Loading...
*  FMS-like tyrosine kinase 3 ligand
... (FLT3L) is an endogenous small molecule that functions as a cytokine and growth factor that ...
*  FLT3LG
Fms-related tyrosine kinase 3 ligand (FLT3LG) is a protein which in humans is encoded by the FLT3LG gene. Flt3 ligand (FL) is a ... FLT3LG fms-related tyrosine kinase 3 ligand". Hannum C, Culpepper J, Campbell D, McClanahan T, Zurawski S, Bazan JF, Kastelein ... 1994). "Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant ... 1994). "Molecular cloning of a ligand for the flt3/flk-2 tyrosine kinase receptor: a proliferative factor for primitive ...
*  CD135
2007). "FMS-like tyrosine kinase 3 in normal hematopoiesis and acute myeloid leukemia". Stem Cells. 24 (5): 1174-84. doi: ... Cluster of differentiation cytokine receptor receptor tyrosine kinase tyrosine kinase oncogene hematopoiesis Lymphopoiesis# ... a juxtamembrane domain and a tyrosine-kinase domain consisting of 2 lobes that are connected by a tyrosine-kinase insert. ... Huret J-L. "FLT3 (FMS-like tyrosine kinase 3)". Atlas of Genetics and Cytogenetics in Oncology and Haematology. University ...
*  Pacritinib
It mainly inhibits Janus kinase 2 (JAK2) and Fms-like tyrosine kinase 3 (FLT3). The drug was in Phase III clinical trials as of ... a Potent Janus Kinase 2/Fms-Like Tyrosine Kinase-3 (JAK2/FLT3) Inhibitor for the Treatment of Myelofibrosis and Lymphoma". ... potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3)". Journal of Computer-Aided Molecular Design. ... Pacritinib (INN) is a macrocyclic Janus kinase inhibitor that is being developed for the treatment of myelofibrosis. ...
*  Midostaurin
... was found to be active against oncogenic CD135 (FMS-like tyrosine kinase 3 receptor, FLT3), in preclinical studies ... "Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412". Cancer Cell. 1 ( ... which renders c-Kit resistant to currently available tyrosine kinase inhibitors. Midostaurin is an investigational treatment in ... Midostaurin (sold under the name Rydapt) is a multi-targeted protein kinase inhibitor that has been investigated for the ...
*  Soluble fms-like tyrosine kinase-1
... (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein that disables proteins that cause blood ... Another VEGF receptor is KDR). sFlt-1 (soluble fms-like tyrosine kinase-1 - also known as soluble VEGF receptor-1) binds and ... Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and ... First Trimester Placental Growth Factor and Soluble Fms-Like Tyrosine Kinase 1 and Risk for Preeclampsia. J Clin Endo 2004;89(2 ...
*  Lestaurtinib
It is an inhibitor of the kinases fms-like tyrosine kinase 3 (FLT3), Janus kinase 2 (JAK2), tropomyosin receptor kinase (trk) A ... Lestaurtinib was identified early on as a trk receptor tyrosine kinase (RTK) inhibitor, with a concentration inhibiting 50% of ... Lestaurtinib (rINN, codenamed CEP-701) is a tyrosine kinase inhibitor structurally related to staurosporine. This semisynthetic ... Janus kinase inhibitor Shabbir M, Stuart R (2010). "Lestaurtinib, a multitargeted tyrosinse kinase inhibitor: from bench to ...
*  ETV6
"Response of ETV6-FLT3-positive myeloid/lymphoid neoplasm with eosinophilia to inhibitors of FMS-like tyrosine kinase 3". Blood ... gene fusion to receptor tyrosine kinases and non-receptor tyrosine kinases may be sensitive to therapy with tyrosine kinase ... It is proposed that tyrosine kinase inhibitors with specificity for NTRK3's tyrosine kinase activity in ETV6-NTRK3 gene- ... The table includes abbreviations for tyrosine kinase receptor (TK receptor), non-receptor tyrosine kinase (non-receptor TK), ...
*  Cabozantinib
... and Fms-like tyrosine kinase-3 (FLT3). Cabozantinib (previously XL184) was granted orphan drug status by the U.S. Food and Drug ... It is a small molecule inhibitor of the tyrosine kinases c-Met and VEGFR2, and also inhibits AXL and RET. It was discovered and ... It inhibits the following receptor tyrosine kinases: MET (hepatocyte growth factor receptor protein) and VEGFR, RET, GAS6 ...
*  Crenolanib
FMS-like Tyrosine Kinase 3), PDGFR α (Platelet-Derived Growth Factor Receptor), and PDGFR β. Unlike most RTK inhibitors, ... SPECIFIC INHIBITOR OF CLASS III RECEPTOR TYROSINE KINASES, PREFERENTIALLY BINDS TO PHOSPHORYLATED KINASES" (PDF). gistsupport. ... mutant-specific inhibitor of Class III receptor tyrosine kinases, preferentially binds to phosphorylated kinases". Cancer ... Type III Receptor tyrosine kinase, including FLT3, PDGFRα and PDGFRβ, have been directly implicated in the pathogenesis of ...
*  List of MeSH codes (D12.776)
... fms-like tyrosine kinase 3 MeSH D12.776.624.664.700.120 - receptor, fibroblast growth factor, type 3 MeSH D12.776.624.664. ... lymphocyte specific protein tyrosine kinase p56(lck) MeSH D12.776.624.664.700.642 - receptor, erbb-2 MeSH D12.776.624.664. ... cdc2 protein kinase MeSH D12.776.167.200.067.500 - cdc28 protein kinase, s cerevisiae MeSH D12.776.167.200.067.875 - cyclin- ... dependent kinase 5 MeSH D12.776.167.200.067.900 - cyclin-dependent kinase 9 MeSH D12.776.167.200.580.500 - cdc2 protein kinase ...
*  Quizartinib
Specifically, Quizartinib selectively inhibits class III receptor tyrosine kinases, including FMS-related tyrosine kinase 3 ( ... and Efficacious FMS-Like Tyrosine Kinase-3 (FLT3) Inhibitor". Journal of Medicinal Chemistry. 52 (23): 7808-7816. doi:10.1021/ ... Quizartinib (AC220) is a small molecule receptor tyrosine kinase inhibitor that is currently under development by Ambit ... FLT3/STK1), colony-stimulating factor 1 receptor (CSF1R/FMS), stem cell factor receptor (SCFR/KIT), and platelet derived growth ...
*  FL
Fms-related tyrosine kinase 3 ligand), a protein FL (complexity), a class of functions in complexity theory FL (programming ...
*  Lymphopoiesis
HSC are technically described as: lacking FMS-like tyrosine kinase 3 (Flt3) and lacking the markers specific to discrete ... Note explaining the barcode parameter details: Flt3 is a cytokine tyrosine kinase receptor thought to be important in early ... The progenitor can also differentiate into (3) natural killer cells (NK) and (4) dendritic cells. T Cells, B Cells and NK Cells ... Stage Three: β-Selection Stage Four: T Cell Receptors Selection Only 2% to 3% of the differentiating thymocytes, those that ...
*  List of MeSH codes (D23)
... fms-like tyrosine kinase 3 MeSH D23.050.301.264.035.285 --- integrin alpha1 MeSH D23.050.301.264.035.287 --- integrin alpha2 ... fms-like tyrosine kinase 3 MeSH D23.101.100.110.285 --- integrin alpha1 MeSH D23.101.100.110.288 --- integrin alpha2 MeSH ... cdc2 protein kinase MeSH D23.348.686.100 --- brain-derived neurotrophic factor MeSH D23.348.686.212 --- ciliary neurotrophic ... ca-15-3 antigen MeSH D23.050.285.050.119 --- ca-19-9 antigen MeSH D23.050.285.050.225 --- ca-125 antigen MeSH D23.050.285.062 ...
*  List of MeSH codes (D12.776.543)
... fms-like tyrosine kinase 3 MeSH D12.776.543.750.060.061 -- receptor, fibroblast growth factor, type 1 MeSH D12.776.543.750. ... toll-like receptor 3 MeSH D12.776.543.750.705.910.500.400 -- toll-like receptor 4 MeSH D12.776.543.750.705.910.500.500 -- toll- ... erbb-3 MeSH D12.776.543.750.060.468 -- receptor, igf type 1 MeSH D12.776.543.750.060.484 -- receptor, insulin MeSH D12.776. ... type 3 MeSH D12.776.543.750.750.400.370.937 -- receptor, fibroblast growth factor, type 4 MeSH D12.776.543.750.750.400.370.968 ...
*  RTK class III
February 2003). "Mutational analysis of class III receptor tyrosine kinases (C-KIT, C-FMS, FLT3) in idiopathic myelofibrosis". ... RTK class III is a class of receptor tyrosine kinases. It includes PDGFRα, PDGFRβ, C-KIT, CSF1R, and FLT3. Abu-Duhier FM, ... 120 (3): 464-70. doi:10.1046/j.1365-2141.2003.04108.x. PMID 12580961. Molecular and Cellular Biology portal. ...
