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*  Factor X
... Ia activates free Factor IX on the surface of activated platelets. The activated Factor IXa with Factor VIIIa forms the ... Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as ... Factor Xa is the activated form of the coagulation factor thrombokinase, known eponymously as Stuart-Prower factor. Factor X is ... The result is a Factor VIIa/TF complex which catalyzes the activation of Factor X and Factor IX. Factor Xa formed on the ...
*  Factor VIII
It is a cofactor to factor IXa in the activation of factor X, which, in turn, with its cofactor factor Va, activates more ... Factor VIII participates in blood coagulation; it is a cofactor for factor IXa which, in the presence of Ca2+ and phospholipids ... Upon activation by thrombin (factor IIa), it dissociates from the complex to interact with factor IXa in the coagulation ... Factor VIII (FVIII) is an essential blood-clotting protein, also known as anti-hemophilic factor (AHF). In humans, factor VIII ...
*  Discovery and development of direct Xa inhibitors
Factors IIa, Xa, VIIa, IXa and XIa are all proteolytic enzymes that have a specific role in the coagulation cascade. Factor Xa ... Inhibition of factor Xa leads to antithrombotic effects by decreasing the amount of thrombin. Directly targeting factor Xa is ... Today there are three factor Xa inhibitors marketed: rivaroxaban, apixaban and edoxaban. Factor Xa was identified as a ... It is defined as the formation of insoluble fibrin by activated coagulation factors, specifically thrombin. These factors ...
*  Haemophilia B
Factor IX becomes active eventually in coagulation by cofactor factor VIII (specifically IXa). Platelets provide a binding site ... Factor IX when activated activates factor X which helps fibrinogen to fibrin conversion. ... which has a longer half life than factor VIII and as such factor IX can be transfused less frequently. Blood transfusions may ... which allows for neatly packaged bottles of factor IX concentrates. With the rise of factor IX concentrates it became easier ...
*  REG1
It involves inhibition of Factor IXa. Becker RC, Chan MY (December 2009). "REG-1, a regimen comprising RB-006, a Factor IXa ...
*  Prothrombinase
The intrinsic tenase complex is composed of both Factor IXa and Factor VIIIa. The activation peptide is released when Factor X ... Both Factor Xa and Factor Va associate with the membrane via their light chains, with Factor Xa binding via its Gla-domain in a ... Factor Xa can help to prevent the inactivation of Factor Va by protecting Factor Va from activated protein C. It is likely that ... Factor X can be activated by both the factor VIIa-tissue factor complex of the extrinsic coagulation pathway and by the tenase ...
*  Antithrombin
Factor IX (IXa), Factor XI (XIa), Factor XII (XIIa) and, to a greater extent, Factor II (thrombin) (IIa), and also the ... Antithrombin inactivates its physiological target enzymes, Thrombin, Factor Xa and Factor IXa with rate constants of 7-11 x 103 ... Increased Factor IXa and Xa inhibition requires the minimal heparin pentasaccharide sequence. The conformational changes that ... The conformational change most relevant for Factor IXa and Xa inhibition involves the P14 and P15 amino acids within the N- ...
*  Carboxyglutamic acid
... were found to partially mediate the binding of factor IXa to platelets and in factor-X activation. In addition, upon mechanical ... "Role of gamma-carboxyglutamic acid residues in the binding of factor IXa to platelets and in factor-X activation". Blood. 79 (2 ... The high-affinity calcium binding sites in the GLA domain of factor IX, which is a serine protease of the coagulation system, ... This GLA domain is known to be found in several proteins, including coagulation factors X, VII, IX, and XIV, vitamin K- ...
*  Ulinastatin
... and factors IXa, Xa, XIa, and XlIa. However, although ulinastatin is a protease inhibitor, its activity toward various ... tissue factor, P-selectin, intercellular adhesion molecule-1, phosphorylation of the extracellular signal-regulated protein ...
*  Plasma kallikrein
... factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: ... Fletcher factor) by factor XIIa. Kallikrein Heimark, R.L.; Davie, E.W. (1981). "Bovine and human plasma prekallikrein". Methods ...
