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*  Factor X
The result is a Factor VIIa/TF complex which catalyzes the activation of Factor X and Factor IX. Factor Xa formed on the ... Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as ... Factor Xa is the activated form of the coagulation factor thrombokinase, known eponymously as Stuart-Prower factor. Factor X is ... In stage 1, Factor VII binds to the transmembrane protein TF on the surface of cells and is converted to Factor VIIa. ...
*  Discovery and development of direct Xa inhibitors
Factors IIa, Xa, VIIa, IXa and XIa are all proteolytic enzymes that have a specific role in the coagulation cascade. Factor Xa ... Inhibition of factor Xa leads to antithrombotic effects by decreasing the amount of thrombin. Directly targeting factor Xa is ... Today there are three factor Xa inhibitors marketed: rivaroxaban, apixaban and edoxaban. Factor Xa was identified as a ... It is defined as the formation of insoluble fibrin by activated coagulation factors, specifically thrombin. These factors ...
*  Recombinant factor VIIa
... (rFVIIa) is a form of blood factor VII that has been manufactured via recombinant technology. The most ... Simpson, E; Lin, Y; Stanworth, S; Birchall, J; Doree, C; Hyde, C (Mar 14, 2012). "Recombinant factor VIIa for the prevention ... In people with hemophilia type A and B who have a deficiency of factors VIII and IX, these two factors are administered for ... rFVIIa, which is an activated form of factor VII, bypasses factors VIII and IX and causes coagulation without the need for ...
*  Thromboelastometry
Patterns of response to recombinant factor VIIa. J Thromb Haemost. 2004;2:102-10. Karger R, Egbring R, Weippert-Kretschmer M, ... Improvement of ROTEM clot stabilization kinetics in a patient with severe factor XIII deficiency after administration of factor ... Therefore, TEM is not meant to replace laboratory assays such as prothrombin time (PT) or factor assays. However, due to the ... The typical assays are not responsive for the effect of von Willebrand factor or platelet antagonists such as aspirin or ...
*  Acute liver failure
Administration of recombinant factor VIIa has shown promise; however, this treatment approach requires further study. The use ... Li XM, Ma L, Yang YB, Shi ZJ, Zhou SS (2005). "Prognostic factors of fulminant hepatitis in pregnancy". Chin Med J (Engl). 118 ... The liver has the central role in the synthesis of almost all coagulation factors and some inhibitors of coagulation and ... Timely availability of an allograft is one of the major factors determining transplant outcomes. In the largest U.S. study, ...
*  Tissue factor
... the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor ... Together with factor VIIa, tissue factor forms the tissue factor or extrinsic pathway of coagulation. This is opposed to the ... The complex of TF with factor VIIa catalyzes the conversion of the inactive protease factor X into the active protease factor ... Tissue factor has been shown to interact with Factor VII. Tissue factor Blood plasma after the addition of tissue factor ...
*  Baxalta
BAX 817 - Recombinant factor VIIa BAX 335 - FIX gene therapy in Phase II. BAX 930 - Recombinant ADAMTS13 BAX 826 - Recombinant ... extended half-life Factor VIII BAX 888 - Factor VIII gene therapy in Phase I trials. Immunology BAX 2200 - Psoriasis drug in ... BAX 111 - submitted as a recombinant von Willebrand factor treatment for von Willebrand disease, filed with the FDA in December ... recombinant factor VIII for prophylactic and on-demand treatment of severe hemophilia A". Blood. 126 (9): 1078-1085. doi: ...
*  Intracerebral hemorrhage
Giving Factor VIIa within 4 hours limits the bleeding and formation of a hematoma. However, it also increases the risk of ... The largest risk factors for spontaneous bleeding are high blood pressure and amyloidosis. Other risk factors include ... Risk factors for ICH include: Hypertension (high blood pressure) Diabetes mellitus Menopause Cigarette smoking Excessive ... "Major Risk Factors for Intracerebral Hamorrhage in the Young Are Modifiable". Stroke. 36: 1881. doi:10.1161/01.str. ...
