"Adipose is a conserved dosage-sensitive antiobesity gene". Cell Metabolism. 6 (3): 195-207. doi:10.1016/j.cmet.2007.08.001. PMC ... Although its discoverers dubbed this gene the adipose gene, it is not a gene responsible for creating adipose tissue. ... Gene defects in the leptin gene (ob) are rare in human obesity.[78] As of July, 2010, only 14 individuals from five families ... Main article: Genetics of obesity § Genes. The thrifty gene hypothesis (also called the famine hypothesis) states that in some ...
Gabriel JM, Erne B, Pareyson D, Sghirlanzoni A, Taroni F, Steck AJ (December 1997). "Gene dosage effects in hereditary ...
Gabriel JM, Erne B, Pareyson D, Sghirlanzoni A, Taroni F, Steck AJ (December 1997). "Gene dosage effects in hereditary ... A 2017 Cochrane systematic review found that daily dosages between (1800 - 3600) mg of gabapentin could provide good pain ... even at high dosages (200 - 400) mg. A 2013 Cochrane systematic review of topimirate found that the included data had a strong ...
... with detection of gene dosage". Am. J. Hum. Genet. 75 (2): 267-281. doi:10.1086/422854. PMC 1216061. PMID 15197683.. ... There may be a gene or genes in the 15q11-q13 region that is/are related to the development of autism in some individuals. ... "Increased Gene Dosage of Ube3a Results in Autism Traits and Decreased Glutamate Synaptic Transmission in Mice". Science ... Array CGH can be used to determine the gene content and magnitude of copy number variation so that the clinical picture can be ...
September 2007). "Adipose is a conserved dosage-sensitive antiobesity gene". Cell Metabolism. 6 (3): 195-207. doi:10.1016/j. ... WDTC1 ("Adipose") is a gene associated with obesity. WDTC1 is a gene that codes for a protein acting as a suppressor in lipid ... "ScienceDaily: 'Skinny Gene' Exists". Retrieved 2007-09-05. Lai CQ, Parnell LD, Arnett DK, García-Bailo B, Tsai MY, Kabagambe EK ... Transgenic expression of the WDTC1 gene in mice showed the opposite effect with mice having less adipose. Suh JM, Zeve D, McKay ...
... discovery of the master control gene involved in sex determination; and studies of gene regulation, particularly dosage ... Meyer's work has revealed mechanisms of sex determination and dosage compensation -- that balance X-chromosome gene expression ... Further analysis of the mechanism underlying dosage compensation produced many key insights into gene regulation. In 1990, ... But it wasn't clear whether the worms accomplished this by upregulating genes on the X chromosome in males or by downregulating ...
The dosage-sensitive genes vary from species to species. Birchler JA, Pal-Bhadra M, Bhadra U (March 2003). "Dosage dependent ... Natural selection occurs efficiently in Drosophila so the genes that are dosage-sensitive are increased. ... X hyperactivation is regulated by the alternative splicing of a gene called sex-lethal. The gene was named sex-lethal due to ... The X chromosome, compared to an autosomal gene, contains more silent genes which influences measuring the amount of influence ...
It is assumed to be a dosage-sensitive gene. When this gene is not available in the 1q21.1 area it leads to microcephaly. ... HYDIN2 is a recent duplication (found only in humans) of the HYDIN gene found on 16q22.2. GJA5 has been identified as the gene ... New genes are expected in the gaps. Because the gaps are still a topic of research, it is hard to find the exact start and end ... In this way the number of chromosomes will be halved in each cell, while all the parts on the chromosome (genes) remain, after ...
It is assumed to be a dosage-sensitive gene. When this gene is not available in the 1q21.1 area, it leads to microcephaly. ... HYDIN2 is a recent duplication (found only in humans) of the HYDIN gene found on 16q22.2. Research on the genes CHD1L and ... New genes are expected in the gaps. Because the gaps are still a topic of research, it is hard to find the exact start and end ... Genes related to 1q21.1 deletion in the distal area are PDE4DIP, HYDIN2, PRKAB2, PDIA3P, FMO5, CHD1L, BCL9, ACP6, GJA5, GJA8, ...
