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*  Factor X
... Ia activates free Factor IX on the surface of activated platelets. The activated Factor IXa with Factor VIIIa forms the ... Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as ... Factor Xa is the activated form of the coagulation factor thrombokinase, known eponymously as Stuart-Prower factor. Factor X is ... The result is a Factor VIIa/TF complex which catalyzes the activation of Factor X and Factor IX. Factor Xa formed on the ...
*  Factor VIII
The active protein (sometimes written as coagulation factor VIIIa) interacts with another coagulation factor called factor IX. ... Activation of factor VIII to factor VIIIa is done by cleavage and release of the B domain. The protein is now divided to a ... Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ... It is a cofactor to factor IXa in the activation of factor X, which, in turn, with its cofactor factor Va, activates more ...
*  Thrombin
In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and ... activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is ... Activated protein C inactivates factors Va and VIIIa. Binding of activated protein C to protein S leads to a modest increase in ... Factor Xa with factor V as a cofactor leads to cleavage of the Gla and two Kringle domains (forming together a fragment called ...
*  Protein C
Factor VIIIa augments Factor X activation by a factor of around 200,000. Because of its importance in clotting, Factor VIII is ... APC proteolyses peptide bonds in activated Factor V and Factor VIII (Factor Va and Factor VIIIa), and one of the amino acids in ... The inactivation of Factor VIIIa is not as well understood. The half-life of Factor VIIIa is only around two minutes unless ... Cofactors in the inactivation of Factor Va and Factor VIIIa include protein S, Factor V, high-density lipoprotein, anionic ...
*  Prothrombinase
The intrinsic tenase complex is composed of both Factor IXa and Factor VIIIa. The activation peptide is released when Factor X ... Once bound to Factor V, activated protein C cleaves and inactivates Factor VIIIa. The mutated form of Factor V present in ... Factor VIIIa is less efficiently inactivated in Factor V Leiden, further increasing the risk of thrombosis. In fact Factor V ... Both Factor Xa and Factor Va associate with the membrane via their light chains, with Factor Xa binding via its Gla-domain in a ...
*  Activated protein C resistance
... degrades Factor Va and Factor VIIIa. Activated protein C resistance is the inability of protein C to cleave Factor Va and/or ... The best known and most common hereditary form is Factor V Leiden. Acquired forms occur in the presence of elevated Factor VIII ... Factor VIIIa, which allows for longer duration of thrombin generation and may lead to a hypercoagulable state. This may be ... Sheppard DR (2000). "Activated protein C resistance: the most common risk factor for venous thromboembolism". J Am Board Fam ...
*  Jeanne Lusher
Development and introduction of recombinant factor VIII--a clinician's experience. Haemophilia 2012;18:483-6. Sonoda T, Solomon ... was the development of inhibitors to Factor VIII or Factor IX, which neutralized the activity of the factor given for treatment ... Recombinant factor VIIa (NovoSeven) in the treatment of internal bleeding in patients with factor VIII and IX inhibitors. ... of recombinant factor IX in patients with hemophilia B. Lusher also participated in a multi-center phase 1 trial of Factor VIII ...
*  Cutaneous myxoma
Staining is positive for vimentin, negative for cytokeratin and desmin, and variable for CD34, Factor VIIIa, SMA, MSA and S-100 ...
*  F8A1
Jenkins PV, Dill JL, Zhou Q, Fay PJ (2004). "Clustered basic residues within segment 484-510 of the factor VIIIa A2 subunit ... Factor VIII intron 22 protein is a protein that in humans is encoded by the F8A1 gene. This gene is contained entirely within ... Unlike factor VIII, this gene is transcribed abundantly in a wide variety of cell types. GRCh38: Ensembl release 89: ... 1992). "Evidence for a third transcript from the human factor VIII gene". Genomics. 14 (3): 585-9. doi:10.1016/S0888-7543(05) ...
*  Protein S deficiency
Decreased (antigen) levels or impaired function of protein S leads to decreased degradation of factor Va and factor VIIIa and ... acts as a nonenzymatic cofactor to activate protein C in the degradation of factor Va and factor VIIIa. ... Protein S is a cofactor of APC both work to degrade factor V and factor VIII. It has been suggested that Zn2+ might be ... Thrombotic disease investigation Factor V Leiden test Among the possibilities for differential diagnosis of protein S ...
*  Scott syndrome
... such as factor VIIIa-IXa (tenase) and factor Va-Xa (prothrombinase). In Scott syndrome, the mechanism for translocating PS to ... Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder. Blood 1979; 54:1015- ... Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a ...
*  List of MeSH codes (D12.776.124)
... factor viiia MeSH D12.776.124.125.375.310 -- factor ixa MeSH D12.776.124.125.400.315 -- factor xa MeSH D12.776.124.125.425.320 ... factor xia MeSH D12.776.124.125.450.324 -- factor xiia MeSH D12.776.124.125.475.500 -- factor xiiia MeSH D12.776.124.125. ... complement factor h MeSH D12.776.124.486.274.920.325.210 -- complement factor i MeSH D12.776.124.486.274.920.662 -- complement ... complement factor d MeSH D12.776.124.486.274.900 -- complement factor b MeSH D12.776.124.486.274.920 -- complement inactivator ...
*  Warfarin
... and therefore reduced degradation of factor Va and factor VIIIa. Although loading doses of warfarin over 5 mg also produce a ... As the body's stores of previously produced active factors degrade (over several days) and are replaced by inactive factors, ... The precursors of these factors require gamma carboxylation of their glutamic acid residues to allow the coagulation factors to ... In addition, reduced levels of protein S lead to a reduction in activity of protein C (for which it is the co-factor) ...
*  List of MeSH codes (D23)
... factor va MeSH D23.119.325.300 --- factor viia MeSH D23.119.350.300 --- factor viiia MeSH D23.119.375.310 --- factor ixa MeSH ... factor xia MeSH D23.119.450.324 --- factor xiia MeSH D23.119.475.500 --- factor xiiia MeSH D23.119.490.265 --- fibrinogens, ... tumor necrosis factor, type i MeSH D23.050.301.264.035.912 --- receptors, tumor necrosis factor, type ii MeSH D23.050.301.264. ... tumor necrosis factor, type i MeSH D23.101.100.110.916 --- receptors, tumor necrosis factor, type ii MeSH D23.101.100.110.925 ...
*  Protein C deficiency
A deficiency results in a loss of the normal cleaving of Factors Va and VIIIa. There are two main types of protein C mutations ... Protein C has a short half life (8 hour) compared with other vitamin K-dependent factors and therefore is rapidly depleted with ... The main function of protein C is its anticoagulant property as an inhibitor of coagulation factors V and VIII. ... Defects in interaction with thrombomodulin, phospholipids, factors V/VIII and others have been described. The majority of ...
*  Thrombophilia
... factor IXa, Xa and XIa), protein C (which inhibits factors Va and VIIIa in the presence of protein S), and protein Z (which ... The combination activates factor X to factor Xa and factor IX to factor IXa. Factor Xa (in the presence of factor V) activates ... factor XIII, factor XI, factor V and factor VIII, TAFI) that enhance the fibrin clot. The process is inhibited by TFPI (which ... These include: elevated levels of factor VIII, factor IX, factor XI, fibrinogen and thrombin-activatable fibrinolysis inhibitor ...
*  Protein S
... where it functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa. Only the free form has cofactor ... Heeb, M J; Mesters R M; Tans G; Rosing J; Griffin J H (Feb 1993). "Binding of protein S to factor Va associated with inhibition ... Protein S is partly homologous to other vitamin K-dependent plasma coagulation proteins, such as protein C and factors VII, IX ... 1989). "Beta-hydroxyaspartic acid in the first epidermal growth factor-like domain of protein C. Its role in Ca2+ binding and ...
*  Tenase
Intrinsic tenase complex contains the active factor IX (IXa), its cofactor factor VIII (VIIIa), the substrate (factor X), and ... inactive factor X) by cleaving it. Extrinsic tenase complex is made up of tissue factor, factor VII, and Ca2+ as an activating ... In coagulation, the procoagulant protein factor X can be activated into factor Xa two ways; extrinsically or intrinsically. The ... These vitamin K-dependent procoagulant factors dock to this surface through their Gla domain with Ca2+ bridges. This makes the ...
*  Callanish Stones
... and many factors such as the weathering and displacement of the stones over the millennia mean there can be no certainty of any ... Callanish VIIIa) - standing stone "Àirigh Nam Bidearan" (Callanish IX) - stones "Na Dromannan" ("Druim Nan Eun") (Callanish X ...
*  Neon
Older numberings described the rare gases as Group 0 or Group VIIIA (sometimes shortened to 8). See also Group (periodic table ... by about a factor of 10, to a level of 1 part in 6,000 by mass. This may indicate that even the ice-planetesimals which brought ...
*  AI Mk. VIII radar
VIIIA was on the night of 20/21 January 1943, when an FIU aircraft caught a Do 217 over the Thames and shot it down in flames ... This has been attributed to a number of factors including overwork by the AMRE team fitting their own equipment, as well as not ... VIIIA arrived at Christchurch in March 1942, but does not appear to have been passed to the FIU. At this point the entire ... VIIIA standard, for delivery at the end of 1942. These would be able to be used with centimetric beacons designed for them, but ...
*  Heinz Guderian
Soon, German troops found themselves suffering from the winter cold, one of the major factors that led to the failure of ... ISBN 978-3-7648-2299-6. Wegmann, Günter (2009). Die Ritterkreuzträger der Deutschen Wehrmacht 1939-1945 Teil VIIIa: ... Panzertruppe Band 2: F-H [The Knight's Cross Bearers of the German Wehrmacht 1939-1945 Part VIIIa: Panzer Force Volume 2: F-H ...