Loading...
*  Epithelial-mesenchymal transition
The epithelial-mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell-cell ... mesenchymal-epithelial transition. Amphioxus forms an epithelial neural tube and dorsal notochord but does not have the EMT ... "Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune- ... "Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ...
*  Mesenchymal-epithelial transition
Epithelial-mesenchymal transition Baum B, Settleman J, Quinlan MP (2008). "Transitions between epithelial and mesenchymal ... A mesenchymal-epithelial transition (MET) is a reversible biological process that involves the transition from motile, ... MET is the reverse process of epithelial-mesenchymal transition (EMT). Unlike epithelial cells - which are stationary and ... 2002). "Epithelial-mesenchymal transitions in tumour progression". Nat Rev Cancer. 2 (6): 442-54. doi:10.1038/nrc822. PMID ...
*  Basigin
... epithelial-mesenchymal transition suppressor complex that if disrupted results in the induction of invasive prostate epithelial ... Epithelial-mesenchymal transition". Rodriguez-Teja M, Gronau JH, Minamidate A, Darby S, Gaughan L, Robson C, Mauri F, Waxman J ... It is expressed by many cell types, including epithelial cells, endothelial cells and leukocytes. The human basigin protein ...
*  Bone morphogenetic protein 7
"BMP-7 fails to attenuate TGF-beta1-induced epithelial-to-mesenchymal transition in human proximal tubule epithelial cells". ... Kalluri R, Weinberg RA (2009). "The basics of epithelial-mesenchymal transition". J. Clin. Invest. 119 (6): 1420-8. doi:10.1172 ... Kalluri R, Neilson EG (2003). "Epithelial-mesenchymal transition and its implications for fibrosis". J. Clin. Invest. 112 (12 ... The epithelial-menenchymal transition is also problematic in cancer metastasis, so the diminution of EMT with recombinant DNA ...
*  Mesenchyme
... and can be followed with a mesenchymal-epithelial transition to produce secondary epithelial tissues. Embryological mesenchymal ... Neural mesenchyme soon undergoes a mesenchymal-epithelial transition under the influence of WNT6 produced by ectoderm to form ... Eger, A; Stockinger, A; Schaffhauser, B; Beug, H; Foisner, R (2000). "Epithelial mesenchymal transition by c-Fos estrogen ... The first emergence of mesenchyme occurs during gastrulation from the epithelial-mesenchymal transition process. This ...
*  Cancer stem cell
In epithelial tumors, the epithelial-mesenchymal transition (EMT) is considered to be a crucial event. EMT and the reverse ... Polyak K, Weinberg RA (April 2009). "Transitions between epithelial and mesenchymal states: acquisition of malignant and stem ... Thiery, JP (June 2002). "Epithelial-mesenchymal transitions in tumour progression". Nature Reviews Cancer. 2 (6): 442-54. doi: ... transition from mesenchymal to an epithelial phenotype (MET) are involved in embryonic development, which involves disruption ...
*  Keratin 5
The expression of K5 is linked to the intermediate phenotype of cells undergoing the epithelial-mesenchymal transition (EMT). ... "The epithelial-mesenchymal transition (EMT) phenomenon". Annals of Oncology. 21 Suppl 7: vii89-vii92. doi:10.1093/annonc/mdq292 ... Rosenberg M, Fuchs E, Le Beau MM, Eddy RL, Shows TB (1991). "Three epidermal and one simple epithelial type II keratin genes ... It dimerizes with keratin 14 and forms the intermediate filaments (IF) that make up the cytoskeleton of basal epithelial cells ...
*  Blastocyst
Vićovac, L; Aplin, JD (1996). "Epithelial-mesenchymal transition during trophoblast differentiation". Acta Anatomica. 156 (3): ...
*  SNAI2
Kalluri R, Weinberg RA (June 2009). "The basics of epithelial-mesenchymal transition". The Journal of Clinical Investigation. ... This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. It regulates differentiation and ... an initial and necessary step for growth factor-induced epithelial-mesenchymal transition". The Journal of Cell Biology. 137 (6 ... SNAI2 induces tightly bound epithelial cells to break into a loose mesenchymal phenotype, allowing gastrulation of mesoderm in ...
*  Paracrine signalling
This epithelial to mesenchymal transition is highly evident in metastasis. Paracrine signaling through the Jak-STAT pathway is ... Kalluri, Raghu; Weinberg, Robert A. (2009). "The basics of epithelial-mesenchymal transition". Journal of Clinical ... necessary in the transition from stationary epithelial cells to mobile mesenchymal cells, which are capable of invading ... Ultimately, it increases the production of extracellular matrix by epithelial cells. TGF-β proteins regulate epithelia by ...
*  Ontogeny
"Epithelial-mesenchymal transitions in development and pathologies". Current Opinion in Cell Biology. 15 (6): 740-746. doi: ...
*  Collective cell migration
Thiery, JP; Acloque, H; Huang, RY; Nieto, MA (25 November 2009). "Epithelial-mesenchymal transitions in development and disease ... cancer cells also undergo epithelial to mesenchymal transition (EMT), that reduces cell-cell adhesions and allows cancer ... epithelial cells) or have transient cell-cell adhesion sites (e.g. mesenchymal cells). They can also migrate in different modes ...
