Estramustine
... phosphate, the C17β phosphate ester of estramustine and a prodrug of estramustine, estromustine, estradiol, and ... Estramustine (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name, BANTooltip British Approved ...
Estramustine phosphate
Estramustine is accumulated in tumor tissue, for instance prostate cancer and glioma tissue, with estramustine levels much ... This may be due to the presence of a specific estramustine-binding protein (EMBP) (Kd = 10-35 nM for estramustine), also known ... The INNMTooltip International Nonproprietary Name is estramustine phosphate. The name estramustine phosphate is a contraction ... "Emcyt estramustine phosphate sodium capsules" (PDF). FDA. Retrieved 14 March 2022. Qin Z, Li X, Zhang J, Tang J, Han P, Xu Z, ...
List of hormonal cytostatic antineoplastic agents
Estramustine phosphate (Emcyt, Estracyt; Leo 299, NSC-89199, Ro 21-8837/001; estradiol 3-[bis(2-chloroethyl)carbamate] ... Estramustine (Leo 275, Ro 21-8837; estradiol 3-(bis(2-chloroethyl)carbamate) ester) Estromustine (Leo 271 f; estrone-cytostatic ...
Pharmacokinetics of estradiol
Gunnarsson PO, Forshell GP (June 1984). "Clinical pharmacokinetics of estramustine phosphate". Urology. 23 (6 Suppl): 22-7. doi ... Bergenheim AT, Henriksson R (February 1998). "Pharmacokinetics and pharmacodynamics of estramustine phosphate". Clin ...
List of EORTC trials
Smith PH, Robinson M, Richards B, Suciu S, De Pauw M, Sylvester R, Denis L (June 1984). "Estramustine phosphate in prostate ... estramustine phosphate 280 mg/day (560 mg/day initially) versus diethylstilbestrol 3 mg/day EORTC 30805 - orchiectomy versus ... medroxyprogesterone acetate and estramustine phosphate used for the treatment of advanced prostatic cancer: results from ...
List of estrogen esters
Estramustine (Leo 275; Ro 21-8837) Estromustine (Leo 271 f; estrone 17β-3-N-bis(2-chloroethyl)carbamate, estrone-cytostatic ... Estramustine phosphate (Emcyt, Estracyt; estradiol 3-normustine 17β-phosphate) A number of other estradiol esters which have ...
Estromustine
... is a major active metabolite of the cytostatic antineoplastic agent and estrogen estramustine phosphate, a medication used in ... "In vivo studies of 3H-estramustine in castrated male rat". Acta Urologica Japonica. 27 (3): 243-50. Medical Subject Headings: ...
Side effects of cyproterone acetate
... medroxyprogesterone acetate and estramustine phosphate used for the treatment of advanced prostatic cancer: results from ... 1.25 for CPA monotherapy relative to estrogen monotherapy with diethylstilbestrol or estramustine phosphate; and 0.60 for CPA ... with 280-560 mg/day oral estramustine phosphate (n = 114). Premenopausal women using depot injectable medroxyprogesterone ...
Metronomic therapy
"Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer". The New England ...
Scandinavian Prostate Cancer Group
The studies conducted by the SPCG include the following: SPCG-1 - estramustine phosphate versus diethylstilbestrol for high- ... high-stage prostate cancer with estramustine phosphate or diethylstilbestrol. A double-blind study. The SPCG-1 Study Group. ...
Estradiol (medication)
Estramustine phosphate is also an estradiol ester, but with a nitrogen mustard moiety attached, and is used as a cytostatic ... December 2011). "The use of estramustine phosphate in the modern management of advanced prostate cancer". BJU International. ...
Gonadotropin-releasing hormone agonist
Shimizu TS, Shibata Y, Jinbo H, Satoh J, Yamanaka H (1995). "Estramustine phosphate for preventing flare-up in luteinizing ... and estramustine phosphate; antiandrogens such as nonsteroidal antiandrogens like flutamide, nilutamide, and bicalutamide; and ...
Alestramustine
It is the L-alanine ester of estramustine, which is a combination of the nitrogen mustard normustine coupled via a carbamate to ... Alestramustine acts as a prodrug to estramustine, and also forms estradiol as a byproduct. The drug, via its active metabolites ...
Chlormethine
It has been derivatized into the estrogen analogue estramustine phosphate, used to treat prostate cancer. It can also be used ...
Cytestrol acetate
... having cytostatic actions via the carbamate-nitrogen mustard moiety analogously to estramustine phosphate. The drug shows ...
Effects of hormones on sexual motivation
In contrast, nearly all patients treated with oestrogens or estramustine phosphate reported loss of sexual potency. [...] In ... comparative therapeutic trials, loss of potency has occurred in all patients treated with stilboestrol or estramustine ...
Estrogen (medication)
In contrast, nearly all patients treated with oestrogens or estramustine phosphate reported loss of sexual potency. [...] In ... comparative therapeutic trials, loss of potency has occurred in all patients treated with stilboestrol or estramustine ...
Fosfestrol
Estramustine phosphate Droz JP, Kattan J, Bonnay M, Chraibi Y, Bekradda M, Culine S (February 1993). "High-dose continuous- ...
Estradiol undecylate
... cyproterone acetate and estramustine phosphate: a preliminary report". Steroid receptors, metabolism and prostatic cancer: ... such as diethylstilbestrol and estramustine phosphate, which have been shown to possess significantly higher cardiovascular ...
Jenny Glusker
... the structure and conformation of estramustine and acridine. They further tested carcinogens such as polycyclic aromatic ...
Estradiol mustard
For this reason, estradiol mustard and other cytostatic-linked estrogens like estramustine phosphate have reduced toxicity ... although estramustine phosphate has been approved for and is used (almost exclusively) in the treatment of prostate cancer. ...
Management of prostate cancer
... as well as the dual estrogenic and cytostatic agent estramustine phosphate. Newer estrogens with improved tolerability and ...
William K. Oh
December 2003). "A phase II study of estramustine, docetaxel, and carboplatin with granulocyte-colony-stimulating factor ...
Nicholas J. Vogelzang
"Phase II Evaluation of Early Oral Estramustine, Oral Etoposide, and Intravenous Paclitaxel Combined with Hormonal Therapy in ...
Antiandrogen
Decreased adrenal androgens with estrogens is apparent with oral and synthetic estrogens like ethinylestradiol and estramustine ...
High-dose estrogen therapy
Estramustine phosphate (an estradiol ester that is also a cytostatic antineoplastic agent; used for prostate cancer only) ...
Normustine
... including estramustine phosphate, alestramustine, cytestrol acetate, and ICI-85966 (stilbostat), but only the former of which ...
Pharmacodynamics of estradiol
... have found that these effects occur with high-dose oral and synthetic estrogens such as ethinylestradiol and estramustine ...
ATC code L01
L01XX03 Altretamine L01XX05 Hydroxycarbamide L01XX07 Lonidamine L01XX08 Pentostatin L01XX10 Masoprocol L01XX11 Estramustine ...
List of MeSH codes (D02)
... estramustine MeSH D02.455.526.728.650.463 - mannomustine MeSH D02.455.526.728.650.529 - mechlorethamine MeSH D02.455.526.728. ...