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*  Factor XII deficiency
... (also Hageman factor deficiency) is a deficiency in the production of factor XII (FXII), a plasma ... "Factor XII Deficiency" (PDF). Pathology, Virginia Commonwealth University. Retrieved February 20, 2017. "Factor XII Deficiency ... hemophilia B with a deficiency in factor IX (Christmas disease), and hemophilia C with a deficiency in factor XI. Other rare ... Pauer HU, Burfeind P, Köstering H, Emons G, Hinney B (2003). "Factor XII deficiency is strongly associated with primary ...
*  Factor XII
Unlike other clotting factor deficiencies, factor XII deficiency is totally asymptomatic and does not cause excess bleeding. ... Factor XII is part of the coagulation cascade and activates factor XI and prekallikrein in vitro. Factor XII itself is ... The gene for factor XII is located on the tip of the long arm of the fifth chromosome (5q33-qter). Factor XII deficiency is a ... or factor XI deficiency. As a result, the main concern related to factor XII deficiency is the unnecessary testing, delay in ...
*  DMOZ - Health: Conditions and Diseases: Blood Disorders: Coagulation Disorders
MedlinePlus: Factor XII Deficiency Also known as Hageman factor, this is a congenital coagulation disorder that causes ... MedlinePlus: Factor V Deficiency Provides brief information about this inherited bleeding disorder, which is similar to ... MedlinePlus: Factor VII Deficiency Brief information about this inherited bleeding disorder including causes, symptoms, and ... MedlinePlus: Factor X Deficiency Information about this inherited disorder that causes abnormal bleeding including causes, ...
*  Metformin
Ting R; Szeto C; Chan M; Ma K; Chow K (2006). "Risk factors of vitamin B(12) deficiency in patients receiving metformin". Arch ... Andrès E; Noel E; Goichot B (2002). "Metformin-associated vitamin B12 deficiency". Arch Intern Med. 162 (19): 2251-52. doi: ... Higher doses and prolonged use are associated with increased incidence of vitamin B12 deficiency, and some researchers ... Gilligan M (2002). "Metformin and vitamin B12 deficiency". Arch Intern Med. 162 (4): 484-85. doi:10.1001/archinte.162.4.484. ...
*  Noonan syndrome
C Partial deficiency of Factor XI:C Partial deficiency of Factor XII:C Platelet dysfunction Combined coagulation defects ... Blood clotting disorders Von Willebrand disease Prolonged activated partial thromboplastin time Partial deficiency of Factor ... 12 (3): 283-5. doi:10.1038/nm0306-283. PMID 16520774. Roberts AE, Araki T, Swanson KD, et al. (2007). "Germline gain-of- ... A 2007 study followed 112 individuals for a mean of 12 years (mean age 25.3, range 12-71). No patient died during follow-up, ...
*  Congenital afibrinogenemia
"Factor I deficiency (Fibrinogen deficiency) - Canadian Hemophilia Society". www.hemophilia.ca. Retrieved 2015-11-12. " ... Factor I Deficiency Neerman-Arbez, Marguerite; De Moerloose, Philippe (2007). "Mutations in the fibrinogen gene cluster ... The only risk factor is if both parents of a child carry the recessive allele linked to the disorder. Individuals with the ... Gallastegui, N.; Kimble, E. L.; Harrington, T. J. (2015-09-01). "Resolution of fibrinogen deficiency in a patient with ...
*  Haemophilia C
"Factor XI Deficiency: Background, Pathophysiology, Epidemiology". "Factor XI deficiency , Disease , Overview , Genetic and Rare ... factor XI deficiency) is centered on prolonged activated partial thromboplastin time.One will find that the factor XI has ... "Orphanet: Congenital factor XI deficiency Hemophilia C". www.orpha.net. Retrieved 2016-07-12. Anderson, J. a. M.; Brewer, A.; ... "OMIM Entry - # 612416 - FACTOR XI DEFICIENCY". omim.org. Retrieved 2016-07-12. Kitchens, Craig S.; Konkle, Barbara A.; Kessler ...