1994). "PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system ... regulation of gene expression. • positive regulation of gene expression. • pallium development. • oligodendrocyte cell fate ... "Genes and Mapped Phenotypes." National Center for Biotechnology Information. U.S. Pax6 is a gene in prenatal development ... "Genes & Development. 28 (17): 1879-1884. doi:10.1101/gad.246140.114. ISSN 0890-9369. PMC 4197948 . PMID 25184676.. ...
developed a novel strategy termed "Gene Dosage Network Analysis" (GDNA) to describe network features in the human circadian ... initiates transcription of target genes such as the core clock genes 'period' genes (PER1, PER2, and PER3) and two cryptochrome ... The first genes identified in the plant clock were TOC1, CCA1 and LHY. The peak expression of the CCA1 and LHY genes occurs at ... Characterization of a subset of these genes demonstrated a dosage-dependent effect on oscillator function. Protein interaction ...
Acampora, D; Avantaggiato, V; Tuorto, F; Simeone, A (1997). "Genetic control of brain morphogenesis through Otx gene dosage ... In zebrafish, it was shown that the expression of two SHH genes, SHH-a and SHH-b (formerly described as twhh) mark the MDO ... Hirata, T.; Nakazawa, M; Muraoka, O; Nakayama, R; Suda, Y; Hibi, M (2006). "Zinc-finger genes Fez and Fez-like function in the ... SHH signaling from the MDO induces a posterior-to-anterior wave of expression the proneural gene Neurogenin1 in the major ( ...
"Dosage sensitivity and the evolution of gene families in yeast". Nature. 424 (6945): 194-197. Bibcode:2003Natur.424..194P. doi: ... Lercher, M.J.; Urrutia, A.O.; Hurst, L.D. (2002). "Clustering of housekeeping genes provides a unified model of gene order in ... This has resulted in work on housekeeping genes, gene orders, and the evolution of drug resistance in Staphylococcus aureus, ... Similarly, in showing that genomes are arranged into gene expression domains, Hurst revealed that genes can affect the ...
CS1 maint: discouraged parameter (link) Chen, Jianping (2009). Molecular Basis of Gene Dosage Sensitivity (Ph.D.). Rice ... Proline-rich 12 (PRR12) is a protein of unknown function encoded by the gene PRR12. The Homo sapiens PRR12 gene is 34,785 base ... Within its gene neighborhood, PRR12 is flanked by PRRG2 and SCAF1 on the sense strand and RRAS and NOSIP on the antisense ... The gene is moderately expressed at even levels in a wide variety of tissue types. The PRR12 transcript encodes a protein that ...
Papp, Balázs; Pál, Csaba; Hurst, Laurence D. (July 2003). "Dosage sensitivity and the evolution of gene families in yeast". ... They demonstrated that gene loss initiates adaptive genomic changes that rapidly restores fitness, but this process has ... They specifically tested what is now known as the dosage balance hypothesis. The hypothesis offers a synthesis on seemingly ... More recently, the Pal lab explored the consequences of compensatory adaptation on gene content evolution. It is well known ...
This results in deletions and duplications of dosage sensitive genes. It has been speculated that CNVs underlie a significant ... Variations near the gene FXYD6 have also been associated with schizophrenia in the UK but not in Japan. In 2008, rs7341475 ... A 2009 study was able to create mice matching symptoms of schizophrenia by the deletion of only one gene set, those of the ... A 2016 study implicated the C4A gene in schizophrenia risk. C4A was found to play a role in synapse pruning, and increased C4A ...
"Imprinted gene dosage is critical for the transition to independent life". Cell Metabolism. 15 (2): 209-221. doi:10.1016/j.cmet ... She moved to the Biology Department at Yale University to undertake a PhD identifying human Hox genes and characterising ... The team identified one of the first endogenous imprinted genes, and showed that the process was epigenetically regulated by ... CS1 maint: discouraged parameter (link) Ferguson-Smith, Anne Carla (1989). A genomic analysis of the human homeobox gene loci ...
