G protein βγ complex G protein GNAQ family members GIT1 and GIT2 PDE6G PRKCB1 Src G protein-coupled receptor kinases G protein ... G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... Media related to G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1) at Wikimedia Commons beta-Adrenergic+ ... and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar ...

G protein-coupled receptor kinases (GPCRKs, GRKs) are a family of protein kinases within the AGC (protein kinase A, protein ... G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... Ma L, Gao J, Chen X (2005). "G Protein-Coupled Receptor Kinases". In Devi LA (ed.). The G Protein-Coupled Receptors Handbook ( ... "G Protein-Coupled Kinases and Desensitization of Receptors". In Bernstein G, Tatsuya H (eds.). G protein-coupled receptors. ...

G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... "Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C". The Journal ... GRK3 was initially called Beta-adrenergic receptor kinase 2 (βARK-2), and is a member of the G protein-coupled receptor kinase ... "Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor ...

"Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase ... is a protein that in humans is encoded by the EDNRB gene. Endothelin receptor type B is a G protein-coupled receptor which ... "Endothelin Receptors: ETB". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... The resulting EDNRB protein is unable to fulfill its role in the development of the embryo, limiting the migration of the ...

"Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C". ... and characterization of the G protein-coupled receptor kinase GRK5". The Journal of Biological Chemistry. 269 (2): 1099-1105. ... with the majority of the receptors being the M2 type. Activation of the M2 receptors, which are coupled to Gi, inhibits the β- ... It is Gi-coupled, reducing intracellular levels of cAMP. The M2 muscarinic receptors are located in the heart, where they act ...

... (EC 2.7.11.14, rod opsin kinase, G-protein-coupled receptor kinase 1, GPCR kinase 1, GRK1, opsin kinase, opsin ... Rhodopsin kinase is a member of the family of G protein-coupled receptor kinases, and is officially named G protein-coupled ... "Substrate-Induced Changes in the Dynamics of Rhodopsin Kinase (G Protein-Coupled Receptor Kinase 1)." Biochemistry, vol. 51, no ... "Regulation of the methylation status of G protein-coupled receptor kinase 1 (rhodopsin kinase)". Cellular Signalling. 24 (12): ...

"Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C". ... is a member of the G protein-coupled receptor superfamily of integral membrane proteins. It is coupled to Gq protein. Binding ... G protein-coupled receptors, Human proteins, Muscarinic acetylcholine receptors). ... "Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein ...

G protein-coupled receptor kinase 2 (GRK2), which phosphorylates and deactivates certain G protein coupled receptors . When the ... Hata JA, Koch WJ (August 2003). "Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease". Molecular ... "Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling ... "Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor". Nature ...

"Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C". ... Like the M1 muscarinic receptor, M3 receptors are coupled to G proteins of class Gq, which upregulate phospholipase C and, ... "Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein ... The calcium function in vertebrates also involves activation of protein kinase C and its effects. Because the M3 receptor is Gq ...

Hu LA, Chen W, Premont RT, Cong M, Lefkowitz RJ (January 2002). "G protein-coupled receptor kinase 5 regulates beta 1- ... or one of the four adrenergic receptors. It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein ... ADRB-1 is a transmembrane protein that belongs to the G-Protein-Coupled Receptor (GPCR) family. GPCRs play a key role in cell ... receptors Alpha-1 adrenergic receptor Alpha-2 adrenergic receptor Beta-2 adrenergic receptor Beta-3 adrenergic receptor GRCh38 ...

2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". J. Biol. Chem. 277 ( ... 1997). "Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that ... Disks large-associated protein 2 is a protein that in humans is encoded by the DLGAP2 gene. The product of this gene is one of ... a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95". Genes Cells. 2 (6): 415-24. doi: ...

"Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2)". Molecular ... "The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation". British Journal of ... Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM6, GRM7 and GRM8 it ... Enz R (Mar 2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Letters ...

"Synucleins are a novel class of substrates for G protein-coupled receptor kinases". J. Biol. Chem. 275 (34): 26515-22. doi: ... Gamma-synuclein is a protein that in humans is encoded by the SNCG gene. Synuclein-gamma is a member of the synuclein family of ... Gamma-synuclein is the least conserved of the synuclein proteins. Gamma-Synucleins expression in breast tumors is a marker for ... Surguchov A, Surgucheva I, Solessio E, Baehr W (1999). "Synoretin--A new protein belonging to the synuclein family". Mol. Cell ...

... and enhance their selectivity toward certain G proteins. PIP2 has been shown to recruit G protein-coupled receptor kinase 2 ( ... "Effect of Lipid Composition on Membrane Orientation of the G protein-coupled Receptor Kinase 2-Gβ1γ2 Complex". Biochemistry. 55 ... PIP2 functions as an intermediate in the IP3/DAG pathway, which is initiated by ligands binding to G protein-coupled receptors ... P2 has been shown to stabilize the active states of Class A G protein-coupled receptors (GPCRs) via direct binding, ...

Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P (April 2003). "The G protein-coupled 5-HT1A receptor causes suppression of ... Repinotan has been found to bind with high to moderate affinity to the receptors alpha-1 and alpha-2 adrenergic, 5-HT7- and 5- ... caspase-3 through MAPK and protein kinase Calpha". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1640 (1): 85- ... G protein-coupled inwardly rectifying K+ channels are activated. This causes hyperpolarization. Because hyperpolarization ...

