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*  Kathie L. Olsen
Whalen, R. E.; Martin, J. V.; Olsen, K. L. (1975). "Effect of oestrogen antagonist on hypothalamic oestrogen receptors". Nature ... Olsen, K. L.; Whalen, R. E. (1982). "Estrogen binds to hypothalamic nuclei of androgen-insensitive (tfm) rats". Experientia. 38 ... Whalen, R. E.; Olsen, K. L. (1978). "Prednisolone modifies estrogen-induced sexual differentiation". Behavioral Biology. 24 (4 ... sex and estrogen treatment". Brain Research. 448 (2): 223-229. doi:10.1016/0006-8993(88)91259-0. PMID 3378147. Olsen, K. L. ( ...
*  Benzestrol
It has been used in the past as a nonsteroidal estrogen antagonist. Benzestrol is described as a very potent estrogen. ... The stilbestrol estrogens, the most well-known of which is diethylstilbestrol (DES) were used extensively in the mid-1900s and ... In any case, it is a very close analogue of the stilbestrol estrogens. Benzestrol is a drug in the stilbestrol family of ... Benzestrol and other stilbestrol were used as synthetic estrogens in order to prevent premature births. Based on the idea that ...
*  Propyl gallate
A 2009 study found that propyl gallate acts as an estrogen antagonist. "Final Report on the Amended Safety Assessment of Propyl ...
*  Fertility medication
Estrogen antagonists and gonadotropins may stimulate multiple follicles and other ovarian hormones leading to multiple birth ... Agents that enhance ovarian activity can be classified as either Gonadotropin releasing hormone, Estrogen antagonists or ... It is used as an ovarian stimulator by inhibiting the negative feedback of estrogen at the hypothalamus. As the negative ... Clomiphene (trademarked as Clomid) is a selective estrogen receptor modulator (SERM). It is the most widely used fertility drug ...
*  Tamoxifen
In breast tissue, 4-OHT acts as an ER antagonist so that transcription of estrogen-responsive genes is inhibited. Tamoxifen has ... Chua, ME; Escusa, KG; Luna, S; Tapia, LC; Dofitas, B; Morales, M (September 2013). "Revisiting oestrogen antagonists ( ... "Estrogen Action, Selective Estrogen Receptor Modulators and Women's Health" Imperial College Press, Singapore. It was not until ... Two books, Estrogen Action, Selective Estrogen Receptor Modulators and Women's Health (Imperial College Press 2013) and ...
*  Methylcholanthrene
Research on the effect of 3-MC in rat uteri concludes that 3-MC acts as an estrogen antagonist. The sexhormone is, like 3-MC, a ... 3-MC and estrogen bind to estrogenreceptors competitively, reducing the estrogen expression. MC is metabolized by rat liver ... AhR ligands can induce formation of an AhR-estrogen receptor (ER) complex. 3-MC was found to elicit estrogenic activity by this ... Shipley, J. M.; Waxman, D.J. (2006). "Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent ...
*  Arzoxifene
It is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density ... Arzoxifene (INN; developmental code name LY-353381) is a selective estrogen receptor modulator (SERM) of the benzothiophene ... 2007). "Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including ...
*  Genistein
... found to increase the rate of proliferation of estrogen-dependent breast cancer when not cotreated with an estrogen antagonist ... Due to its structure similarity to 17β-estradiol (estrogen), genistein can compete with it and bind to estrogen receptors. ... However, genistein shows much higher affinity toward estrogen receptor β than toward estrogen receptor α. Data from in vitro ... Dang, Z. C. (2009). "Dose-dependent effects of soy phyto-oestrogen genistein on adipocytes: Mechanisms of action". Obesity ...