"HLA DQ gene dosage and risk and severity of celiac disease". Clinical Gastroenterology and Hepatology. 5 (12): 1406-12. doi: ... is a human gene and also denotes the genetic locus that contains this gene. The protein encoded by this gene is one of two ... "Entrez Gene: HLA-DQB1 major histocompatibility complex, class II, DQ beta 1". Lau M, Terasaki PI, Park MS (1994). " ... 0302 encode genes that mediate the autoimmune coeliac disease. Homozygotes of DQB1*0201 have a higher risk of developing the ...
... q24.2 by in situ hybridization and gene dosage studies, in Cytogenet. Cell Genet., vol. 57, 2-3, 1991, pp. 105-8, DOI:10.1159/ ... Vidaud M, Gattoni R, Stevenin J, et al., A 5' splice-region G----C mutation in exon 1 of the human beta-globin gene inhibits ... Delfau MH, Picat C, de Rooij FW, et al., Two different point G to A mutations in exon 10 of the porphobilinogen deaminase gene ... Grandchamp B, Picat C, de Rooij F, et al., A point mutation G----A in exon 12 of the porphobilinogen deaminase gene results in ...
Since individuals of either sex will receive two copies of every gene in a pseudoautosomal region, no dosage compensation is ... in females that are heterozygous at the involved gene or genes than in females that are homozygous at that gene or those genes. ... meaning that the Tsix gene overlaps the Xist gene and is transcribed on the opposite strand of DNA from the Xist gene.[31] Tsix ... Expressed genes on the inactive X chromosome[edit]. A fraction of the genes along the X chromosome escape inactivation on the ...
Since individuals of either sex will receive two copies of every gene in a pseudoautosomal region, no dosage compensation is ... in females that are heterozygous at the involved gene or genes than in females that are homozygous at that gene or those genes ... meaning that the Tsix gene overlaps the Xist gene and is transcribed on the opposite strand of DNA from the Xist gene. Tsix is ... The silencing of genes along the Xi occurs soon after coating by Xist RNA. Like Xist, the Tsix gene encodes a large RNA which ...
"Dosage analysis of cancer predisposition genes by multiplex ligation-dependent probe amplification". Br. J. Cancer. 91 (6): ... then the dosage quotient DQ = (a/b) / (A/B). Although dosage quotients may be calculated for any pair of amplicons, it is ... detection of gene copy number, detection of duplications and deletions in human cancer predisposition genes such as BRCA1, ... Dosage quotient analysis is the usual method of interpreting MLPA data. If a and b are the signals from two amplicons in the ...
Tissenbaum, H.A.; L. Guarente (2001). "Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans". Nature. ... For the first nine years, his lab studied gene regulation in yeast. In 1991 his lab started to study genes involved in aging. ... In 1993, Cynthia Kenyon's lab at UCSF discovered that a single-gene mutation in (Daf-2) could double the lifespan of C. elegans ... In 1995 the Guarente lab identified the gene SIR4 (Silent information regulator 4) as a longevity regulator. When SIRT4 was ...
Trieu M, Ma A, Eng SR, Fedtsova N, Turner EE (Jan 2003). "Direct autoregulation and gene dosage compensation by POU-domain ... Trieu M, Ma A, Eng SR, Fedtsova N, Turner EE (Jan 2003). "Direct autoregulation and gene dosage compensation by POU-domain ... This can be explained by gene dosage compensation due to autoregulation, in which expression of the remaining copy of the ... "Entrez Gene: POU4F1 POU domain, class 4, transcription factor 1". Gerrero MR, McEvilly RJ, Turner E, Lin CR, O'Connell S, Jenne ...
For example, increasing the gene dosage of the gene SIR-2, which regulates DNA packaging in the nematode worm Caenorhabditis ... Tissenbaum HA, Guarente L (March 2001). "Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans". Nature. ... The gene designations shown in red, gray or cyan indicate genes frequently epigenetically altered in various types of cancers. ... In particular, the gene-rich, early-replicating regions of the human genome exhibit lower mutation frequencies than the gene- ...