Guo J, Wu Y, Zhang W, Zhao J, Devi LA, Pei G, Ma L (Nov 2000). "Identification of G protein-coupled receptor kinase 2 ... is an inhibitory 7-transmembrane G-protein coupled receptor coupled to the G protein Gi/G0 and has enkephalins as its ... Jordan BA, Devi LA (Jun 1999). "G-protein-coupled receptor heterodimerization modulates receptor function". Nature. 399 (6737 ... "Coincident signalling between the Gi/Go-coupled delta-opioid receptor and the Gq-coupled m3 muscarinic receptor at the level of ...

"The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. ... is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive ... the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation". J. Clin. Invest. 106 (8): ... "Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation". J. Biol. Chem. 277 (18): 15482-5. ...

... involvement of a select array of G protein-coupled receptor kinases". Molecular Pharmacology. 60 (5): 1049-56. doi:10.1124/mol. ... The histamine receptor H2 belongs to the rhodopsin-like family of G protein-coupled receptors. It is an integral membrane ... Inhibition of neutrophil activation and chemotaxis H2-receptor antagonist Histamine H1-receptor Histamine H3-receptor Histamine ... "Inhibition of H2 histamine receptor-mediated cation channel opening by protein kinase C in human promyelocytic cells". Journal ...

These receptors span the plasma membrane seven times and constitute a distinct family of G-protein coupled receptors (GPCRs). ... receptor tyrosine kinase (RTK), and ROR2. Upon activation of the receptor, a signal is sent to the phosphoprotein Dishevelled ( ... Schulte G, Bryja V (October 2007). "The Frizzled family of unconventional G-protein-coupled receptors". Trends in ... protein phosphatase 2A (PP2A), glycogen synthase kinase 3 (GSK3) and casein kinase 1α (CK1α). It degrades β-catenin by ...

... and G protein-coupled receptors. In response to extracellular signals, this kinase translocates to the cell nucleus, where it ... Kamakura S, Moriguchi T, Nishida E (September 1999). "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. ... This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the ... "Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases". The ...

"Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C." J ... G protein-coupled receptors, Human proteins, Muscarinic acetylcholine receptors). ... is a protein that, in humans, is encoded by the CHRM4 gene. M4 muscarinic receptors are coupled to Gi/o heterotrimeric proteins ... Qin K, Dong C, Wu G, Lambert NA (2011). "Inactive-state preassembly of G(q)-coupled receptors and G(q) heterotrimers". Nat. ...

"Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway". The Journal of Biological ... The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a ... Erythropoietin receptor has been shown to interact with: CRKL, Erythropoietin, Grb2, Janus kinase 2, LYN, PIK3R1, PTPN6, SOCS2 ... Bonifacino JS (Jan 2002). "Quality control of receptor-kinase signaling complexes". Developmental Cell. 2 (1): 1-2. doi:10.1016 ...

The PI3K is activated by G protein-coupled receptors and tyrosine kinase receptors. Class I PI3Ks are heterodimeric molecules ... DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR). They are protein serine/threonine kinases. The ... "Cannabinoids protect astrocytes from ceramide-induced apoptosis through the phosphatidylinositol 3-kinase/protein kinase B ... Many of these functions relate to the ability of class I PI3Ks to activate protein kinase B (PKB, aka Akt) as in the PI3K/AKT/ ...

... however in vitro studies strongly suggested that CART binds to a specific G protein-coupled receptor coupled to Gi/Go, ... peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled ... Involvement of CaMKII and Inhibitory G-Protein Coupled Receptor Signaling". Frontiers in Cellular Neuroscience. 11: 244. doi: ... No role as of yet has been proposed for the peculiar location of this protein in these cell types. Studies of CART(54-102) ...

"Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors". ... phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon". J. Biol. Chem. 273 (48): 32016-22. doi:10.1074/jbc.273.48. ... "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and - ... 1995). "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells". Proc. Natl. Acad ...

... of PC-specific PLDs occurs as a consequence of agonist stimulation of both tyrosine kinase and G protein-coupled receptors. PC- ... March 2002). "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 ... March 2002). "Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 ... Scaffolding proteins that interact with PLD2 likely changes its preference of lipid rafts vs PIP2. PLD2 has been shown to ...

"Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in ... does not arise from the classically described mechanisms of receptor desensitization via receptor phosphorylation, beta- ... This receptor has been a drug development target for the treatment of several clinical disorders. The 5-HT7 receptor is encoded ... The h5-HT7(a) is the full length receptor (445 amino acids), while the h5-HT7(b) is truncated at amino acid 432 due to ...

The G protein-coupled receptor kinases (GRKs) are protein kinases that phosphorylate only active GPCRs. G-protein-coupled ... receptor domain by protein kinases. Cyclic AMP-dependent protein kinases (protein kinase A) are activated by the signal chain ... Wikimedia Commons has media related to G protein-coupled receptors. G-protein-coupled+receptors at the U.S. National Library of ... transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors ( ...

... as they are Gαi and/or Gαo coupled receptors, which blocks the activity of adenylyl cyclase. cAMP mediated protein kinase A ... Dopamine receptors can also transactivate Receptor tyrosine kinases. Beta Arrestin recruitment is mediated by G-protein kinases ... Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS ... Dopamine receptors have been shown to heteromerize with a number of other G protein-coupled receptors. Especially the D2 ...

"Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase ... AVPR1A is a G-protein coupled receptor (GPCR) with 7 transmembrane domains that couples to Gaq/11 GTP binding proteins, which ... V1a vasopressin receptor antidiuretic hormone receptor 1A SCCL vasopressin subtype 1a receptor V1-vascular vasopressin receptor ... G protein-coupled receptors, Biology of bipolar disorder). ... 1b receptor genes, but not the Avp 1a receptor gene, ...