*  Antithrombin
Factor XII (XIIa) and, to a greater extent, Factor II (thrombin) (IIa), and also the activated form of Factor VII (VIIa) from ... Persson E, Bak H, Olsen OH (2001). "Substitution of valine for leucine 305 in factor VIIa increases the intrinsic enzymatic ... namely the activated forms of Factor X (Xa), Factor IX (IXa), Factor XI (XIa), ... Antithrombin inactivates its physiological target enzymes, Thrombin, Factor Xa and Factor IXa with rate constants of 7-11 x 103 ...
*  Advanced trauma life support
"Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia". Cochrane Database of ... While it may help control bleeding, there is a risk of arterial thrombosis, and other than in those with factor VII deficiency ...
*  Major trauma
Simpson, E; Lin, Y; Stanworth, S; Birchall, J; Doree, C; Hyde, C (Mar 14, 2012). "Recombinant factor VIIa for the prevention ... For severe bleeding, for example from bleeding disorders, recombinant factor VIIa-a protein that assists blood clotting-may be ... Other controllable factors, such as the use of drugs including alcohol or cocaine, increases the risk of trauma by increasing ... By identifying risk factors present within a community and creating solutions to decrease the incidence of injury, trauma ...
*  Emergency bleeding control
... or medical factors such as haemophilia. Recombinant factor VIIa (rFVIIa) is not, as of 2012, supported by the evidence for most ... Simpson, E; Lin, Y; Stanworth, S; Birchall, J; Doree, C; Hyde, C (Mar 14, 2012). "Recombinant factor VIIa for the prevention ... These may be particularly useful in situations where the wound is not clotting, which can be due to external factors, such as ... and therefore it should only be used in clinical trials or with patients with factor VII deficiency. Internal wounds (usually ...
*  Jehovah's Witnesses
Management of Two Cases Using Fractionated Components and Factor VIIa" (PDF). Anesthesia & Analgesia. 104 (4): 763-5. doi: ... p. 1. Examples of permitted fractions are: Interferon, Immune Serum Globulins and Factor VIII; preparations made from ...
*  PAPOLA
Pendurthi UR, Alok D, Rao LV (1997). "Binding of factor VIIa to tissue factor induces alterations in gene expression in human ... end-processing factor. FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or ... PAPOLA binds to FIP1L1 (Factor interacting with PAPOLA and CPSF1), a subunit of the cleavage and polyadenylation specificity ... 2005). "Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein ...
*  Jeanne Lusher
Recombinant factor VIIa (NovoSeven) in the treatment of internal bleeding in patients with factor VIII and IX inhibitors. ... was the development of inhibitors to Factor VIII or Factor IX, which neutralized the activity of the factor given for treatment ... Lusher later conducted the first studies on the use of recombinant factor VIIa in the treatment of bleeding episodes in ... Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors ...
*  Glanzmann's thrombasthenia
Recombinant factor VIIa, AryoSeven or NovoSeven FDA approved this drug for the treatment of the disease on July 2014. ... Unidentified factors other than the platelet defect itself may have important roles. Glanzmann's thrombasthenia is associated ... The role of GpIb is to enable platelet activation by contact with the von Willebrand factor-collagen complex that is exposed ... as well as von Willebrand factor, fibronectin, and vitronectin), which is required for fibrinogen-dependent platelet-platelet ...
*  Disseminated intravascular coagulation
Upon exposure to blood and platelets, TF binds with activated factor VIIa (normally present in trace amounts in the blood), ... As clotting factors and platelets are used up, bleeding may occur. This may include blood in the urine, blood in the stool, or ... Recombinant factor VII has been proposed as a "last resort" in those with severe hemorrhage due to obstetric or other causes, ... Clotting factors are consumed in the development of multiple clots, which contributes to the bleeding seen with DIC.[citation ...
*  Prothrombinase
Factor X can be activated by both the factor VIIa-tissue factor complex of the extrinsic coagulation pathway and by the tenase ... Both Factor Xa and Factor Va associate with the membrane via their light chains, with Factor Xa binding via its Gla-domain in a ... Factor Xa can help to prevent the inactivation of Factor Va by protecting Factor Va from activated protein C. It is likely that ... Factor Va strengthens the affinity of Factor Xa for the membrane and also increases the kcat of Factor Xa for prothrombin. ...
