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*  Long non-coding RNA
... may be illustrative of a generalised mechanism that tightly regulates important developmental genes with complex expression ... such as the heat shock genes. This additional hierarchy of regulation that exempts individual genes from the generalised ... July 2008). "Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta- ... A recent study observed an inverse expression profile of the p15 gene and an antisense ncRNA in leukaemia. A detailed analysis ...
*  Let-7 microRNA precursor
... yet the expression pattern of let-7 family is indeed temporal during developmental processes. Given that the expression levels ... 2006). "Extensive post-transcriptional regulation of microRNAs and its implications for cancer". Genes Dev. 20 (16): 2202-2207 ... Let-7 has been demonstrated to be a direct regulator of RAS expression in human cells All the three RAS genes in human, K-, N ... The lethal-7 (let-7) gene was first discovered in the nematode as a key developmental regulator and became one of the first two ...
*  Regulation of gene expression
Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, ... Conversely, down-regulation is a process resulting in decreased gene and corresponding protein expression. Up-regulation occurs ... Often, one gene regulator controls another, and so on, in a gene regulatory network. Gene regulation is essential for viruses, ... Regulation of gene expression includes a wide range of mechanisms that are used by cells to increase or decrease the production ...
*  Human evolutionary developmental biology
Regulation of gene expression Mitteroecker, Philipp; Bookstein, Fred (2008-04-01). "The Evolutionary Role of Modularity and ... Evolutionary developmental biology is the study of the evolution of developmental processes across different organisms. It is ... Evolutionary developmental biology is primarily concerned with the ways in which evolution affects development, and seeks to ... Human evolutionary developmental biology or informally human evo-devo is the human-specific subset of evolutionary ...
*  Downstream promoter element
"Regulation of gene expression via the core promoter and the basal transcriptional machinery". Developmental Biology. 339 (2): ... a key component in the regulation of gene expression". Genes & Development. 16 (20): 2583-2592. doi:10.1101/gad.1026202. PMID ... The promoters of nearly all Hox genes of D. melanogaster, with the exception of the evolutionarily most recent genes, Ubx and ... Gene. 389 (1): 52-65. doi:10.1016/j.gene.2006.09.029. PMC 1955227 . PMID 17123746. Kutach, Alan K; Kadonaga, James T (1 July ...
*  Primary transcript
Alternative splicing is crucial for tissue-specific and developmental regulation in gene expression. Alternative splicing can ... The effect of alternative splicing in gene expression can be seen in complex eukaryotes which have a fixed number of genes in ... Furthermore, primary transcript processing provides a control for gene expression as well as a regulatory mechanism for the ... These variables create a wide range of viral gene expression. For example, tissue culture cells actively producing infectious ...
*  M33 (gene)
Vidal, Miguel (2009-01-01). "Role of polycomb proteins Ring1A and Ring1B in the epigenetic regulation of gene expression". The ... "Altered Retinoic Acid Sensitivity and TemporalExpression of Hox Genes in Polycomb-M33-Deficient Mice". Developmental Biology. ... The expression of Sry and Sox9 genes in gonads of XY Cbx2-knockout mice is reduced, suggesting that Cbx2 is required for the ... M33 is a gene. It is a mammalian homologue of Drosophila Polycomb. It localises to euchromatin within interphase nuclei, but it ...
*  List of MeSH codes (G05)
... gene expression regulation, bacterial MeSH G05.315.310 --- gene expression regulation, developmental MeSH G05.315.320 --- gene ... gene expression regulation, plant MeSH G05.315.385 --- gene expression regulation, viral MeSH G05.315.410 --- gene silencing ... gene expression regulation, fungal MeSH G05.315.370 --- gene expression regulation, neoplastic MeSH G05.315.370.500 --- gene ... gene amplification MeSH G05.315.290 --- gene expression regulation, archaeal MeSH G05.315.300 --- ...
*  Small temporal RNA
... a paradigm for RNA-mediated regulation of gene expression". BioEssays. 24 (2): 119-29. doi:10.1002/bies.10046. PMID 11835276. ... Banerjee D, Slack F (February 2002). "Control of developmental timing by small temporal RNAs: ... Small temporal RNA (abbreviated stRNA) regulates gene expression during roundworm development by preventing the mRNAs they bind ... stRNAs exert negative post-transcriptional regulation by binding to complementary sequences in the 3' untranslated regions of ...