*  Fluorine deficiency
"Nutritional Factors in Tooth Development". ADHA. Retrieved 2008-12-30. "Effect of Inorganic Fluoride on Living Organisms of ... Fluoride or fluorine deficiency is a disorder which may cause increased dental caries (or tooth decay, is the breakdown of ... Symptoms such as fractured hips in the elderly or brittle and weak bones are caused due to fluorine deficiency in the body. ... Retrieved 2008-12-30. External link in ,publisher= (help) Wood, A. J. J.; Riggs, B. L.; Melton, L. J. (1992). "The Prevention ...
*  Iodine deficiency
Following is a list of potential risk factors that may lead to iodine deficiency: Low dietary iodine Selenium deficiency ... It has been speculated that deficiency of iodine and other micronutrients may be a possible factor in observed differences in ... Cretinism is a condition associated with iodine deficiency and goiter, commonly characterised by mental deficiency, deafness, ... The diagnostic workup of a suspected iodine deficiency includes signs and symptoms as well as possible risk factors mentioned ...
*  Partial thromboplastin time
Deficiencies of factors VIII, IX, XI and XII and rarely von Willebrand factor (if causing a low factor VIII level) may lead to ... XI and XII. Notably, deficiencies in factors VII or XIII will not be detected with the PTT test. Prolonged APTT may indicate: ... coagulation factor deficiency (e.g., hemophilia) sepsis - coagulation factor consumption presence of antibodies against ... antiphospholipid antibodies or coagulation factor specific inhibitors), while if it does disappear a factor deficiency is more ...
*  Eomesodermin
Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin". Journal of Immunology. 185 ... Wang HT, Ge XS, Xue ZP, Li BQ (Jan 2010). "[Role of transcription factor T-bet and Eomes in IFN-gamma secretion of different ... Costello I, Pimeisl IM, Dräger S, Bikoff EK, Robertson EJ, Arnold SJ (Sep 2011). "The T-box transcription factor Eomesodermin ... "Human Th1 cells that express CD300a are polyfunctional and after stimulation up-regulate the T-box transcription factor ...
*  Lipoprotein-associated phospholipase A2
"Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory ... T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary ... "A mutation in plasma platelet-activating factor acetylhydrolase (Val279Phe) is a genetic risk factor for cerebral hemorrhage ... Min JH, Wilder C, Aoki J, Arai H, Inoue K, Paul L, Gelb MH (Apr 2001). "Platelet-activating factor acetylhydrolases: broad ...
*  Haemophilia
The type of haemophilia known as parahaemophilia is a mild and rare form and is due to a deficiency in factor V. This type can ... Factor VIII is used in haemophilia A and factor IX in haemophilia B. Factor replacement can be either isolated from human blood ... Thalji, N; Camire, RM (September 2013). "Parahemophilia: new insights into factor v deficiency". Seminars in thrombosis and ... In many cases, factor products of any sort are difficult to obtain in developing countries.[citation needed] Clotting factors ...
*  Hymenoxys odorata
Steel, E. G.; Witzel, D. A.; Blanks, A. (1976). "Acquired coagulation factor X activity deficiency connected with Hymenoxys ... site and phenological factors on hymenoxon content of bitterweed (Hymenoxys odorata)". J Anim Sci. 65: 1553-62. Witzel, D. A.; ... as well as inhibition of clotting factors. An ill sheep may be bloated, anorexic, weak, drooling, and vomiting. Acute and ... 37 (12): 1383-6. PMID 999065. Bitter Rubberweed (Hymenoxys odorata) USDA Poisonous Plants Research Jepson Manual Treatment, ...
*  Prekallikrein
PK is cleaved to produce kallikrein by activated Factor XII (Hageman factor). Prekallikrein is homologous to factor XI, and ... The family appeared to have a hereditary deficiency in an unknown coagulation factor, dubbed "Fletcher factor" after the family ... However, unlike factor XI, prekallikrein does not form dimers. Prekallikrein is activated to form kallikrein by factor XII ... Although most cases of prekallikrein deficiency are asymptomatic, a few reports link severe prekallikrein deficiency with ...
*  Factor XI
... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ... allowing factor XI's protease activity on it. Deficiency of factor XI causes the rare hemophilia C; this mainly occurs in ... "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... The zymogen factor is activated into factor XIa by factor XIIa (FXIIa), thrombin, and FXIa itself; due to its activation by ...
*  Factor VIII
Copper is a required cofactor for factor VIII and copper deficiency is known to decrease levels of factor VIII. There is a ... Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ... It is a cofactor to factor IXa in the activation of factor X, which, in turn, with its cofactor factor Va, activates more ... The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. ...
