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*  Plakoglobin
"Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". ... Li Y, Yu WH, Ren J, Chen W, Huang L, Kharbanda S, Loda M, Kufe D (Aug 2003). "Heregulin targets gamma-catenin to the nucleolus ... Plakoglobin, also known as junction plakoglobin or gamma-catenin, is a protein that in humans is encoded by the JUP gene. ... Ozawa M, Terada H, Pedraza C (Nov 1995). "The fourth armadillo repeat of plakoglobin (gamma-catenin) is required for its high ...
*  Adherens junction
γ-catenin or gamma-catenin (plakoglobin) binds the catenin-binding region of the cadherin. α-catenin or alpha-catenin binds the ... Drees F, Pokutta S, Yamada S, Nelson W, Weis W (2005). "Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin ... the authors found that monomeric α-catenin preferentially binds to the cadherin junction complex through β-catenin. Dimeric α- ... ISBN 978-3-527-31882-7. Yamada S, Pokutta S, Drees F, Weis W, Nelson W (2005). "Deconstructing the cadherin-catenin-actin ...
*  Beta-catenin
Plakoglobin (also called gamma-catenin) has a strikingly similar architecture to that of beta-catenin. Not only their ARM ... This is possible because α-catenin and cadherins bind at distinct sites to β-catenin. The β-catenin - α-catenin complex can ... Catenin beta-1, also known as β-catenin, is a protein that in humans is encoded by the CTNNB1 gene. β-catenin is a dual ... On the other hand, BCL9 and BCL9L must compete with α-catenin to access β-catenin molecules. The cellular level of beta-catenin ...
*  HER2/neu
Li Y, Yu WH, Ren J, Chen W, Huang L, Kharbanda S, Loda M, Kufe D (August 2003). "Heregulin targets gamma-catenin to the ... increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". Cancer Research. 61 (4): ... Schroeder JA, Adriance MC, McConnell EJ, Thompson MC, Pockaj B, Gendler SJ (June 2002). "ErbB-beta-catenin complexes are ... "Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma". The EMBO Journal. 10 (8): ...
*  MUC1
Li Y, Yu WH, Ren J, Chen W, Huang L, Kharbanda S, Loda M, Kufe D (August 2003). "Heregulin targets gamma-catenin to the ... Ren J, Li Y, Kufe D (May 2002). "Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin ... MUC1 cytoplasmic tail was shown to interact with Beta-catenin. A SXXXXXSSL motif was identified in MUC1 that is conserved with ... MUC1 blocks the phosphorylation-dependent degradation of beta-catenin by GSK3B. The end result is that increased expression of ...
*  Delta catenin
Like beta-catenin and gamma-catenin, delta-catenins seem to interact with presenilins. These catenin-presenilin interaction ... Delta-1-catenin and Delta-2-catenin are members of a subfamily of proteins with ten Armadillo-repeats. Delta-2-catenin is ... While beta-catenin acts as a transcription reglatory protein in the Wnt/TCF pathway, delta-catenin 1 has been implicated as a ... catenin by DHHC5 mediates activity-induced synapse plasticity". Nature Neuroscience. doi:10.1038/nn.3657. Catenin. ...
*  Desmoglein-2
Ozawa M, Terada H, Pedraza C (Nov 1995). "The fourth armadillo repeat of plakoglobin (gamma-catenin) is required for its high ... Ozawa M, Terada H, Pedraza C (Nov 1995). "The fourth armadillo repeat of plakoglobin (gamma-catenin) is required for its high ... catenin reduce its affinity for desmoglein 2". Journal of Cell Science. 113 (10): 1737-45. PMID 10769205. Bannon LJ, Cabrera BL ... catenin signaling". The Journal of Biological Chemistry. 277 (12): 10512-22. doi:10.1074/jbc.M108765200. PMID 11790773. Syed SE ...
