Ganciclovir
... has also been found to be an effective treatment for herpes simplex virus epithelial keratitis. Ganciclovir (in gel ... Ganciclovir was patented in 1980 and approved for medical use in 1988. Ganciclovir is indicated for: Sight-threatening CMV ... "Ganciclovir". Drug Information Portal. U.S. National Library of Medicine. "Ganciclovir sodium". Drug Information Portal. U.S. ... The primary mechanism of ganciclovir action against CMV is inhibition of the replication of viral DNA by ganciclovir-5'- ...
Kaposi's sarcoma-associated herpesvirus
"Oral ganciclovir for patients with cytomegalovirus retinitis treated with a ganciclovir implant. Roche Ganciclovir Study Group ... Antiviral drugs, such as ganciclovir, that target the replication of herpesviruses such as KSHV have been used to successfully ...
Roche
Cymevene (ganciclovir), for cytomegalovirus infection. Dalmane/Dalmadorm (flurazepam), for insomnia. Dilatrend (carvedilol), ...
Human betaherpesvirus 5
Ganciclovir (Cytovene) treatment is used for people with depressed immunity who have either sight-related or life-threatening ... Drew WL (2000). "Ganciclovir resistance: a matter of time and titre". Lancet. 356 (9230): 609-610. doi:10.1016/S0140-6736(00) ... Ganciclovir (GCV) acts as nucleoside analogue. Its antiviral activity requires phosphorylation by the HCMV protein kinase, ... Foscarnet or cidofovir are only given to people with CMV resistant to ganciclovir, because foscarnet has notable nephrotoxicity ...
Cytomegalovirus esophagitis
Treatment revolves around intravenous treatment of ganciclovir. Alternate treatments involve valganciclovir, or foscarnet. All ...
List of antiviral drugs
"Cytovene IV- ganciclovir sodium injection, powder, lyophilized, for solution". DailyMed. 19 June 2020. Retrieved 21 September ...
Congenital cytomegalovirus infection
The options for treatment are intravenous ganciclovir and oral valganciclovir. After diagnosis, it is important to further ...
Foscarnet
... or ganciclovir-resistant HSV and CMV infections. However, acyclovir- or ganciclovir-resistant mutants with alterations in viral ... In individuals treated with the DNA polymerase inhibitors acyclovir or ganciclovir, HSV or CMV particles can develop mutant ... However, unlike acyclovir and ganciclovir, foscarnet is not activated by viral protein kinases, making it useful in acyclovir- ... Chou S (July 2008). "Cytomegalovirus UL97 mutations in the era of ganciclovir and maribavir". Reviews in Medical Virology. 18 ( ...
Cytomegalovirus retinitis
Intravitreal ganciclovir implant has the benefit of less systemic toxicity. An adverse effect of this is retinal detachment ( ... Campbell RJ, Chow B, Victor G, Kravcik S, Hodge WG (September 2001). "Treatment of CMV retinitis with intravitral ganciclovir ... intravenous ganciclovir, IV foscarnet, and IV cidofovir are all efficient in the treatment of this condition. Also intravitreal ... individuals with CMV retinitis will need surgery for either retinal detachment or intravitreal instillation of ganciclovir. ...
Intravitreal injection
Cytomegalovirus colitis
... specifically ganciclovir or valganciclovir. Severe CMV colitis may lead a colectomy. Crohn's disease Kandiel A, Lashner B ( ...
Douglas Jabs
"Cytomegalovirus resistance to ganciclovir and clinical outcomes of patients with cytomegalovirus retinitis". Am J Ophthalmol. ...
Gap junction
Hamel, W; Magnelli, L; Chiarugi, VP; Israel, MA (June 1996). "Herpes simplex virus thymidine kinase/ganciclovir-mediated ... association of U-87 cell death with ganciclovir-mediated apoptosis of nearby cells and lack of effect in athymic mice". Hum. ... of the herpes simplex virus thymidine kinase/ganciclovir system in vitro". Gene Ther. 3 (1): 85-92. PMID 8929915. Mesnil, Marc ...
Viral hepatitis
Xiong W (November 2010). "[Clinical efficacy of treating infant cytomegalovirus hepatitis with ganciclovir and impact on ...
Marker-assisted selection
An example would be thymidine kinase, which makes the host sensitive to ganciclovir selection. A distinction can be made ...
Selectable marker
An example would be thymidine kinase, which makes the host sensitive to ganciclovir selection.[citation needed] Positive and ...
Multiple drug resistance
Cytomegalovirus can become resistant to ganciclovir and foscarnet under treatment, especially in immunosuppressed patients. ...
Herpes simplex research
The nucleotide from the ganciclovir is what inhibits the DNA polymerization and the replication process. This causes the cell ... The cytotoxic drug used, ganciclovir, is capable of destroying via apoptosis transduced cells and non-transduced cells from the ... The HSVtk expression results in the phosphorylation of drug nucleoside analogues; in this case the drug ganciclovir, an ...
HIV associated cardiomyopathy
Amphotericin B can cause dilated cardiomyopathy, hypertension and bradycardia whereas, Ganciclovir can cause ventricular ...
Thymidine kinase
Some antiviral drugs, such as acyclovir (ATC: J05AB01) and ganciclovir (ATC: J05AB06) as well as other nucleoside analogs make ... Kotini AG, de Stanchina E, Themeli M, Sadelain M, Papapetrou EP (February 2016). "Escape Mutations, Ganciclovir Resistance, and ... Chemical structures of thymidine kinase substrate analogs AZT Stavudine Idoxuridine Aciclovir Ganciclovir Other thymidine ... allowing cells expressing the gene to be killed using ganciclovir. This is desirable in case the recombinant gene causes a ...
Blueberry muffin baby
Most commonly, valganciclovir or ganciclovir are used as first-line antiviral therapy for congenital CMV. If the cause is a ...
Roseola
If encephalitis occurs in immunocompromised children, ganciclovir or foscarnet have inconsistently shown usefulness in ...
Meningoencephalitis
Testing of cerebrospinal fluid is usually performed.[citation needed] Antiviral therapy, such as acyclovir and ganciclovir, ...
Progressive outer retinal necrosis
Treatment for Necrotizing Herpetic Retinopathy, including ARN and PORN, includes the anti-viral medications Ganciclovir and ...
Herpes simplex keratitis
Ganciclovir and brivudine treatments were found to be equally as effective as acyclovir in a systematic review. Valacyclovir, a ...
Thymidine kinase from herpesvirus
Such antivirals include: Purine analogues of guanine: Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, ... "Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir". ...
Emetine
In 2016, a study found that low doses of emetine inhibited cytomegalovirus replication and was synergistic with ganciclovir. " ...
Oncolytic virus
The herpes simplex virus thymidine kinase phosphorylates the pro-drug, ganciclovir, which is then incorporated into DNA, ...
Human artificial chromosome
These targeted tumor cells were successfully, and selectively, terminated by the antiviral drug ganciclovir in a population ...
Vidarabine
... is more toxic and less metabolically stable than many of the other current antivirals such as acyclovir and ganciclovir. Viral ...