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*  Mir-9/mir-79 microRNA precursor family
"Temporal regulation of microRNA expression in Drosophila melanogaster mediated by hormonal signals and broad-Complex gene ... The miR-9 microRNA (homologous to miR-79), is a short non-coding RNA gene involved in gene regulation. The mature ~21nt miRNAs ... "MicroRNA expression in human retinal pigment epithelial (ARPE-19) cells: increased expression of microRNA-9 by N-(4- ... Chao TF, Zhang Y, Yan XQ, Yin B, Gong YH, Yuan JG, Qiang BQ, Peng XZ (2008). "[MiR-9 regulates the expression of CBX7 in human ...
*  Mir-181 microRNA precursor
... new levels of gene regulation in acute myeloid leukemia". Chemico-Biological Interactions. 184 (1-2): 21-5. doi:10.1016/j.cbi. ... miR-181 expression has a reverse correlation with Tcl1 protein expression. mir-181 a and b are over-expressed and act as bad ... miR-181a expression is associated with survival in triple negative breast cancer. Patients with low expression have lower ... miR-181c and miR-181d are activated by the human gene ERBB2, located on the chromosome 17. The expression of miR-181c is ...
*  Mir-2 microRNA precursor
MicroRNA Gene expression Hox genes Marco, A; Hooks, KB; Griffiths-Jones, S (2011). "Evolution and function of the extended miR- ... probably to avoid the co-regulation of multiple products by the same regulatory sequences. In the human parasite Schistosoma ... The repression of rpr and grim by the Hox gene ABD-B prevents apoptosis in neural cells. On the other hand, computational ... The mir-2 microRNA family includes the microRNA genes mir-2 and mir-13 (MIPF0000049). Mir-2 is widespread in invertebrates, and ...
*  Antagomir
Hence, Blockmirs enable modulation of microRNA-based gene regulation with exquisite specificity. Importantly, Blockmirs are ... actually upregulates the expression of the Hepatitis C Virus. Thus, the therapeutic goal in such a case would be to keep miRNA- ... Therefore, in order to target the regulation of Abca1, a Blockmir can be developed that specifically binds to Abca1 mRNA ... However, miRNA-122 also regulates cholesterol (HDL) and the activity of tumor-suppressor genes (oncogenes).This means that not ...
*  MiR-27
... has been found to target and inhibit gene expression of the adenomatous polyposis coli (APC) protein, enabling it to ... Lin Q, Gao Z, Alarcon RM, Ye J, Yun Z (2009). "A role of miR-27 in the regulation of adipogenesis". FEBS J. 276 (8): 2348-58. ... FOXO1 protein expression is down-regulated in breast tumour tissue samples; miR-27a has been identified as one of three miRNAS ... Expression levels of miR-27 are positively correlated with beta-catenin, a key protein in Wnt signalling. There is activation ...
*  Long non-coding RNA
... such as the heat shock genes. This additional hierarchy of regulation that exempts individual genes from the generalised ... July 2008). "Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta- ... A recent study observed an inverse expression profile of the p15 gene and an antisense ncRNA in leukaemia. A detailed analysis ... "Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells". Cell Stem Cell. 18 (5): 637-652. ...
*  MiR-203
demonstrated that miR-203 expression in keratinocytes is dependent on regulation of p53 levels by E6, which may explain how ... MicroRNAs function to regulate the expression levels of other genes by several mechanisms, such as translational repression and ... McKenna DJ, McDade SS, Patel D, McCance DJ (2010). "MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 ... McKenna DJ, McDade SS, Patel D, McCance DJ (2010). "MicroRNA 203 expression in keratinocytes is dependent on regulation of p53 ...
*  Gene chip analysis
Non-significant genes are removed by specifying relative change in expression with respect to normal control. Values for over- ... This information is analyzed for differences in regulation in disease or drug treatment regimen, with respect to normal control ... Based on the ratio, the level of gene expression is determined. Quality control can then be performed. Various statistical ... With the mean intensity ratio adjusted to one, the distribution of the gene expression is centered so that genuine ...
*  Gene expression profiling
One previously mentioned issue has to do with the observation that gene regulation may have no direct impact on protein ... Gene set analysis demonstrated several major advantages over individual gene differential expression analysis. Gene sets are ... Gene expression profiling in cancer Spatiotemporal gene expression Transcriptomics Splice variant analysis "Microarrays ... gene expression profiling is the measurement of the activity (the expression) of thousands of genes at once, to create a global ...