Changes in gene dosage, the number of times a given gene is present in the cell nucleus, can create a genetic imbalance. This ... Diminishing the dosage of most genes produces no obvious change in phenotype. For some genes the phenotypic consequences of a ... For some rare genes, the normal diploid level of gene expression is essential to individual survival; fewer than two copies of ... Genetic imbalance is to describe situation when the genome of a cell or organism has more copies of some genes than other genes ...
The alteration in the gene dosage, which is caused by the loss of a functional allele, is also called allelic insufficiency. An ... The haploinsufficiency is caused by the copy-number variation (CNV) of 28 genes led by the deletion of ~1.6 Mb. These dosage- ... This leads to too many or too few of the dosage sensitive genes. The genomic rearrangements, that is, deletions or duplications ... A mutation in the gene may have erased the production message. One of the two copies of the gene may be missing due to a ...
Coordinate inter-genomic gene expression Duplicated genes often result in increased dosage of gene products. Doubled dosages ... The mechanism of retaining duplicated genes is poorly understood. It has been hypothesized that dosage balance may play a key ... First, the eliminated copy restores the normal gene dosage in the diploid organism. Second, the changes in chromosomal genetic ... The main goals of diploidization are: (1) To ensure proper gene dosage; and (2) to maintain stable cellular division processes ...
Huang GY, Wessels A, Smith BR, Linask KK, Ewart JL, Lo CW (1998). "Alteration in connexin 43 gap junction gene dosage impairs ... Thus, B-catenin is stabilized in the presence of Wnt and regulates gene transcription through interaction with TCF/LEF ... Cardiac neural crest cells express Hox genes that supports the development of arteries 3, 4 and 6 and the simultaneous ... regression of arteries 1 and 2. The ablation of Hox genes on cardiac neural crest cells causes defective outflow septation. One ...
"Foxe3 is required for morphogenesis and differentiation of the anterior segment of the eye and is sensitive to Pax6 gene dosage ... This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.. *v ... "Entrez Gene: forkhead box E3".. *^ Doucette L, Green J, Fernandez B, Johnson G, Parfrey P, Young T (2011). "A novel, non-stop ... Gene ontology. Molecular function. • DNA binding. • sequence-specific DNA binding. • transcription factor activity, sequence- ...
基因劑量(Gene dosage)會對人類的表現型產生龐大的影響,對於染色體中造成疾病的複寫、省略與分裂等現象的形成擁有一定的角色。例如唐氏症患者(21號染色體為三體)有較高的比率得到阿茲海默症,可能是因為與阿茲海默症有關的類澱粉前趨蛋白基因(位在21號 ... of which more than half do not overlap with known gene locations.. Claverie J. Fewer genes, more noncoding RNA.. Science. 2005 ... Watson, JD, Baker TA
... also known by its gene name NR1H4.[15][16][17] Another bile acid receptor is the cell membrane receptor known as G protein- ... with varying results partly related to dosage.[41][42] Genetic variation in the key bile acid synthesis enzyme, CYP7A1, ... "Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression" ...
The pills are created from sulfate salts and are sold in dosages of 100, 200, 333, and 400 mg of indinavir. It is normally used ... As a result, structural proteins, resulting from polypeptide products of gag and gag-pol genes, that are necessary for the HIV ... "Crixivan (Indinavir Sulfate): Side Effects, Interactions, Warning, Dosage & Uses". RxList. Retrieved 2018-11-08.. ...
These gene candidates include certain variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, ... with one study finding that a high dosage reduced inflammatory acne lesions by 73%.[114][115] However, spironolactone and ... Genes[edit]. Acne appears to be strongly inherited; genetics explain 81% of the variation in the population.[15] Studies ... among others.[19] The 308 G/A single nucleotide polymorphism variation in the gene for TNF is associated with an increased risk ...
The HLA genes fall in two categories (Type I and Type II). In general, mismatches of the Type-I genes (i.e. HLA-A, HLA-B, or ... and also serves as a signal to establish an appropriate dosage level for sustained treatment with low levels of ... as members of the same ethnic group are more likely to have matching genes, including the genes for HLA.[24] ... A mismatch of an HLA Type II gene (i.e. HLA-DR, or HLA-DQB1) increases the risk of graft-versus-host disease. In addition, a ...
