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*  Factor XIII
... or fibrin stabilizing factor is an enzyme (EC 2.3.2.13) of the blood coagulation system that crosslinks fibrin. ... Upon activation by thrombin, factor XIIIa acts on fibrin to form γ-glutamyl-Є-lysyl amide cross links between fibrin molecules ... When thrombin has converted fibrinogen to fibrin, the latter forms a proteinaceous network in which every E-unit is crosslinked ... Laki K, Lóránd L (September 1948). "On the Solubility of Fibrin Clots". Science. 108 (2802): 280. doi:10.1126/science.108.2802. ...
*  Fibrinolysis
In fibrinolysis, a fibrin clot, the product of coagulation, is broken down. Its main enzyme plasmin cuts the fibrin mesh at ... When plasmin breaks down fibrin, a number of soluble parts are produced. These are called fibrin degradation products (FDPs). ... Plasmin, in addition to lysing fibrin clots, also cleaves the complement system component C3, and fibrin degradation products ... Although plasminogen cannot cleave fibrin, it still has an affinity for it, and is incorporated into the clot when it is formed ...
*  Discovery and development of direct thrombin inhibitors
But heparin can also form a bridge between thrombin and fibrin which binds to exosite 1 which protects the thrombin from ... DTIs that bind to the anion-binding site have shown to inactivate thrombin without disconnecting thrombin from fibrin, which ... It is the prodrug of a potent, competitive, reversible inhibitor of free and fibrin-bound thrombin called ARH0637. The ... Thrombin also activates factor XIII that stabilizes the fibrin complex and therefore the clot and it stimulates platelets, ...
*  Thrombin
In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and ... Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as ... The covalent bonds increase the stability of the fibrin clot. Thrombin interacts with thrombomodulin. As part of its activity ... Wolberg AS (May 2007). "Thrombin generation and fibrin clot structure". Blood Reviews. 21 (3): 131-42. doi:10.1016/j.blre. ...
*  Congenital hypofibrinogenemia
Lower levels of fibrin may reduce the lysis of early fibrin strand depositions and thereby allow these depositions to develop ... These drugs have been tested in individual patients with fibrin storage disease with some success in reducing evidence of liver ... Duval C, Ariëns RA (2017). "Fibrinogen splice variation and cross-linking: Effects on fibrin structure/function and role of ... thrombosis in a disorder causing a decrease in a critical protein for blood clotting may be due to the function of fibrin (the ...
*  Fibrinolysin
... attacks and inactivates fibrin molecules occurring in undesirable exudates on the surface of the human body and on ...
*  Disseminated intravascular coagulation
The breakdown of fibrinogen and fibrin results in polypeptides called fibrin degradation products (FDPs) or fibrin split ... The activation of the coagulation cascade yields thrombin that converts fibrinogen to fibrin; the stable fibrin clot being the ... A rapidly declining platelet count High levels of fibrin degradation products, including D-dimer, are found owing to the ... The fibrinolytic system then functions to break down fibrinogen and fibrin. Activation of the fibrinolytic system generates ...
*  Left ventricular thrombus
The response is to build a thrombus composed of fibrin, red blood cells and platelets. For several days after AMI, the levels ...
*  Batroxobin
The fibrin-bound batroxobin retains catalytic activity and is a more potent stimulus for fibrin aggregation than fibrin-bound ... 2013). "Batroxobin binds fibrin with higher affinity and promotes clot expansion to a greater extent than thrombin". J Biol ... In the case of batroxobin from the Bothrops moojeni also formation of fibrin I is mediated, however there is also a release of ... Batroxobin from Bothrops atrox mediates the formation of fibrin I. This then renders the blood more prone to coagulation. An ...
*  William D. Spotnitz
He is a notable researcher in the United States in use of fibrin glue (a surgical adhesive used to create hemostasis). Spotnitz ... Spotnitz, William D.; Falstrom, Jeanne K.; Rodeheaver, George T. (1997-06-01). "The Role of Sutures and Fibrin Sealant in Wound ... doi:10.1111/j.1537-2995.2008.01703.x. Spotnitz, William D. (2010-04-01). "Fibrin Sealant: Past, Present, and Future: A Brief ... doi:10.1007/s00268-009-0252-7. Jackson, Mark R (2001-08-01). "Fibrin sealants in surgical practice: An overview". The American ...
*  Thrombin time
... can be prolonged by heparin, fibrin degradation products, and fibrinogen deficiency or abnormality. After ... to fibrin, an insoluble protein. The thrombin time compares the rate of clot formation to that of a sample of normal pooled ...
*  Fibrin
The cross-linked fibrin forms a mesh atop the platelet plug that completes the clot. Excessive generation of fibrin due to ... Reduced, absent, or dysfunctional fibrin is likely to render patients as hemophiliacs. Fibrin from different animal sources is ... polymerized fibrin and other components. Ineffective generation or premature lysis of fibrin increases the likelihood of a ... Fibrin (also called Factor Ia) is a fibrous, non-globular protein involved in the clotting of blood. It is formed by the action ...
*  Fibrin glue
... (also called Fibrin sealant) is a formulation used to create a fibrin clot. It is made up of fibrinogen ( ... "Fibrin Sealant Fibrin Gluing Haemostasis autologous". Sinha S, Schreiner AJ, Biernaskie J, Nickerson D, Gabriel VA (June 2017 ... Spotnitz, W. D.; Mintz, P. D.; Avery, N.; Bithell, T. C.; Kaul, S.; Nolan, S. P. (August 1987). "Fibrin glue from stored human ... Spotnitz, W. . (2009). "Fibrin Sealant: Past, Present, and Future: A Brief Review". World journal of surgery. 34 (4): 632-634. ...