*  Let-7 microRNA precursor
Let-7 has been demonstrated to be a direct regulator of RAS expression in human cells All the three RAS genes in human, K-, N ... 2006). "Extensive post-transcriptional regulation of microRNAs and its implications for cancer". Genes Dev. 20 (16): 2202-2207 ... As one of the four genes involved in induced pluripotent stem (iPS) cells reprogramming, LIN28 expression is reciprocal to that ... 2005). "CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 ...
*  Wellcome Trust Centre for Gene Regulation and Expression
The Wellcome Trust Centre for Gene Regulation and Expression, located within the University of Dundee, pioneers new approaches ... Wellcome Trust Centre for Gene Regulation and Expression website Wellcome Trust website. ... The controlled unravelling of DNA is an important step in the regulation of gene function. Angus Lamond a Wellcome Principal ... The Centre aims to enhance our understanding of how genes are regulated at both the single cell and whole organism level. ...
*  Regulation of gene expression
Conversely, down-regulation is a process resulting in decreased gene and corresponding protein expression. Up-regulation occurs ... Often, one gene regulator controls another, and so on, in a gene regulatory network. Gene regulation is essential for viruses, ... and is informally termed gene regulation. Sophisticated programs of gene expression are widely observed in biology, for example ... Regulation of gene expression includes a wide range of mechanisms that are used by cells to increase or decrease the production ...
*  Enzyme induction and inhibition
Enzymologic Gene Expression Regulation at the US National Library of Medicine Medical Subject Headings (MeSH). ... These processes are particular forms of gene expression regulation. These terms are of particular interest to pharmacology, and ... Enzyme induction is a process in which a molecule (e.g. a drug) induces (i.e. initiates or enhances) the expression of an ... Enzyme inhibition can refer to the inhibition of the expression of the enzyme by another molecule interference at the enzyme- ...
*  Post-transcriptional regulation
... therefore between the transcription and the translation of the gene. It contributes substantially to gene expression regulation ... Post-transcriptional regulation is the control of gene expression at the RNA level, ... "Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability". BMC ... to 4-fold change in protein expression of their target genes. Individual miRNAs often repress several hundred target genes. ...
*  Histone code
For details of gene expression regulation by histone modifications see table below. The hypothesis is that chromatin-DNA ... A very basic summary of the histone code for gene expression status is given below (histone nomenclature is described here): ... H3K27me3 is found in facultatively repressed genes. H3K36me3 is found in actively transcribed gene bodies. H3K9ac is found in ... as specific methylated lysine match well with gene expression states. Methylation of lysines H3K4 and H3K36 is correlated with ...
*  Anti-miRNA oligonucleotides
Kaucsár, Tamás; Rácz, Zsuzsanna; Hamar, Péter (30 November 2010). "Post-transcriptional gene-expression regulation by micro RNA ... the normal expression of these genes can be restored. It is believed that cellular miRNAs inhibit viral gene expression. In a ... This is done by hybridization of the AMOs to miRNA sequences that are involved in the expression of specific genes. The issue ... It was shown that viral gene expression increased after the introduction of anti-miRNAs targeting has-miR-29a and 29b. This ...
*  Intron
While introns do not encode protein products, they are integral to gene expression regulation. Some introns themselves encode ... Some introns are known to enhance the expression of the gene that they are contained in by a process known as intron-mediated ... Furthermore, some introns play essential roles in a wide range of gene expression regulatory functions such as non-sense ... Introns are found in the genes of most organisms and many viruses, and can be located in a wide range of genes, including those ...
*  Interleukin 2
Gene expression regulation for IL-2 can be on multiple levels or by different ways. One of the checkpoints is signaling through ... The gene for human IL-2 was cloned in 1982 after an intense competition. Commercial activity to bring an IL-2 drug to market ... Its expression and secretion is tightly regulated and functions as part of both transient positive and negative feedback loops ... After costimulation from CD28 the optimal activation of expression of IL-2 and these pathways is induced. At the same time Oct- ...
