Loading...
*  Deleted in Colorectal Cancer
"Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204-12. doi:10.1038/nn1330. PMID 15494733. Klingelhutz AJ ... Several phosphorylation events have been established, as have the involvement of several src family kinases and small GTPases, ... and are likely interacting with Src family kinases in regulating responses to netrin-1. Historically, cellular receptors have ... 10 (1): 35-42. PMID 9950216. Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ZF, Song HJ, Mei L, ...
*  NEO1
"Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204-12. doi:10.1038/nn1330. PMID 15494733. Lee JE, Kim HJ ... "Focal adhesion kinase in netrin-1 signaling". Nat. Neurosci. 7 (11): 1204-12. doi:10.1038/nn1330. PMID 15494733. Vielmetter J, ... "Entrez Gene: NEO1 neogenin homolog 1 (chicken)". Ren XR, Ming GL, Xie Y, Hong Y, Sun DM, Zhao ZQ, Feng Z, Wang Q, Shim S, Chen ... Srinivasan K, Strickland P, Valdes A, Shin GC, Hinck L (2003). "Netrin-1/neogenin interaction stabilizes multipotent progenitor ...
*  PPP1CB
296 (1): 6-16. doi:10.1006/viro.2002.1438. PMID 12036313. Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the ... 12 (1): 1-11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. Bharucha DC, Zhou M, Nekhai S, et al. (2002). "A protein ... 79 (1): 113-25. doi:10.1002/1097-4644(2000)79:1. 3.0.CO;2-9. PMID 10906760. Hartley JL, Temple GF, Brasch MA (2001). "DNA ... J. 378 (Pt 1): 229-38. doi:10.1042/BJ20030950. PMC 1223944 . PMID 14640981. Bouwmeester T, Bauch A, Ruffner H, et al. (2004). " ...
*  PTK2
... also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion- ... a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase". ... Girault JA, Labesse G, Mornon JP, Callebaut I (December 1998). "Janus kinases and focal adhesion kinases play in the 4.1 band: ... focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase ...
*  Prostate cancer
... stimulates the focal adhesion kinase (FAK) signaling pathway which leads to prostate cancer cell growth and survival. The ... 90 (6): 340-1. PMC 1296316 . PMID 9227387. Wei ZF, Xu H, Wang H, Wei W, Cheng W, Zhou WQ, Ge JP, Zhang ZY, Gao JP, Yin HL ( ... 1 (1): 34-45. doi:10.1038/35094009. PMID 11900250. Eifler J. B.; Feng Z.; Lin B. M.; Partin M. T.; Humphreys E. B.; Han M.; ... 106 (4): 150-1. PMID 23795527. Archived from the original (PDF) on 2012-07-31. Makarov DV, Desai RA, Yu JB, Sharma R, Abraham N ...
*  TTC7A
... and focal adhesion kinase (FAK) mediated adhesion and differentiation of CD133+CD44+ prostate cancer stem cells". Biochemical ... it has been proposed that Rho kinase inhibitors may be a therapeutic option, although no specific rho kinase inhibitors are ... It has been shown that statins such as Lipitor are useful as Rho kinase inhibitors. Therefore, statins may be helpful for the ... Research indicates that TTC7A deficiency results in "increased Rho kinase activity which disrupts polarity, growth, and ...
*  Insulin-like growth factor 1 receptor
"Concerted activity of tyrosine phosphatase SHP-2 and focal adhesion kinase in regulation of cell motility". Mol. Cell. Biol. 19 ... Tyrosine kinase receptors, including the IGF-1 receptor, mediate their activity by causing the addition of a phosphate groups ... Zhang X, Yee D (2001). "Tyrosine kinase signalling in breast cancer: insulin-like growth factors and their receptors in breast ... Arbet-Engels C, Tartare-Deckert S, Eckhart W (February 1999). "C-terminal Src kinase associates with ligand-stimulated insulin- ...
*  ABL (gene)
... associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae". Mol. Cell. Biol. 16 (7): ... "The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of ... Agami R, Shaul Y (April 1998). "The kinase activity of c-Abl but not v-Abl is potentiated by direct interaction with RFXI, a ... Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the ...
*  NEDD9
Hayashi I, Vuori K, Liddington RC (2002). "The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix ... and sufficient for localizing focal adhesion kinase (FAK) to focal adhesions. It forms a four-helix bundle structure and ... Focal adhesion targeting (FAT) domain The FAT-like C-terminal domain is highly conserved in focal adhesion proteins, ... In response to integrin activation, FAK or the related kinase RAFTK recruits NEDD9 into a focal adhesion site, binds it via the ...
*  BCAR1
"Focal adhesion kinase overexpression enhances ras-dependent integrin signaling to ERK2/mitogen-activated protein kinase through ... similar to those found in other adhesion-related proteins such as focal adhesion kinase (FAK) and vinculin. The remaining ... Cary LA, Han DC, Polte TR, Hanks SK, Guan JL (1998). "Identification of p130Cas as a mediator of focal adhesion kinase-promoted ... Astier A, Avraham H, Manie SN, Groopman J, Canty T, Avraham S, Freedman AS (1997). "The related adhesion focal tyrosine kinase ...
*  Trastuzumab
The pathway initiates the MAP kinase pathway as well as the PI3 kinase/AKT pathway, which in turn activates the NF-κB pathway. ... 2005). "HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways". Cell ... NRG-1 activates the MAPK pathway and the PI3K/AKT pathway as well as focal adhesion kinases (FAK). These are all significant ... 4 (1): 87-95. doi:10.4161/cc.4.1.1360. PMID 15611642. Kute, T; Lack CM; Willingham M; Bishwokama B; Williams H; Barrett K; ...