With the PIN of the device, the scientist could wirelessly control the dosage of the insulin.[71] Anand Raghunathan, a ... Medical laboratory equipment automates or helps analyze blood, urine, genes, and dissolved gases in the blood. ...
... which is dangerous as the required dosage of lithium to treat bipolar disorder is only slightly lower than the toxic dosage.[ ... L. Brown, Theodore; LeMay, Jr., H. Eugene; Bursten, Bruce E.; Burdge, Julia R. (2003). Chemistry: The Central Science (8th ed ...
ref,{{cite journal,author=Lawrence DM,first=,date=May 2009,title=Gene studies shed light on rhinovirus diversity,url=,journal= ... Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in ... more research is needed to determine the optimal dosage, zinc formulation and duration of treatment before a general ...
Barbiturates showed some hydrolytic problems in regard to formulation of liquid dosage forms. The difficulty is -OH catalyzed ... "Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A ... Several efficient benzodiazepines offer choices about dosage form, length of action, metabolic interaction and safety. ...
Wormser, Gary P.; Dattwyler, Raymond J.; Shapiro, Eugene D.; Halperin, John J.; Steere, Allen C.; Klempner, Mark S.; Krause, ... and determine dosage are insufficient because they focus on TSH levels as an indicator of thyroid function and miss a large ...
The role of genes and environment in the etiology of PCOS. Endocrine. 2006, 30 (1): 19-26. PMID 17185788. doi:10.1385/ENDO:30:1 ... Elevated insulin levels have been helpful to predict response to medication and may indicate women needing higher dosages of ... Lin, Eugene C, 编. Imaging in Polycystic Ovary Disease. eMedicine. eMedicine. 20 April 2011 [19 November 2011].. ... Mutations in the genes encoding 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause ...
"Gene-culture coevolution between cattle milk protein genes and human lactase genes". Nature Genetics. 35 (4): 311-3. doi: ... Lactose-sensitive individuals can experiment with both timing and dosage to fit their particular needs. ... The LCT gene provides the instructions for making lactase. The specific DNA sequence in the MCM6 gene helps control whether the ... some humans developed a mutation in the MCM6 gene that keeps the LCT gene turned on even after breast feeding is stopped.[20] ...
Thus only by increasing dosage of the drug will provide the same satisfaction, making it dangerous for the user.[11] ... theory of natural selection in which successful organisms are more likely to prosper and survive to pass on their genes to the ...
Increasingly higher dosages will result in higher toxicity, resembling vitamin A toxicity. Adverse effects include:[23] ... schizophrenia and the retinoid cascade have been linked to the same gene loci;[47] and retinoid dysfunction causes congenital ... Risk factors for skeletal effects include older age, greater dosage and longer course of treatment. Most bone changes cause no ... Sehgal VN, Srivastava G, Sardana K (June 2006). "Isotretinoin--unapproved indications/uses and dosage: a physician's reference ...
Erowid Nicotine Vault : Dosage *↑ Guillem K, Vouillac C, Azar MR, et al. (september 2005). "Monoamine oxidase inhibition ... 2004). "Evidence of association between smoking and alpha7 nicotinic receptor subunit gene in schizophrenia patients". ...
One study suggested that this was possible through the up-regulation of PTEN gene expression in those breast cancer cells.[11] ... It operates as a photosensitizing drug that is as effective or, with high enough dosage, more effective than 8-methoxypsoralen ... the dosage, and the humidity, but the effects may be inconsistent.[7] ...
Prior to the invention of the CT, physicians and physicists had limited knowledge about the true radiation dosage delivered to ...
Homologs of the recA gene, including rad51, play a key role in homologous recombinational repair of DNA during meiosis. A rad51 ... However, even in the case of potatoes, while solanine poisoning resulting from dosages several times normal human consumption ... The C.M. Rick Tomato Genetics Resource Center at UC Davis is a gene bank of wild relatives, monogenic mutants and miscellaneous ... and bananas share the same characteristics and genes, researchers stated the published genome could help to improve food ...
