20alpha-hydroxysteroid dehydrogenase, 17beta-estradiol dehydrogenase, estradiol dehydrogenase, estrogen 17-oxidoreductase, and ... In enzymology, an estradiol 17beta-dehydrogenase (EC 1.1.1.62) is an enzyme that catalyzes the chemical reaction estradiol- ... Kautsky MP, Hagerman DD (1970). "17β-Estradiol Dehydrogenase of Ovine Ovaries". J. Biol. Chem. 245 (8): 1978-84. PMID 4314937. ... Langer LJ, Alexander JA, Engel LL (1959). "Human Placental Estradiol-17β Dehydrogenase. II. Kinetics and substrate ...
In enzymology, an estradiol 17alpha-dehydrogenase (EC 1.1.1.148) is an enzyme that catalyzes the chemical reaction estradiol- ... Other names in common use include 17alpha-estradiol dehydrogenase, 17alpha-hydroxy steroid dehydrogenase, 17alpha-hydroxy ... Renwick AG, Engel LL (1967). "The partial purification of 17 alpha- and 17 beta-estradiol dehydrogenase activities from chicken ... H+ The three substrates of this enzyme are estradiol-17alpha, NAD+, and NADP+, whereas its four products are estrone, NADH, ...
Human placental 17 -estradiol dehydrogenase". Biochemistry. 11 (14): 2699-703. doi:10.1021/bi00764a023. PMID 5045524. Murdock ... Nicolas JC, Harris JI (Jan 1973). "Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an ... and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase". Annals of the New York Academy of Sciences. 595: ... "Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21". ...
"Human placental 17 beta-estradiol dehydrogenase and 20 alpha-hydroxysteroid dehydrogenase. Two activities at a single enzyme ... Other names in common use include 20alpha-hydroxy steroid dehydrogenase, 20alpha-hydroxy steroid dehydrogenase, 20alpha-HSD, ... In enzymology, a 20-α-hydroxysteroid dehydrogenase (EC 1.1.1.149) is an enzyme that catalyzes the chemical reaction 17alpha, ... Akinola LA, Poutanen M, Vihko R, Vihko P (July 1997). "Expression of 17beta-hydroxysteroid dehydrogenase type 1 and type 2, ...
Estrone can then be transformed into estradiol by 17β-hydroxysteroid dehydrogenase. Estropipate was introduced for medical use ... It is a salt of estrone sulfate and piperazine, and is transformed into estrone and estradiol in the body. It is taken by mouth ... Estropipate is a prodrug of estrone and estradiol. Hence, it is an estrogen, or an agonist of the estrogen receptors. ...
"A single step procedure for purification of estradiol 17 beta-dehydrogenase from human placenta". Biochem. Biophys. Res. Commun ... The 17-beta-hydroxysteroid dehydrogenase enzyme (EC 1.1.1.62) oxidizes or reduces estrogens and androgens in mammals and ... Peltoketo H, Nokelainen P, Piao YS, Vihko R, Vihko P (Aug 1999). "Two 17beta-hydroxysteroid dehydrogenases (17HSDs) of ... Ohnesorg T, Adamski J (2005). "Promoter analyses of human and mouse 17beta-hydroxysteroid dehydrogenase type 7". J. Steroid ...
Estrone can also be converted by 17β-hydroxysteroid dehydrogenases into the more potent estrogen estradiol. E1S levels are much ... Related estrogen conjugates include estradiol sulfate, estriol sulfate, estrone glucuronide, estradiol glucuronide, and estriol ... Unlike unconjugated estradiol and estrone, which are lipophilic compounds, E1S is an anion and is hydrophilic. As a result of ... E1S itself is biologically inactive, with less than 1% of the relative binding affinity of estradiol for the ERα and ERβ. ...
It was first identified as a 17-beta-estradiol dehydrogenase (Leenders et al., 1996; van Grunsven et al., 1998). Peroxisomal ... 17beta-hydroxysteroid dehydrogenase 4 and D-3-hydroxyacyl-coenzyme A dehydrogenase/hydratase involved in Zellweger syndrome". ... Green VL, Speirs V, Landolt AM, Foy PM, Atkin SL (April 1999). "17Beta-hydroxysteroid dehydrogenase type 1, 2, 3, and 4 ... Dong Y, Qiu QQ, Debear J, Lathrop WF, Bertolini DR, Tamburini PP (October 1998). "17Beta-hydroxysteroid dehydrogenases in human ...
... does not inhibit 5α-reductase, aromatase, or 3α- or 3β-hydroxysteroid dehydrogenase in vitro. The drug significantly ... increases testosterone and estradiol levels in men. Zanoterone has been found to not significantly inhibit mating performance ...
