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*  Quantitative models of the action potential
The initial term Iext represents the current arriving from external sources, such as excitatory postsynaptic potentials from ... As an example, the cardiac action potential illustrates how differently shaped action potentials can be generated on membranes ... The electric potential φ(x) at any extracellular point x can be solved using Green's identities ϕ ( x ) = 1 4 π σ o u t s i d e ... Op-amp circuits that realize the FHN and van der Pol models of the action potential have been developed by Keener. A hybrid of ...
*  Excitotoxicity
2012). "Excitotoxic potential of the cyanotoxin β-methyl-amino-l-alanine (BMAA) in primary human neurons". Toxicon. 60 (6): ... Exogenous excitotoxins refer to neurotoxins that also act at postsynaptic cells but are not normally found in the body. These ... This occurs when receptors for the excitatory neurotransmitter glutamate (glutamate receptors) such as the NMDA receptor and ... He also assessed that cell death was restricted to postsynaptic neurons, that glutamate agonists were as neurotoxic as their ...
*  Excitatory postsynaptic potential
In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron ... generating an excitatory postsynaptic current. This depolarizing current causes an increase in membrane potential, the EPSP. ... The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC). EPSPs, like IPSPs, are graded (i.e. they ... These are the opposite of inhibitory postsynaptic potentials (IPSPs), which usually result from the flow of negative ions into ...
*  AMPA
... generates fast excitatory postsynaptic potentials (EPSP). AMPA activates AMPA receptors that are non-selective cationic ... channels allowing the passage of Na+ and K+ and therefore have an equilibrium potential near 0 mV. Ampakine Purves, Dale; ...
*  Stimulus (physiology)
In excitatory postsynaptic potentials, an excitatory response is generated. This is caused by an excitatory neurotransmitter, ... This neurotransmitter causes an inhibitory postsynaptic potential in the postsynaptic neuron. This response will cause the ... If a graded potential is strong enough, or if several graded potentials occur in a fast enough frequency, the depolarization is ... In response to stimuli, the sensory receptor initiates sensory transduction by creating graded potentials or action potentials ...
*  Succinic semialdehyde dehydrogenase deficiency
"Gamma-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices". European Journal of Pharmacology ... Potential treatment modalities into biochemical and neurological correction should aim to reduce one or both while not ... This disruption has the potential to impair glutamate homeostasis and may lead to uncoupling of the normal balance between ... simultaneously releasing excitatory neurotransmitters onto motor neurons. Because the number and function of GABAB receptors ...
*  Binding neuron
This kind of memory serves as surrogate of the excitatory postsynaptic potential. The model has a threshold N t h {\ ... denotes magnitude of excitatory postsynaptic potential at moment t {\displaystyle t} ; t k {\displaystyle t_{k}} - is the ... The location of the step is controlled by the level of inhibition potential, see Fig. 1. Due to this type of dependence, the H- ... The BN model originated in a 1998 paper by A. K. Vidybida For a generic neuron the stimuli are excitatory impulses. Normally, ...
*  LTP induction
The AMPA receptor (AMPAR) is the engine that drives excitatory postsynaptic potentials (EPSPs). While some forms of the AMPAR ... the reversal potential of the EPSP current is roughly 0 mV). However, the postsynaptic membrane potential will not change by ... As such, it also spans the electric field generated by the membrane potential. The magnesium binding site within the NMDAR ... This synaptic summation drives the membrane potential toward values that could not be reached with single synaptic stimuli. As ...
*  Low-threshold spikes
An excitatory postsynaptic potential (EPSP) opens the channels, thus generating a LTS. The LTS triggers Na+-dependent action ... such as excitatory postsynaptic potentials (EPSP). Rhythmogenesis in a neuron is due to an instability associated with the ... LTS are often triggered after an inhibitory postsynaptic potential (IPSP) due to the fast recovery of T-type calcium channels ... As with the action potentials that follow them, LTS vary little in amplitude or shape at different holding potentials. This ...
*  Temporal lobe epilepsy
Stimulation of aberrant mossy fibre areas increases the excitatory postsynaptic potential response. However, aberrant mossy ... It has been found that GABA reversal potential is depolarising in the subpopulation of the pyramidal cells due to the lack of ... They project into the hilus of the dentate gyrus and stratum lucidum in the CA3 region giving inputs to both excitatory and ... Loss of mossy cells lowers the threshold of action potentials of the granule cells. In certain patients with temporal lobe ...
*  Action potential
Action potentials are most commonly initiated by excitatory postsynaptic potentials from a presynaptic neuron. Typically, ... The action potential in a normal skeletal muscle cell is similar to the action potential in neurons. Action potentials result ... This all-or-nothing property of the action potential sets it apart from graded potentials such as receptor potentials, ... In contrast to passive spread of electric potentials (electrotonic potential), action potentials are generated anew along ...
*  SYNGAP1
These neurons displayed a higher frequency and larger amplitudes of miniature excitatory postsynaptic potentials (mEPSP). Mice ... SynGAP1 is shown to localize at the postsynaptic density on the dendritic spines of excitatory synapses. Cultured neurons of ... Jaffe H, Vinade L, Dosemeci A (Aug 2004). "Identification of novel phosphorylation sites on postsynaptic density proteins". ...
*  Auditory cortex
alpha-1 adrenergic receptor activation, by norepinephrine, decreases glutamatergic excitatory postsynaptic potentials at AMPA ... The field potentials measured for artificially stimulated CDC were eventually much stronger than that of a normal hearing cat. ... utilized local field potentials to measure cortical plasticity in the auditory cortex. These kittens were stimulated and ... "Preservation of Auditory P300-Like Potentials in Cortical Deafness". PLoS ONE. 7 (1): e29909. doi:10.1371/journal.pone.0029909 ...