*  Transforming growth factor, beta 3
"Epithelial-mesenchymal transition and its implications for fibrosis". The Journal of Clinical Investigation. 112 (12): 1776-84 ... "Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction ... "Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction ... This is caused by failure of epithelial cells in both sides of the developing palate to fuse. TGF-β3 also plays an essential ...
*  S100A4
Kalluri R, Neilson EG (2003). "Epithelial-mesenchymal transition and its implications for fibrosis". J. Clin. Invest. 112 (12 ...
*  Hepatocyte growth factor
Epidermal growth factor Insulin-like growth factor 1 Epithelial-mesenchymal transition Madin-Darby Canine Kidney Cells GRCh38: ... Kalluri R, Neilson EG (December 2003). "Epithelial-mesenchymal transition and its implications for fibrosis". The Journal of ... It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts ... Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial ...
*  TGF beta 2
Kalluri R, Neilson EG (2004). "Epithelial-mesenchymal transition and its implications for fibrosis". J. Clin. Invest. 112 (12 ...
*  Beta-catenin
Kalluri R, Neilson EG (December 2003). "Epithelial-mesenchymal transition and its implications for fibrosis". The Journal of ... Together with TGF-β, an important role of β-catenin is to induce a morphogenic change in epithelial cells. It induces them to ... During this process, epithelial cells lose expression of proteins like E-cadherin, Zonula occludens 1 (ZO1), and cytokeratin. ... These cell-cell adhesion complexes are necessary for the creation and maintenance of epithelial cell layers and barriers. As a ...
*  Intravasation
Epithelial-mesenchymal transition (EMT) has been hypothesized to be an absolute requirement for tumor invasion and metastasis. ... Tsuji, Takanori; Soichiro Ibaragi; Guo-Fu Hu (15 September 2009). "Epithelial-Mesenchymal Transition and Cell Cooperativity in ...
*  NEDD9
Guo W, Ren D, Chen X, Tu X, Huang S, Wang M, Song L, Zou X, Peng X (2013). "HEF1 promotes epithelial mesenchymal transition and ... TGF-beta is a regulator of tissue remodeling and epithelial-mesenchymal transition (EMT) in development, and promotes ... "NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer". PLoS ONE ... "NEDD9 crucially regulates TGF-β-triggered epithelial-mesenchymal transition and cell invasion in prostate cancer cells: ...
*  C-Met
... a mesenchymal phenotype. This process is referred to as epithelial-mesenchymal transition (EMT). Later in embryonic development ... MET is normally expressed by cells of epithelial origin, while expression of HGF/SF is restricted to cells of mesenchymal ... two-layer germinal disc into a three-dimensional body depends on transition of some cells from an epithelial phenotype to ... in a developmental stage in which the epithelial to mesenchymal transformation (EMT) of the endocardial cushion occurs. However ...
*  Twist transcription factor
Wu KJ, Yang MH (Dec 2011). "Epithelial-mesenchymal transition and cancer stemness: the Twist1-Bmi1 connection". Bioscience ... a natural product downregulates TWIST1 transcription factor to reduce epithelial to mesenchymal transition, and thus inhibits ... "Thymoquinone inhibits cancer metastasis by downregulating TWIST1 expression to reduce epithelial to mesenchymal transition". ... of hepatocellular carcinoma metastasis through matrix metalloproteinase activation by epithelial-mesenchymal transition ...
*  Mir-542 microRNA precursor family
"Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma". The Journal of Pathology. 223 (1 ...
*  Morula
Rise and fall of epithelial phenotype: concepts of epithelial-mesenchymal transition. Springer. p. 16. ISBN 978-0-306-48239-7. ... 1997). "Morphogenesis of epithelial cells". In Paul, Leendert C. & Issekutz, Thomas B. Adhesion molecules in health and disease ... 2005). "Epithelium-Mesenchyme Transitions are Crucial Morphogenetic Events Occurring During Early Development". In Savagner, ...
*  Mir-200
"The miR-200 family inhibits epithelial-mesenchymal transition (EMT) and promotes mesenchymal-epithelial transition (MET) by ... May 2008). "The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1". Nat. Cell ... Mongroo PS, Rustgi AK (2010). "The role of the miR-200 family in epithelial-mesenchymal transition". Cancer Biol Ther. 10 (3): ... Korpal M, Kang Y (2008). "The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer ...
*  Migration inducting gene 7
It also promotes epithelial-mesenchymal transition (EMT), a key developmental program that is often activated during, and ... "The epithelial-mesenchymal transition generates cells with properties of stem cells". Cell. 133 (4): 704-15. doi:10.1016/j.cell ... It is not produced by cells of normal human tissues or by cells from patients with inflammation but is expressed by epithelial ... Mig-7 expression is found on, as well as in, epithelial tumor cells at the primary site, secondary (metastatic) sites, and ...
*  Signet ring cell carcinoma
Once those cells lose E-cadherin, their motility increases due to an epithelial-mesenchymal transition. Somatic mutations of ... It is an epithelial malignancy characterized by the histologic appearance of signet ring cells. Primary SRCC tumors are most ...