As a result of the alkylation in 17-C position it is not a substrate for 17β dehydrogenase, an enzyme which transforms natural ... Estradiol and testosterone levels with high-dosage transdermal estradiol in the form of two to six 100 µg/day estradiol patches ... Estradiol-containing birth control pills, which contain 1 to 3 mg/day estradiol or estradiol valerate, have been found to ... Antigonadotropic effects of estradiol Estradiol and testosterone levels with a single intramuscular injection of 2 mg estradiol ...
Subsequently, 20α-hydroxysteroid dehydrogenase and 20β-hydroxysteroid dehydrogenase reduce these metabolites to form the ... Evidence has accrued that normal progesterone (and ovulation), as well as physiological estradiol levels, is necessary during ... This reaction is catalyzed by 3β-hydroxysteroid dehydrogenase/δ5-4-isomerase. Progesterone in turn is the precursor of the ... This is followed by the further reduction of these metabolites via 3α-hydroxysteroid dehydrogenase and 3β-hydroxysteroid ...
Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene. In mice, the Ke6 protein is a 17- ... The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An ... "Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8". Kikuti YY, Tamiya G, Ando A, et al. (1997). "Physical mapping ... 1998). "Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues". J. Biol. ...
Estradiol 17-beta-dehydrogenase 11 is an enzyme that in humans is encoded by the HSD17B11 gene. GRCh38: Ensembl release 89: ... Haeseleer F, Palczewski K (2000). Short-chain dehydrogenases/reductases in retina. Methods in Enzymology. Vol. 316. pp. 372-83 ... "Entrez Gene: HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11". Li KX, Smith RE, Krozowski ZS (1999). "Cloning and expression ... "17 beta-hydroxysteroid dehydrogenase type XI localizes to human steroidogenic cells". Endocrinology. 144 (5): 2084-91. doi: ...
... /dexamethasone (Ell-Cranell Dexa) Estradiol 17α-dehydrogenase List of estrogens J. Elks (14 November 2014). The ... Alfatradiol (17α-estradiol) is distinguished from estradiol (17β-estradiol), the predominant sex hormone in females, only by ... In contrast to 17β-estradiol, 17α-estradiol, while it still binds to the estrogen receptor, has less or no feminizing ... It is a stereoisomer of the endogenous steroid hormone and estrogen 17β-estradiol (or simply estradiol). Alfatradiol is used in ...
Estradiol 17-beta-dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene. The enzyme 17-beta ... an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women". Mol. Endocrinol. 20 (2 ... "Entrez Gene: HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method ... Luu-The V, Tremblay P, Labrie F (2006). "Characterization of type 12 17beta-hydroxysteroid dehydrogenase, ...
... estradiol is dehydrogenated by 17β-hydroxysteroid dehydrogenase into the much less potent estrogen estrone. These reactions ... The four major naturally occurring estrogens are estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4). Estradiol (E2) ... Synthetic steroid estrogens include ethinyl estradiol, estradiol valerate, estropipate, conjugate esterified estrogen, and ... Thus, estradiol is the most important estrogen in non-pregnant females who are between the menarche and menopause stages of ...
"Affinity labeling of arginyl residues at the catalytic region of estradiol 17 beta-dehydrogenase from human placenta by 16- ... Stimmel BF, Grollman A, Huffman MN (June 1950). "The metabolism of 16-ketoestrone and 16-keto-estradiol in man". J. Biol. Chem ... 16-Ketoestrone has been reported to act as an inhibitor of 17β-hydroxysteroid dehydrogenases. 16-Ketoestrone can be converted ... Huffman MN, Lott MH (January 1948). "16-Substituted steroids; 16-keto-alpha-estradiol and 16-ketoestrone". J. Biol. Chem. 172 ( ...
... last phase of steroidogenesis and is responsible for the conversion of androstenedione to testosterone and estrone to estradiol ... 17-β-Hydroxysteroid dehydrogenase III deficiency is a cause of 46,XY disorder of sex development (46,XY DSD) that presents in ... 17β-Hydroxysteroid dehydrogenase III deficiency is caused by mutations found in the 17β-HSD III (17BHSD3) gene.17β-HSD III ... "Testosterone 17-beta-dehydrogenase deficiency - Conditions - GTR - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-03-17. Lee P. A ...
However, small studies with topical 11α-hydroxyprogesterone and 17α-estradiol showed some benefit [38,39]. Morita H, Zhou M, ... October 2004). "11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response". Endocrine ... of 11β-hydroxysteroid dehydrogenase (11β-HSD). It is notably not metabolized by 11β-HSD2. 11α-OHP is a more potent inhibitor of ... "Human 11 beta-hydroxysteroid dehydrogenase: studies on the stably transfected isoforms and localization of the type 2 isozyme ...
... and of estrone into estradiol by 17β-hydroxysteroid dehydrogenase. CEEs (as Premarin) and estrone have been found to be ... A dosage of 0.625 mg/day oral CEEs has been found to increase SHBG levels by 100%. For comparison, 1 mg/day oral estradiol ... Compared to estradiol, certain estrogens in CEEs are more resistant to metabolism, and the medication shows relatively ... However, it has begun to fall out of favor relative to bioidentical estradiol, which is the most widely used form of estrogen ...
... which is subsequently converted to estradiol via 17β-hydroxysteroid dehydrogenase (17β-HSD). During the reproductive years, ... Estradiol is additionally conjugated with an ester into lipoidal estradiol forms like estradiol palmitate and estradiol ... Estradiol is conjugated in the liver to form estrogen conjugates like estradiol sulfate, estradiol glucuronide and, as such, ... Though estradiol levels in males are much lower than in females, estradiol has important roles in males as well. Apart from ...
... position of estradiol as in estradiol valerate reduces the metabolism of estradiol valerate by 17β-hydroxysteroid dehydrogenase ... Along with estradiol cypionate, estradiol undecylate, and estradiol benzoate, estradiol valerate is used as a form of high-dose ... Other common esters of estradiol in use include estradiol cypionate, estradiol enantate, and estradiol acetate, the former two ... and estradiol cypionate (1952), estradiol valerate is one of the most widely used esters of estradiol. Estradiol valerate is ...
"Uterine estradiol and progesterone receptor concentration, activities of certain antioxidant enzymes and dehydrogenases and ...
The birth control drug Ethinyl estradiol inhibits AO, but its typical concentration is so low that the potential for drug-drug ... Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain Gordon AH, Green DE, Subrahmanyan V (May 1940). "Liver ... Some known inhibitors of AO are sterol and phenol compounds, like estradiol. Others include amsacrine, 6,6'-azopurine, ...
... or 17β dehydrogenase may refer to: Estradiol 17beta-dehydrogenase Testosterone 17beta-dehydrogenase 17β- ... Hydroxysteroid dehydrogenase (17β-HSD, HSD17B), also 17-ketosteroid reductases (17-KSR) This set index page lists enzyme ...
... or estradiol (girls) to effect normal pubertal changes. Replacement testosterone or estrogen and progesterone can be initiated ... 3β-HSD II mediates three parallel dehydrogenase/isomerase reactions in the adrenals that convert Δ4 to Δ5 steroids: ... Congenital adrenal hyperplasia due to 3β-hydroxysteroid dehydrogenase deficiency is an uncommon form of congenital adrenal ... 3β-hydroxysteroid dehydrogenase (3β-HSD) type II (HSD3B2). As a result, higher levels of 17α-hydroxypregnenolone appear in the ...
... binds to the ERα and ERβ with similar affinity to that of estradiol (94% and 185% of the relative binding affinity ... allowing it to inhibit the activity of aromatase and 3α-hydroxysteroid dehydrogenase. These enzymes are involved in the ... The chemical shape of coumestrol orients its two hydroxy groups in the same position as the two hydroxy groups in estradiol, ... although the estrogenic activity of coumestrol at both receptors is much less than that of estradiol. In any case, coumestrol ...
... is reversibly oxidized by the enzyme formate dehydrogenase from Desulfovibrio gigas: HCO−2 → CO2 + H+ + 2 e− Formate ... Specific conversions include testosterone to estradiol and androstenedione to estrone. ...
However, it has been found that E2MATE, without being hydrolyzed first, can be converted by 17β-hydroxysteroid dehydrogenase ... Estradiol sulfamate (E2MATE; developmental code names J995, PGL-2, PGL-2001, ZK-190628, others), or estradiol-3-O-sulfamate, is ... It is the C3 sulfamate ester of estradiol, and was originally thought to be a prodrug of estradiol. The drug was first ... As of 2017, E2MATE is in phase II clinical trials for endometriosis.[needs update] Unlike estradiol and other estradiol esters ...
Then, placental 17β-hydroxysteroid dehydrogenase interconverts estrone and estradiol and the two hormones are secreted into the ... Estrone and estradiol are also produced in the placenta during pregnancy. However, in the case of estrone and estradiol, DHEA-S ... estradiol acts as an agonist. Estradiol increases breast cancer cell growth via activation of the GPER (in addition to the ER ... but in the presence of estradiol, it is antiestrogenic. Given by subcutaneous injection in mice, estradiol is about 10-fold ...