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*  Exon junction complex
The core of the EJC contains the protein eukaryotic initiation factor 4A-III (eIF4A-III; a DEAD-box RNA helicase) bound to an ... UAP56 is recognized as an RNA helicase but acts as a splicing factor required for early splicesome assembly. Another factor ... It is organized around the eIF4AIII factor. The factor itself consists of two different types of conformations around the mRNA ... EJCs are also known to take part in NMD in another way; the recruitment of the surveillance factors UPF1, UPF2 and UPF3. These ...
*  Protein kinase R
"Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated ... Once active, PKR is able to phosphorylate the eukaryotic translation initiation factor eIF2α. This inhibits further cellular ... or eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) is an enzyme that in humans is encoded by the EIF2AK2 ... EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2". Feng GS, Chong K, Kumar A, Williams BR (June 1992). " ...
*  EIF5A2
Eukaryotic translation initiation factor 5A-2 is a protein that in humans is encoded by the EIF5A2 gene. GRCh38: Ensembl ... EIF5A2 eukaryotic translation initiation factor 5A2". Jenkins ZA, Hååg PG, Johansson HE (2001). "Human eIF5A2 on chromosome ... "Overexpression of eukaryotic initiation factor 5A2 enhances cell motility and promotes tumor metastasis in hepatocellular ... "Identification and characterization of eukaryotic initiation factor 5A-2". Eur. J. Biochem. 270 (21): 4254-63. doi:10.1046/j. ...
*  EIF2
... is a eukaryotic initiation factor. It is required for most forms of eukaryotic translation initiation. eIF2 mediates the ... Eukaryotic initiation factors The three sub-units of eIF2: α - EIF2S1 β - EIF2S2 γ - EIF2S3 Kinases of eIF2 HRI (Heme-regulated ... eukaryotic translation initiation factor 2 alpha kinase 4) GEF EIF2B (consists of the sub-units EIF2B1, EIF2B2, EIF2B3, EIF2B4 ... "Eukaryotic initiation factor eIF2". Int. J. Biochem. Cell Biol. 31 (1): 25-9. doi:10.1016/S1357-2725(98)00128-9. PMID 10216940 ...
*  METAP2
Datta B, Datta R, Mukherjee S, Zhang Z (1999). "Increased phosphorylation of eukaryotic initiation factor 2alpha at the G2/M ... Moreover, studies have demonstrated that MetAP2 copurifies and interacts with the α subunit of eukaryotic initiation factor 2 ( ... Wu S, Rehemtulla A, Gupta NK, Kaufman RJ (June 1996). "A eukaryotic translation initiation factor 2-associated 67 kDa ... "Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide". Biochemistry. 32 (19): 5151-9. doi: ...
*  EIF2B4
... the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and ... "Entrez Gene: EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa". Welsh GI, Miyamoto S, Price NT, et al ... 2003). "Ovarian failure related to eukaryotic initiation factor 2B mutations". Am. J. Hum. Genet. 72 (6): 1544-50. doi:10.1086/ ... "Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B ...
*  EIF2S3
Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene. ... "Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa". Ray MK, Chakraborty A, Datta B, et al ... Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary ... 1993). "Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide". Biochemistry. 32 (19): 5151-9. ...
*  EIF2S1
Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene. The ... 1993). "Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 ... "Entrez Gene: EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa". National Center for Biotechnology ... Berlanga JJ, Santoyo J, De Haro C (1999). "Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor ...
*  40S ribosomal protein S3
"Entrez Gene: RPS3 ribosomal protein S3". Bommer UA, Lutsch G, Stahl J, Bielka H (1992). "Eukaryotic initiation factors eIF-2 ... Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with ... 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, ... 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. Jang CY, Lee JY, Kim J (2004). "RpS3, a DNA repair endonuclease and ...
