... is the only known iron exporter. After dietary iron is absorbed into the cells of the small intestine, ferroportin ... Ferroportin is inhibited by hepcidin, which binds to ferroportin and internalizes it within the cell. This results in the ... Ferroportin is also associated with African iron overload. Ferroportin and hepcidin are critical proteins for the regulation of ... Ferroportin may also function as a manganese exporter. Ferroportin is found on the basolateral membranes of intestinal ...
In HEK 293 cells, Q248H was as predisposed to the activities of hepcidin-25 as wild type ferroportin. Ferroportin Q248H also ... In xenopus oocytes and HEK 293 cells, the expression of wild type ferroportin was similar to the expression of ferroportin ... Ferroportin SLC40A1 Q248H mutation in exon 6 occurs as a polymorphism in individuals of sub-Saharan African descent, but it was ... This indicates the ferroportin Q248H is associated with mild clinical phenotype or causes iron disorder in the presence of ...
It has been shown that hepcidin is able to bind to the central cavity of ferroportin, thus occluding iron export from the cell ... In macrophages, ferroportin inhibition causes iron sequestration within the cell. Increased hepcidin activity is partially ... It inhibits iron transport by binding to the iron export channel ferroportin which is located in the basolateral plasma ... When the hepcidin level is abnormally low such as in hemochromatosis, iron overload occurs due to increased ferroportin ...
Both ferritin and ferroportin contain an IRE in their 5' UTRs, so that under iron deficiency their translation is repressed by ... In contrast, ferroportin is post-translationally repressed by hepcidin, a 25-amino acid peptide hormone. The body regulates ... Another player assisting ferroportin in effecting cellular iron export is GAPDH. A specific post translationally modified ... Ganz T (Mar 2005). "Cellular iron: ferroportin is the only way out". Cell Metabolism. 1 (3): 155-7. doi:10.1016/j.cmet.2005.02. ...
Both ferritin and ferroportin contain an IRE in their 5' UTRs, so that under iron deficiency their translation is repressed by ... In contrast, ferroportin is post-translationally repressed by hepcidin, a 25-amino acid peptide hormone. The body regulates ... Another player assisting ferroportin in effecting cellular iron export is GAPDH. A specific post translationally modified ... Ganz T (Mar 2005). "Cellular iron: ferroportin is the only way out". Cell Metabolism. 1 (3): 155-7. doi:10.1016/j.cmet.2005.02. ...
McKie AT, Barlow DJ (February 2004). "The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1)". Pflügers Archiv ...
The iron exporter ferroportin (Slc40a1) is essential for iron homeostasis. Cell Metabolism 2005; 1:191-200. Gunshin H, Fujiwara ... Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter. Nature 2000; 403:776-81. Andrews ...
"Oral ferroportin inhibitor ameliorates ineffective erythropoiesis in a model of β-thalassemia". The Journal of Clinical ...
In the blood, ferroportin is then converted to transferrin to reach other tissues. The gastrointestinal (GI) absorption process ... Upon stimulation, iron can be transported out as ferroportin and oxidized into transferrin in the sites of action, such as the ... Rouault, Tracey (2019). "Ferroportin in Erythrocytes: Importance for Iron Homeostasis and its Role in Infection". Blood. 134 ( ... Upon stimulation, the reduction of iron storage Fe3+ in the enterocyte to Fe2+ ferroportin allows the passage of iron through ...
Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated with decreased intracellular ... "Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation" (PDF). Journal of ...
Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated with decreased intracellular Mn ... "Ferroportin is a manganese-responsive protein that decreases manganese cytotoxicity and accumulation" (PDF). Journal of ...
Yin, Z.; Jiang, H.; Lee, E. S.; Ni, M.; Erikson, K. M.; Milatovic, D.; Bowman, A. B.; Aschner, M. (2010). "Ferroportin is a ... Increased ferroportin protein expression in human embryonic kidney (HEK293) cells is associated with decreased intracellular Mn ...
