the ABL gene at 9q34 and BCR at 22q11. The hybrid gene product ABL/BCR is ... Most of biphenotypic leukemia in children is due to the rearrangement of MLL Besides them, other gene abnormalities has been ... It is a positive regulator for gene transcription. It has been shown that associates with Host cell facor C1, CREB binding ... The detection of BCR-ABL1 chimeric gene neutrophils was also found a good method for diagnosis some cases of BAL. Totally, ...
*  Dumeril's monitor
2008). Timing of a mtDNA gene rearrangement and intercontinental dispersal of varanid lizards. Genes Genet. Syst. 83: 275-280. ...
*  Extrachromosomal DNA
They are thought to be the products of gene rearrangements. Double minute chromosomes (DMs) are also extrachromosomal elements ... these genes are broken down into 2 rRNA genes and 22 tRNA genes. The size of an animal mtDNA plasmid is roughly 16.6 kb and ... Colosimo, A.; V. Guida; G. Palka; B. Dallapiccola (2002). "Extrachromosomal genes: a powerful tool in gene targeting approaches ... the circular mtDNA chromosome contains 13 genes that encode proteins that are part of the electron transport chain and 24 genes ...
*  Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer
The "Molecular Biology Associations Searcher" compile gene rearrangements in cancer. The "Clinical Associations Searcher" is ... in Oncology and Haematology COSMIC cancer database Ensembl genome database project Entrez Gene GenBank Gene Wiki HUGO Gene ... The Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer is a free access database devoted to chromosomes, ... genes, and cancer. A recent review noted that "It was first published in 1983 as a book named "The Catalog of Chromosome ...
*  Organization and expression of immunoglobulin genes
Vk gene segments can join with either one of the Jk functional gene segments. The overall rearrangements result in a gene ... a partial rearrangement of the heavy-chain gene occurs which is followed by complete rearrangement of heavy-chain gene. Here at ... Only genes flank by 12 -bp that join to the genes flank by 23-bp spacer during the rearrangements and combinations to maintain ... They are referred to as gene segments and are separated by non-coding regions. The rearrangement and organization of these gene ...
*  Ian A. Graham
This has led to new understanding of how genome rearrangement has shaped the evolution of plant metabolism. The discovery of a ... The discovery of a novel Cytochrome P450 - oxidoreductase gene fusion described the last unknown step in synthesis of morphine ... Graham, I. A.; Denby, K. J.; Leaver, C. J. (1994). "Carbon Catabolite Repression Regulates Glyoxylate Cycle Gene Expression in ... "The malate synthase gene of cucumber". Plant Molecular Biology. 13 (6): 673-684. doi:10.1007/BF00016022. PMID 2491683. ...
*  Thymus
Immature thymocytes each make distinct T-cell receptors by a process of gene rearrangement. This process is error-prone, and ... The cortex is the location of the earliest events in thymocyte development, where T-cell receptor gene rearrangement and ... Thymocytes that reach the medulla have already successfully undergone T-cell receptor gene rearrangement and positive selection ... and recombination activating gene deficiency. The gene that codes for the enzyme called ADA (adenine deaminase), is located on ...