*  Gcn2
Eukaryotic initiation factors The three subunits of eIF2: α - EIF2S1 β - EIF2S2 γ - EIF2S3 Kinases of eIF2 HRI (Heme-regulated ... GCN2 is the only known eukaryotic initiation factor 2α kinase (eIF2α) in Saccharomyces cerevisiae. It inactivates eIF2α by ... "Structural basis for autoinhibition and mutational activation of eukaryotic initiation factor 2alpha protein kinase GCN2". J. ... homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha ...
*  EIF2AK3
"Entrez Gene: EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3". Søvik O, Njølstad PR, Jellum E, Molven A (May ... Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR)-like endoplasmic reticulum ... Sood R, Porter AC, Ma K, Quilliam LA, Wek RC (2000). "Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in ... The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading ...
*  ABCF1
Tyzack JK, Wang X, Belsham GJ, Proud CG (2000). "ABC50 interacts with eukaryotic initiation factor 2 and associates with the ... This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancement of protein synthesis and the ... a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes". Genomics. 53 (2): 137 ... 1461 (2): 237-62. doi:10.1016/s0005-2736(99)00161-3. PMID 10581359. You KT, Li LS, Kim NG, et al. (2007). "Selective ...
*  EIF2A
Eukaryotic translation initiation factor 2A (eIF2A) is a protein that in humans is encoded by the EIF2A gene. The eIF2A protein ... "Entrez Gene: EIF2A eukaryotic translation initiation factor 2A, 38kDa". Kim JH, Park SM, Park JH, Keum SJ, Jang SK (Jun 2011 ... "Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A". The ... "Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 ...
*  PRKRIR
1998). "Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in ... or tyrosine at residue 51 in eukaryotic initiation factor 2alpha". J. Biol. Chem. 274 (45): 32198-203. doi:10.1074/jbc.274.45. ... Mellor H, Proud CG (1991). "A synthetic peptide substrate for initiation factor-2 kinases". Biochem. Biophys. Res. Commun. 178 ... 18 (2): 859-71. doi:10.1128/mcb.18.2.859. PMC 108797 . PMID 9447982. "Entrez Gene: PRKRIR protein-kinase, interferon-inducible ...
*  TBC domain
... of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2". The ... of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2". The ... The TBC (Tre-2/Bub2/Cdc16) is identified as a domain of some proteins or as a protein motif and widely recognized as a ... 52 (2): 147-53. doi:10.1016/0024-3205(93)90134-o. PMID 8394962. Lamarche N, Hall A (1994). "GAPs for rho-related GTPases". ...
*  EIF4EBP1
Eukaryotic translation initiation factor 4E-binding protein 1 (also known as 4E-BP1) is a protein that in humans is encoded by ... "Entrez Gene: EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1". Rual JF, Venkatesan K, Hao T, Hirozane- ... The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the ... Feigenblum D, Schneider RJ (1996). "Cap-binding protein (eukaryotic initiation factor 4E) and 4E-inactivating protein BP-1 ...
*  EIF4EBP2
Eukaryotic translation initiation factor 4E-binding protein 2 is a protein that in humans is encoded by the EIF4EBP2 gene. ... "Entrez Gene: EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2". Gkogkas CG, Khoutorsky A, Ran I, ... the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to ... and chromosome mapping of mouse and human eukaryotic initiation factor 4E-binding proteins 1 and 2". Genomics. 38 (3): 353-63. ...
*  EIF2AK1
Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene. EIF2AK1 ... "Entrez Gene: EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1". Hu RM, Han ZG, Song HD, et al. (2000). "Gene ... Studies in rat and rabbit suggest that the HRI gene product phosphorylates the alpha subunit of eukaryotic initiation factor 2 ... Hwang SY, Kim MK, Kim JC (2001). "Cloning of hHRI, human heme-regulated eukaryotic initiation factor 2alpha kinase: down- ...
