"Factor XIa Inhibitors as New Anticoagulants". Journal of Medicinal Chemistry. 61 (17): 7425-7447. doi:10.1021/acs.jmedchem. ...
... is a factor XIa inhibitor which acts as an anticoagulant. It is taken by mouth. As of late 2021, it was under study ... small molecule factor XIa inhibitor". Clinical and Translational Science. 15 (2): 330-342. doi:10.1111/cts.13148. PMC 8841437. ...
Warn-Cramer BJ, Bajaj SP (Dec 1985). "Stoichiometry of binding of high molecular weight kininogen to factor XI/XIa". ... Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein that in humans is encoded by the KNG1 gene. ... Thompson RE, Mandle R, Kaplan AP (Oct 1979). "Studies of binding of prekallikrein and Factor XI to high molecular weight ... Gailani D, Broze GJ (Aug 1991). "Factor XI activation in a revised model of blood coagulation". Science. 253 (5022): 909-12. ...
... inhibits coagulation factor XIa and thrombin, Therefore, exhibiting anti-coagulant behavior. Furthermore, cystamine ... Multiple factors of potential cystamine toxicity have been described relating to hepatoxicity, anti-coagulant activity and skin ...
Factor XIa and XIIa are two main factors involved in the plasminogen activator. Factor XI (FXI) is a serine protase produced by ... Factor XIIa is another plasma protein that is involved in the activation of zymogen factor is activated into factor XIa. This ... "Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa". The ... Walsh PN (July 2001). "Roles of platelets and factor XI in the initiation of blood coagulation by thrombin". Thrombosis and ...
... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ... "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... The zymogen factor is activated into factor XIa by factor XIIa (FXIIa), thrombin, and FXIa itself; due to its activation by ... Factor IXa, in turn, forms a complex with Factor VIIIa (FIXa-FVIIIa) and activates factor X. Physiological inhibitors of factor ...
"Domain V of beta2-glycoprotein I binds factor XI/XIa and is cleaved at Lys317-Thr318". J Biol Chem. 280 (2): 907-12. doi: ... β2-GP1 also inhibits the generation of factor Xa in the presence of platelets. β2-GP1 also inhibits that activation of factor ... Since protein C is involved in factor Va degradation Apo-H indirectly inhibits the degradation of factor Va. This inhibitory ... Normally, β2-GP1 assumes an anticoagulation activity in serum (by inhibiting coagulation factors); however, changes in blood ...
2003). "Unusual proteolytic activation of pro-hepatocyte growth factor by plasma kallikrein and coagulation factor XIa". J. ... This protease has been shown to cleave and activate hepatocyte growth factor/scatter factor, and urokinase plasminogen ... Lee SL, Dickson RB, Lin CY (2001). "Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, ... hepatocyte growth factor activator inhibitor (HAI)-1. Activation of the matriptase zymogen requires sequential N-terminal ...
"Total Synthesis of Clavatadine A Analogs to Produce a Viable Reversible Inhibitor for Factor XIa" (PDF). MS Thesis. Central ...
Factor XIa activates free Factor IX on the surface of activated platelets. The activated Factor IXa with Factor VIIIa forms the ... Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as ... The result is a Factor VIIa/TF complex, which catalyzes the activation of Factor X and Factor IX. Factor Xa formed on the ... And they may be more effective against Factor Xa in that they inhibit both free Factor Xa and Factor Xa in the prothrombinase ...
Factor XIa activates FIX, which with its co-factor FVIIIa form the tenase complex, which activates FX to FXa. The minor role ... If a coagulation factor is part of the contact activation or tissue factor pathway, a deficiency of that factor will affect ... Tissue factor, FV and FVIII are glycoproteins, and Factor XIII is a transglutaminase. The coagulation factors circulate as ... Assignment of numerals ceased in 1963 after the naming of Factor XIII. The names Fletcher Factor and Fitzgerald Factor were ...
Factors IIa, Xa, VIIa, IXa and XIa are all proteolytic enzymes that have a specific role in the coagulation cascade. Factor Xa ... Inhibition of factor Xa leads to antithrombotic effects by decreasing the amount of thrombin. Directly targeting factor Xa is ... Today there are four factor Xa inhibitors marketed: rivaroxaban, apixaban, edoxaban and betrixaban. Factor Xa was identified as ... It is defined as the formation of insoluble fibrin by activated coagulation factors, specifically thrombin. These factors ...
Grima, Brigitte; Chélot, Elisabeth; Xia, Ruohan; Rouyer, François (14 October 2004). "Morning and evening peaks of activity ... Pigment dispersing factor (pdf) is a gene that encodes the protein PDF, which is part of a large family of neuropeptides. Its ... Pigment dispersing factor (pdf) was first discovered in the central nervous system of arthropods by K. Ranga Rao and John P. ... This demonstrates PDF's role as a coupling factor between the M and E oscillators and its role in generating anticipation for ...
... and factors IXa, Xa, XIa, and XlIa. However, although ulinastatin is a protease inhibitor, its activity toward various ... tissue factor, P-selectin, intercellular adhesion molecule-1, phosphorylation of the extracellular signal-regulated protein ...
Liu, Lei; Kong, Nana; Xia, Guoliang; Zhang, Meijia (2013). "Molecular control of oocyte meiotic arrest and resumption". ... Gonadotropin surge-attenuating factor (GnSAF) is a nonsteroidal ovarian hormone produced by the granulosa cells of small antral ... AIYER, M. S.; CHIAPPA, SHARON A.; FINK, G. (1974). "A Priming Effect of Luteinizing Hormone Releasing Factor on the Anterior ... Danforth, D. R.; Cheng, C. Y. (1993). "The identification of gonadotrophin surge inhibiting factor and its role in the ...
"Misleading Metrics - Beall's List". Xia J, Smith MP (2018). "Alternative journal impact factors in open access publishing". ... Therefore, their impact factor is high, and not the contrary. As impact factors are a journal-level metric, rather than an ... The impact factor (IF) or journal impact factor (JIF) of an academic journal is a scientometric index calculated by Clarivate ... Thus impact factors cannot be used to compare journals across disciplines. Impact factors are sometimes used to evaluate not ...
Protein Z-dependent protease inhibitor (ZPI) is a protein circulating in the blood which inhibits factors Xa and XIa of the ... but this only applies to its inhibition of factor X. It is about 72 kDa heavy and 444 amino acids large. It is produced by the ...
The most promising ones act on the contact activation system (factor XIIa and factor XIa); it is anticipated that this may ... As of November 2021[update], the direct factor XIa inhibitor milvexian is in Phase II clinical trials for the prevention of ... Andexanet alfa is a recombinant modified human factor Xa decoy that reverses the effect of factor Xa inhibitors by binding at ... The activated AT then inactivates factor Xa, thrombin, and other coagulation factors. Heparin can be used in vivo (by injection ...
2006). "Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the ... 1993). "Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor ... 1987). "A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins". Cell. 47 (5 ...
Lindquist PA, Fujikawa K, Davie EW (March 1978). "Activation of bovine factor IX (Christmas factor) by factor XIa (activated ... Russellysin (EC 3.4.24.58, Russell's viper venom factor X activator, RVV-X, blood-coagulation factor X activating enzyme, ... including coagulation factor X, coagulation factor IX and protein C by cleavage of -Arg- bonds. Has no action on insulin B ... Takeya H, Nishida S, Miyata T, Kawada S, Saisaka Y, Morita T, Iwanaga S (July 1992). "Coagulation factor X activating enzyme ...
... but they are 100,000 times better at inhibiting factor Xa and factor Xia. These inhibitory properties as well as their ... Further, when CU-2010 and CU-2020 are continuously infused, the greater inhibition of factors Xa and XIa compared to that by ... The prolongation of coagulation (or prothrombin time, PT) occurs following either tissue factor or contact-phase stimulation ...
Activated blood coagulation factor XI may refer to: Coagulation factor IXa, an enzyme Coagulation factor XIa, an enzyme This ... disambiguation page lists articles associated with the title Activated blood coagulation factor XI. If an internal link led you ...
