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*  PTK2
... protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by ... Lineage for Protein: Focal adhesion kinase 1 Q00944 "Entrez Gene: PTK2 PTK2 protein tyrosine kinase 2". Guan JL, Shalloway D ( ... a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase". ... "Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation". Nature ...
*  Masitinib
... lymphocyte-specific protein tyrosine kinase (Lck), focal adhesion kinase (FAK) and fibroblast growth factor receptor 3 (FGFR3 ... Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumours in animals, specifically dogs. Since its ... Masitinib inhibits the receptor tyrosine kinase c-Kit which is displayed by various types of tumour. It also inhibits the ...
*  Paxillin
The proteins that bind to paxillin are diverse and include protein tyrosine kinases, such as Src and focal adhesion kinase (FAK ... a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase". ... "Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling". The Journal of ... "Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol ...
*  FYN
Normal FAK is a tyrosine kinase that gets recruited to focal adhesion sites and plays a key role in directed cell movement. ... Fyn is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been ... Fyn is a tyrosine-specific phospho-transferase that is a member of the Src family of non-receptor tyrosine protein kinases. ( ... This family also includes Abl, Src, focal adhesion kinase and Janus kinase.) Fyn is located downstream of several cell surface ...
*  SKAP2
"Identification and characterization of a novel Pyk2/related adhesion focal tyrosine kinase-associated protein that inhibits ... The protein encoded by this gene belongs to the src family kinases. This protein is similar to the src kinase associated ... serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells". ... "RA70 is a src kinase-associated protein expressed ubiquitously". Biochemical and Biophysical Research Communications. 252 (3): ...
*  Tyrosine kinase
... focal adhesion kinase), due to its aforementioned presence in cellular focal adhesions. The protein tyrosine kinase pp125 is ... Protein tyrosine kinase plays a role in this task, too. A protein tyrosine kinase called pp125 is likely at hand in the ... Tyrosine kinases are a subclass of protein kinase. The phosphate group is attached to the amino acid tyrosine on the protein. ... This protein tyrosine kinase is up to about 70% unique compared to some other protein tyrosine kinases, a figure that is unlike ...
*  TFG (gene)
... mitogen-activated kinase activity through a pathway that involves related adhesion focal tyrosine kinase and protein kinase C ... receptor is coupled to mitogen-activated protein kinase via protein kinase C and epidermal growth factor receptor kinase". The ... Syk and ZAP-70 tyrosine kinases in TCR-mediated phosphorylation of the adapter protein Shc". European Journal of Immunology. 28 ... Protein TFG is a protein that in humans is encoded by the TFG gene. TFG (gene) has been shown to interact with PLSCR1. GRCh38: ...
*  Janus kinase
Wilks (1989). "Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction". PNAS. 86 (5 ... this domain is also found in the focal adhesion kinase (FAK) family and is involved in association of JAKs with cytokine ... The four JAK family members are: Janus kinase 1 (JAK1) Janus kinase 2 (JAK2) Janus kinase 3 (JAK3) Tyrosine kinase 2 (TYK2) ... Janus kinase (JAK) is a family of intracellular, nonreceptor tyrosine kinases that transduce cytokine-mediated signals via the ...
*  PTPN6
"Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase ... "Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase". J. Biol. ... Yoshida K, Kufe D (December 2001). "Negative regulation of the SHPTP1 protein tyrosine phosphatase by protein kinase C delta in ... "Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine ...
*  GRB7
The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). ... GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to ... Han DC, Shen TL, Guan JL (Sep 2000). "Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase ... Han DC, Guan JL (Aug 1999). "Association of focal adhesion kinase with Grb7 and its role in cell migration". The Journal of ...
*  PTPN1
Janus kinase 2, TYK2, and focal adhesion kinase as well as other tyrosine-phosphorylated proteins, including BCAR1, DOK1, beta- ... "Phosphorylated alpha-actinin and protein-tyrosine phosphatase 1B coregulate the disassembly of the focal adhesion kinase x Src ... Tyrosine-protein phosphatase non-receptor type 1 also known as protein-tyrosine phosphatase 1B (PTP1B) is an enzyme that is the ... Receptor Kinase Activity by Protein Tyrosine Phosphatase 1B (PTP-1B) and Enhanced IGF-I-Mediated Suppression of Apoptosis and ...
*  List of MeSH codes (D08)
... protein-tyrosine kinase MeSH D08.811.913.696.620.682.725.049 --- focal adhesion protein-tyrosine kinases MeSH D08.811.913.696. ... focal adhesion kinase 2 MeSH D08.811.913.696.620.682.725.200 --- mitogen-activated protein kinase kinases MeSH D08.811.913.696. ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 2 MeSH D08.811.913.696.620.682.700.559.300 --- map kinase kinase kinase 3 MeSH D08.811.913.696.620.682 ...
