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*  Heparin cofactor II
... (HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibits IIa, and is a ... 107 (7): 2753-8. doi:10.1182/blood-2005-09-3755. PMC 1895383 . PMID 16339402. Liu T, Qian WJ, Gritsenko MA, et al. (2006). " ... 14 (9): 1711-8. doi:10.1101/gr.2435604. PMC 515316 . PMID 15342556. Corral J, Aznar J, Gonzalez-Conejero R, et al. (2006). " ... 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. Schillinger M, Exner M, Sabeti S, et al. (2005). "High plasma ...
*  Factor VIII
... (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ... Factor VIII was first characterized in 1984 by scientists at Genentech. The gene for factor VIII is located on the X chromosome ... Copper is a required cofactor for factor VIII and copper deficiency is known to decrease levels of factor VIII. There is a ... "NIH: F8 - coagulation factor VIII". National Institutes of Health. "Entrez Gene: F8 coagulation factor VIII, procoagulant ...
*  Haemophilia
Factor VIII is used in haemophilia A and factor IX in haemophilia B. Factor replacement can be either isolated from human blood ... the Y-chromosome in the male has no gene for factors VIII or IX. If the genes responsible for production of factor VIII or ... such as porcine factor VIII.[citation needed] If a person becomes refractory to replacement coagulation factor as a result of ... which occurs due to not enough clotting factor VIII, and haemophilia B, which occurs due to not enough clotting factor IX. They ...
*  Discovery and development of direct thrombin inhibitors
Furthermore, it activates factors V, VIII and XI, all by cleaving the sequences GlyGlyGlyValArg-GlyPro and PhePheSerAlaArg- ... When a blood vessel ruptures or gets injured, factor VII comes into contact with tissue factors which starts a process called ... Most of those drugs are in the class of direct factor Xa inhibitors, but there is one DTI called AZD0837, which is a follow-up ... Thrombin also activates factor XIII that stabilizes the fibrin complex and therefore the clot and it stimulates platelets, ...
*  Discovery and development of direct Xa inhibitors
Factors IIa, Xa, VIIa, IXa and XIa are all proteolytic enzymes that have a specific role in the coagulation cascade. Factor Xa ... Inhibition of factor Xa leads to antithrombotic effects by decreasing the amount of thrombin. Directly targeting factor Xa is ... Today there are three factor Xa inhibitors marketed: rivaroxaban, apixaban and edoxaban. Factor Xa was identified as a ... It is defined as the formation of insoluble fibrin by activated coagulation factors, specifically thrombin. These factors ...
*  Plasmin
... and factor XII (Hageman factor). Fibrin is a cofactor for plasminogen activation by tissue plasminogen activator. Urokinase ... It cleaves fibrin, fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin, like trypsin, belongs to the ... "Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice". Proc. Natl. Acad. Sci. U.S. ... "Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3". Am. J. Physiol. 275 (2 Pt 1): ...
*  Thrombin
In the blood coagulation pathway, thrombin acts to convert factor XI to XIa, VIII to VIIIa, V to Va, fibrinogen to fibrin, and ... activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is ... Lenting PJ, van Mourik JA, Mertens K (December 1998). "The life cycle of coagulation factor VIII in view of its structure and ... Factor Xa with factor V as a cofactor leads to cleavage of the Gla and two Kringle domains (forming together a fragment called ...
*  Thromboelastography
... it is a reflection of coagulation factor activity. Coagulation factors are essentially enzymes that drive clot formation. Thus ... A RapidTEG uses tissue factor in addition to kaolin thereby further speeding up the reaction. In this assay, the R-value is ... fibrinolysis and other factors which can be affected by genetics, illness, environment and medications. The patterns of changes ... which measure coagulation factor function, but TEG also can assess platelet function, clot strength, and fibrinolysis which ...
