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*  Nitric oxide synthase
"The First 35 Amino Acids and Fatty Acylation Sites Determine the Molecular Targeting of Endothelial Nitric Oxide Synthase into ... It is synthesized by many cell types in response to cytokines and is an important factor in the response of the body to attack ... Biological functions of nitric oxide Nitric-oxide synthase (NAD(P)H-dependent) Nitric oxide synthase 2 (inducible) PDB: 3N5P​; ... NO Synthase Nitric Oxide Synthase in Proteopedia Molecular and Cellular Biology portal. ...
*  Ketoacyl synthase
... such as type I fatty acid synthases (FASs) and polyketide synthases (PKSs). KSs are divided into five families: KS1, KS2, KS3, ... There are three main types of polyketides: Type I, type II and type III. Type I is very similar to the FAS type I, in that it ... Fatty acid synthase (FAS) is the enzyme system involved in de novo fatty acid synthesis. FAS is an iterative multienzyme ... The most common enzymes in this family are 3-ketoacyl-CoA synthases, fatty acid elongases and very long-chain fatty acid ...
*  Fatty acid metabolism
... or other types of hyperlipidemia. These may be familial or acquired. Familial types of disorders of fatty acid metabolism are ... In animals, as well as some fungi such as yeast, these same reactions occur on fatty acid synthase I (FASI), a large dimeric ... "Fatty Acid Biosynthesis." Trans Fatty Acids. Oxford: Blackwell Pub., 2008. 12. Print. "MetaCyc pathway: superpathway of fatty ... The fatty acids in the fats obtained from land animals tend to be saturated, whereas the fatty acids in the triglycerides of ...
*  Beta-ketoacyl-ACP synthase
... synthase from the mitochondrial type II fatty acid synthase". Protein Science. 16 (2): 261-272. doi:10.1110/ps.062473707. ISSN ... "Regulating effect of β-ketoacyl synthase domain of fatty acid synthase on fatty acyl chain length in de novo fatty acid ... synthase from the mitochondrial type II fatty acid synthase". Protein Science. 16 (2): 261-72. doi:10.1110/ps.062473707. PMC ... "fatty acid transport tunnels" within the beta-ketoacyl-ACP synthase domain that lead to one of many "fatty acid cavities", ...
*  Fatty acid synthase
... palmitic acid). There are two principal classes of fatty acid synthases. Type I systems utilise a single large, multifunctional ... Fatty acid synthesis Fatty acid metabolism Fatty acid degradation Enoyl-acyl carrier protein reductase List of fatty acid ... Fatty acid synthase (FAS) is an enzyme that in humans is encoded by the FASN gene. Fatty acid synthase is a multi-enzyme ... Jayakumar A, Chirala SS, Wakil SJ (1997). "Human fatty acid synthase: assembling recombinant halves of the fatty acid synthase ...
*  Apicoplast
This conclusion is supported by the discovery of Type II Fatty Acid Synthase (FAS) machinery in the apicoplast. The apicoplast ... If unable to synthesize sufficient fatty acids the parasite is unable to form the parasitophorous vacuole (PV) that is ... The apicoplast has also been implicated with heme synthesis and amino acid synthesis. It is also suggested to have a role in ...
*  Zwittermicin A
Most likely, all of the synthases are located on one megasynthase much like a type I fatty acid synthase. Based on mutant ... Genes encoding for the seven component hybrid synthase responsible for the assembly of the backbone is likely located on the ... This is done by tethering the amino acid to a peptidal carrier protein via a non-ribosomal peptide synthetase. Subsequently ... Finally, condensation of 2,3-diaminopropionate with the carried molecule by a second nonribosomalpeptide synthase produces the ...
*  Biosynthesis of doxorubicin
This process is very similar to fatty acid synthesis, by fatty acid synthases and to Type I polyketide synthesis. But, in ... The PKS may "borrow" the MAT from its own fatty acid synthase and this may be the primary way ACP receives its malonate group ... "Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length ... Meurer G, Gerlitz M, Wendt-Pienkowski E, Vining LC, Rohr J, Hutchinson CR (1997). "Iterative type II polyketide synthases, ...
*  6-methylsalicylic-acid synthase
... similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: ... In enzymology, a 6-methylsalicylic-acid synthase (EC 2.3.1.165) is an polyketide synthase that catalyzes the chemical reaction ... Richardson MT, Pohl NL, Kealey JT, Khosla C (1999). "Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase ... Spencer JB, Jordan PM (December 1992). "Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum ...
*  acyl-carrier-protein) S-malonyltransferase
Fatty acid synthase pathways are divided into two distinct molecular forms: Type I and Type II. In Type I, Fatty Acid Synthase ... Fatty acid biosynthesis is carried out by the ubiquitous Fatty Acid Synthase. ... fatty acid biosynthesis yields the most energy dense products. As a result, microbial fatty acid derivatives are emerging as a ... Yu X, Liu T, Zhu F, Khosla C (Nov 2011). "In vitro reconstitution and steady-state analysis of the fatty acid synthase from ...
*  Rhamnolipid
... rather than hydroxyacyl-CoA suggesting that it catalyses the formation of HAAs directly from the type II fatty acid synthase ... They have a glycosyl head group, in this case a rhamnose moiety, and a 3-(hydroxyalkanoyloxy)alkanoic acid (HAA) fatty acid ... Rehm BH, Mitsky TA, Steinbüchel A (July 2001). "Role of fatty acid de novo biosynthesis in polyhydroxyalkanoic acid (PHA) and ... The substrate for RhlB is the fatty acid moiety of the detergent, produced by RhlA. The reason that Pseudomonas aeruginosa ...
*  MCAT (gene)
The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid ... and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein". ... complexes rather than the type I human cytosolic complex. Two transcript variants encoding different isoforms have been found ...
*  Carbohydrate-responsive element-binding protein
... and fatty acid synthase. GRCh38: Ensembl release 89: ENSG00000009950 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Kawaguchi T, Takenoshita M, Kabashima T, Uyeda K (2002). "Glucose and cAMP regulate the L-type pyruvate kinase gene by ... 2002). "Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive ... ChREBP mediates activation of several regulatory enzymes of glycolysis and lipogenesis including L-type pyruvate kinase (L-PK ...
*  Metabolism
... all these fatty acid synthase reactions are carried out by a single multifunctional type I protein, while in plant plastids and ... Fatty acids are made by fatty acid synthases that polymerize and then reduce acetyl-CoA units. The acyl chains in the fatty ... The fats are a large group of compounds that contain fatty acids and glycerol; a glycerol molecule attached to three fatty acid ... Fats are catabolised by hydrolysis to free fatty acids and glycerol. The glycerol enters glycolysis and the fatty acids are ...
*  Taxifolin
By inhibiting the fatty acid synthase in cancer cells, taxifolin is able to prevent the growth and spread of cancer cells. The ... Taxifolin is a flavanonol, a type of flavonoid. It can be found in conifers like the Siberian larch, Larix sibirica, in Russia ... Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity. JBC ... Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity. JBC ...
*  Fatty-acyl-CoA synthase
... and is of Type I Fatty Acid Synthesis (FAS). Yeast fatty acid synthase plays a pivotal role in fatty acid synthesis. It is a ... Synthesis of fatty acids is generally performed by fatty acid synthase (FAS). Though the syntheses of fatty acids are very ... Yeast fatty acyl synthase belongs to the Type I FAS and was the first of Type I FAS to be studied. Yeast fatty acyl synthase, ... There are two types of fatty acid synthesis (FAS) mechanisms: type I FAS and type II FAS. Type I FAS exists in eukaryotes, ...
*  Aflatoxin B1
... is derived from both a dedicated fatty acid synthase (FAS) and a polyketide synthase (PKS), together known as ... "Definition of Aspergillosis , Aspergillosis , Types of Fungal Diseases , Fungal Diseases , CDC". www.cdc.gov. Retrieved 2017-05 ... norsolorinic acid synthase. The biosynthesis begins with the synthesis of hexanoate by the FAS, which then becomes the starter ... A reductase then catalyzes the reduction of the ketone on the norsolorinic acid side-chain to yield averantin. Averantin is ...
*  Polyketide synthase
... the products of which are fatty acid derivatives Each type I polyketide-synthase module consists of several domains with ... Type II polyketide synthases are aggregates of monofunctional proteins. Type III polyketide synthases do not use ACP domains. ... Castoe, T. A.; Stephens, T.; Noonan, B. P.; Calestani, C. (2007). "A novel group of type I polyketide synthases (PKS) in ... Wawrik, B.; Kerkhof, L.; Zylstra, G. J.; Kukor, J. J. (2005). "Identification of Unique Type II Polyketide Synthase Genes in ...
