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*  Fluorouracil
Fluorouracil's efficacy is decreased when used alongside allopurinol, which can be used to decrease fluorouracil induced ... "Fluorouracil". International Drug Price Indicator Guide. Retrieved 8 December 2016. "Fluorouracil Prices, Coupons & Patient ... "fluorouracil" is the INN, USAN, USP name, and BAN. The form "5-fluorouracil" is often used; it shows that there is a fluorine ... Fluorouracil (5-FU), sold under the brand name Adrucil among others, is a medication used to treat cancer. By injection into a ...
*  List of OMIM disorder codes
DHH 5-fluorouracil toxicity; 274270; DPYD 6-mercaptopurine sensitivity; 610460; TPMT Aarskog-Scott syndrome; 305400; FGD1 ABCD ...
*  Chemotherapy
The fluoropyrimidines include fluorouracil and capecitabine. Fluorouracil is a nucleobase analogue that is metabolised in cells ... "Body Surface Area-based Dosing of 5-Fluorouracil Results in Extensive Interindividual Variability in 5-Fluorouracil Exposure in ... "Modeling the 5-fluorouracil area under the curve versus dose relationship to develop a pharmacokinetic dosing algorithm for ... Topical chemotherapies, such as 5-fluorouracil, are used to treat some cases of non-melanoma skin cancer. If the cancer has ...
*  Male breast cancer
Chemotherapeutic options include: Cyclophosphamide plus methotrexate plus fluorouracil (CMF). Cyclophosphamide plus doxorubicin ... plus fluorouracil (CAF). Trastuzumab (monoclonal antibody therapy). Hormonal options include: Orchiectomy.[citation needed] ...
*  Actinic cheilitis
Topical 5-fluorouracil (5-FU, Efudex, Carac) has been shown to be an effective therapy for diffuse, but minor actinic cheilitis ... 5-fluorouracil works by blocking DNA synthesis. Cells that are rapidly growing need more DNA, so they accumulate more 5- ... Treatment options include 5-fluorouracil, imiquimod, scalpel vermillionectomy, chemical peel, electrosurgery, and carbon ... fluorouracil, resulting in their death. Normal skin is much less affected. The treatment usually takes 2-4 weeks depending on ...
*  Pyrimidine analogue
5-Fluorouracil (5FU) which inhibits thymidylate synthase. Floxuridine (FUDR) Cytarabine (Cytosine arabinoside) 6-azauracil (6- ... AU) Pyrimidine Fluorouracil Floxuridine Gemcitabine Pyrimidine antimetabolites are commonly used to treat cancer by interfering ...
*  Dendrimer
Bhadra, D.; Bhadra, S.; Jain, S.; Jain, N.K. (2003). "A PEGylated, dendritic nanoparticulate carrier of fluorouracil". ...
*  Adjuvant therapy
... and fluorouracil Cyclophosphamide, methotrexate, and fluorouracil. Docetaxel and cyclophosphamide. Docetaxel,[doxorubicin, and ... Studies have shown that fluorouracil is an effective adjuvant chemotherapy among patients with microsatellite stability or low- ... July 2003). "Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy ... fluorouracil, and methotrexate) and radiotherapy, especially after lumpectomy, and hormonal therapy (tamoxifen, femara). ...
*  Thymineless death
Longley, D. B.; Harkin, D. P.; Johnston, P. G. (2003). "5-Fluorouracil: Mechanisms of action and clinical strategies". Nature ... Methotrexate and Fluorouracil. The phenomenon was first reported in 1954 by Hazel D. Barner and Seymour S. Cohen in Escherichia ... "The Mode of Action of 5-Fluorouracil and Its Derivatives". Proceedings of the National Academy of Sciences of the United States ...
*  Foldamer
Longley, DB; Harkin DP; Johnston PG (May 2003). "5-fluorouracil: mechanisms of action and clinical strategies". Nat. Rev. ...
*  MTDH
"Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United ...
*  Michael L. Brodman
Treatment with a laser and topical 5-fluorouracil". J Reprod Med. 37 (5): 453-6. PMID 1324311. Navot, D; Fox, JH; Williams, M; ...
*  Folinic acid
Fluorouracil: Folinic acid may increase the toxicity associated with fluorouracil if the two are administered together. Some ... It is also used in combination with 5-fluorouracil to treat colorectal cancer, may be used to treat folate deficiency that ... In this case, folinic acid is not used for "rescue" purposes; rather, it enhances the effect of 5-fluorouracil by inhibiting ... Trissel, L. A.; Martinez, J. F.; Xu, Q. A. (1995). "Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin ...