*  Antiestrogen
... s, also known as estrogen antagonists or estrogen blockers, are a class of drugs which prevent estrogens like ... They act by blocking the estrogen receptor (ER) and/or inhibiting or suppressing estrogen production. Antiestrogens are one of ... 7-. ISBN 978-3-0348-0664-0. V Craig Jordan (27 May 2013). Estrogen Action, Selective Estrogen Receptor Modulators and Women's ... the ER silent antagonist and selective estrogen receptor degrader (SERD) fulvestrant, aromatase inhibitors (AIs) like ...
*  Enclomifene
... an estrogen receptor antagonist for the treatment of testosterone deficiency in men" (PDF). IDrugs. 12 (2): 109-19. PMID ... Enclomifene acts by antagonizing the estrogen receptor (ER) in the pituitary gland, which reduces negative feedback by estrogen ... Enclomifene (INN) (tentative brand name Androxal), or enclomiphene (USAN), is a nonsteroidal selective estrogen receptor ...
*  Zuclomifene
... an estrogen receptor antagonist for the treatment of testosterone deficiency in men" (PDF). IDrugs. 12 (2): 109-19. PMID ... In accordance, unlike enclomifene, zuclomifene is antigonadotropic due to activation of the estrogen receptor and is able to ... Zuclomifene (INN), or zuclomiphene (USAN), is a nonsteroidal selective estrogen receptor modulator (SERM) of the ...
*  Somatic evolution in cancer
... and co-regulatory proteins may influence whether the SERM acts as an estrogen antagonist or as an estrogen agonist. Reduced ... Selective estrogen receptor modulators (SERMs) are a commonly used adjuvant therapy in estrogen-receptor positive (ERα+) breast ... These include: Loss of estrogen receptor alpha (ERα)Although this may be a mechanism of resistance in a minority of women, most ... June 1999). "Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist". Cancer Res. 59 ( ...
*  List of MeSH codes (D06)
... estrogen antagonists MeSH D06.347.360.315.300 --- estradiol antagonists MeSH D06.347.360.827 --- selective estrogen receptor ... estrogens, conjugated (usp) MeSH D06.472.334.851.437.994 --- estrogens, esterified (usp) MeSH D06.472.334.851.437.996 --- ... estrogens, catechol MeSH D06.472.334.851.437.984.350 --- hydroxyestrones MeSH D06.472.334.851.437.988 --- ...
*  Estriol
"Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells". Molecular and Cellular Endocrinology. ... Estriol is an estrogen, specifically an agonist of the estrogen receptors ERα and ERβ. It is a far less potent estrogen than is ... Estriol (E3), also spelled oestriol, is a steroid, a weak estrogen, and a minor female sex hormone. It is one of three major ... In addition to acting as an agonist of the nuclear ERs, estriol also acts as an antagonist of the GPER at high concentrations, ...
*  Poor ovarian reserve
Fisch JD, Keskintepe L, Sher G (February 2008). "Gonadotropin-releasing hormone agonist/antagonist conversion with estrogen ... Gonadotropin-releasing hormone agonist/antagonist conversion with estrogen priming (AACEP) protocol. Fisch, Keskintepe and Sher ... Ethinylestradiol or other synthetic estrogens along with luteal phase progesterone (twice daily 200 mg vaginal suppositories) ... "Effects of pretreatment with estrogens on ovarian stimulation with gonadotropins in women with premature ovarian failure: a ...
*  Benita Katzenellenbogen
"Antagonists Selective for Estrogen Receptor α". Endocrinology. 143 (3): 941-7. doi:10.1210/endo.143.3.8704. PMID 11861516. ... "Transcriptional Profiling of Estrogen-Regulated Gene Expression via Estrogen Receptor (ER) α or ERβ in Human Osteosarcoma Cells ... and estrogen receptor subtype-selective ligands in various estrogen target tissues. "Endocrine Society Announces 2016 Laureate ... "Characterization of the Biological Roles of the Estrogen Receptors, ERα and ERβ, in Estrogen Target Tissues in Vivo through the ...
*  Baicalein
... is also an antagonist of the estrogen receptor, or an antiestrogen. The flavonoid has been shown to inhibit certain ...