*  LONP1
... is also a DNA-binding protein that participates in mtDNA maintenance and gene expression regulation. LONP1 degrades ... A similar protease expressed in E. coli regulates gene expression by targeting specific regulatory proteins for degradation. ... Lon protease homolog, mitochondrial is an enzyme that in humans is encoded by the LONP1 gene. This gene encoded a mitochondrial ... "Entrez Gene: LONP1 lon peptidase 1, mitochondrial". Pinti M, Gibellini L, Liu Y, Xu S, Lu B, Cossarizza A (December 2015). " ...
*  Sudhir Kumar Sopory
Gene expression Regulation of gene expression Jawaharlal Nehru University, Delhi India portal Science portal "Vice Chancellor ... His researches on the gene expression and the activity of nitrate reductase revealed the effect of light on the turnover of ... Based on his work on dehydration stress and salinity-related gene regulation, he is known to have developed a new methodology ... In the early Nineties, he worked under R. Hermann on promoter analysis of light regulated genes encoding proteins involved in ...
*  Reverse transcription polymerase chain reaction
"Carrier and prenatal diagnosis of Lesch-Nyhan disease due to a defect in HPRT gene expression regulation". Gene. 511 (2): 306-7 ... It is frequently used in the expression analysis of single or multiple genes, and expression patterns for identifying ... This mutation was hypothesized to selectively abolish Gal expression. To confirm this, gene expression levels of yeast cells ... and genes used for normalisation should be referred to as reference genes instead of housekeeping genes. It is also proposes ...
*  Epigenome-wide association study (EWAS)
The main type of DNAm is at cytosines within CpG dinucleotides which is known to be involved in gene expression regulation. ... The array still only covers less than 2% of the CpG sites in the genome, but does attempt to cover all known genes with a high ... In the past, the 27k Illumina array covered on average two CpG sites in the promoter regions of approximately 14,000 genes and ... In a normal cell, the bulk genome is highly methylated at CpGs whereas CpG islands (CPI) at gene promoter regions remain highly ...
*  Chuan He
... known for his work in discovering and deciphering reversible RNA methylation in post-transcriptional gene expression regulation ... He and co-workers have revealed the DNA N6-methyldeoxyadenosine as a new methylation mark that could affect gene expression in ... "N6-Methyladenosine-dependent regulation of messenger RNA stability". Nature. 505 (7481): 117-120. Bibcode:2014Natur.505..117W. ...
*  Xiaoliang Sunney Xie
Gene Expression and Regulation Chong, Shasha; Chen, Chongyi; Ge, Hao; Xie X. Sunney. "Mechanism of Transcriptional Bursting in ... Gene expression and regulation, Epigenetics, Mechanism of cell differentiation and reprogramming, Chromosome structure and ... "Probing Gene Expression in Live Cells, One Protein Molecule at a Time," Science 311, 1600-1603 (2006). Cai, Long; Friedman, Nir ... "Stochastic Protein Expression in Individual Cells at the Single Molecule Level," Nature 440, 358-362 (2006). Single Molecule ...
*  Nonsense-mediated decay
... the data supports the view that the coupling of alternative splicing and NMD is a pervasive means of gene expression regulation ... The results were that balanced gene expression between X and autosomes gene expression was decreased by 10-15% no matter the ... This pathway has a significant effect in the way genes are translated resulting in the amount of gene expression. It is still a ... Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain premature stop codons. ...
*  G1 phase
... inhibitory gene regulatory proteins suppress major cyclin genes from expression (*the way this is phrased it is unclear whether ... Within the cell cycle, there is a stringent set of regulations known as the cell cycle control system that controls the timing ... generally because gene regulatory proteins of the E2F family have become unrestrained and increase G1/S cyclin gene expression ... Foster, D. A.; Yellen, P.; Xu, L.; Saqcena, M. (2011). "Regulation of G1 Cell Cycle Progression: Distinguishing the Restriction ...
*  Junctional diversity
... which has consequences for gene expression regulation. Generation of junctional diversity starts as the proteins, recombination ... However, the rearrangement of several lambda variable subgenes can activate expression of an overlapping miRNA gene, ... "MicroRNA-650 expression is influenced by immunoglobulin gene rearrangement and affects the biology of chronic lymphocytic ... The immunoglobulin lambda light chain locus contains protein-coding genes that can be lost with its rearrangement. This is ...