Epstein-Barr virus nuclear-antigen internal ribosomal entry site
Epstein-Barr virus stable intronic-sequence RNAs Isaksson A, Berggren M, Ricksten A (January 2003). "Epstein-Barr virus U ... The Epstein-Barr virus nuclear-antigen internal ribosome entry site (EBNA IRES) is an internal ribosome entry site (IRES) that ... untranslated region of the Epstein-Barr virus nuclear antigen 1 (EBNA1) gene. The EBNA IRES allows EBNA1 translation to occur ... The EBNA IRES is located in the U leader exon, which is a portion of the mRNA of the Epstein-Barr virus common to all four ...
Epstein-Barr virus nuclear antigen 2
The Epstein-Barr virus nuclear antigen 2 (EBNA-2) is one of the six EBV viral nuclear proteins expressed in latently infected B ... Zimber-Strobl U, Kremmer E, Grässer F, Marschall G, Laux G, Bornkamm GW (January 1993). "The Epstein-Barr virus nuclear antigen ... Palermo RD, Webb HM, Gunnell A, West MJ (August 2008). "Regulation of transcription by the Epstein-Barr virus nuclear antigen ... December 1997). "Both Epstein-Barr viral nuclear antigen 2 (EBNA2) and activated Notch1 transactivate genes by interacting with ...
Epstein-Barr virus nuclear antigen 1
Epstein-Barr nuclear antigen 1 (EBNA1) is a multifunctional, dimeric viral protein associated with Epstein-Barr virus (EBV). It ... 1995). "Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1". Nature. ... Wilson, J.B.; J.L. Bell; A.J. Levine (1996). "Expression of Epstein-Barr virus nuclear antigen-1 induces B cell neoplasia in ... "Adoptive transfer of epstein-barr virus (EBV) nuclear antigen 1-specific t cells as treatment for EBV reactivation and ...
Epstein-Barr virus nuclear antigen 3
The Epstein-Barr virus nuclear antigen 3 (EBNA-3) is a family of viral proteins associated with the Epstein-Barr virus. A ... Knight JS, Sharma N, Robertson ES (2005). "SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen". Mol. Cell ... and genetic comparisons of Epstein-Barr virus nuclear antigen 3A, 3B, and 3C homologues encoded by the rhesus lymphocryptovirus ... Knight JS, Sharma N, Robertson ES (2005). "Epstein-Barr virus latent antigen 3C can mediate the degradation of the ...
FCRL5
2006). "Epstein-Barr virus nuclear antigen 2 induces FcRH5 expression through CBF1". Blood. 107 (11): 4433-9. doi:10.1182/blood ...
EBNA1BP2
Henning D, Valdez BC (2001). "Expression of p40/Epstein-Barr virus nuclear antigen 1 binding protein 2". Biochem. Biophys. Res ... a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance". J ... Kapoor P, Lavoie BD, Frappier L (2005). "EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by ... Kapoor P, Frappier L (2003). "EBNA1 partitions Epstein-Barr virus plasmids in yeast cells by attaching to human EBNA1-binding ...
Proteasome
Zhang M, Coffino P (March 2004). "Repeat sequence of Epstein-Barr virus-encoded nuclear antigen 1 protein interrupts proteasome ... certain Epstein-Barr virus gene products bearing this sequence can stall the proteasome, helping the virus propagate by ... Peptide antigens are displayed by the major histocompatibility complex class I (MHC) proteins on the surface of antigen- ... Cvek B, Dvorak Z (2007). "Targeting of nuclear factor-kappaB and proteasome by dithiocarbamate complexes with metals". Current ...
RALY
I. Immunoglobulin M autoantibodies to proteins mimicking and not mimicking Epstein-Barr virus nuclear antigen-1". J. Clin. ... gene encodes an autoantigen that cross-reacts with EBNA-1 of the Epstein Barr virus and which may be a heterogeneous nuclear ... One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family. GRCh38: Ensembl release ... 1995). "Epstein-Barr virus-induced autoimmune responses. ...
RBPJ
Zhao B, Marshall DR, Sample CE (July 1996). "A conserved domain of the Epstein-Barr virus nuclear antigens 3A and 3C binds to a ... Tong X, Drapkin R, Yalamanchili R, Mosialos G, Kieff E (September 1995). "The Epstein-Barr virus nuclear protein 2 acidic ... April 2000). "Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus". Journal of Virology. 74 (7): 3082- ... Hsieh JJ, Nofziger DE, Weinmaster G, Hayward SD (March 1997). "Epstein-Barr virus immortalization: Notch2 interacts with CBF1 ...
Inflammatory demyelinating diseases of the central nervous system
August 2019). "Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple ... Wekerle H (March 2022). "Epstein-Barr virus sparks brain autoimmunity in multiple sclerosis". Nature. 603 (7900): 230-232. ... June 2016). "Nuclear Receptor NR1H3 in Familial Multiple Sclerosis". Neuron. 90 (5): 948-954. doi:10.1016/j.neuron.2016.04.039 ... a closely related disorder in which a known virus or vaccine triggers autoimmunity against myelin. Around 40% of the ADEM cases ...