*  Eomesodermin
T-box genes encode transcription factors, which control gene expression, involved in the regulation of developmental processes ... Eomesodermin/Tbr2 controls the expression of cardiac specific genes Mesp1, Myl7, Myl2, Myocardin,Nkx2.5 and Mef2c. Additionally ... The Eomesodermin/Tbr2 gene, EOMES, encodes a member of a conserved protein family that shares a common DNA-binding domain, the ... Kimura N, Nakashima K, Ueno M, Kiyama H, Taga T (Jun 1999). "A novel mammalian T-box-containing gene, Tbr2, expressed in mouse ...
*  Regulator gene
In the regulation of gene expression, studied in evolutionary developmental biology (evo-devo), both activators and repressors ... boundless-biology-textbook/gene-expression-16/regulation-of-gene-expression-111/prokaryotic-versus-eukaryotic-gene-expression- ... A regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. ... An example of a regulator gene is a gene that codes for a repressor protein that inhibits the activity of an operator gene (a ...
*  Epigenome-wide association study (EWAS)
The main type of DNAm is at cytosines within CpG dinucleotides which is known to be involved in gene expression regulation. ... DNA methylation (DNAm) patterns change over time, and vary between developmental stage and tissue type. ... The array still only covers less than 2% of the CpG sites in the genome, but does attempt to cover all known genes with a high ... In the past, the 27k Illumina array covered on average two CpG sites in the promoter regions of approximately 14,000 genes and ...
*  Shiv I.S. Grewal
... regulation of chromosome structure that govern diverse cellular processes including stable inheritance of gene expression, ... proper regulation of developmental states, and preserving genomic integrity, providing broad implications for human biology and ... Then he joined National Cancer Institute as a postdoctoral fellow and found that the silenced states of gene expression can be ... He continued to pursue his interests in the areas of epigenetic control of gene expression and development, joining Cold Spring ...
*  Handedness
Sebastian Ocklenburg (2017). "Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric ... Developmental Psychology, 2014. 50(3): p. 809-814. "A lefty's lament". Harvard Gazette. ... Epigenetic regulation of lateralized fetal spinal gene expression underlies hemispheric asymmetries. Elife. 2017 Feb 1;6. pii: ... 2017 found that asymmetric methylation of CpG sites plays a key role for gene expression asymmetries that have been related to ...
*  Alexander Stark
... studies the regulation of gene expression in response to developmental or environmental stimuli to learn how ... Alexander Stark (born 1974) is a biochemist and computational biologist working on the regulation of gene expression in ... He is on the editorial boards of "Genes & Development" and "Molecular Systems Biology". Alexander Stark's lab http://www. ... transcription and transcriptional networks define cellular and developmental programs. More specifically, he investigates how ...
*  Cornelia de Lange Syndrome
... chromosome segregation and the regulation of developmental gene expression. Defects in these functions likely underlie many of ... The latter two genes seem to correlate with a milder form of the syndrome. In July 2012, the fourth "CdLS gene"-HDAC8-was ... Since then, additional genes have been found (SMC1A, SMC3 and HDAC8) that cause CdLS when changed. There are likely other genes ... HDAC8 is an X-linked gene, meaning it is located on the X chromosome. Individuals with CdLS who have the gene change in HDAC8 ...
*  Gary Stormo
Stormo's research combines experimental and computational approaches to understand regulation of gene expression. His ... Cellular and Developmental Biology, becoming a professor before moving to Washington University in St. Louis in 1999. ... "Computational and Experimental Approaches to Modeling Gene Regulation @ uncCharlotte". UNC Charlotte Department of ... and their contributions to the regulatory networks that control gene expression. Stormo initially majored in physics as an ...
*  Illumina Methylation Assay
... which in the last decade has been recognized to be important in the regulation of gene expression, development and genetic ... Changes in the methylation pattern and level have been shown to contribute to cancer and various developmental diseases. For ... These genes include RefSeq genes from the NCBI CCDS Database, cancer genes that show differential methylation patterns during ... Allows integration of data between other platforms such as gene expression and microRNA profiling. The method looks at ~2 CpG ...
