During his post-doc, he studied the molecular motor protein, dynein using X-ray crystallography and single molecule ... "Find people in the EMBO Communities". people.embo.org. Retrieved 26 August 2018. "58 life science researchers elected as new ... "LMB Student Prize - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology. Retrieved 26 August 2018. " ... He obtained a PhD in 2003 from the MRC Laboratory of Molecular Biology where he worked with Venki Ramakrishnan on the ribosome ...

In bacteria, branch migration is facilitated by the RuvABC complex or RecG protein, molecular motors that use the energy of ATP ... Chemical analysis in the 1980s showed that the junction actually preferred the antiparallel conformation, a finding that was ... ISBN 0-9631172-1-1. West SC (2003). "Molecular views of recombination proteins and their control". Nature Reviews Molecular ... Such proteins distort the structure of the junction in various ways, often pulling the junction into an unstacked conformation ...

To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... The aim is to find therapies and learn more about how to resolve issues with mutations. The common effects have been ... Shaw DR, Ennis HL (1993). "Molecular cloning and developmental regulation of Dictyostelium discoideum homologues of the human ... developmental delays, ranging from motor delays to minimal expressive language. GRCh38: Ensembl release 89: ENSG00000087191 - ...

Schaefer and Greengard found that the microRNA miR-128 is involved in modulating neuronal excitability and motor activity. ... When they suppressed BET proteins they found decreased neuronal gene expression and neuronal dysfunction which suggested a role ... In 2011, Schaefer was part of a team that filed a patent for a method of translational profiling and molecular phenotyping of ... She found that a deficiency in argonaute 2 (a gene known to regulate the generation of miRNA) in the dopamine receptor 2 (Drd2 ...

Xie J, Schultz PG (August 2006). "A chemical toolkit for proteins--an expanded genetic code". Nature Reviews Molecular Cell ... Although much circumstantial evidence has been found to suggest that fewer amino acid types were used in the past, precise and ... Boillée, S; Vande Velde, C; Cleveland, D. W. (2006). "ALS: A disease of motor neurons and their nonneuronal neighbors". Neuron ... which truncates the protein. These mutations may impair the protein's function and are thus rare in in vivo protein-coding ...

Peripherin found in peripheral neurons. Vimentin, the most widely distributed of all IF proteins, can be found in fibroblasts, ... Kinesin is being researched and is suggested to connect vimentin to tubulin via motor proteins. Keratin filaments in epithelial ... 2000). Molecular Cell Biology. New York: W. H. Freeman. p. Section 19.6, Intermediate Filaments. ISBN 978-0-07-243940-3. Wang Q ... There are four proteins classed as type III intermediate filament proteins, which may form homo- or heteropolymeric proteins. ...

The BTBD9 gene through the use of iron regulatory protein-2 in human cell line is found to be associated with the regulation of ... DeAndrade MP, Johnson RL, Unger EL, Zhang L, van Groen T, Gamble KL, Li Y (September 2012). "Motor restlessness, sleep ... Zhang L, Fu YH (January 2020). "The molecular genetics of human sleep". The European Journal of Neuroscience. 51 (1): 422-428. ... proteins is understood to contain genes encoding protein-protein interactions. BTBD9 is a protein located in cellular cytosol ...

... was found to be a potent ligand for the "peripheral benzodiazepine receptor", later renamed to mitochondrial ... Xiao J, Liang D, Zhang H, Liu Y, Li F, Chen YH (April 2010). "4'-Chlorodiazepam, a translocator protein (18 kDa) antagonist, ... February 2008). "Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats". The European Journal ... Journal of Molecular and Cellular Cardiology. 78: 90-99. doi:10.1016/j.yjmcc.2014.09.024. PMC 4268014. PMID 25268650. Obame FN ...

In pure AD, NFT are predominantly found at a high frequency: In AD+DLB, the distribution of NFT frequency was found to be ... Despite the decrease in density of NFTs, motor and memory deficits were not seen to improve following treatment. Additionally, ... These aggregations of hyperphosphorylated tau protein are also referred to as PHF, or "paired helical filaments"). The precise ... 2005). "Tau phosphorylation in Alzheimer's disease: pathogen or protector?". Trends in Molecular Medicine. 11 (4): 164-169. doi ...

... may be due to precise molecular changes that occur in vivo with sustained exercise. It has been found that the ... Some reasons why fatigue is found are due to action potentials of motor units having a similar pattern of repolarization, fast ... fatigue through increased intracellular calcium or increases fatigue through reduced sensitivity of contractile proteins to ... Fatigue has been found to play a big role in limiting performance in just about every individual in every sport. In research ...

