"Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced ... They also discovered several lymphangiogenic factors that potentially contribute to cancer metastasis. Cao proposed a new ... is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in mice". The Journal of Experimental Medicine ... "Kringle 5 of plasminogen is a novel inhibitor of endothelial cell growth". The Journal of Biological Chemistry. 272 (36): 22924 ...

In 2005, PLAC1 expression in differentiating fibroblasts was shown to be regulated by fibroblast growth factor 7 (FGF7)[56]. ... evidence for regulatory interactions with the fibroblast growth factor-7 (FGF-7) axis. Mol Reprod Dev. Jul;71(3):299-304.PMID ... is expressed throughout pregnancy in the human placenta and modulated by keratinocyte growth factor. Mol Reprod Dev. Dec;63(4): ... through Factor 9 (F9) were screened for any sequences similar to PLAC1. The screen showed that PLAC1 appeared in the animal ...

Fibroblast growth factor 8 (FGF8) transcription factors are essential for regulating the addition of secondary heart field ... Molecules such as Wnt, fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) provide signals which induce the ... Appropriate outflow tract formation relies on a morphogen concentration gradient set up by fibroblast growth factor (FGF) ... A variety of growth factors and transcription factors in the extracellular matrix signal cells and direct them toward a ...

... glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor ... Platelet-activating factor Platelet-derived growth factor GRCh38: Ensembl release 89: ENSG00000163737 - Ensembl, May 2017 ... Maurer AM, Zhou B, Han ZC (December 2006). "Roles of platelet factor 4 in hematopoiesis and angiogenesis". Growth Factors. 24 ( ... "The control of angiogenesis and tumor invasion by platelet factor-4 and platelet factor-4-derived molecules". Seminars in ...

FGF23 (fibroblast growth factor 23) inhibits phosphate transport in the renal tubule and reduces calcitriol production by the ... tumor is an extremely rare benign neoplasm of soft tissue and bone that inappropriately produces fibroblast growth factor 23. ... Children present with difficulty in walking, stunted growth and deformities of the skeleton (features of rickets). There can ... May 2001). "Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia". Proceedings of the ...

2006). "Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2". ...

Hair length is determined by the gene for fibroblast growth factor 5, with inactive copies of this gene causing long hair. The ... Kehler JS, David VA, Schäffer AA (2007). "Four independent mutations in the feline fibroblast growth factor 5 gene determine ... the cat is an excellent animal to study the coat genetics of hair growth and coloration. Several genes interact to produce cats ...

Britto, J A; J C T Chan; R D Evans; R D Hayward; B M Jones (May 2001). "Differential expression of fibroblast growth factor ... Wilkie published a paper showing evidence that acrocephalosyndactyly is caused by a defect on the fibroblast growth factor ... KGFR, keratinocyte growth factor receptor, is an isoform active in the metaphysis and interphalangeal joints. FGFR1 is an ... A flat or concave face may develop as a result of deficient growth in the mid-facial bones, leading to a condition known as ...

Jaffe has studied the processes that give rise to the fibroblast growth factor (FGF)-induced inhibition of bone growth. ... In the ovaries, this causes the cGMP to resume meiotic function, whilst it diminishes growth within bones. 2007 Elected Fellow ...

The movement is coordinated by a Wnt signaling pathway which is activated by fibroblast growth factors from the hypoblast. The ... to the center of the epiblast following the activation of the Wnt planar cell polarity pathway by fibroblast growth factors ...

The current research indicates fibroblast growth factor receptors (FGFR) FGFR2 and FGFR3 as the leading factors in causing the ... This syndrome is caused by a mutation in the fibroblast growth factor receptor 2 (FGFR2), located on chromosome 10. The ... These two transmembrane proteins are two of four fibroblast growth factor receptors involved in osteoblast differentiation ... Thus, normal bone growth cannot occur. Fusion of different sutures leads to abnormal patterns of growth of the skull. A ...

