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*  Nitric oxide synthase
"The First 35 Amino Acids and Fatty Acylation Sites Determine the Molecular Targeting of Endothelial Nitric Oxide Synthase into ... It is synthesized by many cell types in response to cytokines and is an important factor in the response of the body to attack ... The FMN binding domain is homologous to flavodoxins, and the two domain fragment containing the FAD and NADPH binding sites is ... Biological functions of nitric oxide Nitric-oxide synthase (NAD(P)H-dependent) Nitric oxide synthase 2 (inducible) PDB: 3N5P​; ...
*  Ketoacyl synthase
KSs exist as individual enzymes, as they do in type II fatty acid synthesis and type II polyketide synthesis, or as domains in ... There are three main types of polyketides: Type I, type II and type III. Type I is very similar to the FAS type I, in that it ... There are two types of FASs: type I and type II. Type I FASs are highly integrated multidomain enzymes. They contain discrete ... Fatty acid synthase (FAS) is the enzyme system involved in de novo fatty acid synthesis. FAS is an iterative multienzyme ...
*  Fatty acid metabolism
These reactions are performed by fatty acid synthase II (FASII), which in general contain multiple enzymes that act as one ... or other types of hyperlipidemia. These may be familial or acquired. Familial types of disorders of fatty acid metabolism are ... "Fatty Acid Biosynthesis." Trans Fatty Acids. Oxford: Blackwell Pub., 2008. 12. Print. "MetaCyc pathway: superpathway of fatty ... The fatty acids in the fats obtained from land animals tend to be saturated, whereas the fatty acids in the triglycerides of ...
*  Beta-ketoacyl-ACP synthase
... synthase from the mitochondrial type II fatty acid synthase". Protein Science. 16 (2): 261-272. doi:10.1110/ps.062473707. ISSN ... FAS has two types, aptly named type I and II. Type I is found in animals, fungi, and "lower eukaryotes." Type II is found in ... "Regulating effect of β-ketoacyl synthase domain of fatty acid synthase on fatty acyl chain length in de novo fatty acid ... synthase from the mitochondrial type II fatty acid synthase". Protein Science. 16 (2): 261-72. doi:10.1110/ps.062473707. PMC ...
*  Apicoplast
This conclusion is supported by the discovery of Type II Fatty Acid Synthase (FAS) machinery in the apicoplast. The apicoplast ... If unable to synthesize sufficient fatty acids the parasite is unable to form the parasitophorous vacuole (PV) that is ... The two inner membranes are called the outer (OEM) and inner envelope membrane (IEM) and are derived from the plastid envelope ... The apicoplast has also been implicated with heme synthesis and amino acid synthesis. It is also suggested to have a role in ...
*  Rhamnolipid
... rather than hydroxyacyl-CoA suggesting that it catalyses the formation of HAAs directly from the type II fatty acid synthase ... fatty acid tail, such as 3-hydroxydecanoic acid. Specifically there are two main classes of rhamnolipids: mono-rhamnolipids and ... Rehm BH, Mitsky TA, Steinbüchel A (July 2001). "Role of fatty acid de novo biosynthesis in polyhydroxyalkanoic acid (PHA) and ... The substrate for RhlB is the fatty acid moiety of the detergent, produced by RhlA. The reason that Pseudomonas aeruginosa ...
*  MCAT (gene)
The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid ... and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein". ... Two transcript variants encoding different isoforms have been found for this gene. The enzyme encoded by the MCAT gene, along ... complexes rather than the type I human cytosolic complex. ...
*  acyl-carrier-protein) S-malonyltransferase
Fatty acid synthase pathways are divided into two distinct molecular forms: Type I and Type II. In Type I, Fatty Acid Synthase ... Fatty acid biosynthesis is carried out by the ubiquitous Fatty Acid Synthase. ... two major components of Mycobacterium tuberculosis fatty acid synthase II". The Journal of Biological Chemistry. 276 (30): ... Rock CO, Cronan JE (Jul 1996). "Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis ...
*  Biosynthesis of doxorubicin
This process is very similar to fatty acid synthesis, by fatty acid synthases and to Type I polyketide synthesis. But, in ... "Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length ... is an inherent characteristic of Type II ACPs. In summary, a given Type II PKS may provide its own MAT (s), it may borrow one ... The PKS may "borrow" the MAT from its own fatty acid synthase and this may be the primary way ACP receives its malonate group ...