*  Eukaryotic initiation factor
Eukaryotic initiation factors (eIFs) are proteins or protein complexes involved in the initiation phase of eukaryotic ... There exist many more eukaryotic initiation factors than prokaryotic initiation factors, reflecting the greater biological ... multiple initiation factors, and cellular and viral mRNA. In mammals, eIF3 is the largest initiation factor, made up of 13 ... Eukaryotic Initiation Factors at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  ILF2
"Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated ... Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. ... Interleukin enhancer-binding factor 2 is a protein that in humans is encoded by the ILF2 gene. ... Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and ...
*  ILF3
"Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated ... "Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated ... Interleukin enhancer-binding factor 3 is a protein that in humans is encoded by the ILF3 gene. Nuclear factor of activated T- ... Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and ...
*  Eukaryotic initiation factor 4F
... freeing eIF4E to bind eIF4G and participate in translation initiation. Eukaryotic translation Eukaryotic initiation factor 5' ... Eukaryotic initiation factor 4F (eIF4F) is a heterotrimeric protein complex that binds the 5' cap of messenger RNAs (mRNAs) to ... Wells SE, Hillner PE, Vale RD, Sachs AB (July 1998). "Circularization of mRNA by eukaryotic translation initiation factors". ... Cencic R, Pelletier J (January 2016). "Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A". ...
*  Eukaryotic initiation factor 3
... (eIF3) is a multiprotein complex that functions during the initiation phase of eukaryotic ... "Human-Like Eukaryotic Translation Initiation Factor 3 from Neurospora crassa". PLoS ONE. 8 (11): e78715. doi:10.1371/journal. ... "Unified nomenclature for the subunits of eukaryotic initiation factor 3". Trends Biochem. Sci. 26 (5): 284. doi:10.1016/S0968- ... Is Associated with the Conserved Core Subunits of Eukaryotic Translation Initiation Factor 3". Journal of Biological Chemistry ...
*  Eukaryotic translation initiation factor 4E family
In molecular biology, the eukaryotic translation initiation factor 4E family (eIF-4E) is a family of proteins that bind to the ... This article incorporates text from the public domain Pfam and InterPro IPR001040 Eukaryotic Linear Motif resource motif class ... cap during an early step in the initiation of protein synthesis and facilitate ribosome binding to an mRNA by inducing the ... 68 (2): 177-180. doi:10.1016/0092-8674(92)90461-K. PMID 1733496. Ueda H, Iyo H, Doi M, Inoue M, Ishida T, Morioka H, Tanaka T, ...
*  43S preinitiation complex
Sokabe, Masaaki; Fraser, Christopher S. (2014-09-22). "Human Eukaryotic Initiation Factor 2 (eIF2)-GTP-Met-tRNAiTernary Complex ... The 43S PIC contains the small ribosomal subunit (40S) bound by the initiation factors eIF1, eIF1A, eIF3, and the eIF2-Met- ... "Structural Insights into the Mechanism of Scanning and Start Codon Recognition in Eukaryotic Translation Initiation". Trends in ... is a ribonucleoprotein complex that exists during an early step of eukaryotic translation initiation. ...
*  Baum-Welch algorithm
Now whether or not the chicken has laid eggs for collection depends on some unknown factors that are hidden. We can however ( ... The GENSCAN webserver is a gene locator capable of analyzing eukaryotic sequences up to one million base-pairs (1 Mbp) long. ... to have increased specificity and accuracy compared with its predecessors with regard to predicting translation initiation ... We then repeat for if N came from S 1 {\displaystyle S_{1}} and for if N and E came from S 2 {\displaystyle S_{2}} and ...
*  DEAD box
... protein highly related to Ded1 plays a part in translation initiation by interacting with eukaryotic initiation factor ... The eIF4A translation initiation factor was the first DEAD box protein found to have a RNA dependent ATPase activity. It has ... Sonenberg N (1988). "Cap-binding proteins of eukaryotic messenger RNA: functions in initiation and control of translation". ... "Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase ...