G protein βγ complex G protein GNAQ family members GIT1 and GIT2 PDE6G PRKCB1 Src G protein-coupled receptor kinases G protein ... G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar ... "Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor ...

G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... "Phosphorylation of the type 1A angiotensin II receptor by G protein-coupled receptor kinases and protein kinase C". The Journal ... and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar ... "Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor ...

GRK7 is a member of the family of G protein-coupled receptor kinases, and is officially named G protein-coupled receptor kinase ... G-protein-coupled receptor kinase 7 (EC 2.7.11.14, GRK7, cone opsin kinase, iodopsin kinase) is a serine/threonine-specific ... "The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase ... members of the family of G protein-coupled receptors that recognize light of various wavelengths (red, green, blue). ...

G protein-coupled receptor kinases (GPCRKs, GRKs) are a family of protein kinases within the AGC (protein kinase A, protein ... G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... Ma L, Gao J, Chen X (2005). "G Protein-Coupled Receptor Kinases". In Devi LA (ed.). The G Protein-Coupled Receptors Handbook ( ... "G Protein-Coupled Kinases and Desensitization of Receptors". In Bernstein G, Tatsuya H (eds.). G protein-coupled receptors. ...

"Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase ... is a protein that in humans is encoded by the EDNRB gene. Endothelin receptor type B is a G protein-coupled receptor which ... "Endothelin Receptors: ETB". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... The resulting EDNRB protein is unable to fulfill its role in the development of the embryo, limiting the migration of the ...

This gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ... "beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase- ... The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 ... "Entrez Gene: GIT2 G protein-coupled receptor kinase interactor 2". "Hot plate data for Git2". Wellcome Trust Sanger Institute ...

"G Protein-Coupled Receptor Kinase 2 Promotes Flaviviridae Entry and Replication." PLoS Negl Trop Dis PLoS Neglected Tropical ... Entebbe Bat Virus is an enveloped virus, which means that it has to bind its envelope proteins to a cell surface protein on the ... The genome encodes 3 structural proteins (Capsid, prM, and Envelope) and 8 non-structural proteins (NS1, NS2A, NS2B, NS3, NS4A ... and the fusion peptide is directed toward the cell membrane The viral envelope protein E attaches to host receptors, which ...

Le Sommer C, Barrows NJ, Bradrick SS, Pearson JL, Garcia-Blanco MA (2012). Michael SF (ed.). "G protein-coupled receptor kinase ... A G protein-coupled receptor kinase 2 (also known as ADRBK1) appears to be important in entry and replication for several ... The virus encodes these activities in its non-structural proteins. The NS3 protein encodes a RNA triphosphatase within its ... In general, the genome encodes three structural proteins (Capsid, prM, and Envelope) and seven non-structural proteins (NS1, ...

"Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C". ... and characterization of the G protein-coupled receptor kinase GRK5". The Journal of Biological Chemistry. 269 (2): 1099-1105. ... with the majority of the receptors being the M2 type. Activation of the M2 receptors, which are coupled to Gi, inhibits the β- ... It is Gi-coupled, reducing intracellular levels of cAMP. The M2 muscarinic receptors are located in the heart, where they act ...

... a G protein-coupled receptor kinase interacting ArfGAP, the cytoplasmic protein HAP1; Huntingtin-associated protein 1, IMMT, an ... Coiled-coil domain-containing protein 113 also known as HSPC065, GC16Pof6842 and GC16P044152, is a protein that in humans is ... alpha prime polypeptide contains a protein kinase domain and a catalytic domain. GINS3 is essential for the initiation of DNA ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ...

G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, and is most ... 2003). "Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4". Kidney Int. 62 (3): 790-8 ... Premont RT, Inglese J, Lefkowitz RJ (1995). "Protein kinases that phosphorylate activated G protein-coupled receptors". FASEB J ...

"Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein ... kinase C-independent pathway". The Journal of Biological Chemistry. 269 (33): 21103-21109. doi:10.1016/S0021-9258(17)31935-X. ... May 1994). "Transfected muscarinic acetylcholine receptors selectively couple to Gi-type G proteins and Gq/11". Molecular ... The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor that ...

"Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2". J. Biol. Chem. 275 ( ... Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector ... "Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor". J. Biol. ... Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 is a protein that in humans is encoded by the GNB1 gene. ...

"A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene. NME3 has been shown to interact with ... "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

The NDUFB10 protein weighs 21 kDa and is composed of 172 amino acids. NDUFB10 is a subunit of the enzyme NADH dehydrogenase ( ... Yano M, Terada K, Mori M (Oct 2003). "AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and ... "p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling". Proceedings of the National Academy of ... The protein encoded by this gene is an accessory subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I) that is ...

2000). "Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2". J. Biol. Chem ... Heterotrimeric G proteins play vital roles in cellular responses to external signals. The specificity of a G protein-receptor ... 2004). "A single Gbeta subunit locus controls cross-talk between protein kinase C and G protein regulation of N-type calcium ... 1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase". J. Biol. Chem. 270 (24): ...

"A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi:10.1016/j.cell ... Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL (2006). "p90 ribosomal S6 kinase 2 ... exerts a tonic brake on G protein-coupled receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4717-22. doi:10.1073/ ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/ ...