*  Fatty-acyl-CoA synthase
There are two types of fatty acid synthesis (FAS) mechanisms: type I FAS and type II FAS. Type I FAS exists in eukaryotes, ... and is of Type I Fatty Acid Synthesis (FAS). Yeast fatty acid synthase plays a pivotal role in fatty acid synthesis. It is a ... Synthesis of fatty acids is generally performed by fatty acid synthase (FAS). Though the syntheses of fatty acids are very ... Yeast fatty acyl synthase belongs to the Type I FAS and was the first of Type I FAS to be studied. Yeast fatty acyl synthase, ...
*  Metabolism
The enzymes of fatty acid biosynthesis are divided into two groups: in animals and fungi, all these fatty acid synthase ... White S, Zheng J, Zhang Y (2005). "The structural biology of type II fatty acid biosynthesis". Annu Rev Biochem. 74: 791-831. ... Fatty acids are made by fatty acid synthases that polymerize and then reduce acetyl-CoA units. The acyl chains in the fatty ... The fats are a large group of compounds that contain fatty acids and glycerol; a glycerol molecule attached to three fatty acid ...
*  Fatty acid synthase
... palmitic acid). There are two principal classes of fatty acid synthases. Type I systems utilise a single large, multifunctional ... Fatty acid synthesis Fatty acid metabolism Fatty acid degradation Enoyl-acyl carrier protein reductase List of fatty acid ... Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene. Fatty acid synthase is a multi-enzyme ... Jayakumar A, Chirala SS, Wakil SJ (1997). "Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase ...
*  Polyhydroxyalkanoates
... hydroxy fatty acids as substrates. The two classes of PHA synthases differ in the specific use of hydroxy fatty acids of short ... The resulting PHA is of the two types: Poly (HA SCL) from hydroxy fatty acids with short chain lengths including three to five ... synthesize copolyester from the above two types of hydroxy fatty acids, or at least possess enzymes that are capable of part of ... PHB copolymers, which may include other fatty acids such as beta-hydroxyvaleriate acid, may be elastic. Structure of poly-3- ...
*  Polyketide synthase
... the products of which are fatty acid derivatives Each type I polyketide-synthase module consists of several domains with ... Type II polyketide synthases are aggregates of monofunctional proteins. Type III polyketide synthases do not use ACP domains. ... Wawrik, B.; Kerkhof, L.; Zylstra, G. J.; Kukor, J. J. (2005). "Identification of Unique Type II Polyketide Synthase Genes in ... "Biogeography of Actinomycete Communities and Type II Polyketide Synthase Genes in Soils Collected in New Jersey and Central ...
*  Fatty acid synthesis
Straight-chain fatty acids occur in two types: saturated and unsaturated. Much like β-oxidation, straight-chain fatty acid ... results in 10-methylstearic acid Fatty acid Essential fatty acid Fatty acid metabolism Fatty acid synthase The position of the ... Fatty acid synthesis is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid ... fatty acid synthase and branch-chain fatty acid synthase is substrate specificity of the enzyme that catalyzes the reaction of ...
*  Beta-ketoacyl-(acyl-carrier-protein) synthase III
... or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The role of FabH in fatty acid synthesis has ... synthase III enzyme is designated mtFabH and is a crucial link between the fatty acid synthase-I and fatty acid synthase-II ... The C16 acyl-CoA product acts as a substrate for the synthesis of meromycolic acid by FAS-II, whereas the C26 fatty acid ... This enzyme participates in fatty acid biosynthesis. β-Ketoacyl-acyl-carrier-protein synthase III is involved in the ...
*  Chalcone synthase
... an early stage enzyme of type II fatty acid biosynthesis. Although higher plant chalcone synthases have been extensively ... Abe I, Morita H (Jun 2010). "Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases ... Austin MB, Noel JP (February 2003). "The chalcone synthase superfamily of type III polyketide synthases". Nat Prod Rep. 20 (1 ... Other light sensitive domains include Box I, Box II, Box III, Box IV or three copies of H-box (CCTACC). The chalcone synthase ...
*  6-Deoxyerythronolide B synthase
NADPH to reduce the double bond from the organic compound Fatty acid synthesis in most prokaryotes occurs by a type II synthase ... Type two synthases contain active sites distributed among several smaller polypeptides, and type three synthases are large ... This Type I synthase includes discrete domains on which individual reactions are catalyzed. In both fatty acid synthesis and ... the specific mechanism by which fatty acid chain length remains unknown but it is expected that ACP-bound fatty acid chains of ...
