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*  Cryptic self epitopes
In immunology, cryptic self epitopes are a source of autoimmunity. Self epitopes, which are found in high concentration on the ... However, self epitopes which appear in very low concentration on APC are termed cryptic in the sense that they do not delete ... Lanzavecchia, A (1995). "How can cryptic epitopes trigger autoimmunity?" (PDF). J. Exp. Med. 181: 1945-8. doi:10.1084/jem.181.6 ... are known as dominant epitopes. These are stimulants of negative selection mechanisms to remove potentially self destructing ...
*  Epitope
The epitopes of protein antigens are divided into two categories, conformational epitopes and linear epitopes, based on their ... A database of B-cell epitopes SYFPEITHI - First online database of T cell epitopes IEDB - Database of T and B cell epitopes ... A linear epitope is formed by a continuous sequence of amino acids from the antigen. T cell epitopes are presented on the ... The proportion of epitopes that are conformational is unknown.[citation needed] By contrast, linear epitopes interact with the ...
*  Epitope mapping
Linear epitopes are formed by a continuous sequence of amino acids in a protein, while conformational epitopes are composed of ... Epitope mapping is the process of experimentally identifying the binding sites, or 'epitopes', of antibodies on their target ... Epitope mapping is also crucial to developing vaccines against prevalent viral diseases such as Dengue virus. Epitope mapping ... "Epitope Mapping". www.covalx.com/epitope2. Retrieved 2017-02-23. Epitope mapping at the US National Library of Medicine Medical ...
*  Linear epitope
A linear or a sequential epitope is an epitope that is recognized by antibodies by its linear sequence of amino acids, or ... Such segments are called epitopes. Likewise, it is only paratope of the antibody that comes in contact with the epitope. ... Therefore, antibodies that recognize linear epitopes instead of conformational epitopes are chosen for immunodetection. In ... antibodies are preferred that recognize conformational epitopes. Conformational epitope Polyclonal B cell response Goldsby, ...
*  Conformational epitope
These are known as linear epitopes. Antigen Linear epitope Epitope mapping, finding (on an antigen protein) the epitope(s) for ... Such segments are called epitopes. Likewise, it is only paratope of the receptor that comes in contact with the epitope. ... A conformational epitope is a sequence of sub-units (usually amino acids) composing an antigen that come in direct contact with ... a new method to predict conformational epitopes using phage display peptide sequences. ...
*  Epitope binning
... is referenced in the literature under different names such as epitope mapping and epitope characterization. ... Epitope Binning is used in the discovery and development of new therapeutics, vaccines, and diagnostics. Autoimmunity Epitope ... Epitope binning is a competitive immunoassay used to characterize and then sort a library of monoclonal antibodies against a ... Closely related binning profiles indicate that the antibodies have the same or a closely related epitope and are "binned" ...
*  Immune Epitope Database and Analysis Resource
... which contains a collection of tools to predict and analyze epitopes. Immune Epitope Database IEDB Analysis Resource La Jolla ... The Immune Epitope Database and Analysis Resource (IEDB) is a project hosted by scientists at the La Jolla Institute for ... In addition, epitopes from other infectious agents, allergens and autoantigens are being curated. The database also contains ... The IEDB contains data related to antibody and T cell epitopes for humans, non-human primates, rodents, and other animal ...
*  Antigen-presenting cell
In MHC class I and class II molecules, only certain epitopes of an internalized peptide can be presented. These epitopes are ... The internalized antigen is digested into smaller peptides containing epitopes, which are then presented to T cells by the MHC ...
*  Immunofluorescence
The specific region an antibody recognizes on an antigen is called an epitope. There have been efforts in epitope mapping since ... If the topology of a cell membrane has yet to be determined, epitope insertion into proteins can be used in conjunction with ... The primary antibody recognizes the target molecule (antigen) and binds to a specific region called the epitope. The attached ... Ladner, Robert C. (2007-01-01). "Mapping the Epitopes of Antibodies". Biotechnology and Genetic Engineering Reviews. 24 (1): 1- ...
*  HLA-A9
Fussell H, Thomas M, Street J, Darke C (1996). "HLA-A9 antibodies and epitopes". Tissue Antigens. 47 (4): 307-12. doi:10.1111/j ...
*  Cross-reactive carbohydrate determinants
However, IgE antibodies against the α-Gal epitope should be taken into account in the diagnosis of milk and meat allergy. It is ... Much later, both xylose and core α1,3-fucose were revealed as heart pieces of two independent glycan epitopes for rabbit IgG. ... Still, because of the two possible epitopes and the different carrier structures, the plural CCDs is in frequent use even ... 1993). "Fucose alpha 1,3-linked to the core region of glycoprotein N-glycans creates an important epitope for IgE from honeybee ...
*  HLA-B49
Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563-8. PMID 1385528. Marsh SG, Albert ED, Bodmer WF, et al. ( ...
*  Systemic lupus erythematosus
Antibody binding subsequently spread to other epitopes. The similarity and cross-reactivity between the initial targets of nRNP ... and Sm autoantibodies identifies a likely commonality in cause and a focal point for intermolecular epitope spreading. Elevated ...
*  Immunodominance
Epitopes that are not targeted or targeted to a lower degree during an immune response are known as subdominant epitopes. The ... The immunodominant epitope will be a BCR that has a particular 'goldilocks' amount of affinity for its epitope determined by ... If subdominant epitopes are introduced without the dominant epitope, the immune response will be focused to that subdominant ... Meanwhile, if the dominant epitope is introduced with the subdominant epitope, the immune response will be directed against the ...
*  Computational immunology
PMC 4682376 . Sun J, Kudahl UJ, Simon C, Cao Z, Reinherz EL, Brusic V (2014). "Large-Scale Analysis of B-Cell Epitopes on ... There are also tools which are used for T and B cell epitope mapping, proteasomal cleavage site prediction, and TAP- peptide ... Saha S, Bhasin M, Raghava GP (2005). "Bcipep: a database of B-cell epitopes". BMC Genomics. 6 (1): 79. doi:10.1186/1471-2164-6- ... The immune epitope database and analysis resource. Pattern Recognition in Bioinformatics, Proceedings 4146, 126-132 (2006). ...
*  Immune system
The simplest approach is to rapidly change non-essential epitopes (amino acids and/or sugars) on the surface of the pathogen, ... Saha S, Bhasin M, Raghava GP (2005). "Bcipep: a database of B-cell epitopes". BMC Genomics. 6: 79. doi:10.1186/1471-2164-6-79. ... A publicly accessible database has been established for the cataloguing of epitopes from pathogens known to be recognizable by ... Söllner J, Mayer B (2006). "Machine learning approaches for prediction of linear B-cell epitopes on proteins". Journal of ...
*  Charles DeLisi
The use of bioinformatics for identifying class I restricted T cell epitopes. Methods (Epitope Mapping Issue). Bill Kwok, ...
*  HLA-DR1
DRB1*0101 and most DR4 have in common a 'shared epitope'. In this hypothesis a common region of the beta chain, positions 67 to ... Morel PA, Erlich HA, Fathman CG (1988). "A new look at the shared epitope hypothesis". Am. J. Med. 85 (6A): 20-22. doi:10.1016/ ... Gorman JD, David-Vaudey E, Pai M, Lum RF, Criswell LA (2004). "Particular HLA-DRB1 shared epitope genotypes are strongly ... 2007). "Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of ...
*  La Jolla Institute for Allergy and Immunology
"Immune Epitope Database (IEDB)". Immuneepitope.org. 2012-10-08. Retrieved 2012-10-13. "La Jolla Institute for Allergy & ... The database interface is designed to be intuitive and easily searched and to propel the dissemination of immune epitope ... the Immune Epitope Database and Analysis Resource (IEDB). The IEDB is groundbreaking because it contains antibody and T cell ... epitope data curated from scientific literature, presented collectively to facilitate basic research. ...
*  HLA-DRB1
Several alleles of DRB1 (shared epitope alleles) are associated with an increased incidence of rheumatoid arthritis. The ... "The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis". ...
*  Major urinary proteins
2000). "Crystal structure of the allergen Equ c 1. A dimeric lipocalin with restricted IgE-reactive epitopes". The Journal of ...
*  Proteus penneri
Certain LPS epitopes have been examined to determine their function in antigenic specificity. The particular groups on the ... Determination of some LPS epitopes responsible for specificity". Adv Exp Med Biol. 485: 339-44. doi:10.1007/0-306-46840-9_47. ... Palusiak A, Sidorczyk Z (2010). "Characterization of epitope specificity of Proteus penneri 7 lipopolysaccharide core region". ... Progress in serological classification of further strains from genus Proteus and determination of epitopes and new serogroups. ...
*  Vasant Honavar
El-Manzalawy, Y., Dobbs, D., and Honavar, V. (2017). In silico prediction of linear B-cell epitopes on proteins. In: Y. Zhou, E ... Y. and Honavar, V. (2014). Building Classifier Ensembles for B-Cell Epitope Prediction. In: De, R.K. and Tomar, N. (Ed). ... El-Manzalawy, Y. and Honavar, V. (2010). Recent Advances in B-Cell Epitope Prediction Methods. Immunome Research Suppl. 2:S2. ... El-Manzalawy, Y., Dobbs, D., and Honavar, V. (2008). Predicting linear B-cell epitopes using string kernels. Journal of ...
*  Odotope theory
The word itself is an analogy to epitopes. Shape theory of olfaction Vibration theory of olfaction "The scent of life. The ...
*  Ovomucoid
At least four IgE epitopes have been identified. Three other egg white proteins are also identified as allergenic: ovalbumin ( ... "Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy". ...