*  PAK1
"Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1". Biochemical Pharmacology. 85 (2): ... Shin YJ, Kim YB, Kim JH (September 2013). "Protein kinase CK2 phosphorylates and activates p21-activated kinase 1". Molecular ... STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl transferase V, B-Raf proto-oncogene, casein kinase 2 ... "The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1". The Journal of Biological ...
*  Neuregulin 1
... and focal adhesion kinase (FAK). The beneficial effects of neuregulin-1 make recombinant human neuregulin-1 (rhNRG-1) a ... Mutations in human L1 cell adhesion molecules are reported to cause a number of neuronal disorders. In addition, recent ... The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through their displayed ... Wang JY, Frenzel KE, Wen D, Falls DL (August 1998). "Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic ...
*  Paxillin
"Activation of pyk2/related focal adhesion tyrosine kinase and focal adhesion kinase in cardiac remodeling". The Journal of ... a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase". ... The proteins that bind to paxillin are diverse and include protein tyrosine kinases, such as Src and focal adhesion kinase (FAK ... focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase ...
*  TLN1
"Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion ... Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL (Jul 1995). "Interaction of focal adhesion kinase with ... and focal adhesion kinase. Talin-1 N-terminal region also binds acidic phospholipids for insertion into lipid bilayers. The rod ... "Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions". Nature. 420 (6911): 89-93. doi: ...
*  Role of cell adhesions in neural development
... modulates Src family kinase and focal adhesion kinase phosphorylation and subcellular localization, and fibroblast migration, ... though mechanistic work is still needed to better understand thy-1's involvement in this condition. Murase, S (Oct 1999). "The ... These focal adhesion plaques are highly dynamic in nature and undergo a maturation process through which they have altered ... Due to this functionality, adhesions and adhesion molecules have been a topic of study within the scientific community. ...
*  RGS1
2005). "CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by ... Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian ... 2001). "GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways". Mol. ... Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene. This gene encodes a member of the ...
*  Κ-opioid receptor
"Kappa-opioid receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 ... These include extracellular signal-regulated kinase, p38 MAP kinases, and c-Jun N-terminal kinases. The synthetic alkaloid ... evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade". Journal of ... "Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes ...
*  MAPK14
"Doxazosin induces activation of GADD153 and cleavage of focal adhesion kinase in cardiomyocytes en route to apoptosis". ... TGFβ-activated kinase (TAK1), TAO1-3, mixed-lineage kinase 2/3 (MLK2/3), and apoptosis signal-regulating kinase 1/2 (ASK1/2), ... "Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase". Proceedings of the National ... The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple ...
*  CD61
"Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. ... Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling. Defectively expressed β3 ... 157 (1): 149-60. doi:10.1083/jcb.200109079. ISSN 0021-9525. PMC 2173263 . PMID 11927607. Chung, J; Gao A G; Frazier W A (June ... 4 (1): 17-22. PMID 12690916. Smith FB, Connor JM, Lee AJ, et al. (2004). "Relationship of the platelet glycoprotein PlA and ...
*  Integrin, beta 5
"Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling". J. ... Niu JK, Zhang WJ, Ye LY, Wu LQ, Zhu GJ, Yang ZH, Grau GE, Lou JN (2007). "The role of adhesion molecules, alpha v beta 3, alpha ... Zhou M, Graham R, Russell G, Croucher PI (2001). "MDC-9 (ADAM-9/Meltrin gamma) functions as an adhesion molecule by binding the ... Liliental J, Chang DD (1998). "Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit". J. Biol ...
*  TLN2
"Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion ... Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL (Jul 1995). "Interaction of focal adhesion kinase with ... "Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions". Nature. 420 (6911): 89-93. doi: ... Shoeman RL, Hartig R, Hauses C, Traub P (2002). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 ...
*  PTK2B
"Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". J. Biol. Chem. ... Schlaepfer DD, Hauck CR, Sieg DJ (1999). "Signaling through focal adhesion kinase". Prog. Biophys. Mol. Biol. 71 (3-4): 435-78 ... Avraham S, Avraham H (1997). "Characterization of the novel focal adhesion kinase RAFTK in hematopoietic cells". Leuk. Lymphoma ... "The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to ...
*  MMP16
Shofuda T, Shofuda K, Ferri N (2004). "Cleavage of focal adhesion kinase in vascular smooth muscle cells overexpressing ... Wang SC, Lien HC, Xia W (2004). "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB- ... 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474. Mattei MG, Roeckel N, Olsen BR, Apte SS (1997). "Genes of the ... 40 (1): 168-9. doi:10.1006/geno.1996.4559. PMID 9070935. Shofuda K, Yasumitsu H, Nishihashi A (1997). "Expression of three ...
*  Chinmoy Sankar Dey
... focal adhesion kinase) could be stopped by inhibiting the activity of the insulin receptor tyrosine kinase, which was a new ... he demonstrated that focal adhesion kinases and p38 mitogen-activated protein kinases could be used as possible drug targets. ... doi:10.1007/s00125-007-0591-6. CS1 maint: Multiple names: authors list (link) Bisht B, Dey CS (2008). "Focal Adhesion Kinase ... Bisht B, Goel HL, Dey CS (2007). "Focal adhesion kinase regulates insulin resistance in skeletal muscle". Diabetologia. 50 (5 ...
*  Proto-oncogene tyrosine-protein kinase Src
c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein ... It also regulates angiogenic factors and vascular permeability after focal cerebral ischemia-reperfusion, and regulates matrix ... A number of tyrosine kinase inhibitors that target c-Src tyrosine kinase (as well as related tyrosine kinases) have been ... It belongs to a family of non-receptor tyrosine kinases called Src family kinases. This gene is similar to the v-Src gene of ...