Gangliosides at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Overview of gangliosides at lipidlibrary. ... Natural and semisynthetic gangliosides are considered possible therapeutics for neurodegenerative disorders. Gangliosides are ... More than 60 gangliosides are known, which differ from each other mainly in the position and number of NANA residues. It is a ... A ganglioside is a molecule composed of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acids (e.g. ...
In organic chemistry, GM2 is a type of ganglioside. G refers to ganglioside, the M is for monosialic (as in it has one sialic ... Ganglioside GM2 activator protein Sphingolipidoses Structures of GM1, GM2, GM3 gangliosides Guetta E, Peleg L (2008). Rapid ... Ganglioside+GM2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (Articles without KEGG source, ... acid), and 2 refers to the fact that it was the second monosialic ganglioside discovered. It is associated with GM2 ...
In enzymology, a ganglioside galactosyltransferase (EC 2.4.1.62) is an enzyme that catalyzes the chemical reaction UDP- ... Yip GB, Dain JA (1970). "The enzymic synthesis of ganglioside. II. UDP-galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl) ... UDP-galactose-GM2 ganglioside galactosyltransferase, and GM1-synthase. This enzyme participates in glycosphingolipid ... "Conversion of Tay-Sachs ganglioside to monosialoganglioside by brain uridine diphosphate D-galactose: glycolipid ...
... they are not always available for each ganglioside. Therefore, indirect measurement of ganglioside expression by quantifying ... GD1a, ganglioside also serves as SeV receptor and is found in large quantities on the surfaces of breast cancer stem cells. ... "Correction: Specific Gangliosides Function as Host Cell Receptors for Sendai Virus". Proceedings of the National Academy of ... For example, GD1a, which is a ganglioside and sialylated glycan (glycolipid), is found in large quantities on the surfaces of ...
Separation of membranes with different ratios of ganglioside sialylating activity to gangliosides". Biochem. J. 168 (3): 325-32 ... Landa CA, Maccioni HJ, Arce A, Caputto R (1977). "The biosynthesis of brain gangliosides. ...
Higuchi, Ryuichi; Inagaki, Masanori; Yamada, Koji; Miyamoto, Tomofumi (2007). "Biologically active gangliosides from ...
Seyfried, Thomas N.; Yu, Robert K.; Miyazawa, Nobuko; Lai, Yin‐Lok (1982). "Retinal Gangliosides in RCS Mutant Rats". Journal ...
Gangliosides: the most complex animal glycolipids. They contain negatively charged oligosacchrides with one or more sialic acid ... Ariga T, McDonald MP, Yu RK (June 2008). "Role of ganglioside metabolism in the pathogenesis of Alzheimer's disease--a review ... They may be as complicated a set of compounds as the negatively charged gangliosides in animals. Glycophosphatidylinositols: a ... residues; more than 200 different gangliosides have been identified. They are most abundant in nerve cells. Globosides: ...
Certain aspects of lipid rafts inhibit EGF receptor function: the ganglioside component of lipid rafts was shown to inhibit ... For example, fluorophores conjugated to cholera-toxin B-subunit, which binds to the raft constituent ganglioside GM1 is used ... Miljan, Erik A; Bremer, Eric G. (2002). "Regulation of growth factor receptors by gangliosides". Sci STKE. 2002 (160): RE15. ... ganglioside GM1 located in lipid rafts and major histocompatibility (MHC) class I molecule. Binding of SV40 with MHC class I ...
The molecule GM2 ganglioside occurs normally but, due to an enzyme defect, builds up pathologically in the cells of victims of ... At the beginning of the 1960s, Klenk again made gangliosides the focus of his work. He elucidated the structures of many ... Klenk, Ernst (1942). "Über die Ganglioside des Gehirns bei der infantilen amaurotischen Idiotie vom Typ Tay-Sachs". Berichte ... In 1935 Klenk discovered a new group of glycosphingolipids in the nervous tissue, which he called gangliosides. ( ...
GM2A (GM2 ganglioside activator) has been viewed as a member of the SAP family and has been called SAP-3 (sphingolipid ... Hiraiwa M, Soeda S, Kishimoto Y, O'Brien JS (1993). "Binding and transport of gangliosides by prosaposin". Proc. Natl. Acad. ... 1990). "The complete amino-acid sequences of human ganglioside GM2 activator protein and cerebroside sulfate activator protein ... GM1 ganglioside activator, dispersin, and nonspecific. It has been observed that this particular saposin activates many enzymes ...
GM1 gangliosides are found in lipid rafts on the cell surface. B subunit complexes labelled with fluorescent tags or ... Enterotoxin Ganglioside Ryan KJ; Ray CG, eds. (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. p. 375. ISBN 978-0- ... Cholera toxin acts by the following mechanism: First, the B subunit ring of the cholera toxin binds to GM1 gangliosides on the ... 2018). "GM1 ganglioside-independent intoxication by Cholera toxin". PLOS Pathogens. 14 (2): e1006862. doi:10.1371/journal.ppat. ...
Holmgren, J.; Lönnroth, I.; Månsson, J.; Svennerholm, L. (1975). "Interaction of cholera toxin and membrane GM! ganglioside of ... the GM1 ganglioside, then the first-ever structurally defined biologic receptor molecule. They were also the first to describe ...
... s include: Cerebrosides Gangliosides Globosides Gangliosides are mainly found in the cell membranes of the ... However, gangliosides are also found in other cells. Sialic acids are, for example, part of the so-called sialyl-Lewis-x ... While in gangliosides sialic acids are found, sulfatides have a sulfate group. The structural similarity of most glycolipids is ... in case of gangliosides it affects the gangliosidoses (e.g. Tay-Sachs disease) . Sphingomyelin Charles Chalfant; Maurizio Del ...
Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell ... 2006). "Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers ... 1997). "Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis". Science. 277 (5332): 1652-5. doi:10.1126/ ... is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides ...
... uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase, ganglioside GM2 synthase, ganglioside GM3 ... Dicesare JL, Dain JA (March 1971). "The enzymic synthesis of ganglioside. IV. UDP-N-acetylgalactosamine: (N-acetylneuraminyl)- ... "Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions". ... ceramide This enzyme catalyses the formation of the gangliosides (i.e. sialic-acid-containing glycosphingolipids) GM2, GD2 and ...
Anti-ganglioside antibodies "Mitumomab - AdisInsight". Adisinsight.springer.com. 2005-06-13. Retrieved 2017-01-06. Clinical ...
Her thesis is titled "Structure and Function of Gangliosides". Between 1995 and 1997 she was head of the Department of Clinical ...
MPyV capsid protein VP1 binds to sialic acids of gangliosides GD1a and GT1b on the cell surface. The functions of VP2 and VP3 ... Tsai, B; Gilbert, JM; Stehle, T; Lencer, W; Benjamin, TL; Rapoport, TA (1 September 2003). "Gangliosides are receptors for ...
GM2 and GD2 gangliosides are sialic acid-containing glycosphingolipids. GalNAc-T is the enzyme involved in the biosynthesis of ... 4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides". J Biol Chem. 267 (17): ... 4 N-acetylgalactosaminyltransferase cDNAs that determine the expression of GM2 and GD2 gangliosides". J. Biol. Chem. 269 (9): ...
Both the ganglioside and the GPI-anchored protein are located in lipid microdomains and both are requisite for specific TeNT ... Winter, A; Ulrich, WP; Wetterich, F; Weller, U; Galla, HJ (17 June 1996). "Gangliosides in phospholipid bilayer membranes: ...
Tsai B, Gilbert JM, Stehle T, Lencer W, Benjamin TL, Rapoport TA (September 2003). "Gangliosides are receptors for murine ... including some gangliosides, on the surfaces of cells to initiate the process of viral infection. The VP1 protein, along with ... including some gangliosides, on the cell surface. Canonically, VP1 interacts specifically with α(2,3)-linked and α(2,6)-linked ...
... (monosialotetrahexosylganglioside) the "prototype" ganglioside, is a member of the ganglio series of gangliosides which ... Sphingolipidoses Structures of GM1, GM2, GM3 gangliosides Mocchetti I (2005). "Exogenous gangliosides, neuronal plasticity and ... The secreted toxin attaches to the surface of the host mucosa cell by binding to GM1 gangliosides. GM1 consists of a sialic ... 1994). "IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls". J. Clin. Pathol. 47 (4 ...
Antibodies to ganglioside are found to be elevated in coeliac disease. Recent studies show that gliadin can cross-link to ... IgA to gangliosides have been observed in Guillain-Barré syndrome. IgM. IgM antibodies have been detected in early work, but ... Autoantigenic gangliosides that are currently known are GD3, GM1, GQ3 and GT1. Anti-GD3 antibodies have been found in ... 1994). "IgM ganglioside GM1 antibodies in patients with autoimmune disease or neuropathy, and controls". J. Clin. Pathol. 47 (4 ...
Horowitz SH (1984). "Ganglioside (Cronassial) Therapy in Diabetic Neuropathy". Ganglioside Structure, Function, and Biomedical ... Beginning in 1975, she supported the drug Cronassial (a particular mixture of gangliosides) produced by Fidia from bovine brain ... Staughton RC, Good J (1990). "Double-blind, placebo-controlled clinical trial of a mixture of gangliosides ('Cronassial') in ... While working for Fidia, she improved the understanding of gangliosides. ...
The mutation disrupts the activity of the enzyme, which results in the build-up of the molecule GM2 ganglioside within cells, ... The hydrolysis of GM2-ganglioside requires three proteins. Two of them are subunits of hexosaminidase A; the third is a small ... This red spot is a retinal area that appears red because of gangliosides in the surrounding retinal ganglion cells. The ... Deficiency in any one of these proteins leads to ganglioside storage, primarily in the lysosomes of neurons. Tay-Sachs disease ...
... (monosialodihexosylganglioside) is a type of ganglioside. The letter G refers to ganglioside, and M is for monosialic acid ... GM3 serves as a precursor for other, more complex gangliosides. Like other gangliosides, GM3 is synthesized in the Golgi ... Chung TW, Choi HJ, Kim SJ, Kwak CH, Song KH, Jin UH, Chang YC, Chang HW, Lee YC, Ha KT, Kim CH (2014-05-14). "The ganglioside ... Wang H, Isaji T, Satoh M, Li D, Arai Y, Gu J (January 2013). "Antitumor effects of exogenous ganglioside GM3 on bladder cancer ...
Bachhawat has contributed to the knowledge on the metabolism of mucopolysaccharides, gangliosides and cerebrosulphatides, ... "Interaction between lectin from Ricinus communis and liposome containing gangliosides". Nature. 257 (5529): 802-804. Bibcode: ...
There he isolated two glysosphingolipids and studied antibodies to gangliosides. These findings were useful to further ... Rapport, Maurice (1990). "Implications of Altered Brain Ganglioside Profiles in Amyotrophic Lateral Sclerosis (ALS)" (PDF). ...
Shirure VS, Henson KA, Schnaar RL, Nimrichter L, Burdick MM (March 2011). "Gangliosides expressed on breast cancer cells are E- ... and gangliosides were identified as E-selectin ligands present on breast cancer cells. On human neutrophils the ...