*  Alpha-1 adrenergic receptor
In particular, norepinephrine decreases glutamatergic excitatory postsynaptic potentials by the activation of α1-adrenergic ... ISBN 0-87893-725-0. Chou EC, Capello SA, Levin RM, Longhurst PA (2003). "Excitatory α1-adrenergic receptors predominate over ...
*  Kainic acid
Kainate receptors likely control a sodium channel that produces excitatory postsynaptic potentials (EPSPs) when glutamate binds ... ISBN 978-0-205-23939-9. Moloney, Mark G. (1998). "Excitatory amino acids". Natural Product Reports. 15 (2): 205-219. doi: ... the principal excitatory neurotransmitter in the central nervous system. Glutamate is produced by the cell's metabolic ... preparations to study of the physiological effect of excitotoxicity and assess the neuroprotective capabilities of potential ...
*  Biological neural network
Excitatory and inhibitory synaptic transmission is realized mostly by inhibitory postsynaptic potentials and excitatory ... strongly on the relative timing of the onset of the excitatory postsynaptic potential and the postsynaptic action potential. ... potentials at the post-synaptic membrane will summate in the cell body). Later models also provided for excitatory and ... One principle by which neurons work is neural summation, i.e. potentials at the post synaptic membrane will sum up in the cell ...
*  Long-term depression
... theory BCM theory Electrical synapse Excitatory postsynaptic potential Homeostatic plasticity Inhibitory postsynaptic potential ... Depressed excitatory postsynaptic potentials (EPSPs) result from this particular stimulation pattern. The magnitude of calcium ... When postsynaptic action potential firing occurs prior to presynaptic afferent firing, both presynaptic endocannabinoid (CB1) ... Spike timing-dependent plasticity (STDP) refers to the timing of presynaptic and postsynaptic action potentials. STDP is a form ...
*  Trk receptor
Increased NT-3/trkC binding results in larger monosynaptic excitatory postsynaptic potentials (EPSPs) and reduced polysynaptic ... reducing the size of monosynaptic excitatory postsynaptic potentials (EPSPs) and increasing polysynaptic signaling. In the ... Entrectinib (formerly RXDX-101) is an investigational drug developed by Ignyta, Inc., which has potential antitumor activity. ...
*  Adenosine reuptake inhibitor
"The involvement of adenosine neuromodulation in pentobarbital-induced field excitatory postsynaptic potentials depression in ... Boissard CG, Gribkoff VK (1993). "The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and ... on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia". Br J Pharmacol. 100 ... barbiturates and propofol of excitatory synaptic transmissions mediated by adenosine neuromodulation]". Masui. 55 (6): 684-691 ...
*  Cochlear nucleus
Electrical stimuli to the auditory nerve evoke a graded excitatory postsynaptic potential in the octopus cells. These EPSPs are ... excitatory and inhibitory input through the outermost molecular layer and the basal dendrites receiving excitatory and ... Excitatory acoustic input comes from auditory nerve fibers and also from stellate cells of the VCN. Acoustic input is also ... They are also called chopper cells, in reference to their ability to fire a regularly spaced train of action potentials for the ...
*  Silent synapse
This localized depolarization is called an excitatory postsynaptic potential (EPSP). Silent synapses release glutamate as do ... Silent synapses were proposed as an explanation for differences in quantal content of excitatory postsynaptic currents (EPSCs) ... In neuroscience, a silent synapse is an excitatory glutamatergic synapse whose postsynaptic membrane contains NMDA-type ... When glutamate binds to AMPARs located on the postsynaptic membrane, they permit a mixed flow of Na+ and K+ to cross the cells ...
*  N-Methyl-D-aspartic acid
The excitatory postsynaptic potential (EPSP) produced by activation of an NMDA receptor also increases the concentration of ... In fact, normal operation of the NMDA receptor allows individuals to respond to excitatory stimuli through the interrelated ...
*  Population spike
... they can be classified as a type of field excitatory postsynaptic potentials. In some areas of the brain, such as the ... In neuroscience, a population spike (PS) is the shift in electrical potential as a consequence of the movement of ions involved ... Because these neurons are in the same orientation, the extracellular signals from the generation of action potentials don't ... The first interpretations of hippocampal field potentials were developed by Per Andersen.. ...
*  NMDA receptor
The excitatory postsynaptic potential (EPSP) produced by activation of an NMDA receptor increases the concentration of Ca2+ in ... link) "Pre- and postsynaptic localization of NMDA receptor subunits at hippocampal mossy fibre synapses". Neuroscience. 230. ... Removal of D-serine can block NMDA-mediated excitatory neurotransmission in many areas. Recently, it has been shown that D- ... Unlike many other NO donors, alkyl nitrates do not have potential NO associated neurotoxic effects. Alkyl nitrates donate NO in ...
*  Chromatolysis
... in chromatolytic motor neurons is the significant reduction in size of the monosynaptic excitatory postsynaptic potentials ( ... This functional change to the anterior horn neurons could result in the elimination of certain excitatory synaptic inputs and ... then potential therapies could be developed for halting the chromatolytic response of neurons and ameliorating the detrimental ...
*  Pre-Bötzinger complex
In CS pacemakers, NE increases only the amplitude of the depolarizing drive potential and the number of action potentials ... This is due to the reduction of excitatory synaptic transmission in a nucleus and increased excitability in motor neurons ... P/Q-type calcium channels are mainly responsible for the release of neurotransmitters that excite, or activate, postsynaptic ... which allows neurons to intrinsically fire action potentials at sub-threshold membrane potentials. Studies have shown that the ...
*  Megaselia scalaris
In comparison to Drosophila melanogaster, M. scalaris has decreased excitatory postsynaptic potentials (EPSPs) and facilitation ...