*  PTPRT
... beta-catenin, gamma-catenin/plakoglobin, p120 catenin, desmoglein, E-cadherin, N-cadherin, and VE-cadherin. Purified wild-type ... alpha-actinin Alpha catenin Beta-catenin Breakpoint cluster region protein (BCR) Desmoglein E-cadherin Fyn N-cadherin gamma- ... catenin p120-catenin Paxillin Neuroligin Neurexin STAT3 VE-cadherin/Cadherin-5 GRCh38: Ensembl release 89: ENSG00000196090 - ... Using this technique, the authors identified that PTPrho interacts with alpha-actinin, alpha-catenin, ...
*  TCF7L2
"Interactions Between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma on Neuroinflammation, Demyelination, and ... It is a member of the TCF family that can form a bipartite transcription factor (β-catenin/TCF) alongside β-catenin. Bipartite ... TCF7L2 is downstream of the WNT/β-catenin pathways. The activation of the WNT/β-catenin pathways have been associated ... nuclear import of alpha-catenin by the beta-catenin/Tcf complex". Experimental Cell Research. 255 (2): 207-20. doi:10.1006/excr ...
*  Vinculin family
Three different types of catenins seem to exist: alpha, beta, and gamma. Alpha-catenins are proteins of about 100 kDa which are ... Catenins are proteins that associate with the cytoplasmic domain of a variety of cadherins. The association of catenins to ... In terms of their structure the most significant differences are the absence, in alpha-catenin, of the repeated domain and of ... Vinculin InterPro: IPR000633 Alpha-catenin InterPro: IPR001033 CTNNA1; CTNNA2; CTNNA3; CTNNAL1; VCL; Otto JJ (1990). "Vinculin ...
*  Catenin alpha-1
"Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". J ... αE-catenin has no homology to established actin-binding proteins. The N-terminus of αE-catenin binds β-catenin or γ-catenin/ ... "Identification of the domain of alpha-catenin involved in its association with beta-catenin and plakoglobin (gamma-catenin)". J ... αE-catenin, also known as Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. αE-catenin is highly ...
*  PTPRK
... and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional ... where it colocalizes and co-immunoprecipitates with β-catenin and plakoglobin/γ-catenin β-catenin may be a PTPkappa substrate. ... PTPkappa interacts by co-immunoprecipitation with E-cadherin, α-catenin and β-catenin in pancreatic acinar cells prior to the ... which consequently reduces the level of nuclear β-catenin and reduces the expression of the β-catenin-regulated genes, cyclin ...
*  Cadherin-catenin complex in learning and memory
Murata, Y; Hamada, S; Morishita, H; Mutoh, T; Yagi, T (2004). "Interaction with protocadherin-gamma regulates the cell surface ... α-catenins, β-catenins, and p120ctn family catenins. β-catenins and p120ctns bind cadherin's intracellular domain at the distal ... will associate with the cadherin-catenin complex via β-catenins. In homodimeric form, α-catenins do not bind β- catenins, but ... β-catenin localizes reserve pool vesicles (RPVs) at presynaptic sites. The deletion of β-catenin in vivo results in a decrease ...
*  UBR1
2007). "Thiazolidinediones modulate the expression of beta-catenin and other cell-cycle regulatory proteins by targeting the F- ... box proteins of Skp1-Cul1-F-box protein E3 ubiquitin ligase independently of peroxisome proliferator-activated receptor gamma ...
*  Janus kinase 3
... gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice". ... Tyr30, Tyr64, and Tyr86 in the N-terminal domain (NTD) of β-catenin. However, prior phosphorylation of β-catenin at Tyr654 was ... protein β-catenin. Jak3 expression in these cells was essential for AJ localization of β-catenin and maintenance of epithelial ... domains of Jak3 interacted with β-catenin, the NTD domain of β-catenin facilitated its interactions with Jak3. Physiologically ...
*  PSEN1
... and stabilize beta-catenin. Mutant of presenilin-1 that reduces the ability to stabilize beta-catenin complex leads to ... Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in ... "Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in ... Beta-catenin is coupled by presenilin-1 and undergoes a sequential phosphorylation by two kinase activities. The study also ...
*  MAP3K7IP1
"Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade". Nat. Cell Biol. 5 (3): 224-30. doi: ... pathway to antagonize Wnt/beta-catenin signaling". Mol. Cell. Biol. 23 (1): 131-9. doi:10.1128/MCB.23.1.131-139.2003. PMC ...