*  Haemophilia B
Factor IX becomes active eventually in coagulation by cofactor factor VIII (specifically IXa). Platelets provide a binding site ... which has a longer half life than factor VIII and as such factor IX can be transfused less frequently. Blood transfusions may ... Factor IX when activated activates factor X which helps fibrinogen to fibrin conversion. ... which allows for neatly packaged bottles of factor IX concentrates. With the rise of factor IX concentrates it became easier ...
*  Thromboelastometry
Improvement of ROTEM clot stabilization kinetics in a patient with severe factor XIII deficiency after administration of factor ... experience of eight years and 829 LTX. Joint International Congress of ILTS, ELITA & LICAGE, July 9-12, 2008, Paris, France ( ... Therefore, TEM is not meant to replace laboratory assays such as prothrombin time (PT) or factor assays. However, due to the ... The typical assays are not responsive for the effect of von Willebrand factor or platelet antagonists such as aspirin or ...
*  Isthmic organizer
The transcription factor En1 is expressed in the MHB. In cells that express both Otx2 and Irx1, En1 is activated by Fgf8 ... The interaction between Otx2 and Gbx2 at the MHB results in the expression of fibroblast growth factor 8 (Fgf8). Out of the ... The development and location of the MHB is mediated by the transcription factors Otx2 and Gbx2. Otx2 is expressed in the ... These two homeodomain transcription factors are activated by Irx1 and then cross inhibit one another in the developing central ...
*  HLF (gene)
"Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor ... "Entrez Gene: HLF hepatic leukemia factor". LeBrun DP (May 2003). "E2A basic helix-loop-helix transcription factors in human ... Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene. This gene encodes a member of the proline and ... Falvey E, Fleury-Olela F, Schibler U (September 1995). "The rat hepatic leukemia factor (HLF) gene encodes two transcriptional ...
*  DBP (gene)
"Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics. 13 (2 ... "Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutation". Nature Genetics ...
*  Teodora Sava
X Factor Romania 2017, season 7 - The Duels; passed to the next stage 2017 - Firework - X Factor Romania 2017, season 7 - Four- ... X Factor Romania 2017, season 7 - second of the final shows (live, second round); eliminated 2017 - Listen - X Factor Romania ... "X FACTOR, 8 decembrie 2017. Alina Mocanu- Teodora Sava, DUEL copleșitor- VIDEO. Delia, DECIZIE". DC News (in Romanian). dcnews. ... Lecție de muzică predată de un copil de 16 ani pe scena X Factor!". A1.RO (in Romanian). Retrieved 27 December 2017. "Cu ochii ...
*  List of OMIM disorder codes
GLA Factor V and factor VIII, combined deficiency of; 227300; MCFD2 Factor V deficiency; 227400; F5 Factor XI deficiency, ... F11 Factor XII deficiency; 234000; F12 Factor XIIIA deficiency; 613225; F13A1 Factor XIIIB deficiency; 613235; F13B Failure of ... RAG2 Combined factor V and VIII deficiency; 227300; LMAN1 Combined hyperlipidemia, familial; 144250; LPL Combined ... C1NH Complement factor H deficiency; 609814; HF1 Complement factor I deficiency; 610984; CFI Complex I, mitochondrial ...
*  Lower gastrointestinal bleeding
Recombinant activated factor VII has been approved for use in patients with hemophilia A and B with factor VIII and IX ... The history in these patients should focus on factors that could be associated with potential causes: blood coating the stool ... 30 (2): 377-407, viii. PMID 11432297. Dutta G, Panda M (2008). "An uncommon cause of lower gastrointestinal bleeding: a case ... although the optimal dose is unclear and recombinant activated factor VII is very expensive. The following are possible causes ...
*  Miles Laboratories
... manufacturer of such diverse products as insect repellent and synthetic human Factor VIII clotting factor for hemophiliacs. In ...