"Tissue regeneration observed in a basic fibroblast growth factor-loaded porous acellular bovine pericardium populated with ... the natural site of red-blood-cell growth. Erythropoietin, a growth factor, is added, coaxing the stem cells to complete ... of heart muscle cells Stimulating growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors In ... Stem cells can also be used to stimulate the growth of human tissues. In an adult, wounded tissue is most often replaced by ...

... glycoprotein and platelet factor 4 mask heparan sulfate proteoglycans recognized by acidic and basic fibroblast growth factor ... Barillari G, Gendelman R, Gallo RC, Ensoli B (1993). "The Tat protein of human immunodeficiency virus type 1, a growth factor ... Lyon M, Deakin JA, Mizuno K, Nakamura T, Gallagher JT (1994). "Interaction of hepatocyte growth factor with heparan sulfate. ... "HIV-tat protein is a heparin-binding angiogenic growth factor". Oncogene. 12 (2): 289-97. PMID 8570206. Soussi-Yanicostas N, ...

Low grade cancer are known to harbor mutations in RAS pathway and the fibroblast growth factor receptor 3 (FGFR3) gene, both of ... In people with fibroblast growth factor receptors (FGFR) mutations and fail standard platinum based chemotherapy erdafitinib ... In addition to these major risk factors there are also numerous other modifiable factors that are less strongly (i.e. 10-20% ... The six prognostic factors included in the EORTC model are number of tumors, recurrence rate, T-stage, presence of carcinoma-in ...

The interaction between Otx2 and Gbx2 at the MHB results in the expression of fibroblast growth factor 8 (Fgf8). Out of the ... The transcription factor En1 is expressed in the MHB. In cells that express both Otx2 and Irx1, En1 is activated by Fgf8 ... The development and location of the MHB is mediated by the transcription factors Otx2 and Gbx2. Otx2 is expressed in the ... These two homeodomain transcription factors are activated by Irx1 and then cross inhibit one another in the developing central ...

Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors". ... IRAK2 and tumor necrosis factor receptor-associated factor (TRAF) 6. TRAF6 is a ubiquitin E3 ligase, that in association with ... IL-1F7 has also been found in the nucleus where it can function as a nuclear factor. This cytokine may bind or may itself be a ... IL-18 is known as a factor that induces the production of interferon gamma (IFN-γ). It is a pro-inflammatory cytokine that ...

Badman, MK; Pissios, P; Kennedy, AR; Koukos, G; Flier, JS; Maratos-Flier, E (2007). "Hepatic fibroblast growth factor 21 is ... "Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic ... "Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury ... "Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic ...

... neurotrophins and fibroblast growth factors have been identified in aiding neuronal growth. These signals guide the developing ... Positive growth is characterized by growing towards a stimulus and negative growth is growing away from the stimulus. ... In response the tube develops a defined tip growth area that promotes directional growth and elongation of the pollen tube due ... Each cell type releases a unique pheromone: a- or α-factor. By secreting these factors a chemical gradient is formed that ...

Known for his studies on Fibroblast growth factor receptor, Dutt is a Wellcome Trust / DBT India Alliance Intermediate Fellow. ... It is reported that the research collaboration Dutt had with Kumar Prabhash of Tata Memorial Centre led to the Epidermal Growth ... Factor Receptor (EGFR) and KRAS mutation profiling of Indian lung cancer patients for the first time. The research association ...

Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors". ... These include granulocyte colony-stimulating factor (GCSF) and myelomonocytic growth factor (MGF). GCSF acts in hematopoiesis ... Schindler R, Dinarello CA (1990). "Interleukin 1". In Habenicht A (ed.). Growth Factors, Differentiation Factors, and Cytokines ... T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and "Heidikine") and interleukin 2 (TSF, ...

NCAM is thought to signal to induce neurite outgrowth via the fibroblast growth factor receptor (FGFR) and act upon the p59Fyn ... it associates with fibroblast growth factor receptor (FGFR) and stimulates tyrosine kinase activity of receptor to induce ...

