In the reactive stroma hypothesis, tumor cells cause the proliferation of fibroblasts and subsequent secretion of collagen. The ... Myofibroblastic cells in tumors are differentiated from fibroblasts for their positive staining of smooth-muscle actin (SMA). ... These scars are hypercellular with fibroblasts, myofibroblasts, and some immune cells present. The immature scars can be ... The tumor-induced stromal change hypothesis claims that tumor cells can dedifferentiate into fibroblasts and, themselves, ...
... mouth gingival fibroblasts; and eye (corneal endothelium and keratocytes, trabecular cells, ciliary epithelium, and ...
... and basic fibroblast growth factor-induced osteoclast formation; bone taken from EP4(-/-) mice to re-absorb bone when induced ... and gingival fibroblasts. Standard prostanoids have the following relative efficacies in binding to and activating EP4: PGE2> ... mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts". The ...
... a fibroblast cell line); rat PA adventitia fibroblasts; Baby hamster kidney cells; and diverse types of vascular endothelial ... "Hydroxyeicosatetraenoic acids released through the cytochrome P-450 pathway regulate 3T6 fibroblast growth". The Journal of ...
Inhibitors of fibroblast proliferation Invasins Chemotactic inhibitors Collagenase Bacteriocins Immunosuppressive proteins Bone ...
PDGF[1][2] is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells. In ... PDGF is a required element in cellular division for fibroblasts, a type of connective tissue cell that is especially prevalent ... It has also been shown that fibroblast growth factor (FGF) activates a signaling pathway that positively regulates the PDGF ... of mesenchymal cells such as fibroblasts, osteoblasts, tenocytes, vascular smooth muscle cells and mesenchymal stem cells as ...
Fibroblast. .mw-parser-output .nobold{font-weight:normal}. FGF receptor ligands:. *FGF1/FGF2/FGF5 ...
Fibroblast growth factor 20 is a protein which in humans is encoded by the FGF20 gene.[1] ... The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad ...
Fibroblast. .mw-parser-output .nobold{font-weight:normal}. FGF receptor ligands:. *FGF1/FGF2/FGF5 ...
KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b).[1] For signalling to occur, a ...
Fibroblast. .mw-parser-output .nobold{font-weight:normal}. FGF receptor ligands:. *FGF1/FGF2/FGF5 ...
These appear similar to fibroblasts. The stroma also contains ordinary connective tissue such as reticular fibers and collagen ...
Hayflick and Moorhead mixed equal numbers of normal human male fibroblasts that had divided many times (cells at the 40th ... It has been speculated that the limited replicative capability of human fibroblasts in culture may have significance for human ... CS1 maint: BOT: original-url status unknown (link) Carrel A, Ebeling AH (1921). "Age and multiplication of fibroblasts". J. Exp ... He supported this hypothesis by claiming to have cultivated fibroblasts from chicken hearts and to have kept the culture ...
ISBN 0-08-020575-5. Milo G E; Casto B C (1990). Transformation of human diploid fibroblasts. CRC Press. p. 104. ISBN 0-8493- ...
Fibroblast growth. ↑Apoptosis Antithrombotic ↓Thromboxane-A2. ↓PDGF ↓Platelet aggregation. ↓Platelet adherence to vessel wall ...
It is expressed in lung fibroblasts. The protein is neddylated, which enhances the ubiquitination activity of SCF. Deneddylated ...
Fibroblasts are the most common cell type in connective tissue ECM, in which they synthesize, maintain, and provide a ... Wang JH, Thampatty BP, Lin JS, Im HJ (2007). "Mechanoregulation of gene expression in fibroblasts". Gene. 391: 1-15. doi: ... Elastins are synthesized by fibroblasts and smooth muscle cells. Elastins are highly insoluble, and tropoelastins are secreted ... Hadjipanayi E, Mudera V, Brown RA (2009). "Close dependence of fibroblast proliferation on collagen scaffold matrix stiffness ...
Fibroblasts, including periodontal fibroblasts, synthesize osteonectin. This protein is synthesized by macrophages at sites of ... It disrupts focal adhesions in fibroblasts. It also regulates the proliferation of some cells, especially endothelial cells, ... Osteonectin is expressed by a wide variety of cells, including chondrocytes, fibroblasts, platelets, endothelial cells, ... "An osteonectinlike protein in porcine periodontal ligament and its synthesis by periodontal ligament fibroblasts". Canadian ...
These include fibroblasts and endocrine cells. The symptoms of a sex-cord or stromal ovarian tumor can differ from other types ... and fibroblast growth factor 23. Use of blood test panels may help in diagnosis. The OVA1 panel includes CA-125, beta-2 ...
There is no increase in fibroblasts. Over time, secondary hyperkeratosis may occur, which may become verruciform. Many of these ... The serum contains circulating factors which stimulate fibroblasts to increase synthesis of glycosaminoglycans. There are ...
The FGF (Fibroblast Growth Factor) pathway stimulation leads to Smad4 phosphorylation by Erk of the canonical MAPK site located ... It is also produced by fibroblasts. The functional SMAD 4 participates in the regulation of the TGF-β signal transduction ... "TGF-beta1 stimulates human AT1 receptor expression in lung fibroblasts by cross talk between the Smad, p38 MAPK, JNK, and PI3K ...
Carcinoma associated fibroblasts (CAFs) are a heterogenous group of fibroblasts whose function is pirated by cancer cells and ... fibroblast specific protein 1 (FSP-1) and fibroblast activation protein (FAP). None of these factors can be used to ... As fibroblasts, CAFs are able to rework the ECM to include more paracrine survival signals such as IGF-1 and IGF-2, thus ... As many fibroblasts are transformed into CAFs during carcinogenesis, this reduces the amount of ECM produced and the ECM that ...
Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ (May 1986). "Human fibroblast collagenase. Complete primary ... Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme that in ... "1.56 A structure of mature truncated human fibroblast collagenase". Proteins. 19 (2): 98-109. doi:10.1002/prot.340190203. PMID ...
Collagenase Goldberg, G.I.; Wilhelm, S.M.; Kronberger, A.; Bauer, E.A.; Grant, G.A.; Eisen, A.Z. (1986). "Human fibroblast ... Fields, G.B.; Van Wart, H.E.; Birkedal-Hansen, H. (1987). "Sequence specificity of human skin fibroblast collagenase. Evidence ... Sottrup-Jensen, L.; Birkedal-Hansen, H. (1989). "Human fibroblast collagenase-α-macroglobulin interactions. Localization of ...
Increased circulating IGF may lead to keratinocyte and dermal fibroblast proliferation. Fibroblast growth factor. Hereditary ...