*  SALL4
... expression and up-regulation of caudal-type homeobox 2 (Cdx2) gene expression. Sall4 is part of the transcriptional regulatory ... The various SALL4-null mouse models mimic human mutations in the SALL4 gene, which were shown to cause developmental problems ... Kühnlein RP, Brönner G, Taubert H, Schuh R (Aug 1997). "Regulation of Drosophila spalt gene expression". Mechanisms of ... SALL4 can alter gene expression changes through its interaction with many co-factors and epigenetic complexes. It is also known ...
*  NAA15
"Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex". The Journal of Biological ... Developmental Dynamics. 218 (2): 300-15. doi:10.1002/(sici)1097-0177(200006)218:2. 3.0.co;2-k. PMID 10842358. Willis DM, Loewy ... "Serological identification and expression analysis of gastric cancer-associated genes". Br. J. Cancer. 86 (11): 1824-30. doi: ... Gene. 371 (2): 291-5. doi:10.1016/j.gene.2005.12.008. PMID 16507339. Vinarová E, Vinar O, Zvolský P (July 1977). "Predictors of ...
*  Janet Sawicki
Sawicki's research also entails identifying stem cells in normal developmental processes and the gene-expression profiles of ... she expanded her research interests to gene regulation/expression in early mammalian development. In 1981, Sawicki moved back ... These studies have contributed to an understanding of the role that HuR plays in regulating the expression of genes that help ... "Evidence for expression of the paternal genome in the two-cell mouse embryo". Nature. 294: 450-451. 1981-12-03. doi:10.1038/ ...
*  FLRT2
"Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development". ... Developmental Biology. 297 (1): 14-25. doi:10.1016/j.ydbio.2006.04.004. PMID 16872596. "Entrez Gene: FLRT2 fibronectin leucine ... Fibronectin leucine-rich repeat transmembrane protein FLRT2 is a protein that in humans is encoded by the FLRT2 gene. This gene ... Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery ...
*  Kabuki syndrome
... and play a part in the regulation of gene expression. These enzymes transfer methyl groups on and off histones to regulate ... Epigenetic activation of certain developmental genes is impaired by loss of either enzyme and developmental abnormalities occur ... This gene is located on the X chromosome. These two genes belong to a family of genes called chromatin-modifying enzymes. ... The specific developmental genes have not been fully identified. It is seen that a majority of these cases are due to de novo ...
*  Establishment of sister chromatid cohesion
... chromosome segregation and the regulation of developmental gene expression. Defects in these functions likely underlie many of ... The Pds5 gene was also identified in yeast as necessary for the establishment of cohesion. In humans, the gene has two homologs ... The Eco1/Ctf7 gene (yeast) was one of the first genes to be identified as specifically required for the establishment of ... Genetic alterations in genes NIPBL, SMC1A, SMC3, RAD21 and HDAC8 are associated with Cornelia de Lange Syndrome. The proteins ...
*  Flavin-containing monooxygenase 3
1996). "Differential developmental and tissue-specific regulation of expression of the genes encoding three members of the ... 1999). "Two novel mutations of the FMO3 gene in a proband with trimethylaminuria". Hum. Mutat. 13 (5): 376-9. doi:10.1002/(SICI ... 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149- ... "Entrez Gene: FMO3 flavin containing monooxygenase 3". "Trimethylamine monooxygenase (Homo sapiens)". BRENDA. Technische ...
*  Death-associated protein 6
"Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region". DNA Cell ... and has been implicated in many nuclear processes including transcription and cell cycle regulation. This gene encodes a ... TGF-β regulates a variety of different cellular developmental processes including growth, differentiation, proliferation, and ... No expression of Daxx leads to malfunction of S phase and cells with two nuclei are formed. Another centromeric component, CENP ...
*  Santa J. Ono
He focused much of his research in the next decade on the regulation of MHC gene expression. He showed that the different class ... mapping of its chromosomal location and assessment of its developmental expression". Immunology. 106 (2): 173-81. doi:10.1046/j ... Enhanced MHC class I heavy-chain gene expression in pancreatic islets". Diabetes. 37 (10): 1411-8. doi:10.2337/diabetes.37.10. ... March 2005). "IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1". International ...