... leukemia inhibitory factor, insulin-like growth factor, and fibroblast growth factor. These factors together create a favorable ... "Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts". The ... Schwann cells emit growth factors that attract new axonal sprouts growing from the proximal stump after complete degeneration ... It is supported by Schwann cells through growth factors release. CNS regeneration is much slower, and is almost absent in most ...

... is made out of living fibroblasts. These fibroblasts proliferate and produce growth factors, collagen, and ECM proteins, that ... Growth factors, hormones, specific metabolites or nutrients, chemical and physical stimuli are sometimes required. For example ... Scientific advances in biomaterials, stem cells, growth and differentiation factors, and biomimetic environments have created ... Examples include fibroblasts used for skin repair or renewal, chondrocytes used for cartilage repair (MACI-FDA approved product ...

Silicone-related products can reduce the growth factor production of fibroblasts in hypertrophic scars and keloids. However, ... Collagen production exacerbates the growth of hypertrophic scars and keloids and thus should be avoided. Hydrating a scar over ... Another non-invasive treatment is compression therapy, in which patients wear pressure garments to control the growth of scars ... Through the signaling cascade, the epidermis regulates dermal fibroblast extracellular matrix production. Delayed ...

... such as secreting vascular endothelial growth factor (VEGF), fibroblast growth factors (FGFs), platelet-derived growth factor ( ... basic fibroblast growth factor (bFGF), insulin-like growth factors (IGF1 and IGF2), TGF-β, EGF, heparin-binding EGF-like growth ... platelet-derived growth factor receptor α (PDGFR-α), platelet-derived growth factor receptor β (PDGFR-β), fibroblast specific ... "Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts". Cancer Research. 51 ...

Yuan W, Varga J (October 2001). "Transforming growth factor-beta repression of matrix metalloproteinase-1 in dermal fibroblasts ... Warner BJ, Blain SW, Seoane J, Massagué J (September 1999). "Myc downregulation by transforming growth factor beta required for ... Growth Factor Reviews. 17 (1-2): 41-58. doi:10.1016/j.cytogfr.2005.09.009. PMID 16310402. Sjöblom T, Jones S, Wood LD, Parsons ... to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling". The Journal of Biological Chemistry. 291 (1): 382-92. doi: ...

"Self-renewal and differentiation of a basic fibroblast growth factor-dependent multipotent hematopoietic cell line derived from ... 2005). "Leukemia inhibitory factor as an anti-apoptotic mitogen for pluripotent mouse embryonic stem cells in a serum-free ... Lane MA, Chen AC, Roman SD, Derguini F, Gudas LJ (November 1999). "Removal of LIF (leukemia inhibitory factor) results in ... Nemetz C, Hocke GM (March 1998). "Transcription factor Stat5 is an early marker of differentiation of murine embryonic stem ...

In 2016, she contributed an article to the Annual Review of Physiology on the physiology of Fibroblast Growth Factor 21. 1971 ... "Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States ... "Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States ...

The synthesis of bile acids in the liver is negatively regulated by the ileal hormone fibroblast growth factor 19 (FGF19), and ... "Fibroblast growth factor 19 in patients with bile acid diarrhoea: a prospective comparison of FGF19 serum assay and SeHCAT ...

"Fibroblast growth factor receptor-3 regulates Paneth cell lineage allocation and accrual of epithelial stem cells during murine ... "Essential Role of CR6-interacting Factor 1 (Crif1) in E74-like Factor 3 (ELF3)-mediated Intestinal Development". Journal of ... Park, M. J.; Kim, H. Y.; Kim, K.; Cheong, J. (2009). "Homeodomain transcription factor CDX1 is required for the transcriptional ... Visco, V.; Bava, F. A.; d'Alessandro, F.; Cavallini, M.; Ziparo, V.; Torrisi, M. R. (2009). "Human colon fibroblasts induce ...