*  List of MeSH codes (D12.644)
... cdc2 protein kinase MeSH D12.644.360.275 --- eif-2 kinase MeSH D12.644.360.287 --- focal adhesion protein-tyrosine kinases MeSH ... map kinase kinase kinase 1 MeSH D12.644.360.400.200 --- map kinase kinase kinase 2 MeSH D12.644.360.400.300 --- map kinase ... kinase kinase 3 MeSH D12.644.360.400.400 --- map kinase kinase kinase 4 MeSH D12.644.360.400.500 --- map kinase kinase kinase 5 ... map kinase kinase 6 MeSH D12.644.360.440.700 --- map kinase kinase 7 MeSH D12.644.360.450 --- mitogen-activated protein kinases ...
*  MAPK8IP3
"A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine- ... "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine- ... 2006). "JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration". J. Biol. Chem ... C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene. The protein ...
*  Integrin
... when a receptor tyrosine kinase is activated, integrins co-localise at focal adhesion with the receptor tyrosine kinases and ... So the focal adhesions contain integrin ligand, integrin molecule, and associate plaque proteins. Binding is propelled by ... These act by regulating kinases such as FAK (focal adhesion kinase) and Src kinase family members to phosphorylate substrates ... in cell signaling by modulating the cell signaling pathways of transmembrane protein kinases such as receptor tyrosine kinases ...
*  PTK2B
"Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". J. Biol. Chem. ... "The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to ... "Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol ... "Negative regulation of PYK2/related adhesion focal tyrosine kinase signal transduction by hematopoietic tyrosine phosphatase ...
*  LPXN
... a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also ... encoded by this gene is preferentially expressed in hematopoietic cells and is most homologous to the focal adhesion protein, ... 2003). "Leupaxin is a critical adaptor protein in the adhesion zone of the osteoclast". J. Bone Miner. Res. 18 (4): 669-85. doi ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
*  TENC1
The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin ... "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem ... "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem ... TENC1 has been shown to interact with AXL receptor tyrosine kinase. GRCh38: Ensembl release 89: ENSG00000111077 - Ensembl, May ...
*  Metastatic breast cancer
... increased tyrosine phosphorylytion of the focal adhesion kinase, and activation and nuclear translocation of mitogen-activated ... Experimental medications: sorafenib a combined Tyrosine protein kinases inhibitor. Scheduling of drug treatments and ... The ECM protein tenascin C (TNC) is up-regulated in metastatic breast cancer. TNC is an adhesion-modulating extracellular ... Integrin-mediated tumor cell adhesion to ECM proteins can trigger signal transduction and cause upregulation of gene expression ...
*  Filopodia
... form focal adhesions with the substratum, linking it to the cell surface. Many types of migrating cells display ... Growth factors bind to receptor tyrosine kinases resulting in the polymerization of actin filaments, which, when cross-linked, ... Rho activity also results in activation by phosphorylation of ezrin-moesin-radixin family proteins that link actin filaments to ... They contain actin filaments cross-linked into bundles by actin-binding proteins, e.g. fascin and fimbrin. ...
*  RAPGEF2
... and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase". J. Biol. Chem. 277 (14): 12463-73. doi: ... 1999). "nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding ... Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene. RAPGEF2 is a cyclic AMP ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141-50. ...
*  ARHGEF12
... and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase". J. Biol. Chem. 277 (14): 12463-73. doi: ... The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein is observed to form ... Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. Rho GTPases play a ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141-50. ...
*  Non-receptor tyrosine kinase
... an integrin-binding domain and a focal adhesion-binding domain (Fak family). The nRTK Abl possess the SH2 and SH3 domains, but ... to tyrosine residues in proteins. Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that ... Unlike the receptor tyrosine kinases (RTKs), the second subgroup of tyrosine kinases, the non-receptor tyrosine kinases are ... Non-receptor tyrosine kinases do not contain only a tyrosine kinase domain, nRTKs also possess domains that mediate protein- ...
*  FERM domain
Focal-adhesion kinases (FAKs), cytoplasmic protein tyrosine kinases involved in signalling through integrins. Janus tyrosine ... Non-receptor tyrosine-protein kinase TYK2. Protein-tyrosine phosphatases PTPN3 and PTPN4, enzymes that appear to act at ... Protein-tyrosine phosphatases PTPN14 and PTP-D1, PTP-RL10 and PTP2E. Caenorhabditis elegans protein phosphatase ptp-1. Chishti ... Ezrin, moesin, and radixin are highly related proteins (ERM protein family), but the other proteins in which the FERM domain is ...
*  Adapter molecule crk
"Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src ... "Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts". J. Cell ... "Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces ... 1994). "Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src". Mol. Cell. Biol ...
*  Proto-oncogene tyrosine-protein kinase Src
c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein ... It also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion, and regulates matrix ... A number of tyrosine kinase inhibitors that target c-Src tyrosine kinase (as well as related tyrosine kinases) have been ... Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine ...