... death-inducing ligands that kill cells (viz., Fas ligand, TRAIL, and TNFSF12); cellular receptors for these ligands (viz., Fas ... Humans, it is estimated, express more than 10,000 different HLA class I proteins, 3,000 different HLA class II proteins, and ... the protein is degraded in APC to drug-bound peptides which are loaded onto the groove in HLA proteins and then presented to T ... on foreign proteins. These proteins are taken up by antigen-presenting cells (APC) and degraded into small peptides. The ...

FOXO1 upregulates Fas ligand (FasL) transcriptionally resulting in apoptotic cell death. Additionally, FOXO1 trans-activate Bim ... Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by ... "DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in ... FOXO1A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ...

These pathways are the cytotoxic protein pathway and the Fas ligand pathway. Apoptosis is the primary mechanism for both of ... The other pathway is the Fas ligand pathway. In this pathway, a Fas ligand (FasL) on the CTL binds to Fas receptor (FasR) on ... One pathway is the cytotoxic protein pathway. In this pathway perforins and granzymes are taken up by the target cell. In this ...

... also known as mega-FasLigand is a recombinant fusion protein. This protein was derived from the pro-apoptotic human Fas ligand ... A current target is Heat Shock Protein 90 (HSP90). HSP90 is key in protein folding and maturation. TopoTarget is currently ... FasL) protein. APO010 causes cell death of cancerous cells through a mechanism of targeting Fas receptors on the surface of ... Zemab comprises an antibody-toxin for the treatment of specific types of cancers in the form of a protein product., pg 20 The ...

For example, the Fas Ligand binds the FasR receptor at the receptor's extracellular surface; this activates the death domains ... which is facilitated by binding to adaptor proteins via protein-protein interaction motifs that are collectively referred to as ... Caspase-1 activation is mediated by a repertoire of proteins, allowing detection of a range of pathogenic ligands. Some ... The adaptor protein FADD will recruit (by a Death domain-Death domain interaction) pro-Caspase 8 via the DED domain. This FasR ...

"A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells". FEBS Lett. 581 (23): ... This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. The specific function ... Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene. This gene encodes a member of the sorting nexin ... Seet LF, Hong W (Sep 2006). "The Phox (PX) domain proteins and membrane traffic". Biochim Biophys Acta. 1761 (8): 878-96. doi: ...

"HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". The Journal of Biological ... Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 (also termed Krox20) is a ... The protein encoded by Krox20 contains two cys2his2-type zinc fingers. Krox20 gene expression is restricted to the early ... When the Krox20 is deleted in mice, the protein coding ability of the Krox20 gene (including the DNA-binding domain of the zinc ...

SPI-2 expression also inhibits the apoptotic pathway activated by Fas-ligand and TNFα. Deletion of SPI-2 leads to virus ... CS1: long volume value, Protein articles without symbol, Protein pages needing a picture, Viral nonstructural proteins). ... The translated protein stays in the cytoplasm of the host cell. SPI-2 shares 92% of its amino acid sequence with the cowpox ... Legrand FA, Verardi PH, Chan KS, Peng Y, Jones LA, Yilma TD (February 2005). "Vaccinia viruses with a serpin gene deletion and ...

Yoo YG, Lee MO (2004). "Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional ... "HIV Tat binds Egr proteins and enhances Egr-dependent transactivation of the Fas ligand promoter". J Biol Chem. 277 (22): 19482 ... Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene. The gene encodes a transcriptional regulator ... EGR3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ...

Some cytokines, such as Fas ligand, are used as "death" signals; they cause target cells to undergo programmed cell death or ... Individual growth factor proteins tend to occur as members of larger families of structurally and evolutionarily related ... Usually it is a secreted protein or a steroid hormone. Growth factors are important for regulating a variety of cellular ... However, as different lines of research converged, it became clear that some of the same signaling proteins which the ...

... and proteins that can deliver death signals in leukocytes (Fas ligand and galectin-1). The formation of a leukocyte infiltrate ...

... has been shown to interact with: AKAP9, DNM1, Fas ligand SNX2, and TNKS. GRCh38: Ensembl release 89: ENSG00000187239 - ... Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene. The protein encoded by this gene is a member ... The protein contains an N-terminal Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain followed by a coiled-coil ... This protein binds sorting nexin 2 (SNX2), tankyrase (TNKS), and dynamin; an interaction between this protein and formin has ...

... hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase". The ... PC12 cells treated with CRH (1-10 nM) showed increased numbers of apoptotic cells and upregulation of the Fas ligand via p38 ... Administration of Antalarmin (10 nM) completely blocked the CRH-induced apoptosis response and inhibited Fas ligand expression ... Griebel G (April 1999). "Is there a future for neuropeptide receptor ligands in the treatment of anxiety disorders?". ...

2009). "Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein ... Amyloid beta A4 precursor protein-binding family B member 1-interacting protein (APBB1IP), also known as APBB1-interacting ... "Entrez Gene: amyloid beta (A4) precursor protein-binding". Inagaki T, Suzuki S, Miyamoto T, Takeda T, Yamashita K, Komatsu A, ... 1997). "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila ...

FAS-associated factor 1 is a protein that in humans is encoded by the FAF1 gene. Interaction of Fas ligand (TNFSF6) with the ... The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS ... "Entrez Gene: FAF1 Fas (TNFRSF6) associated factor 1". Chu K, Niu X, Williams LT (1996). "A Fas-associated protein factor, FAF1 ... 2003). "Protein kinase CK2 phosphorylates the Fas-associated factor FAF1 in vivo and influences its transport into the nucleus ...

... leading to the expression of FAS ligand (FasL), which activates its specific, ubiquitous receptor, Fas. This leads to the ... As such, TSP-1 is designated a multifunctional protein. TSP-1 has multiple receptors, among which CD36, CD47 and integrins are ... Due to their dynamic role within the extracellular matrix they are considered matricellular proteins. The first member of the ... The thrombospondins are a family of multifunctional proteins. The family consists of thrombospondins 1-5 and can be divided ...

These mice revealed that CTLs could resort to a second lytic pathway initiated by Fas ligand (FasL), a now well-established ... "novel cytoplasmic protein complex" involving what is now known as Mitochondrial Antiviral-signaling protein (MAVS), also known ... "Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape". Science. 274 (5291): 1363-1366. ... "viral and mammalian forms of the caspase-8-related protein FLIP" (FLICE-Like Inhibitory Protein, where "FLICE" is an alias for ...

... or FasL is a homotrimeric type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. It ... Fas forms the death-inducing signaling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface ... Fas ligand (FasL or CD95L or CD178) is a type-II transmembrane protein expressed on cytotoxic T lymphocytes and natural killer ... Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions ...

... interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to ... Optineurin is a protein that in humans is encoded by the OPTN gene. This gene encodes the coiled-coil containing protein ... "Interaction of an adenovirus E3 14.7-kilodalton protein with a novel tumor necrosis factor alpha-inducible cellular protein ... and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein ...

Fas, TNF, and TRAIL) and death receptors. Upon activation, the receptor protein, Fas-associated death domain protein, forms ... WO application 2017192820, Monia, Brett P.; Prakash, Thazha P. & Kinberger, Garth A. et al., "GLP-1 receptor ligand moiety ... It is a member of the CCAAT/enhancer-binding protein (C/EBP) family of DNA-binding transcription factors. The protein functions ... CHOP is a relatively small (29kDa) protein that differs from most C/EBP proteins in several amino acid substitutions, which ...

Other studies suggest that Hsp70 may play an anti-apoptotic role at other steps, but is not involved in Fas-ligand-mediated ... Binding immunoglobulin protein (BiP or Grp78) is a protein localized to the endoplasmic reticulum. It is involved in protein ... When Hsp70 proteins are ADP bound, the lid is closed, and peptides are tightly bound to the substrate binding domain. Protein ... Hsp70 proteins can act to protect cells from thermal or oxidative stress. These stresses normally act to damage proteins, ...

... is a transmembrane protein of the TNF family which binds the Fas ligand (FasL). The interaction between Fas and FasL results in ... HIV may increase the level of cellular proteins that prompt Fas-mediated apoptosis. HIV proteins decrease the amount of CD4 ... The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ... Examples of viral Bcl-2 proteins include the Epstein-Barr virus BHRF1 protein and the adenovirus E1B 19K protein. Some viruses ...

... of pro-caspase 8 initiates apoptosis via signaling from cell-surface death receptors such as Fas proteins and their ligands ... Upregulation of Fas and FADD protein has occurred in mice models after a 24h period of ischemic injury. This is also shown in ... Misfolded and unfolded proteins accumulate in the endoplasmic reticulum. This triggers the unfolded protein response (UPR). The ... This shows that the Fas-pathway may play a role in the pathogenesis of the apoptosis of tubule cells during the early ischemic- ...

... is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-induced apoptosis. Dcr3 was ... It acts as a decoy receptor that competes with death receptors for ligand binding. The encoded protein is postulated to play a ... TNFRSF6B has been shown to interact with: TNFSF14 Fas ligand. GRCh38: Ensembl release 89: ENSG00000243509 - Ensembl, May 2017 " ... 2003). "Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic ...

When a TC is activated it starts to express the surface protein FAS ligand (FasL)(Apo1L)(CD95L), which can bind to Fas (Apo1)( ... However, this Fas-Fas ligand interaction is thought to be more important to the disposal of unwanted T lymphocytes during their ... Engagement of Fas with FasL allows for recruitment of the death-induced signaling complex (DISC). The Fas-associated death ... In addition, they can recognise microbial toxic shock proteins and self-cell stress proteins. T γδ cells possess a wide ...

... has been shown to interact with: Fas ligand, PACSIN1, and PACSIN3. GRCh38: Ensembl release 89: ENSG00000100266 - ... Protein kinase C and casein kinase substrate in neurons protein 2 (Pacsin 2) is a protein that in humans is encoded by the ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

Fas ligand, and gamma interferon. Additionally, DAP3 interacts with the factor IPS-1 to activate caspases 3, 8, and 9, ... 28S ribosomal protein S29, mitochondrial, also known as death-associated protein 3 (DAP3), is a protein that in humans is ... The DAP3 gene encodes a 46 kDa protein located in the lower area of the small mitoribosomal subunit. This protein contains a P- ... Hulkko SM, Wakui H, Zilliacus J (Aug 2000). "The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the ...

In addition to activation by straurosporine and FAS ligand, STK3 has been found to be activated through dissociation of GLRX ... Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene. Protein kinase activation is a ... and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., ... This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' ( ...

Lack of a functional Fas ligand / Fas receptor system has been linked to abnormal follicle development, and increased numbers ... Fas antigen, a cell surface receptor protein, that is expressed on granulosa cells, mediates signals that induce apoptosis by ... and receptors Fas ligand and receptors TNF-related apoptosis-inducing ligand (TRAIL; also called APO-2) and receptors APO-3 ... Yang R, Xu S, Zhao Z, Li J (February 2012). "Fas ligand expression and mediated activation of an apoptosis program in bovine ...

Fas ligand, GAB1, GAB2, Glycoprotein 130, Granulocyte colony-stimulating factor receptor, HER2/neu, HNRNPC, Huntingtin, INPP5D ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... GRB2+Adaptor+Protein at the U.S. National Library of Medicine Medical Subject Headings (MeSH) The Grb2 protein page on The SH2 ... In humans, the GRB2 protein is encoded by the GRB2 gene. The protein encoded by this gene binds receptors such as the epidermal ...

They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ... β-Propeller structures provide a large flat surface that is thought to be involved in protein-protein interactions. This ... Excess MMPs degrade the structural proteins of the aortic wall. Disregulation of the balance between MMPs and TIMPs is also a ... Trexler M, Briknarová K, Gehrmann M, Llinás M, Patthy L (2003). "Peptide ligands for the fibronectin type II modules of matrix ...