It can be performed in various dosage forms such as pills, tablets, or capsules. The drug may contain a single or multiple ... gene therapy, monoclonal antibodies and cell therapy (for instance, stem-cell therapies). Other ways to classify medicines are ... Medical errors include overprescription and polypharmacy, misprescription, contraindication and lack of detail in dosage and ... they should therefore be available at all times in adequate amounts and in appropriate dosage forms, at a price the community ...
Its use is now restricted to the relief of nausea and vomiting and the dosage and duration of use have been reduced. It should ... the voltage-gated potassium channel KCNH2 gene (hERG/Kv11.1), and the α1D-adrenoceptor ADRA1D gene.[58] ... To induce lactation, domperidone is used at a dosage of 10 to 20 mg 3 or 4 times per day by mouth.[30] Effects may be seen ... Rathbone, Michael J.; Hadgraft, Jonathan; Roberts, Michael S. (2002). "The Zydis Oral Fast-Dissolving Dosage Form". Modified- ...
... the dosage must be higher than for other methods of administration.[5][6][14] ... the gene for aromatic amino acid decarboxylase (AADC), the major enzyme involved in the synthesis of the trace amines, is ...
Standardization of purity and dosage is not mandated in the United States, but even products made to the same specification may ... Phytochemical researcher Varro Eugene Tyler described paraherbalism as "faulty or inferior herbalism based on pseudoscience", ... few high-quality clinical trials and standards for purity or dosage exist.[2] The scope of herbal medicine is sometimes ...
About one in 3000 white North Americans is homozygous (i.e. has two copies of the abnormal gene) for the most common atypical ... Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the ...
Strong evidence shows that the genes encoding the GluN2 subunits in vertebrates have undergone at least two rounds of gene ... in addition to their unique effects at elevated dosages such as dissociation. When certain NMDA receptor antagonists are given ... Homozygous disruption of the gene for GluN2B in mice causes perinatal lethality, whereas disruption of the GluN2A gene produces ... and two GluN3 subunit encoding genes, and each gene may produce more than one splice variant. ...
The term rheology was coined by Eugene C. Bingham, a professor at Lafayette College, in 1920, from a suggestion by a colleague ... Study of flow properties of liquids is important for pharmacists working in the manufacture of several dosage forms, such as ...
... genes that control the growth rate of cells) and tumor suppressor genes (genes that help to prevent cancer), which gives cancer ... Dosage[edit]. Dose response relationship of cell killing by chemotherapeutic drugs on normal and cancer cells. At high doses ... Upregulation of these genes can overcome the DNA damage and prevent the induction of apoptosis. Mutations in genes that produce ... With more copies of the gene, the drug can not prevent all expression of the gene and therefore the cell can restore its ...
Specific genes used for this are genes for barring and wing feather growth. Crosses of this sort create what are sold as Black ... parental genome dosage and hybridity contributions to heterosis in Arabidopsis thaliana". The New Phytologist. 209 (2): 590-599 ... Fewer genes are under-expressed in the homozygous individual. Gene expression in the offspring is equal to the expression of ... Over-expression of certain genes in the heterozygous offspring. (The size of the circle depicts the expression level of gene A) ...
Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E (January 2005). "Meta-analysis: high-dosage vitamin E ... Brigelius-Flohé R, Davies KJ (July 2007). "Is vitamin E an antioxidant, a regulator of signal transduction and gene expression ... the urate oxidase gene is nonfunctional, so that UA is not further broken down.[87][88] The evolutionary reasons for this loss ... gene structures, evolution, and expression". Free Radical Biology & Medicine. 33 (3): 337-49. doi:10.1016/S0891-5849(02)00905-X ...
Certain progestins such as medroxyprogesterone acetate (MPA) and megestrol acetate (MGA) are used at very high dosages as a ... Other than genetically-stimulated appetite abnormalities, there are physiological ones that do not require genes for activation ...
Optimal dosages for melatonin supplementation therapy in older adults: a systematic review of current literature. 2014. ... Lincoln GA, Andersson H, Loudon A (October 2003). "Clock genes in calendar cells as the basis of annual timekeeping in mammals ... "Melatonin: Side Effects, Uses, Dosage (Kids/Adults)". Drugs.com. Retrieved 9 January 2019.. ... "Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the ...