... fibrin modulating agents MeSH D27.505.519.421.500 - antifibrinolytic agents MeSH D27.505.519.421.750 - fibrinolytic agents MeSH ... angiogenesis modulating agents MeSH D27.505.696.377.077.077 - angiogenesis inducing agents MeSH D27.505.696.377.077.099 - ... antiviral agents MeSH D27.505.954.122.388.077 - anti-retroviral agents MeSH D27.505.954.122.388.077.088 - anti-hiv agents MeSH ... tocolytic agents MeSH D27.505.954.016 - anti-allergic agents MeSH D27.505.954.122 - anti-infective agents MeSH D27.505.954.122. ...

Indeed, this polymer modulates its mechanical and biophysical properties accordingly to enzymatic activities associated with ... Natural hydrogels such as Matrigel, collagen and fibrin have been used as entrapment matrices, wherein the cells to be injected ... cell signaling agents to induce the regeneration of an organ or damaged tissue. In an ideal scenario, regenerated tissue would ...

"A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis". Science Translational ... She has applied these materials to medical imaging contrast agents and energy storage technologies. Pozzo's research page can ... "Fibrin clot structure and mechanics associated with specific oxidation of methionine residues in fibrinogen". Biophysical ...

... fibrin-stabilizing factor). Fibroblasts play a major role in wound healing by adhering to fibrin. Fibroblast adhesion to fibrin ... The "synergy site" is in III9 and has a role in modulating fibronectin's association with α5β1 integrins. Fibronectin also ... carcinoma cells to fibronectin enhances tumorigenicity and confers resistance to apoptosis-inducing chemotherapeutic agents. ... Along with fibrin, plasma fibronectin is deposited at the site of injury, forming a blood clot that stops bleeding and protects ...

Sequential single agent chemotherapy may have a more positive effect on progression-free survival. Taxanes are very active in ... Fibronectin is an extracellular glycoprotein that can bind to integrins and other ECM components like collagen, fibrin and ... TNC is an adhesion-modulating extracellular matrix glycoprotein. It is highly expressed in tumor stroma and stimulates tumor- ... MMP-2 is unlike other MMP's as its activity is modulated by metalloproteases called tissue inhibitor of metalloproteases (TIMP ...

Flare is the leakage of various proteins (such as fibrin and cytokines) into the ocular anterior chamber, as a manifestation of ... Immunosuppressive agents include T-cell inhibitors such as cyclosporine and tacrolimus; antimetabolites such as azathioprine, ... It has also been suggested that corticosteroids may be capable of modifying the trabecular meshwork cells, modulating their ... Other treatments, including systemic immunosuppressive agents - which require close monitoring - may be considered where ...

Following invasion, the breach in the uterine epithelium made by the blastocyst's entry is sealed by a fibrin plug. The fibrin ... immunosuppressive agents. Such agents include platelet-activating factor, human chorionic gonadotropin, early pregnancy factor ... Both types of cytokines modulate the activity of proteases, including MMPs, plasminogen activators, and cathepsins. It is ... By day 13 the penetration site in the endometrium has usually been closed by a fibrin plug but increased blood flow into the ...

Pig organs are anatomically comparable in size, and new infectious agents are less likely since they have been in close contact ... fibrin deposition, and hemorrhage. The result is thrombosis and necrosis of the xenograft. Since hyperacute rejection presents ... and include administering a synthetic thrombin inhibitor to modulate thrombogenesis, depletion of anti-galactose antibodies ( ... Baboons and pigs carry myriad transmittable agents that are harmless in their natural host, but extremely toxic and deadly in ...

The fibrin is slowly dissolved by the fibrinolytic enzyme, plasmin, and the platelets are cleared by phagocytosis. Platelets ... Platelets are rapidly deployed to sites of injury or infection, and potentially modulate inflammatory processes by interacting ... Simplistically, bound and activated platelets degranulate to release platelet chemotactic agents to attract more platelets to ... William Addison in 1842 drew pictures of a platelet-fibrin clot. Lionel Beale in 1864 was the first to publish a drawing ...