It is also found in different compartments of the digestive tract, including pancreas, stomach, jejunum, ileum, and colon. In ... Yu CY (1998). "Molecular genetics of the human MHC complement gene cluster". Experimental and Clinical Immunogenetics. 15 (4): ... A member of the tenascin family, tenascin X (TN-X) also known as flexillin or hexabrachion-like protein is a 450kDa ... Endo T, Ariga H, Matsumoto K (January 2009). "Truncated form of tenascin-X, XB-S, interacts with mitotic motor kinesin Eg5". ...

Due to slight protein binding, strychnine leaves the bloodstream quickly and distributes to the tissues. Approximately 50% of ... February 2010). "The molecular receptive ranges of human TAS2R bitter taste receptors". Chemical Senses. 35 (2): 157-170. doi: ... It primarily affects the motor nerve fibers in the spinal cord which control muscle contraction. An impulse is triggered at one ... In persons killed by strychnine, the highest concentrations are found in the blood, liver, kidney and stomach wall. The usual ...

This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ... "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". The ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ... 14-3-3 protein gamma is a protein that in humans is encoded by the YWHAG gene. This gene product belongs to the 14-3-3 protein ...

We found that overexpressed TAZ in HDAC9-knockdown cells abrogated the effects induced by HDAC9 silencing both in vitro and in ... The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous ... Motor innervation controls chromatin acetylation in skeletal muscle and that histone deacetylase 9 (HDAC9) is a signal- ... These findings show a molecular mechanism to account for the control of chromatin acetylation by presynaptic neurons and the ...

Found at the cytoplasmic end of the linker domain, the FtsKC segment of the protein is responsible for enabling the activity of ... Aussel L, Barre FX, Aroyo M, Stasiak A, Stasiak AZ, Sherratt D (January 2002). "FtsK Is a DNA motor protein that activates ... "The FtsK family of DNA translocases finds the ends of circles". Journal of Molecular Microbiology and Biotechnology. 24 (5-6): ... Protein pages needing a picture, Single-pass transmembrane proteins, Bacterial proteins). ...

... and clockwork motors in wind-up toys use elastic energy. In biological systems, molecular motors, like myosins in muscles, use ... Found in all forms of life, ATP is often referred to as the "molecular unit of currency" of intracellular energy transfer. ... Enzyme Enzymes are proteins that act as biological catalysts (biocatalysts). Catalysts accelerate chemical reactions. The ... DC motor An electrical motor driven by direct current. Decibel A logarithmic unit of ratios. Definite integral The integral of ...

... and semen proteins whose aggregation enhances HIV infection. Importantly, the molecular tweezers have been found to be ... "A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein". Neurotherapeutics. 14 (4): 1107-1119. doi: ... Amyloid β-protein Assembly: The Effect of Molecular Tweezer CLR01 and CLR03. J. Phys. Chem. B, 2015; 119: 4831-4841. S ... Lysine-specific molecular tweezers are broad-spectrum inhibitor of aggregation and toxicity of amyloid proteins. J. Am. Chem. ...

Glial fibrillary acidic protein (GFAP), and Protein 0. These proteins are seen in other glial cells such as Myelinating Schwann ... Motor-end plate potentials were unaltered in the pre-ablated and the 5 hour ablated models, showing that PSCs are not essential ... It was found that these newly discovered cells were present in nerve degeneration models, showing their non-neural nature. The ... These cultures are used to understand the molecular basis for which PSCs promote synaptogenesis. From these cultures it has ...

Protein separate techniques, such as 2D PAGE, are limited in that they cannot handle very high or low molecular weight protein ... It is necessary then to study each protein individually and find a correlation between the different proteins to determine the ... With more and more neurons affected along this chain of cell death, permanent loss of sensory or motor function may be the ... proteins, while NGF resulted in an increase in proteins associated with the ribosome and synthesis of other proteins. JNJ460 ...

The MOP3 protein, as it was originally known by the Hogenesch group, was found to dimerize with MOP4, CLOCK, and hypoxia- ... Ko CH, Takahashi JS (October 2006). "Molecular components of the mammalian circadian clock". Human Molecular Genetics. 15 Spec ... and motor learning disabilities. These changes are associated with hyperactivation of the mTOR signaling pathway in the brain ... The protein encoded by the BMAL1 gene in mammals binds with a second bHLH-PAS protein via the PAS domain, CLOCK (or its paralog ...