"G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". The Journal of Biological ... or one of the four adrenergic receptors. It is a G-protein coupled receptor associated with the Gs heterotrimeric G-protein ... ADRB-1 is a transmembrane protein that belongs to the G-Protein-Coupled Receptor (GPCR) family. GPCRs play a key role in cell ... As the name suggests, GPCRs are coupled to G-proteins that are heterotrimeric in nature. Heterotrimeric G-proteins consist of ...

2000). "Phosphorylation of phosducin and phosducin-like protein by G protein-coupled receptor kinase 2". J. Biol. Chem. 275 (38 ... 2001). "Modulation of the G protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3 ... Lee RH, Brown BM, Lolley RN (1990). "Protein kinase A phosphorylates retinal phosducin on serine 73 in situ". J. Biol. Chem. ... Phosducin, also known as PDC, is a human protein and gene. It belongs to the phosducin family of proteins. This gene encodes a ...

G protein-coupled receptor kinases phosphorylate activated G protein-coupled receptors, which promotes the binding of an ... This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, and is most ... "Different G protein-coupled receptor kinases govern G protein and beta-arrestin-mediated signaling of V2 vasopressin receptor ... 1998). "β2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor ...

2012-09-21). "Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility". ... The adrenergic receptors or adrenoceptors are a class of G protein-coupled receptors that are targets of many catecholamines ... Beta adrenergic receptor kinase Beta adrenergic receptor kinase-2 There is no α1C receptor. There was a subtype known as C, but ... α2B and α2C β receptors are subdivided into β1, β2 and β3. All 3 are coupled to Gs proteins, but β2 and β3 also couple to Gi Gi ...

"Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2". Cell. 129 (3): 511 ... Null mice show increased levels of S-nitrosated proteins, increased beta adrenergic receptor numbers in lung and heart, ... Nitrosylated thioredoxin, via directed protein-protein interaction, trans-nitrosylates the active site cysteine of caspase-3 ... Deleting the GSNOR gene from both yeast and mice increased the cellular levels of GSNO and nitrosylated proteins, and the yeast ...

2002). "G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95". J. Biol. Chem. 277 ( ... 1997). "Characterization of guanylate kinase-associated protein, a postsynaptic density protein at excitatory synapses that ... a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95". Genes Cells. 2 (6): 415-24. doi: ... 2000). "Association of synapse-associated protein 90/ postsynaptic density-95-associated protein (SAPAP) with neurofilaments". ...

"The metabotropic glutamate receptor 4 is internalized and desensitized upon protein kinase C activation". British Journal of ... Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene. Together with GRM6, GRM7 and GRM8 it ... Enz R (Mar 2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Letters ... "p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing ...

"Synucleins are a novel class of substrates for G protein-coupled receptor kinases". J. Biol. Chem. 275 (34): 26515-22. doi: ... The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain ... Two transcript variants encoding the same protein have been found for this gene. Beta-synuclein is a synuclein protein found ... This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in ...

"Monocyte chemoattractant protein-1-induced CCR2B receptor desensitization mediated by the G protein-coupled receptor kinase 2 ... This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1 (CCL2), a chemokine which specifically ... "Chemokine Receptors: CCR2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ... CCR2 is a CC chemokine receptor. This CCR2 gene is located in the chemokine receptor gene cluster region. Two alternatively ...

McCrink KA, Brill A, Lymperopoulos A (2015). "Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous ... beta receptors into subtypes β1, β2, and β3. All of these function as G protein-coupled receptors, meaning that they exert ... Alpha-1 receptors and all three types of beta receptors usually have excitatory effects. Inside the brain norepinephrine ... These amino acids are found in nearly every protein and, as such, are provided by ingestion of protein-containing food, with ...

S1P can be recognized by the G protein-coupled receptors S1P1 through S1P5. Which one of these receptors is relevant in the ... Sphingosine kinase 1 and sphingosine kinase 2 have been linked to S1P generation during apoptosis through different pathways. ... The receptor on the monocyte or other phagocyte for ATP and UTP signals has been shown to be P2Y2 in vivo. The receptor on the ... The receptors on monocytes that are able to detect the presence of CX3CL1 are CX3R1 receptors, as shown in both in vivo and in ...

... and enhance their selectivity toward certain G proteins. PIP2 has been shown to recruit G protein-coupled receptor kinase 2 ( ... "Effect of Lipid Composition on Membrane Orientation of the G protein-coupled Receptor Kinase 2-Gβ1γ2 Complex". Biochemistry. 55 ... PtdIns(4,5)P2 has been shown to stabilize the active states of Class A G protein-coupled receptors (GPCRs) via direct binding, ... PIP2 functions as an intermediate in the IP3/DAG pathway, which is initiated by ligands binding to G protein-coupled receptors ...

G protein-coupled receptor kinase 2 mediated, phosphorylation of ribosomal protein P2". Biochemistry. 41 (42): 12850-12857. doi ... "Analysis of the protein-protein interactions between the human acidic ribosomal P-proteins: evaluation by the two hybrid system ... "Analysis of the protein-protein interactions between the human acidic ribosomal P-proteins: evaluation by the two hybrid system ... Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C ...