... glycosylated and then cleaved by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway) to produce a ... and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa. Factor IX is inhibited by ... Zhong D, Bajaj MS, Schmidt AE, Bajaj SP (Feb 2002). "The N-terminal epidermal growth factor-like domain in factor IX and factor ... "The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating ...
... coagulation factor XIa EC 3.4.21.28: Now EC 3.4.21.74, venombin A EC 3.4.21.29: Now EC 3.4.21.74, venombin A EC 3.4.21.30: Now ... limulus clotting factor C EC 3.4.21.85: limulus clotting factor B EC 3.4.21.86: limulus clotting enzyme EC 3.4.21.87: Now EC ... coagulation factor VIIa EC 3.4.21.22: coagulation factor IXa EC 3.4.21.23: Deleted EC 3.4.21.24: Deleted EC 3.4.21.25: ... complement factor I EC 3.4.21.46: complement factor D EC 3.4.21.47: alternative-complement-pathway C3/C5 convertase EC 3.4. ...
... factor viiia MeSH D23.119.375.310 - factor ixa MeSH D23.119.400.315 - factor xa MeSH D23.119.425.320 - factor xia MeSH D23.119. ... fibroblast growth factor 1 MeSH D23.348.383.120 - fibroblast growth factor 2 MeSH D23.348.383.130 - fibroblast growth factor 3 ... fibroblast growth factor 5 MeSH D23.348.383.160 - fibroblast growth factor 6 MeSH D23.348.383.170 - fibroblast growth factor 7 ... fibroblast growth factor 9 MeSH D23.348.479.750.200 - fibroblast growth factor 10 MeSH D23.348.479.875 - nerve growth factors ...
Mao Z, Bonni A, Xia F, Nadal-Vicens M, Greenberg ME (1999). "Neuronal activity-dependent cell survival mediated by ... nuclear factor 1, myocyte-specific enhancer-binding factor 2, and COMP1 factor". Proc. Natl. Acad. Sci. U.S.A. 89 (20): 9484-8 ... Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor ... "Entrez Gene: MEF2A MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)". Mao Z, Nadal-Ginard B ...
Xia X, Li L, Choi YS (January 1992). "Human recombinant IL-3 is a growth factor for normal B cells". Journal of Immunology. 148 ... T cell Replacing Factor), CSF (colony-stimulating factors), MAF (macrophage activation factors), and lymphotoxin. Most factors ... B-cell growth factor I or B-cell-stimulating factor, provisional 1) is a differentiation factor for resting B cells and may not ... "B cell growth factors and B cell differentiation factor from human T hybridomas. Two distinct kinds of B cell growth factor and ...
Sun S, Sun W, Xia L, Liu L, Du R, He L, et al. (November 2014). "The T-box transcription factor Brachyury promotes renal ... and is the most highly expressed superenhancer-associated transcription factor. Brachyury is an important factor in promoting ... Xia B, Zhang W, Wudzinska A, Huang E, Brosh R, Pour M, et al. (2021-09-16). "The genetic basis of tail-loss evolution in humans ... T-box transcription factor T, also known as Brachyury protein, is encoded for in humans by the TBXT gene. Brachyury functions ...
Masood R, Kundra A, Zhu S, Xia G, Scalia P, Smith DL, Gill PS (May 2003). "Malignant mesothelioma growth inhibition by agents ... Vascular endothelial growth factor C (VEGF-C) is a protein that is a member of the platelet-derived growth factor / vascular ... Krebs R, Jeltsch M (Dec 2013). "Die lymphangiogenic growth factors VEGF-C and VEGF-D. Part 2: The role of VEGF-C and VEGF-D in ... Lee J, Gray A, Yuan J, Luoh SM, Avraham H, Wood WI (March 1996). "Vascular endothelial growth factor-related protein: a ligand ...
S2CID 8068690 Xia, Ge (2013), "The stretch factor of the Delaunay triangulation is less than 1.998", SIAM Journal on Computing ... The parameter t is called the stretch factor or dilation factor of the spanner. In computational geometry, the concept was ...