... +protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CHRNA6 genome location and ... The CHRNA6 gene codes for the α6 nicotinic receptor subunit that is found in certain types of nicotinic acetylcholine receptors ... Calabresi P, Massimiliano D (Oct 2008). "ACh/Dopamine Crosstalk in Motor Control and Reward: A Crucial Role for α6-Containing ... Molecular Pharmacology. 72 (1): 52-61. doi:10.1124/mol.107.035998. PMID 17409284. S2CID 25281990. Zeiger JS, Haberstick BC, ...

... molecular switches (DNA tweezers), and autonomous molecular motors (DNA walkers). Theoretical research in molecular computing ... Two or more proteins may bind to each other via binding of their interactions sites, and form a dynamic protein complex ( ... To find the best path between the nest and a source of food, ants rely on indirect communication by laying a pheromone trail on ... Such modifications cause changes to available binding sites of proteins. There are tens of thousands of proteins in a cell, and ...

... molecular protein folding models, and neural network models. A symbolic model is expressed in characters, usually non-numeric ... Children 2 years old were found to make an error similar to the A-not-B error when searching for toys hidden in a sandbox. ... This CPG contains three motor neurons to control the foot, backward swing, and forward swing effectors of the leg. Outputs of ... Early work in the application of dynamical systems to cognition can be found in the model of Hopfield networks. These networks ...

... protein heteromer and the intact snRNP core". Journal of Molecular Biology. 265 (2): 87-94. doi:10.1006/jmbi.1996.0713. PMID ... "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA. 10 (6): 929-41. ... "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): ... "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". ...

An evolutionarily related pre-rRNA processing protein, which lacks the Gly/Arg-rich domain, has been found in various archaea. ... Pellizzoni L, Baccon J, Charroux B, Dreyfuss G (Jul 2001). "The survival of motor neurons (SMN) protein interacts with the ... along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP". Molecular and Cellular Biology. 22 (23): ... The 15.5-kDa protein has sequence similarity to other RNA-binding proteins such as ribosomal proteins S12, L7a, and L30 and the ...

Zhou ZD, Selvaratnam T, Lee JC, Chao YX, Tan EK (February 2019). "Molecular targets for modulating the protein translation ... One meta-analysis found a risk ratio of 1.6 for ever being exposed to a pesticide, with herbicides and insecticides showing the ... Goal-based exercises are often developed with the guidance of a physical therapist to use movement to improve motor task ... The role of the SNCA gene is significant in PD because the alpha-synuclein protein is the main component of Lewy bodies, which ...

Morano I (July 1999). "Tuning the human heart molecular motors by myosin light chains". Journal of Molecular Medicine. 77 (7): ... Two alternatively spliced transcript variants encoding the same protein have been found for this gene. Relative to ventricular ... a molecular motor". Science. 261 (5117): 50-8. doi:10.1126/science.8316857. PMID 8316857. Petzhold D, Lossie J, Keller S, ... Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 ...

cGMP is involved in the regulation of some protein-dependent kinases. For example, PKG (protein kinase G) is a dimer consisting ... Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP (September 2000). "Molecular mechanism of cGMP-mediated smooth muscle ... Studies have found that cGMP synthesis in the olfactory is due to sGC activation by nitric oxide, a neurotransmitter. cGMP also ... "Presynaptic cGMP sets synaptic strength in the striatum and is important for motor learning". EMBO Reports. 23 (8): e54361. doi ...

They have been found to help alleviate motor symptoms when used as monotherapy (on their own); when used in conjunction with ... perhaps through molecular mimicry of viral proteins. Alpha-synuclein, and its aggregate form, Lewy bodies, can bind to ... They assess motor symptoms (bradykinesia, rest tremors, etc.) using clinical diagnostic criteria. The finding of Lewy bodies in ... Olanow CW, Stocchi F, Lang AE (2011). "The non-motor and non-dopaminergic features of PD". Parkinson's Disease: Non-Motor and ...

Stolz, Samuel; Gröning, Oliver; Prinz, Jan; Brune, Harald; Widmer, Roland (15 June 2020). "Molecular motor crossing the ... "Study finds that patterns formed by spiral galaxies show that the universe may have a defined structure". phys.org. Retrieved 2 ... Their study may have implications in viral pathobiology and vaccine design and shows that the protein's coating is relatively ... "The smallest motor in the world". phys.org. Retrieved 4 July 2020. "Nano-motor of just 16 atoms runs at the boundary of quantum ...