*  Mycolactone
Type A and B KRs refer to the two directions of ketoreduction that are correlated with specific amino acids in the active site ... and a third polyketide synthase, encoded by the mlsB gene, produces the fatty acid-acyl side chain. Three putative accessory ... 12 on the fatty acid side chain. The gene encoding a FabH-like, type III ketosynthase (KS), located upstream of mlsA1, encodes ... and a type II thioesterase (TE II) gene (MUP038) is located between mlsA2 and mlsB. Mycolactone consists of a 12-membered ...
*  Neurodegeneration with brain iron accumulation
Fatty acid hydroxylase-associated neurodegeneration) Kufor-Rakeb syndrome Neuroferritinopathy Aceruloplasminemia Woodhouse- ... The first type is considered to be the classic presentation, while the second type is the atypical presentation. Phenotypes of ... Patients typically fall into two different categories: (1) early onset, rapid progression or (2) late onset, slow progression. ... Sakati syndrome CoPAN (CoA synthase protein-associated neurodegeneration) Idiopathic NBIA Neurodegeneration with brain iron ...
*  Polyketide
... type II polyketides (often aromatic molecules produced by the iterative action of dissociated enzymes), and type III ... through the decarboxylative condensation of malonyl-CoA derived extender units in a similar process to fatty acid synthesis (a ... Robinson JA (1991). "Polyketide synthase complexes: their structure and function in antibiotic biosynthesis". Philos Trans R ... They are broadly divided into three classes: type I polyketides (often macrolides produced by multimodular megasynthases), ...
*  Malonyl-CoA
... constitutes the minimal PKS of type II polyketides. Malonyl-CoA is a highly regulated molecule in fatty acid synthesis; as such ... The enzyme MCAT together with an acyl carrier protein (ACP), and a polyketide synthase (PKS) and chain-length factor ... it inhibits the rate-limiting step in beta-oxidation of fatty acids. Malonyl CoA inhibits fatty acids from associating with ... Malonyl-CoA is a coenzyme A derivative of malonic acid. It plays a key role in chain elongation in fatty acid biosynthesis and ...
*  Lipoxygenase
... eicosapentaenoic acid, docosahexaenoic acid, and alpha-linolenic acid; and the omega-9 fatty acid, mead acid. Certain types of ... and 15-lipoxygenase type II), in contrast to ALOX15B which metabolizes arachidonic acid principally to 15-HpETE and to a lesser ... acids to their corresponding epoxy alcohol and epoxy keto derivatives and thereby is also classified as a hepoxilin synthase. ... arachidonic acid, linoleic acid, dihomo-γ-linolenic acid, and adrenic acid; the omega-3 fatty acids, ...
*  6-methylsalicylic-acid synthase
... similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: ... In enzymology, a 6-methylsalicylic-acid synthase (EC 2.3.1.165) is an polyketide synthase that catalyzes the chemical reaction ... Richardson MT, Pohl NL, Kealey JT, Khosla C (1999). "Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase ... Spencer JB, Jordan PM (December 1992). "Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum ...
*  Glyoxylate cycle
Fatty acids from lipids are commonly used as an energy source by vertebrates as fatty acids are degraded through beta oxidation ... Mammals are incapable of executing the pathway due to the lack of two enzymes, isocitrate lyase and malate synthase, which are ... species of fungi that lacked ICL were also significantly less virulent in studies with mice compared to the wild type. The ... The two initial steps of the glyoxylate cycle are identical to those in the citric acid cycle: acetate → citrate → isocitrate. ...
*  Prostaglandin-endoperoxide synthase 2
Fatty Acids. 73 (3-4): 141-62. doi:10.1016/j.plefa.2005.05.002. PMID 16005201. Wang Q1, He Y, Shen Y, Zhang Q, Chen D, Zuo C, ... may have benefit in the prevention and treatment of these types of cancer. COX-2 expression was found in human idiopathic ... Fatty Acids. 66 (1): 13-8. doi:10.1054/plef.2001.0335. PMID 12051953. Saukkonen K, Rintahaka J, Sivula A, Buskens CJ, Van Rees ... Arachidonic acid can bind to E-cat and E-allo, but the affinity of AA for E-allo is 25 times that for Ecat. Palmitic acid, an ...
*  PGDS
"Hematopoietic prostaglandin D synthase". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2-3): 163-7. doi:10.1016/S0952-3278(03 ... lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Arch. Biochem ... 1998). "Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma". Biol. Reprod. 58 (2): ... 2000). "Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep". Proc. Natl. Acad. Sci. U. ...