Pagano JS, Blaser M, Buendia MA, Damania B, Khalili K, Raab-Traub N, Roizman B (December 2004). "Infectious agents and cancer: ... Wroblewski LE, Peek RM, Wilson KT (October 2010). "Helicobacter pylori and gastric cancer: factors that modulate disease risk ... fibrin-associated diffuse large B-cell lymphoma and intravascular NK/T cell lymphomas. It also appears to cause some cases of ... "Fibrin-associated EBV-positive Large B-Cell Lymphoma: An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell ...

A fasciacyte is a type of biological cell that produces hyaluronan-rich extracellular matrix and modulates the gliding of ... Granulation tissue is the perfused, fibrous connective tissue that replaces a fibrin clot in healing wounds. It typically grows ... "Dressings and topical agents containing hyaluronic acid for chronic wound healing". Cochrane Database of Systematic Reviews. ... and minimal stabilisation of the HA chains through chemical agents such as NASHA (non-animal stabilised hyaluronic acid) are ...

An example would be the coagulation cascade of secondary hemostasis which leads to fibrin formation, and thus, the initiation ... allowing these to detect action potentials and modulate neuronal activity, contributing for intra and extracellular homeostasis ... cascades in lymphocytes is the secretion of molecules that can suppress altered cells or eliminate pathogenic agents, through ... the tissue factor pathway in the coagulation cascade of secondary hemostasis is the primary pathway leading to fibrin formation ...

Leakage of fibrinogen from veins as well as deficiencies in fibrinolysis may also cause fibrin to build up around the vessels, ... Norman G, Westby MJ, Rithalia AD, Stubbs N, Soares MO, Dumville JC (June 2018). "Dressings and topical agents for treating ... There is low certainty evidence that protease modulating matrix treatment is helpful in the healing of venous ulcer. Flavonoids ... It is not certain which dressings and topical agents are most effective for healing venous leg ulcers. Silver-containing ...

In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and ... Thrombin, combined with fibrinogen, is sold under the brand name Fibrimex for use as a binding agent for meat. Both proteins in ... Esmon CT (July 1995). "Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the ... In the conversion of fibrinogen into fibrin, thrombin catalyzes the cleavage of fibrinopeptides A and B from the respective Aα ...

Acumentin, an actin modulating protein of rabbit pulmonary macrophages. Biochemistry. 1982; 21:6321-6326. 75. Thorstensson R, ... Plasma gelsolin is a marker and potential therapeutic agent in sepsis. 2006. Crit Care Med, 35: 849-855. 139. Osborne, T, ... Effects of semi-dilute actin solutions on the mobility of fibrin protofibrils during clot formation. Biochim Biophys Acta. 1985 ... Effects of actin filaments of fibrin clot structure and lysis. US Patent Number 5,691,160, issued November 25, 1997. 5. Janmey ...

... antimicrotubule agent - antimitotic agent - antineoplastic - antineoplastic antibiotic - antioxidant - antiparasitic - ... fibrin sealant - fibroblast - fibroid - fibromatosis - fibrosarcoma - fibrosis - fibrous - fifth cranial nerve - filgrastim - ... Intensity Modulated Radiation Therapy - intercalator - interferon - interleukin - interleukin-1 - interleukin-1-alpha - ... alkylating agent - ALL - all-trans retinoic acid - allogeneic - allogeneic bone marrow transplantation - allogeneic stem cell ...

This has been used in combination with lifetime by one group., not only in fluorescence but as NMR agent for imaging with a ... fibrin, agarose, pullulan), or synthetic (PEG, PLA, PLGA, PCL, PHB, PVA, PNVP, P(HEMA),[clarification needed] p(biscarboxy- ... hence modulating its intensity based on glucose concentration. The majority of hydrogels are attached to the fibre, one ...

These agents have several theoretical advantages over current therapy. They may be given orally. They have rapid onset of ... This large burst of thrombin is responsible for fibrin polymerization to form a thrombus. Factor Xa also plays a role in other ... Sinha U, Wolf DL (February 1993). "Carbohydrate residues modulate the activation of coagulation factor X". The Journal of ... These agents known as vitamin K antagonists (VKA), inhibit the vitamin K-dependent carboxylation of Factors II (prothrombin), ...