*  Prostaglandin EP2 receptor
G beta-gamma complexes (i.e. Gβγ). The Gαs- Gβγ complexes dissociate into their Gαs and Gβγ subunits which in turn regulate ... Beta-catenin pathway which regulates not only cell-cell adhesion but also activates the Wnt signaling pathway which, in turn, ...
*  MiR-27
Expression levels of miR-27 are positively correlated with beta-catenin, a key protein in Wnt signalling. There is activation ... to negatively regulate adipocyte differentiation through regulation of the peroxisome proliferator-activated receptor gamma ( ... of Wnt signalling through nuclear accumulation of this protein, which is in response to inhibition of the beta-catenin ...
*  Casein kinase 1
... gamma 2, gamma 3, delta, and epsilon. Isoforms range from 22 to 55 kDa and have been identified in the membranes, nucleus, and ... Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y, Zhang Z, Lin X, He X (2002). "Control of β-Catenin Phosphorylation/Degradation ... In humans there are three casein kinase 1 gamma enzymes. Xenopus casein kinase 1 gamma (CK1gamma) is associated with the cell ... In contrast, in several important targets, NF-AT and beta-catenin, CKI does not require n − 3 priming but, instead, ...
*  Actin
The head domain of vinculin associates to E-cadherin via α-catenin, β-catenin, and γ-catenin. The tail domain of vinculin binds ... gamma actin 1 ACTG2 - gamma actin 2, smooth muscle, enteric Actin remodeling - effect on cell structure and shape Actin-binding ... The beta and gamma actins coexist in most cell types as components of the cytoskeleton, and as mediators of internal cell ... Mammals have at least six actin isoforms coded by separate genes, which are divided into three classes (alpha, beta and gamma) ...
*  Palmitoylation
... of delta catenin seems to coordinate activity-dependent changes in synaptic adhesion molecules, synapse ... "The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2". Cell. 83 (6): 1047-58. doi:10.1016/0092-8674(95)90220-1 ... catenin by DHHC5 mediates activity-induced synapse plasticity". Nature Neuroscience. 17: 522-532. doi:10.1038/nn.3657. Smotrys ...
*  ALCAM
2000). "Coordinate recruitment of E-cadherin and ALCAM to cell-cell contacts by alpha-catenin". Biochem. Biophys. Res. Commun. ... 1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma- ...
*  CD97
GSK-3β, inhibited in some cancer, regulates the stability of β-catenin in cytoplasm and subsequently, cytosolic β-catenin moves ... the peroxisome proliferator-activated receptor-gamma agonist, induces antiproliferation and redifferentiation in human thyroid ... Ectopic CD97 expression upregulates the expression of N-cadherin and β-catenin in HT1080 fibrosarcoma cells leading to enhanced ... Transgenic expression of a CD97 in mice enhanced levels of nonphosphorylated membrane-bound β-catenin and phosphorylated Akt. ...
*  Hepatoblastoma
Also beta-catenin mutations have been shown to be common in sporadic hepatoblastomas, occurring in as many as 67% of patients. ... Sarto, I.; Klausberger, T.; Ehya, N.; Mayer, B.; Fuchs, K.; Sieghart, W. (2002). "A novel site on gamma 3 subunits important ... Anna CH, Sills RC, Foley JF, Stockton PS, Ton TV, Devereux TR (June 2000). "Beta-catenin mutations and protein accumulation in ... A Novel Target of the Wnt/β-Catenin Pathway in Liver". Gastroenterology. 129 (1): 285-302. doi:10.1053/j.gastro.2005.04.013. ...
*  NEDD9
Consistent with these findings is a study demonstrating downregulation of epithelial markers (E-cadherin, occludin, β-catenin) ... Fc gamma RI)". J. Immunol. 161 (10): 5555-63. PMID 9820532. Astier A, Manié SN, Law SF, Canty T, Haghayghi N, Druker BJ, Salgia ... and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG ( ...