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*  Factor XI
... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ... "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. Factor XI (FXI) ... Low levels of factor XI also occur in many other disease states, including Noonan syndrome. High levels of factor XI have been ...
*  Theiler's disease
However, not all horses that tested positive for this virus showed clinical signs, so additional causative factors such as ... Plasma transfusions may be needed if spontaneous bleeding occurs, to replace clotting factors. Antibiotics are sometimes ...
*  Discovery and development of direct thrombin inhibitors
Furthermore, it activates factors V, VIII and XI, all by cleaving the sequences GlyGlyGlyValArg-GlyPro and PhePheSerAlaArg- ... When a blood vessel ruptures or gets injured, factor VII comes into contact with tissue factors which starts a process called ... Most of those drugs are in the class of direct factor Xa inhibitors, but there is one DTI called AZD0837, which is a follow-up ... Thrombin also activates factor XIII that stabilizes the fibrin complex and therefore the clot and it stimulates platelets, ...
*  Thrombin
... thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and XIII to XIIIa. Factor XIIIa is a ... activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is ... Factor Xa with factor V as a cofactor leads to cleavage of the Gla and two Kringle domains (forming together a fragment called ... Thrombin is produced by the enzymatic cleavage of two sites on prothrombin by activated Factor X (Xa). The activity of factor ...
*  High-molecular-weight kininogen
It is also necessary for the activation of factor XI by factor XIIa. HMWK is also a precursor of bradykinin; this vasodilator ... In the past, HMWK has been called HMWK-kallikrein factor, Flaujeac factor (1975), Fitzgerald factor (1975), and Williams- ... the other three are Factor XII, Factor XI and prekallikrein. HMWK is not enzymatically active, and functions only as a cofactor ... prekallikrein and factor XI binding (amino acids 420 to 510)(histidine rich) HMWK is one of four proteins which interact to ...
*  Thrombomodulin
"The structure of a 19-residue fragment from the C-loop of the fourth epidermal growth factor-like domain of thrombomodulin". ... regulates C3b inactivation by factor I. Mutations in the thrombomodulin gene (THBD) have also been reported to be associated ... 165 (11): 6037-46. doi:10.4049/jimmunol.165.11.6037. PMID 11086035. Dzionek A, Inagaki Y, Okawa K, Nagafune J, Röck J, Sohma Y ...
*  KLK6
... as a possible new risk factor for Alzheimer's disease". Annals of the New York Academy of Sciences. 977: 216-23. doi:10.1111/j. ... 1350 (1): 11-4. doi:10.1016/s0167-4781(96)00187-x. PMID 9003450. Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis ... 1 (1): 11. doi:10.1186/1755-7682-1-11. PMC 2475518 . PMID 18620574. Anisowicz A, Sotiropoulou G, Stenman G, Mok SC, Sager R ( ... 49 (11): 1431-41. doi:10.1177/002215540104901111. PMID 11668196. Bernett MJ, Blaber SI, Scarisbrick IA, Dhanarajan P, Thompson ...
*  Peroxisomal biogenesis factor 11
... (PEX11) are peroxisomal membrane proteins which promote peroxisome division in eukaryotic ...
*  X Factor (Denmark season 11)
"Danmarks bedste tv-vært er tilbage i X Factor , X Factor , DR" (in Danish). Retrieved 21 September 2017. "X Factor ny sæson - ... "Ny dommer klar til X Factor , X Factor , DR" (in Danish). Retrieved 21 September 2017. "Tre tv-stationer interesseret i at ... X Factor is a Danish television music competition to find new singing talent. Sofie Linde Lauridsen returned to host the show ... This season may mark the end of X Factor Denmark on DR, followed an announcement made by DR in 16 August[citation needed]. ...
*  X Factor (Italy series 11)
"X Factor: Fabio Rovazzi sostituisce Fedez nel promo. TvZoom.it". YouTube. "X Factor 11: intervista a Lorenzo Licitra". Rolling ... X Factor is an Italian television music competition to find new singing talent; the winner receives a recording contract with ... Manuel Agnelli chose Manchester as the location for his group category and was joined by former X-Factor Italy judge and mentor ...
*  The X Factor (UK series 11)
"X Factor: Mel B and Simon Cowell row over Fleur East 'vocal cheat'". Digital Spy. "X Factor's Mel B praises Fleur East for ... 2012 US X Factor finalists Fifth Harmony, 2013 X Factor winner Sam Bailey, and Idina Menzel and Michael Bublé performed on the ... "The X Factor auditions are coming to you!". The X Factor. ITV. 2014. Retrieved 30 March 2014. Darvill, Josh (19 June 2014). "X ... "The X Factor". The X Factor. itv.com. 1 October 2014. Retrieved 1 October 2014. Hewett, Emily (11 October 2014). "The X Factor ...
*  Haemophilia C
... factor XI deficiency) is centered on prolonged activated partial thromboplastin time.One will find that the factor XI has ... "Factor XI Deficiency: Background, Pathophysiology, Epidemiology". "Factor XI deficiency , Disease , Overview , Genetic and Rare ... "Orphanet: Congenital factor XI deficiency Hemophilia C". www.orpha.net. Retrieved 2016-07-12. Anderson, J. a. M.; Brewer, A.; ... In these cases, fresh frozen plasma or recombinant factor XI may be used, but only if necessary. The afflicted may often suffer ...
*  PAN domain
Emsley J, McEwan PA, Gailani D (Apr 2010). "Structure and function of factor XI". Blood. 115 (13): 2569-77. doi:10.1182/blood- ... the apple domains of the plasma prekallikrein/coagulation factor XI family, and domains of various nematode proteins belong to ... It has been shown that the N-terminal domains of members of the plasminogen/hepatocyte growth factor family, ... the N-terminal domains of plasminogen and hepatocyte growth factor are homologous with the apple domains of the prekallikrein ...
*  Plasminogen activator
Factor XI (FXI) is a serine protase produced by the liver and circulates in its inactive form. Deficiency in factor XI is known ... "Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa". The ... Factor XIIa is another plasma protein that is involved in the activation of zymogen factor is activated into factor XIa. This ... Walsh PN (July 2001). "Roles of platelets and factor XI in the initiation of blood coagulation by thrombin". Thrombosis and ...
*  Fortunato Zampaglione
"X Factor 11: vince Lorenzo Licitra. Le ragioni della vittoria , TV Sorrisi e Canzoni". TV Sorrisi e Canzoni (in Italian). 2017- ... "X Factor: Ecco cosa c'è da sapere sugli inediti di stasera". Rolling Stone Italia (in Italian). Retrieved 2017-12-01. "CARNABY ... competitor to X Factor Italy series 11 December 2017 he wrote with the Carnaby band a song titled "Christmas Girl" and debuts ... as a director of the music video on 14 December 2017 Lorenzo Licitra wins X Factor Italy series 11, singing "in the name of ...
*  KLF11
... is a mesoderm derived, zinc finger transcription factor in the Krüppel-like factor (KLF) family. It binds to SP1- like GC ... Ou XM, Chen K, Shih JC (May 2004). "Dual functions of transcription factors, transforming growth factor-beta-inducible early ... This transcription factor binds to promoters of genes involved in cholesterol, prostaglandin, neurotransmitter, fat, and sugar ... Krüppel-like factors Maturity onset diabetes of the young GRCh38: Ensembl release 89: ENSG00000172059 - Ensembl, May 2017 ...
*  Kininogen 1
Thompson RE, Mandle R, Kaplan AP (Oct 1979). "Studies of binding of prekallikrein and Factor XI to high molecular weight ... Gailani D, Broze GJ (Aug 1991). "Factor XI activation in a revised model of blood coagulation". Science. 253 (5022): 909-12. ... Warn-Cramer BJ, Bajaj SP (Dec 1985). "Stoichiometry of binding of high molecular weight kininogen to factor XI/XIa". ... Williams-Fitzgerald-Flaujeac factor or the HMWK-kallikrein factor is a protein that in humans is encoded by the KNG1 gene. ...
*  GDF11
Growth differentiation factor 11 (GDF11) also known as bone morphogenetic protein 11 (BMP-11) is a protein that in humans is ... In 2014, GDF11 was described as an anti-aging factor in two publications based on the results of a parabiosis experiments with ... GDF11 has been identified as a blood circulating factor that has the ability to reverse age-related cardiac hypertrophy in mice ... These results have led to claims that GDF11 may be an anti-aging rejuvenation factor. These previous findings have been ...
*  Coagulation
In 1957, an American group identified the same factor in a Mr. Rufus Stuart. Factors XI and XIII were identified in 1953 and ... If a coagulation factor is part of the contact activation or tissue factor pathway, a deficiency of that factor will affect ... Secondary hemostasis occurs simultaneously: Additional coagulation factors or clotting factors beyond Factor VII (listed below ... factor IX deficiency or "Christmas disease") and hemophilia C (factor XI deficiency, mild bleeding tendency). Hemophilia A and ...
*  FGF11
"Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". ... Fibroblast growth factor 11 also known as FGF11 is a human gene. The protein encoded by this gene is a member of the ... intracellular fibroblast growth factor family. Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland ...
*  ACVR2B
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) ... "Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone". J. Biol. Chem. 276 (22): 19495-502. doi: ... "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 ... interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332 ...
*  Factor XII
... is part of the coagulation cascade and activates factor XI and prekallikrein in vitro. Factor XII itself is ... Coagulation factor XII, also known as Hageman factor, is a plasma protein. It is the zymogen form of factor XIIa, an enzyme (EC ... or factor XI deficiency. As a result, the main concern related to factor XII deficiency is the unnecessary testing, delay in ... In humans, factor XII is encoded by the F12 gene. Human Factor XII is 596 amino acids long and consists of two chains, the ...
*  Apolipoprotein H
"Domain V of beta2-glycoprotein I binds factor XI/XIa and is cleaved at Lys317-Thr318". J Biol Chem. 280 (2): 907-12. doi: ... Apo-H also inhibits the generation of factor Xa in the presence of platelets. Apo-H also inhibits that activation of factor ... Since protein C is involved in factor Va degradation Apo-H indirectly inhibits the degradation of factor Va. This inhibitory ... Normally Apo-H assumes an anti-coagulation activity in serum (by inhibiting coagulation factors); however, changes in blood ...
*  PEX11G
... is a human gene that encodes the peroxisomal biogenesis factor 11 gamma for peroxisomes. It is located on chromosome 19 ...
*  KLKB1
Fujikawa K, Chung DW, Hendrickson LE, Davie EW (1986). "Amino acid sequence of human factor XI, a blood coagulation factor with ... Thompson RE, Mandle R, Kaplan AP (1980). "Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen ... "Studies of binding of prekallikrein and Factor XI to high molecular weight kininogen and its light chain". Proc. Natl. Acad. ... Henderson LM, Figueroa CD, Müller-Esterl W, Bhoola KD (1994). "Assembly of contact-phase factors on the surface of the human ...
*  New Melones Dam
A deciding factor in the rescinding of the water-level limit was the prevention of $50 million in damages by New Melones Dam in ... 1974-11-04. Retrieved 2017-02-24. Palmer 1984, p. 161. "I'm Here to Speak for Life: River Guardian Mark Dubois". International ... 2008-11-05. Retrieved 2012-08-22. "Chapter 2: Water Resources" (PDF). Evaluation of San Joaquin River Flow and Southern Delta ... 2008-11-05. Retrieved 2012-04-06. "New Melones Dam Hydraulics & Hydrology". New Melones Unit Project. U.S. Bureau of ...
*  Prekallikrein
PK is cleaved to produce kallikrein by activated Factor XII (Hageman factor). Prekallikrein is homologous to factor XI, and ... However, unlike factor XI, prekallikrein does not form dimers. Prekallikrein is activated to form kallikrein by factor XII ... The family appeared to have a hereditary deficiency in an unknown coagulation factor, dubbed "Fletcher factor" after the family ... cleavage of a bond homologous to the corresponding bond cleaved during factor XI activation. Hereditary deficiencies in PK are ...