*  Knuckle pads
ISBN 0-7216-2921-0. Weiss, E; Amini, S (2007). "A Novel Treatment for Knuckle Pads With Intralesional Fluorouracil". Arch ... there has been some effectiveness with intralesional fluorouracil. Skin lesion List of cutaneous conditions Garrod's pad Mackey ...
*  Actinic keratosis
Topical fluorouracil (5-FU) destroys AKs by blocking methylation of thymidylate synthetase, thereby interrupting DNA and RNA ... Robins, P; Gupta, AK (August 2002). "The use of topical fluorouracil to treat actinic keratosis". Cutis. 70 (2 Suppl): 4-7. ... Askew, DA; Mickan, SM; Soyer, HP; Wilkinson, D (May 2009). "Effectiveness of 5-fluorouracil treatment for actinic keratosis--a ... Gupta, AK; Davey, V; Mcphail, H (October 2005). "Evaluation of the effectiveness of imiquimod and 5-fluorouracil for the ...
*  Black salve
... fluorouracil and ingenol mebutate; radiation therapy; and surgical excision, including Mohs surgery (microscopically controlled ...
*  Breast cancer
... and fluorouracil (or "CMF"). Most chemotherapy medications work by destroying fast-growing and/or fast-replicating cancer cells ...
*  Thymidylate synthase
The most widely used inhibitor is 5-fluorouracil (5-FU), which acts as an antimetabolite that irreversibly inhibits TS by ... Upon entering the cell, 5-fluorouracil (5-FU) is converted to a variety of active metabolites, intracellularly. One such ... 2002). "Induction of thymidylate synthase as a 5-fluorouracil resistance mechanism". Biochim. Biophys. Acta. 1587 (2-3): 194- ... Fluorouracil (5-FU) Activity edit]] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601 ...
*  Organofluorine chemistry
For example, both uracil and 5-fluorouracil are colourless, high-melting crystalline solids, but the latter is a potent anti- ... In 1957, the anticancer activity of 5-fluorouracil was described. This report provided one of the first examples of rational ... Examples include 5-fluorouracil, fluoxetine (Prozac), paroxetine (Paxil), ciprofloxacin (Cipro), mefloquine, and fluconazole. ... Examples include 5-fluorouracil, flunitrazepam (Rohypnol), fluoxetine (Prozac), paroxetine (Paxil), ciprofloxacin (Cipro), ...
*  Dihydropyrimidine dehydrogenase deficiency
Individuals with this condition may develop life-threatening toxicity following exposure to 5-fluorouracil (5-FU), a ... Site dedicated exclusively to DPD Deficiency and Fluorouracil (5-FU) Toxicity related issues - dpd-deficiency.com ... biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity" (Free full text). J Clin Invest. 81 (1 ... impact of pharmacogenetics on 5-fluorouracil therapy". Clinical Advances in Hematology & Oncology. 2 (8): 527-532. ISSN 1543- ...
*  Charles D. Phelps
Fluorouracil Filtering Surgery Study Group, Alward WLM, Farrell T, Hayreh S, Kolder H, Carney B, et al. Three-Year Follow-Up of ... Five-year follow-up of the fluorouracil filtering surgery study. American Journal of Ophthalmology 1996;121(4):349-366. ... the Fluorouracil Filtering Surgery Study. American Journal of Ophthalmology 1993;115(1):82-92. Phelps CD, Corbett JJ. Migraine ...
*  Tegafur
5-fluorouracil (ftorafur) to 5-fluorouracil by soluble enzymes". Cancer Research. 43 (9): 4039-44. PMID 6409396. Sweetman, S, ... Tegafur (INN, BAN, USAN) is a chemotherapeutic prodrug of 5-fluorouracil (5-FU) used in the treatment of cancers. It is a ... Central neurotoxicity is more common with tegafur than with fluorouracil. The dihydropyrimidine dehydrogenase (DPD) enzyme is ... Fluorouracil (5-FU) Activity edit]] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601 ...
*  MRPL23
"Entrez Gene: MRPL23 mitochondrial ribosomal protein L23". Sun XX, Dai MS, Lu H (2007). "5-fluorouracil activation of p53 ...
*  DPYD
Schneider HB, Becker H (May 2003). "Impact of dihydropyrimidine dehydrogenase on 5-fluorouracil treatment in cancer patients". ... Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity". The Journal of Clinical Investigation ... Fluorouracil (5-FU) Activity edit]] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601 ... an enzyme associated with 5-fluorouracil toxicity and congenital thymine uraciluria". The Journal of Biological Chemistry. 269 ...