... mutant ferroportin can associate with wild-type ferroportin in multimers and interfere with the function of normal ferroportin ... The misregulation of ferroportin in type 4 hemochromatosis can involve a failure of ferroportin to be properly expressed at the ... When hepcidin binds ferroportin, ferroportin is phosphorylated, endocytosed, tagged with ubiquitin, and degraded. More than 39 ... Ferroportin disease is rare. Roetto, A.; Camaschella, C. (2005). "New insights into iron homeostasis through the study of non- ...
By suppressing hepcidin, ERFE increases the function of the cellular iron export channel, ferroportin. This then results in ...
2014). "Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload". Cell Metab. ...
One model suggests that APP acts to stabilize the iron efflux protein ferroportin in the plasma membrane of cells thereby ... facilitating iron export through interaction with ferroportin; it seems that this activity is blocked by zinc trapped by ... "sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin". ... the mechanism of APP-modulated iron efflux from ferroportin has come under scrutiny. ...
Solute carrier family Ferroportin Vastermark A, Wollwage S, Houle ME, Rio R, Saier MH (October 2014). "Expansion of the APC ...
... ferroportin 1) gene". Blood Cells Mol Dis. 31 (3): 299-304. doi:10.1016/S1079-9796(03)00164-5. PMID 14636642. "Summaries for ... This led investigators to the discovery of a gene polymorphism in the gene for ferroportin, which predisposes some people of ...
Hepcidin production and release shuts down ferroportin, a protein that controls export of iron from the gut and from iron ... Hepcidin in turn causes increased internalisation of ferroportin molecules on cell membranes which prevents release from iron ... Inflammatory cytokines also appear to affect other important elements of iron metabolism, including decreasing ferroportin ...
In very rare instances, mutations in ferroportin result in ferroportin resistance to hepcidin's negative regulatory effects, ... In response to elevated plasma iron levels, hepcidin inhibits the ferroportin transporter leading to decreased iron ... transferrin receptor-2 and ferroportin. Hereditary hemochromatosis is characterized by an accelerated rate of intestinal iron ... or mobilized out of storage in liver hepatocytes or from macrophages in the bone marrow by the transmembrane ferroportin ...
Hepcidin binds to and induces the degradation of ferroportin, which is responsible for exporting iron from cells and mobilizing ...
... encoding the ferroportin) CDC42BPA , CDC14A, EPAS1. In humans, 12 genes have been shown to be transcribed with the canonical ...
... raised levels of hepcidin act on macrophage ferroportin channels, leading to iron remaining within the macrophages.[citation ... is released from the haemoglobin is either stored internally in ferritin or is released into the circulation via ferroportin. ...
... ferroportin 1. To a lesser extent hephaestin has been detected in colon, spleen, kidney, breast, placenta and bone trabecular ... ferroportin (Ireg1) and hephaestin protein, thus minimizing iron absorption from the enterocytes into the circulation. ...
Rouault's group discovered that the Q248H mutation of ferroportin likely protects against malaria because it reduces iron ... ferroportin, HIF2 alpha, and several other transcripts. IRP1 acquires an iron-sulfur cluster in iron-replete cells that ...
So, in people with ferroportin proteins that transport iron out of cells without responding to hepcidin's signals to stop, they ... people who have mutations in the gene for ferroportin, prove the rule: these people have plenty of hepcidin, but their cells ...
... together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the basolateral ...
Family 2.A.100 The Ferroportin (Fpn) Family 2.A.101 The Malonate Uptake (MatC) Family (Formerly UIT1) 2.A.102 The 4-Toluene ...
... the ferroportin/IREG1 transporter exports it across the cell membrane where is it oxidized to Fe3+ on the surface of the cell ...
... a software architecture Ferroportin, a protein Filtered-popping network in computer science Fixed-pattern noise in digital ...