HLA-A11
September 1999). "Epstein-Barr virus (EBV) nuclear antigen (EBNA)-4 mutation in EBV-associated malignancies in three different ... "Recognition of the Epstein-Barr virus-encoded nuclear antigens EBNA-4 and EBNA-6 by HLA-A11-restricted cytotoxic T lymphocytes ... April 1994). "T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from ... "Down-regulation of class I HLA antigens and of the Epstein-Barr virus-encoded latent membrane protein in Burkitt lymphoma lines ...
C-C chemokine receptor type 7
"Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2". ... This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects ... Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G, Kieff E (April 1993). "Epstein-Barr virus-induced genes: first lymphocyte- ... "Human B cells immortalized with Epstein-Barr virus upregulate CCR6 and CCR10 and downregulate CXCR4 and CXCR5". Journal of ...
Henrik Zetterberg (neurochemist)
Zetterberg, Henrik (2003). Transcriptional regulation of the Epstein-Barr virus nuclear antigen 1 gene in latent and lytic ... He completed his doctoral thesis in 2003 on the subject of the Epstein-Barr virus. He performed postdoctoral research at ...
Anti-citrullinated protein antibody
Pratesi F, Tommasi C, Anzilotti C, Chimenti D, Migliorini P (March 2006). "Deiminated Epstein-Barr virus nuclear antigen 1 is a ... deiminated Epstein-Barr Virus Nuclear Antigen 1 and vimentin, which is a member of the intermediate filament family of proteins ... Unfortunately, these artificial antigens are not expressed in the affected tissue, and therefore are probably not directly ... If their shapes are significantly altered, the proteins may be seen as antigens by the immune system, thereby generating an ...
SUMO3
Lin J, Johannsen E, Robertson E, Kieff E (January 2002). "Epstein-Barr virus nuclear antigen 3C putative repression domain ... such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002).[supplied by OMIM] ...
Aled Edwards
... and crystallization of the DNA binding and dimerization domains of the Epstein-Barr virus nuclear antigen 1". The Journal of ... "Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein EBNA 1". Cell. 83 (1): 39-46. doi: ... "Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA". Cell. 84 (5 ... "The Drosophila nuclear receptor e75 contains heme and is gas responsive". Cell. 122 (2): 195-207. doi:10.1016/j.cell.2005.07. ...
Episome
"Sequence-specific DNA binding of the Epstein-Barr virus nuclear antigen (EBNA-1) to clustered sites in the plasmid maintenance ... As of 1985, in the case of latent Epstein-Barr virus infection, episomes seemed to be associated with nuclear proteins of the ... Episomes can be observed in nature in certain types of long-term infection by adeno-associated virus or Epstein-Barr virus. In ...
List of MeSH codes (D23)
... htlv-i antigens MeSH D23.050.327.150.510 - htlv-ii antigens MeSH D23.050.327.300 - epstein-barr virus nuclear antigens MeSH ... tissue polypeptide antigen MeSH D23.050.290.249 - epstein-barr virus nuclear antigens MeSH D23.050.290.500 - ki-67 antigen MeSH ... antigens, cd15 MeSH D23.101.100.900.131 - antigens, cd31 MeSH D23.101.100.920 - antigens, ly MeSH D23.101.100.930 - antigens, ... forssman antigen MeSH D23.050.285.018 - antigens, cd24 MeSH D23.050.285.025 - antigens, cd30 MeSH D23.050.285.040 - antigens, ...
Diffuse large B-cell lymphoma associated with chronic inflammation
Epstein-Barr virus nuclear antigen 2 (EBNA-2) (a protein which stimulates infected cells to make >300 gene products some of ... Farrell PJ (2019). "Epstein-Barr Virus and Cancer". Annual Review of Pathology. 14: 29-53. doi:10.1146/annurev-pathmechdis- ... Draborg A, Izarzugaza JM, Houen G (July 2016). "How compelling are the data for Epstein-Barr virus being a trigger for systemic ... Li ZX, Zeng S, Wu HX, Zhou Y (February 2019). "The risk of systemic lupus erythematosus associated with Epstein-Barr virus ...
EP300
Subramanian C, Hasan S, Rowe M, Hottiger M, Orre R, Robertson ES (May 2002). "Epstein-Barr virus nuclear antigen 3C and ... Ban N, Yamada Y, Someya Y, Miyawaki K, Ihara Y, Hosokawa M, Toyokuni S, Tsuda K, Seino Y (May 2002). "Hepatocyte nuclear factor ... Eid JE, Kung AL, Scully R, Livingston DM (September 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of ... Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (May 1999). "Identification of nuclear receptor corepressor as a ...