*  Plateletpheresis
The number of transfusions may be reduced if these patients are given recombinant human factor VIIa since the underlying cause ... A more conservative threshold of 20,000/┬ÁL should be used in those with a fever or other risk factors for bleeding. Those with ... Platelets are the clotting factor of the blood, and when donated, frequently go to cancer patients, because due to chemotherapy ...
*  Abdominal pregnancy
... with others even using tranexamic acid and recombinant factor VIIa, which both minimize blood loss. Generally, unless the ... Risk factors are similar to tubal pregnancy with sexually transmitted disease playing a major role; however about half of those ... with ectopic pregnancy have no known risk factors (which include damage to the Fallopian tubes from previous surgery or from ...
*  List of MeSH codes (D12.776.124)
... factor viia MeSH D12.776.124.125.350.300 -- factor viiia MeSH D12.776.124.125.375.310 -- factor ixa MeSH D12.776.124.125. ... 400.315 -- factor xa MeSH D12.776.124.125.425.320 -- factor xia MeSH D12.776.124.125.450.324 -- factor xiia MeSH D12.776. ... complement factor h MeSH D12.776.124.486.274.920.325.210 -- complement factor i MeSH D12.776.124.486.274.920.662 -- complement ... complement factor d MeSH D12.776.124.486.274.900 -- complement factor b MeSH D12.776.124.486.274.920 -- complement inactivator ...
*  LRP1
Factor IXa, Factor VIIa, Fibronectin, Gentamicin, GIPC1, Heat shock proteins gp96, hsp70, hsp90, heparin cofactor II, Hepatic ... Tat, Thrombin, THBS1, Thrombospondin 2, TIMP1, TIMP2, TIMP3, Tissue factor pathway inhibitor, PLAT, Transforming growth factor- ... It is thought that a causal factor in Alzheimer's is the malfunction of this process which damages neurons by starving them of ... These repeats bind extracellular matrix proteins, growth factors, proteases, protease inhibitor complexes, and other proteins ...
*  Direct Xa inhibitor
... recombinant factor VIIa) in this setting is limited to healthy human volunteers, animal models, and in vitro studies. Clinical ... Direct factor Xa inhibitors ('xabans') are a class of anticoagulant drugs which act directly upon Factor X in the coagulation ... Direct Factor Xa Inhibitors as Anticoagulants , PharmaXChange.info - A review and presentation on the available factor Xa ... Direct factor Xa inhibitors are being used clinically. Clinical trials have shown promise for these compounds as substitutes ...
*  Factor VII
... the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor ... The complex of factor VIIa with TF catalyzes the conversion of factor IX and factor X into the active proteases, factor IXa and ... Factor VII (EC 3.4.21.21, blood-coagulation factor VIIa, activated blood coagulation factor VII, formerly known as proconvertin ... Factor VII shares a common domain architecture with factors IX and X. The gene for factor VII is located on chromosome 13 ( ...
*  Factor IX
... or factor VIIa (of the tissue factor pathway) to produce a two-chain form where the chains are linked by a disulfide bridge. ... and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa. Factor IX is inhibited by ... Zhong D, Bajaj MS, Schmidt AE, Bajaj SP (Feb 2002). "The N-terminal epidermal growth factor-like domain in factor IX and factor ... "The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating ...
*  Cangene
... recombinant blood clotting factors VIIa, VIII and IX, the latter of which is in clinical trials. In February 2014, the company ...
*  List of EC numbers (EC 3)
... coagulation factor VIIa EC 3.4.21.22: coagulation factor IXa EC 3.4.21.23: Deleted entry: Vipera russelli proteinase EC 3.4. ... Limulus clotting factor C EC 3.4.21.85: Limulus clotting factor B EC 3.4.21.86: Limulus clotting enzyme EC 3.4.21.87: ... Now EC 3.4.21.43, classical-complement-pathway C3/C5 convertase EC 3.4.21.45: complement factor I EC 3.4.21.46: complement ... Snake venom factor V activator EC 3.4.21.96: Lactocepin EC 3.4.21.97: assemblin EC 3.4.21.98: hepacivirin EC 3.4.21.99: ...