*  List of MeSH codes (D08)
... receptor protein-tyrosine kinases MeSH D08.811.913.696.620.682.725.400.020 --- fms-like tyrosine kinase 3 MeSH D08.811.913.696. ... map kinase kinase kinases MeSH D08.811.913.696.620.682.700.559.100 --- map kinase kinase kinase 1 MeSH D08.811.913.696.620.682. ... map kinase kinase kinase 2 MeSH D08.811.913.696.620.682.700.559.300 --- map kinase kinase kinase 3 MeSH D08.811.913.696.620.682 ... map kinase kinase kinase 4 MeSH D08.811.913.696.620.682.700.559.500 --- map kinase kinase kinase 5 MeSH D08.811.913.696.620.682 ...
*  Colony stimulating factor 1 receptor
"Identification of a second Grb2 binding site in the v-Fms tyrosine kinase". Oncogene. 15 (13): 1565-72. doi:10.1038/sj.onc. ... The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein ... Mutations in the tyrosine kinase domain have been associated with hereditary diffuse leukoencephalopathy with spheroids. ... c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms". J. Biol. Chem. 277 (17): 14635-40. doi:10.1074/jbc. ...
*  Endoglin
Luft FC (Nov 2006). "Soluble endoglin (sEng) joins the soluble fms-like tyrosine kinase (sFlt) receptor as a pre-eclampsia ... TGF beta receptor II can bind endoglin with an inactive and active kinase domain. The kinase is active when it is ... Some mutations that lead to this disorder are: a Cytosine (C) to Guanine (G) substitution which converts a tyrosine to stop ... Unlike TGF beta receptor I which can only bind the cytoplasmic tail when its kinase domain is inactive, ...
*  VEGFR1
... closely related to the fms family". Oncogene. 5 (4): 519-24. PMID 2158038. "Entrez Gene: FLT1 fms-related tyrosine kinase 1 ( ... 1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM] The ablation of VEGFR1 by chemical ... Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA (May 2005). "Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction ... it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The ...
*  Vascular endothelial growth factor
Fms-like tyrosine kinase-1 (flt-1) was shown to be a VEGF receptor by Ferrara et al. in 1992. The kinase insert domain receptor ... de Vries, C; Escobedo, JA; Ueno, H; Houck, K; Ferrara, N; Williams, LT (21 February 1992). "The fms-like tyrosine kinase, a ... All members of the VEGF family stimulate cellular responses by binding to tyrosine kinase receptors (the VEGFRs) on the cell ... triggering a Tyrosine Kinase Pathway leading to angiogenesis. The expression of angiopoietin-2 in the absence of VEGF leads to ...
*  Chromosome 8 (human)
... fms-related tyrosine kinase 2, Pfeiffer syndrome) FGL1: Fibrinogen-like protein 1 GDAP1: ganglioside-induced differentiation- ... cAMP-dependent protein kinase inhibitor alpha PLEC: plectin PNMA2: paraneoplastic antigen Ma2 PREX2: phosphatidylinositol-3,4,5 ... 20 (1): 70-3. doi:10.1038/1734. PMID 9731535. Gurling HM, Kalsi G, Brynjolfson J, et al. (March 2001). "Genomewide genetic ... 68 (3): 661-73. doi:10.1086/318788. PMC 1274479 . PMID 11179014. Suarez BK, Duan J, Sanders AR, et al. (February 2006). " ...
*  GRB2
"Identification of a second Grb2 binding site in the v-Fms tyrosine kinase". Oncogene. 15 (13): 1565-72. doi:10.1038/sj.onc. ... Pratt RL, Kinch MS (Oct 2002). "Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade". ... "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and ... "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". The Journal of Biological ...
*  FLT4
Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene. This gene encodes ... FLT4 fms-related tyrosine kinase 4". Galland F, Karamysheva A, Mattei MG, Rosnet O, Marchetto S, Birnbaum D (June 1992). " ... Pajusola K, Aprelikova O, Armstrong E, Morris S, Alitalo K (November 1993). "Two human FLT4 receptor tyrosine kinase isoforms ... "FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell ...
*  Index of biochemistry articles
... protein-tyrosine kinase - protein-tyrosine-phosphatase - proteinoid - proteomics - protirelin - proto-oncogene - proto-oncogene ... fms gene - Formaldehyde - fos gene - free energy - freezing point - FSH receptor - functional group - fungal protein - fungi - ... receptor protein-tyrosine kinase - recombinant fusion protein - recombinant interferon-gamma - recombinant protein - ... Tyrosine - tyrosine 3-monooxygenase - Ubiquitin - Urea - Urea cycle - Uric acid - UV/VIS spectroscopy - vaccine - vacuole - ...