Proline-rich 12
... a nuclear antigen of the virus). This Epstein-Barr virus antigen is associated with autoimmune systemic connective tissue ... "Elevated immunoglobulin G antibodies to the proline-rich amino-terminal region of Epstein-Barr virus nuclear antigen-2 in sera ... QSER1 does not contain the AT binding regions or Epstein-Barr virus antigen that is found in PRR12. The most distant relative ... One study on the Epstein-Barr virus found close homology between a proline rich region in PRR12 and a 65 amino acid long region ...
Transfection
Cell lines expressing the Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) or the SV40 large-T antigen allow episomal ... Viruses used to date include retrovirus, lentivirus, adenovirus, adeno-associated virus, and herpes simplex virus.[citation ... DNA can also be introduced into cells using viruses as a carrier. In such cases, the technique is called transduction, and the ... Since the DNA introduced in the transfection process is usually not integrated into the nuclear genome, the foreign DNA will be ...
Nasopharyngeal carcinoma
The detection of nuclear antigen associated with Epstein-Barr virus (EBNA) and viral DNA in NPC type 2 and 3, has revealed that ... The viral influence is associated with infection with Epstein-Barr virus (EBV). The Epstein-Barr virus is one of the most ... Barr virus (EBV), unknown factors that result in rare familial clusters, and heavy alcohol consumption. Epstein- Barr virus ... Very rarely does Epstein-Barr virus lead to cancer, which suggests a variety of influencing factors. Other likely causes ...
Epstein-Barr virus latent membrane protein 2
Epstein-Barr nuclear antigen-2 responsiveness, and the ability to make LMP2B transcripts are conserved. This implies that an ... Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein-Barr virus. LMP2A/LMP2B are ... Epstein-Barr virus (EBV) establishes a lifelong latent infection in B lymphocytes. Viral LMP2A mRNA is frequently detected in ... Lynch, D.T.; Zimmerman, J.S.; Rowe, D.T. (2002). "Epstein-Barr virus latent membrane protein 2B (LMP2B) co-localizes with LMP2A ...
Interferon
... and EBV nuclear antigen 2 (EBNA-2) from Epstein-Barr virus, the large T antigen of Polyomavirus, the E7 protein of Human ... Viruses that inhibit IFN signaling include Japanese Encephalitis Virus (JEV), dengue type 2 virus (DEN-2), and viruses of the ... Some viruses escape the anti-viral activities of interferons by gene (and thus protein) mutation. The H5N1 influenza virus, ... Viral proteins proven to affect IFN signaling include EBV nuclear antigen 1 (EBNA1) ...
LANA
June 1998). "Restricted expression of Epstein-Barr virus (EBV)-encoded, growth transformation-associated antigens in an EBV- ... The latency-associated nuclear antigen (LANA-1) or latent nuclear antigen (LNA, LNA-1) is a Kaposi's sarcoma-associated ... "Human herpesvirus 8 LANA interacts with proteins of the mSin3 corepressor complex and negatively regulates Epstein-Barr virus ... Kellam P, Boshoff C, Whitby D, Matthews S, Weiss RA, Talbot SJ (1997). "Identification of a major latent nuclear antigen, LNA-1 ...
Gammaherpesvirinae
Gammaherpesviruses are of primary interest due to the two human viruses, EBV (Epstein-Barr virus) and KSHV (Kaposi's sarcoma- ... The episomal maintenance protein for MHV68 is a latency-associated nuclear antigen (mLANA; ORF73). M2 protein mediates ... The main stages in the lifecycle of Gamma herpes virus are namely • Virus attachment and entry • Viral DNA injection through ... "Virus Taxonomy: 2020 Release". International Committee on Taxonomy of Viruses (ICTV). March 2021. Retrieved 10 May 2021. ...
Transient expression
... such as SV40 virus or Epstein-Barr virus (EBV), which are notable for their high retention of plasmid DNA in an episomal state ... and the EBV-derived nuclear antigen-1 (EBNA-1) protein to its associated origin of replication (oriP). Typical historical ... These later sublines were consequently identified to have two interacting components: the SV40 large T-antigen binding to the ... However, mammalian cell systems' slow growth, precise growth requirements, and potential risk of infection by animal viruses ...
Hepatitis
Other viruses can also cause liver inflammation, including cytomegalovirus, Epstein-Barr virus, and yellow fever virus. Other ... In the case of hepatitis B, blood tests exist for multiple virus antigens (which are different components of the virion ... Auto-antibodies found in patients with autoimmune hepatitis include the sensitive but less specific anti-nuclear antibody (ANA ... or by viruses (such as hepatitis A, Epstein-Barr virus, or measles). Autoimmune hepatitis can present anywhere within the ...
Castleman disease
Epstein-Barr virus, human immunodeficiency virus, tuberculosis Autoimmune diseases: Systemic lupus erythematosus, rheumatoid ... Staining with latency-associated nuclear antigen (LANA-1), a marker for HHV-8 infection, should be measured in all forms of ...