*  PHTPP
... estrogen receptor ligands possessing estrogen receptor beta antagonist activity". J. Med. Chem. 47 (24): 5872-93. doi:10.1021/ ... PHTPP is a synthetic, nonsteroidal, and highly selective antagonist of ERβ that is used in scientific research to study the ... It possesses 36-fold selectivity for ERβ over ERα, and is a silent antagonist of ERβ. Propylpyrazoletriol (PPT) ...
*  Aminoestradiol
"A multiplexed screening method for agonists and antagonists of the estrogen receptor protein". Anal Bioanal Chem. 403 (5): 1373 ... steroidal estrogen and a 17β-aminoestrogen with anticoagulant effects that was never marketed. It is an analogue of estradiol ... "Synthesis of new amino acid and peptide derivatives of estradiol and their binding affinities for the estrogen receptor". ...
*  Hot flash
SERMs are a category of compounds that act selectively as agonists or antagonists on the estrogen receptors throughout the body ... Lignans are thought to have estrogen agonist and antagonist effects as well as antioxidant properties. Flaxseed and its lignans ... When estrogen as estradiol is used transdermally as a patch, gel, or pessary with micronized progesterone this may avoid the ... There are hints at reduced levels of estrogen as the primary cause of hot flashes. There are indications that hot flashes may ...
*  Primary hypertrophic osteoathropathy
... an estrogen receptor antagonist. Tamoxifen and several of its metabolites competitively bind to estrogen receptors on tissue ... In vitro studies showed that tamoxifen acts as an estrogen agonist on bone and inhibits the resorbing activity of osteoclasts ( ...
*  Site-specific recombinase technology
... an estrogen receptor antagonist), the Cre-ERt construct is able to penetrate the nucleus and induce targeted mutation. ERt ... inducing specific temporal Cre activity involves fusing the enzyme with a mutated ligand-binding domain for the human estrogen ... binds tamoxifen with greater affinity than endogenous estrogens, which allows Cre-ERt to remain cytoplasmic in animals ...
*  Onapristone
207-. ISBN 978-0-7514-0499-9. Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. ... It is a silent antagonist of the progesterone receptor (PR), in contrast to the related antiprogestogen mifepristone (which is ... a progesterone receptor antagonist, as first-line therapy in primary breast cancer". Eur. J. Cancer. 35 (2): 214-8. PMID ...
*  Nonsteroidal
Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. Springer Science & Business ... 322-. ISBN 978-0-19-802645-7. Miquel JF, Gilbert J (1988). "A chemical classification of nonsteroidal antagonists of sex- ... Examples include the following: Estrogens: benzestrol, bifluranol, estrobin (DBE), diethylstilbestrol (stilbestrol), dienestrol ... Nonsteroidal antiandrogen Nonsteroidal estrogen Buer JK (Oct 2014). "Origins and impact of the term 'NSAID'". ...
*  Nilutamide
Edward J. Pavlik (6 December 2012). Estrogens, Progestins, and Their Antagonists: Health Issues. Springer Science & Business ... Studies in Estrogen-Treated Agonadal Subjects and Eugonadal Subjects Treated with a Novel Nonsteroidal Antiandrogen". The ... Nilutamide acts as a selective antagonist of the androgen receptor (AR), preventing the effects of androgens like testosterone ... Both nilutamide alone and the combination of nilutamide and estrogen were regarded as resulting in effective and favorable ...
*  Nonsteroidal antiandrogen
An over-the-counter histamine H2 receptor antagonist that also shows very weak activity as an AR antagonist. Also inhibits ... androgen receptor modulator N-Terminal domain antiandrogen Discovery and development of antiandrogens Nonsteroidal estrogen ... They are typically selective and full or silent antagonists of the androgen receptor (AR) and act by directly blocking the ... Similar to enzalutamide and apalutamide, but with increased efficacy as an AR antagonist, little or no central nervous system ...