*  Pleiotrophin
... neurite growth-promoting factor 1)". Rauvala H, Pihlaskari R (1987). "Isolation and some characteristics of an adhesive factor ... "Biochemical and mitogenic properties of the heparin-binding growth factor HARP". Prog. Growth Factor Res. 6 (1): 25-34. doi: ... Pleiotrophin is an 18-kDa growth factor that has a high affinity for heparin. It is structurally related to midkine and ... Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite ...
*  Mixing study
If the patient has a high titer antibody against factor VIII, try porcine factor VIII or prothrombin complex concentrates to ... Spontaneous specific inhibitors against clotting factors occur (i.e. not in hemophiliacs), most often against factor VIII. This ... or specific factor inhibitors, such as antibodies directed against factor VIII. Mixing studies take advantage of the fact that ... factor assays will need to be done to look for factor deficiency, starting with VIII and IX since they are the most common ...
*  Arthur L. Bloom
In 2017 an episode of BBC Panorama alleged that Bloom had knowingly downplayed the risks of contracting HIV from Factor VIII ... Bloom, A. L. (1 September 1978). "Clotting Factor Concentrates for Resistant Haemophilia". British Journal of Haematology. 40 ( ... http://taintedblood.info/timeline.php http://www.penroseinquiry.org.uk/preliminary-report/chapter-8/ "UKHCDO Haemophilia ...
*  X-linked recessive inheritance
Hemophilia A, a blood clotting disorder caused by a mutation of the Factor VIII gene and leading to a deficiency of Factor VIII ... a blood clotting disorder caused by a mutation of the Factor IX gene and leading to a deficiency of Factor IX. It is rarer than ... 8 October 2009). "Case Closed: Famous Royals Suffered From Hemophilia". ScienceNOW Daily News. AAAS. Retrieved 9 October 2009. ...
*  Discoidin domain-containing receptor 2
This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII- ... a new subclass of receptor tyrosine kinases with a factor VIII-like domain". Oncogene. 8 (12): 3433-40. PMID 8247548. Hillier ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Karn T, Holtrich U, Bräuninger A, Böhme B, Wolf G, Rübsamen- ...
*  VLDL receptor
"Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and ... In addition, being that apoE, a major ligand of VLDLR, is a leading genetic risk factor for Alzheimer's disease, VLDLR may play ... This binding of THBS1, however, does not induce the subsequent degradation of these transcription factors, as reelin does, and ... Mimicking this general structure, VLDLR has eight, 40 amino acid long cysteine-rich repeats in its extracellular N-terminal ...
*  Cranial neural crest
"In vitro odontoblast-like cell differentiation of cranial neural crest cells induced by fibroblast growth factor 8 and dentin ... 32 (6): 671-8. doi:10.1016/j.cellbi.2008.01.293. PMID 18339562. Nie X, Zhang YJ, Tian WD, et al. (January 2007). "Improvement ...
*  George William Penrose, Lord Penrose
HIV infections from NHS Scotland treatment with blood and blood products such as Factor VIII. "Birthday's today". The Telegraph ... His 818-page report was published on 8 March 2004. He also headed the Penrose Inquiry into Hepatitis C & ... dated 8 March 2004 "Timeline: Equitable Life scandal" on the BBC News website, dated 8 March 2004. ...
*  Stadion An der Alten Försterei
... the outdated stadium proved only one of a number of factors that hampered the club's push for promotion to higher leagues. ... the stadium was re-opened on 8 July 2009 in time for a friendly against fellow Berlin side Hertha BSC. Originally planned for ...
*  Von Willebrand disease
Factor VIII levels are also performed because factor VIII is bound to vWF which protects the factor VIII from rapid breakdown ... Monoclonally purified factor VIII concentrates and recombinant factor VIII concentrates contain insignificant quantity of vWF, ... Type 2N may be considered if factor VIII levels are disproportionately low, but confirmation requires a "factor VIII binding" ... The von Willebrand factor is undetectable in the vWF antigen assay. Since the vWF protects coagulation factor VIII from ...