*  Von Willebrand factor
In the 1950s, vWD was shown to be caused by a plasma factor deficiency (instead of being caused by platelet disorders), and, in ... Factor VIII is released from vWF by the action of thrombin. In the absence of vWF, factor VIII has a half-life of 1-2 hours; ... GeneReviews/NCBI/NIH/UW entry on von Willebrand Factor Deficiency. Includes: Type 1 von Willebrand Disease, Type 2A von ... Von Willebrand factor's primary function is binding to other proteins, in particular factor VIII, and it is important in ...
*  Race and intelligence
Explanations based on factors of caste and culture may be appropriate, but so far have little direct empirical support. There ... For example, iodine deficiency causes a fall, on average, of 12 IQ points. Such impairments may sometimes be permanent, ... The following environmental factors are some of those suggested as explaining a portion of the differences in average IQ ... These factors are not mutually exclusive with one another, and some may, in fact, contribute directly to others. Furthermore, ...
*  KLF4
Li J, Zheng H, Yu F, Yu T, Liu C, Huang S, Wang TC, Ai W (June 2012). "Deficiency of the Kruppel-like factor KLF4 correlates ... Kruppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a zinc-finger transcription factor, and it was first ... Kruppel-like factors Published version Amr M Ghaleb, Vincent W Yang (22 February 2017). "Krüppel-like factor 4 (KLF4): What we ... Mreich E, Chen XM, Zaky A, Pollock CA, Saad S (June 2015). "The role of Krüppel-like factor 4 in transforming growth factor-β- ...
*  Dihydropyrimidine dehydrogenase deficiency
Is ethnicity a risk factor?". JOP. 9 (2): 226-9. PMID 18326935. Site dedicated exclusively to DPD Deficiency and Fluorouracil ( ... Dihydropyrimidine dehydrogenase deficiency (DPD deficiency) is an autosomal recessive metabolic disorder in which there is ... 5-FU) Toxicity related issues - dpd-deficiency.com Dihydropyrimidine dehydrogenase deficiency at NIH's Office of Rare Diseases ... DPD deficiency is inherited in an autosomal recessive manner. This means the defective gene responsible for the disorder is ...
*  Multimerin 1
Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have ... 1996). "An autosomal dominant, qualitative platelet disorder associated with multimerin deficiency, abnormalities in platelet ... A unique protein with RGDS, coiled-coil, and epidermal growth factor-like domains and a carboxyl terminus similar to the ... 2005). "Identification of the MMRN1 binding region within the C2 domain of human factor V". J. Biol. Chem. 279 (49): 51466-71. ...
*  Robert McCarrison
"The Influence of Deficiency of Accessory Food Factors on the Intesting", British Medical Journal, 2 (3054): 36-39, 12 July 1919 ... "Dietetic Deficiency And Endocrine Activity, With Special Reference To Deficiency Oedemas", British Medical Journal, 2 (3111): ... His 1921 book Studies in Deficiency Disease was considered notable at the time, being published at a time when knowledge of ... McCarrison himself noted that prior to publication of his studies on the pathogenesis of deficiency disease "no systemic post- ...
*  List of OMIM disorder codes
F11 Factor XII deficiency; 234000; F12 Factor XIIIA deficiency; 613225; F13A1 Factor XIIIB deficiency; 613235; F13B Failure of ... GLA Factor V and factor VIII, combined deficiency of; 227300; MCFD2 Factor V deficiency; 227400; F5 Factor XI deficiency, ... partial deficiency of; 120790; C1NH Complement factor H deficiency; 609814; HF1 Complement factor I deficiency; 610984; CFI ... deficiency of; 606367; IL2RA Intestinal pseudoobstruction, neuronal; 300048; FLNA Intrinsic factor deficiency; 261000; GIF ...
*  Oncogenomics
"A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1". ... whereas a deficiency in only one of these genes does not. The deficiencies can arise through mutations, epigenetic alterations ... Watanabe R, Ui A, Kanno S, Ogiwara H, Nagase T, Kohno T, Yasui A (2014). "SWI/SNF factors required for cellular resistance to ... Synthetic lethality arises when a combination of deficiencies in the expression of two or more genes leads to cell death, ...