*  Fibrin scaffold
Fibrin glue or fibrin sealant is also referred to as a fibrin based scaffold and used to control surgical bleeding, speed wound ... Fibrin can be provided from individuals to be treated many times so that gels from autologous fibrin have no undesired ... Results show that fibrin glue fixation is easy, reliable and efficient with the corneal surface. Because fibrin fulfills the ... Fibrin satisfies many requirements of scaffold functions. Biomaterials made up of fibrin can attach many biological surfaces ...
*  Fibrin ring granuloma
... s may also be seen in Hodgkin's disease and infectious mononucleosis. Granuloma Rosen, MD, Yale. "Fibrin ... A fibrin ring granuloma, also known as doughnut granuloma, is a histopathological finding that is characteristic of Q fever. On ... de Bayser L, Roblot P, Ramassamy A, Silvain C, Levillain P, Becq-Giraudon B (July 1993). "Hepatic fibrin-ring granulomas in ... Tjwa M, De Hertogh G, Neuville B, Roskams T, Nevens F, Van Steenbergen W (2001). "Hepatic fibrin-ring granulomas in ...
*  Fibrin degradation product
... s (FDPs), also known as fibrin split products, are components of the blood produced by clot ... When the clot and fibrin net dissolve, fragments of protein are released into the body. These fragments are fibrin degradation ... Clotting, also called coagulation, at the wound site produces a mass of fibrin threads called a net that remains in place until ... The most notable subtype of fibrin degradation products is D-dimer. The levels of these FDPs rise after any thrombotic event. ...
*  Platelet-rich fibrin
... (PRF) or leucocyte- and platelet-rich fibrin (L-PRF) is a second-generation PRP where autologous platelets ... A platelet-rich fibrin can be used if a sinus lift is required for a dental implant. PRF is used in guided bone and tissue ... A platelet-rich fibrin (PRF) membrane containing bone growth enhancing elements can be stitched over the wound or a graft ... Khiste, Sujeet Vinayak; Naik Tari, Ritam (2013). "Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration". ISRN Biomaterials ...
*  Platelet-rich fibrin matrix method
The "platelet-rich fibrin matrix" (PRFM) method, marketed in the United States as Selphyl, TruPRP, Emcyte, Regen, and Pure Spin ... Sclafani AP (February 2011). "Safety, Efficacy, and Utility of Platelet-Rich Fibrin Matrix in Facial Plastic Surgery". Arch ...
*  Fibrinogen beta chain
Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots ... Everse SJ (2003). "New insights into fibrin (ogen) structure and function". Vox Sang. 83 Suppl 1: 375-82. doi:10.1111/j.1423- ... Scott EM, Ariëns RA, Grant PJ (2005). "Genetic and environmental determinants of fibrin structure and function: relevance to ... Lord ST (2007). "Fibrinogen and fibrin: scaffold proteins in hemostasis". Curr. Opin. Hematol. 14 (3): 236-41. doi:10.1097/MOH. ...
*  Fibrinogen alpha chain
Impaired fibrin gel formation but normal fibrin-facilitated plasminogen activation catalyzed by tissue-type plasminogen ... Ichinose A, Takio K, Fujikawa K (Jul 1986). "Localization of the binding site of tissue-type plasminogen activator to fibrin". ... Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin, which is the most abundant component of blood ... Check date values in: ,year= / ,date= mismatch (help) Everse SJ (Aug 2002). "New insights into fibrin (ogen) structure and ...
*  Glued IOL
Fibrin glue takes only 20 seconds to act in the scleral bed, and it helps in adhesion and hemostasis. Fibrin glue has been ... "Fibrin Glue and Glaucoma Surgery". glaucomatoday.com//. 2008-06-01. Retrieved 2015-05-28. "Antibiotic-Impregnated Fibrin Glue ... Fibrin glue has been used previously in various medical specialties as a hemostatic agent to arrest bleeding, seal tissues and ... There is less incidence of uveitis-glaucoma-hyphema syndrome in fibrin glue-assisted IOL implantation as compared with sutured ...
*  Annexin
The destruction of fibrin is a natural preventative measure because it prevents the formation of blood clots by fibrin networks ... "Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo". J. Clin. Invest. 113 (1): 38-48. doi:10.1172/JCI19684. ... because it can be utilized in treatments for various cardiovascular diseases that thrive on blood clotting through fibrin ...
*  Dysfibrinogenemia
In the final common pathway fibrin is cross-linked by activated clotting factor XIII (termed factor XIIIa) to form mature gel- ... Blood clot lysis: The Aα fibrin chain formed from fibrinogen binds tissue plasminogen activator, an agent that breaks down ... Fibrinogen and its Aα fibrin chain have several functions in this process: Blood clotting: fibrinogen concentration is the rate ... Duval C, Ariëns RA (2017). "Fibrinogen splice variation and cross-linking: Effects on fibrin structure/function and role of ...
*  Hodgkin's lymphoma
A fibrin ring granuloma may be seen. Microscopy Microscopic examination of the lymph node biopsy reveals complete or partial ...
*  Infectious mononucleosis
A fibrin ring granuloma may be present. About 10% of people who present a clinical picture of infectious mononucleosis do not ...