*  Beta-ketoacyl-(acyl-carrier-protein) synthase III
... or type II) fatty-acid biosynthesis system that occurs in plants and bacteria. The role of FabH in fatty acid synthesis has ... synthase III enzyme is designated mtFabH and is a crucial link between the fatty acid synthase-I and fatty acid synthase-II ... This enzyme participates in fatty acid biosynthesis. β-Ketoacyl-acyl-carrier-protein synthase III is involved in the ... The C16 acyl-CoA product acts as a substrate for the synthesis of meromycolic acid by FAS-II, whereas the C26 fatty acid ...
*  Polyhydroxyalkanoates
... hydroxy fatty acids as substrates. The two classes of PHA synthases differ in the specific use of hydroxy fatty acids of short ... The resulting PHA is of the two types: Poly (HA SCL) from hydroxy fatty acids with short chain lengths including three to five ... PHB copolymers, which may include other fatty acids such as beta-hydroxyvaleriate acid, may be elastic. Structure of poly-3- ... synthesize copolyester from the above two types of hydroxy fatty acids, or at least possess enzymes that are capable of part of ...
*  6-Deoxyerythronolide B synthase
This Type I synthase includes discrete domains on which individual reactions are catalyzed. In both fatty acid synthesis and ... Type two synthases contain active sites distributed among several smaller polypeptides, and type three synthases are large ... There have been three categories of polyketide synthases identified to date, type 1, 2 and 3. Type one synthases involve large ... the specific mechanism by which fatty acid chain length remains unknown but it is expected that ACP-bound fatty acid chains of ...
*  Fatty acid synthesis
... results in 10-methylstearic acid Fatty acid Essential fatty acid Fatty acid metabolism Fatty acid synthase The position of the ... Straight-chain fatty acids occur in two types: saturated and unsaturated. Much like β-oxidation, straight-chain fatty acid ... Fatty acid synthesis is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid ... fatty acid synthase and branch-chain fatty acid synthase is substrate specificity of the enzyme that catalyzes the reaction of ...
*  Mycolactone
12 on the fatty acid side chain. The gene encoding a FabH-like, type III ketosynthase (KS), located upstream of mlsA1, encodes ... and a third polyketide synthase, encoded by the mlsB gene, produces the fatty acid-acyl side chain. Three putative accessory ... Type A and B KRs refer to the two directions of ketoreduction that are correlated with specific amino acids in the active site ... The lactone core is produced by two polyketide synthases (PKS) that are encoded by the genes, mlsA1 and mlsA2, ...
*  Mycolic acid
... as trehalose via the antigen 85 complex The fatty acid synthase-I and fatty acid synthase-II pathways producing mycolic acids ... Most mycolic acids also contain various functional groups. M. tuberculosis produces three main types of mycolic acids: alpha-, ... These were summarised as follows: Synthesis of the C26 saturated straight chain fatty acids by the enzyme fatty acid synthase-I ... Mycolic acids are long fatty acids found in the cell walls of the Mycolata taxon, a group of bacteria that includes ...
*  PGDS
"Hematopoietic prostaglandin D synthase". Prostaglandins Leukot. Essent. Fatty Acids. 69 (2-3): 163-7. doi:10.1016/S0952-3278(03 ... lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Arch. Biochem ... 1998). "Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma". Biol. Reprod. 58 (2): ... 2000). "Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep". Proc. Natl. Acad. Sci. U. ...
*  Prostaglandin-endoperoxide synthase 2
While metabolizing arachidonic acid primarily to PGG2, COX-2 also converts this fatty acid to small amounts of a racemic ... Consequently, inhibiting PTGS2 (COX-2) may have benefit in the prevention and treatment of these types of cancer. COX-2 ... Fatty Acids. 73 (3-4): 141-62. doi:10.1016/j.plefa.2005.05.002. PMID 16005201. Wang Q1, He Y, Shen Y, Zhang Q, Chen D, Zuo C, ... Fatty Acids. 66 (1): 13-8. doi:10.1054/plef.2001.0335. PMID 12051953. Saukkonen K, Rintahaka J, Sivula A, Buskens CJ, Van Rees ...
*  Echinocandin
... fatty acid derivatives of a disaccharide that also blocked the same target, 1,3-β glucan synthase - and had action only on ... One of the first echinocandins of the pneumocandin type, discovered in 1974, echinocandin B, could not be used clinically due ... and anidulafungin are similar cyclic hexapeptide antibiotics linked to long modified N-linked acyle fatty acid chains. The ... cyclic hexapeptides linked to a long-chain fatty acid) Echinocandin B not clinically used, risk of hemolysis Cilofungin ...