If a phagocyte fails to engulf its target, these toxic agents can be released into the environment (an action referred to as " ... 13-16 Freund I, Eigenbrod T, Helm M, Dalpke AH (January 2019). "RNA Modifications Modulate Activation of Innate Toll-Like ... "Fibronectin fragmentation promotes alpha4beta1 integrin-mediated contraction of a fibrin-fibronectin provisional matrix". ... "frustrated phagocytosis"). As these agents are also toxic to host cells, they can cause extensive damage to healthy cells and ...

Janmey, P. A.; Lamb, J. A.; Ezzell, R. M.; Hvidt, S.; Lind, S. E. (1992-08-15). "Effects of actin filaments on fibrin clot ... Sun, Hui-qiao; Lin, Keng-mean; Yin, Helen L. (1997-08-25). "Gelsolin Modulates Phospholipase C Activity In Vivo through ... "Plasma gelsolin is a marker and therapeutic agent in animal sepsis*". Critical Care Medicine. 35 (3): 849-855. doi:10.1097/01. ... pGSN removes 60% of actin trapped in fibrin clots in vitro leading to an increased rate of clot lysis. Although pGSN is capable ...

Barritault D, Caruelle JP (March 2006). "[Regenerating agents (RGTAs): a new therapeutic approach]" [Regenerating agents (RGTAs ... Fibrin and fibronectin cross-link together and form a plug that traps proteins and particles and prevents further blood loss. ... It has been shown that the growth of tissue and extent of scar formation can be controlled by modulating the stress at a wound ... This fibrin-fibronectin plug is also the main structural support for the wound until collagen is deposited. Migratory cells use ...

These agents have shown inhibitory effects against S. aureus embedded in biofilms. A class of enzymes have been found to have ... S. aureus also produces lipase to digest lipids, staphylokinase to dissolve fibrin and aid in spread, and beta-lactamase for ... By directly modulating efflux pumps' activity or decreasing their expression, it may be possible to modify the resistant ... One topical agent that is prescribed is Mupirocin, a protein synthesis inhibitor that is produced naturally by Pseudomonas ...

Molecular agents has been also used to detect specific features, such as stent fibrin accumulation and enzymatic activity ... Finally, through modulating photosynthesis, the fluorescent proteins may also serve as a means of regulating the activity of ... 2015). "Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence ...

For example, the drug torcetrapib is the most effective agent currently known for raising HDL (by up to 60%). However, in ... Immunomodulation of atherosclerosis is the term for techniques that modulate immune system function to suppress this macrophage ... fibrin, proteoglycans, collagen, elastin, and cellular debris. In advanced plaques, the central core of the plaque usually ... vascular smooth muscle cells also give rise to many of the cell types found within the plaque core and can modulate their ...

Small molecule inhibitors of EMT are suggested to not act as a replacement for traditional chemotherapeutic agents but are ... January 2005). "Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination ... and stem cell properties through modulating miRNAs". Nat Cell Biol. 13 (3): 317-323. doi:10.1038/ncb2173. PMC 3075845. PMID ... "Protein kinase CK2α is overexpressed in colorectal cancer and modulates cell proliferation and invasion via regulating EMT- ...

Brown, Elvie E.; Hu, Dehong; Abu Lail, Nehal; Zhang, Xiao (2013). "Potential of Nanocrystalline Cellulose-Fibrin Nanocomposites ... diapers or as wound dressing The use of nanocellulose as a composite coating agent in cosmetics e.g. for hair, eyelashes, ... "Lipid emulsion interfacial design modulates human in vivo digestion and satiation hormone response". Food & Function. 13 (17): ... as an excipient in pharmaceutical compositions Nanocellulose in compositions of a photoreactive noxious substance purging agent ...

"Fibrin glue mesh fixation combined with mesenchymal stem cells or exosomes modulates the inflammatory reaction in a murine ... to specialize in cell-cell communications and provide an exclusive approach for the delivery of various therapeutic agents to ... June 2010). "Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of ...

Enzymes that degrade the biofilm matrix may be useful as anti-biofilm agents. Evidence has shown that a fatty acid messenger, ... Membrane vesicle HGT has also been shown to modulate phage-bacteria interactions in Bacillus subtilis SPP1 phage-resistant ... such as erythrocytes and fibrin. The final stage of biofilm formation is known as development, and is the stage in which the ... GTAs, or gene transfer agents, are phage-like particles produced by the host bacteria and contain random DNA fragments from the ...