*  Factor XI
... factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds. Factor IXa ... "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ... The zymogen factor is activated into factor XIa by factor XIIa (FXIIa), thrombin, and FXIa itself; due to its activation by ... Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. Factor XI (FXI) ...
*  LRP1
Factor IXa, Factor VIIa, Fibronectin, Gentamicin, GIPC1, Heat shock proteins gp96, hsp70, hsp90, heparin cofactor II, Hepatic ... Tat, Thrombin, THBS1, Thrombospondin 2, TIMP1, TIMP2, TIMP3, Tissue factor pathway inhibitor, PLAT, Transforming growth factor- ... It is thought that a causal factor in Alzheimer's is the malfunction of this process which damages neurons by starving them of ... These repeats bind extracellular matrix proteins, growth factors, proteases, protease inhibitor complexes, and other proteins ...
*  List of EC numbers (EC 3)
... coagulation factor VIIa EC 3.4.21.22: coagulation factor IXa EC 3.4.21.23: Deleted entry: Vipera russelli proteinase EC 3.4. ... Limulus clotting factor C EC 3.4.21.85: Limulus clotting factor B EC 3.4.21.86: Limulus clotting enzyme EC 3.4.21.87: ... Now EC 3.4.21.43, classical-complement-pathway C3/C5 convertase EC 3.4.21.45: complement factor I EC 3.4.21.46: complement ... Snake venom factor V activator EC 3.4.21.96: Lactocepin EC 3.4.21.97: assemblin EC 3.4.21.98: hepacivirin EC 3.4.21.99: ...
*  List of MeSH codes (D23)
... factor va MeSH D23.119.325.300 --- factor viia MeSH D23.119.350.300 --- factor viiia MeSH D23.119.375.310 --- factor ixa MeSH ... factor xia MeSH D23.119.450.324 --- factor xiia MeSH D23.119.475.500 --- factor xiiia MeSH D23.119.490.265 --- fibrinogens, ... tumor necrosis factor, type i MeSH D23.050.301.264.035.912 --- receptors, tumor necrosis factor, type ii MeSH D23.050.301.264. ... tumor necrosis factor, type i MeSH D23.101.100.110.916 --- receptors, tumor necrosis factor, type ii MeSH D23.101.100.110.925 ...
*  Scott syndrome
... such as factor VIIIa-IXa (tenase) and factor Va-Xa (prothrombinase). In Scott syndrome, the mechanism for translocating PS to ... Deficiency of factor Xa-factor Va binding sites on the platelets of a patient with a bleeding disorder. Blood 1979; 54:1015- ... Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a ...
*  Draculin
It functions as an anticoagulant, inhibiting coagulation factors IX (IXa) and X (Xa), thus keeping the blood of the bitten ... "Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X." ... "Purification and partial characterization of draculin, the anticoagulant factor present in the saliva of vampire bats (Desmodus ... the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule ...
*  Factor IX
"The factor IXa second epidermal growth factor (EGF2) domain mediates platelet binding and assembly of the factor X activating ... and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa. Factor IX is inhibited by ... Zhong D, Bajaj MS, Schmidt AE, Bajaj SP (Feb 2002). "The N-terminal epidermal growth factor-like domain in factor IX and factor ... Brandstetter H, Bauer M, Huber R, Lollar P, Bode W (Oct 1995). "X-ray structure of clotting factor IXa: active site and module ...
*  Thrombophilia
The combination activates factor X to factor Xa and factor IX to factor IXa. Factor Xa (in the presence of factor V) activates ... factor XIII, factor XI, factor V and factor VIII, TAFI) that enhance the fibrin clot. The process is inhibited by TFPI (which ... inactivates the first step catalyzed by factor VIIa/tissue factor), antithrombin (which inactivates thrombin, factor IXa, Xa ... These include: elevated levels of factor VIII, factor IX, factor XI, fibrinogen and thrombin-activatable fibrinolysis inhibitor ...
*  Disseminated intravascular coagulation
This complex further activates factor IX and X to IXa and Xa, respectively, leading to the common coagulation pathway and the ... As clotting factors and platelets are used up, bleeding may occur. This may include blood in the urine, blood in the stool, or ... Recombinant factor VII has been proposed as a "last resort" in those with severe hemorrhage due to obstetric or other causes, ... Clotting factors are consumed in the development of multiple clots, which contributes to the bleeding seen with DIC.[citation ...
*  Protein C
The half-life of Factor VIIIa is only around two minutes unless Factor IXa is present to stabilise it. Some have questioned the ... Factor VIIIa augments Factor X activation by a factor of around 200,000. Because of its importance in clotting, Factor VIII is ... It acts as a serine protease zymogen: APC proteolyses peptide bonds in activated Factor V and Factor VIII (Factor Va and Factor ... Cofactors in the inactivation of Factor Va and Factor VIIIa include protein S, Factor V, high-density lipoprotein, anionic ...
*  Factor VII
The complex of factor VIIa with TF catalyzes the conversion of factor IX and factor X into the active proteases, factor IXa and ... the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor ... Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, ... Factor VII shares a common domain architecture with factors IX and X. The gene for factor VII is located on chromosome 13 ( ...
*  List of MeSH codes (D12.776.124)
... factor viiia MeSH D12.776.124.125.375.310 -- factor ixa MeSH D12.776.124.125.400.315 -- factor xa MeSH D12.776.124.125.425.320 ... factor xia MeSH D12.776.124.125.450.324 -- factor xiia MeSH D12.776.124.125.475.500 -- factor xiiia MeSH D12.776.124.125. ... complement factor h MeSH D12.776.124.486.274.920.325.210 -- complement factor i MeSH D12.776.124.486.274.920.662 -- complement ... complement factor d MeSH D12.776.124.486.274.900 -- complement factor b MeSH D12.776.124.486.274.920 -- complement inactivator ...
*  List of MeSH codes (D08)
... factor ixa MeSH D08.811.277.656.300.760.315 --- factor xa MeSH D08.811.277.656.300.760.320 --- factor xia MeSH D08.811.277.656. ... peptide elongation factor g MeSH D08.811.277.040.330.300.100.700 --- peptide elongation factor tu MeSH D08.811.277.040.330.300. ... fibroblast growth factor, type 1 MeSH D08.811.913.696.620.682.725.400.037 --- receptor, fibroblast growth factor, type 2 MeSH ... adp-ribosylation factors MeSH D08.811.277.040.330.300.400.100.100 --- ADP-ribosylation factor 1 MeSH D08.811.277.040.330.300. ...
*  TCF7
... down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 ... novel isoforms due to alternative splicing and usage of a new exon IXA". Biochim. Biophys. Acta. 1263 (2): 169-72. doi:10.1016/ ... Transcription factor 7 is a protein that in humans is encoded by the TCF7 gene. GRCh38: Ensembl release 89: ENSG00000081059 - ... Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related ...
*  Tenase
Intrinsic tenase complex contains the active factor IX (IXa), its cofactor factor VIII (VIIIa), the substrate (factor X), and ... inactive factor X) by cleaving it. Extrinsic tenase complex is made up of tissue factor, factor VII, and Ca2+ as an activating ... In coagulation, the procoagulant protein factor X can be activated into factor Xa two ways; extrinsically or intrinsically. The ... These vitamin K-dependent procoagulant factors dock to this surface through their Gla domain with Ca2+ bridges. This makes the ...
*  List of Star Trek planets (A-B)
Beltane IX - A trading planet of some merchant marine repute within a shuttlecraft's range of Relva VII. Jake Kurland, a ... ISBN 0-671-79109-5. TNG: "The Vengeance Factor" TNG: "Captain's Holiday" DS9: "When It Rains…" TNG: "Data's Day" DS9: "Doctor ... "The Icarus Factor" TOS: "All Our Yesterdays" TNG: "Tin Man" "The Guardians of the Pole , EarthSky.org". earthsky.org. Retrieved ... Bashir, I Presume?" DS9: "...Nor the Battle to the Strong" Ent: "Civilization" Voy: "The Chute" Voy: "Prime Factors" TNG: "When ...