The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor ... The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members ... "Signalling by the type 1 insulin-like growth factor receptor: interplay with the epidermal growth factor receptor". Growth ... "Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor". Biochemistry. ...

... epidermal growth factor receptor, cathepsin-D, and p53 in saliva among women with breast carcinoma". Cancer Invest. 18 (2): 101 ... Streckfus C, Bigler L, Dellinger T, Dai X, Kingman A, Thigpen JT (June 2000). "The presence of soluble c-erbB-2 in saliva and ... Streckfus C, Bigler L, Tucci M, Thigpen JT (2000). "A preliminary study of CA15-3, c-erbB-2, ... 22 (2): 136-40. doi:10.1016/j.niox.2009.10.007. PMID 19887114. Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, ...

... a Mechanism of action is inhibition of receptor dimerization and receptor trans-autophosphorylation induced by epidermal growth ... PCI blocks the formation and activation of ErbB1/ErbB-2 (EGFR and HER2) heterodimers that have a prominent role in carcinoma ... is an epidermal growth factor antagonist that inhibits tumor cell growth". J. Biol. Chem. 273 (20): 12370-7. doi:10.1074/jbc. ... a Sun PD, Davies DR (1995). "The cystine-knot growth-factor superfamily". Annu Rev Biophys Biomol Struct. 24: 269-91. doi: ...

... epidermal growth factor receptor - epidiorite - epigenetics - epinephrine - equine gonadotropin - erbA gene - erbB gene - erbB- ... transforming growth factor alpha - transforming growth factor beta - transforming growth factor beta receptor - transient ... fc receptor - feedback inhibition - fermentation - fetal protein - fibroblast growth factor - fibroblast growth factor receptor ... nerve growth factor - nerve growth factor receptor - nerve tissue protein - nerve tissue protein S 100 - nervous system - ...

... is a member of the human epidermal growth factor receptor (HER/EGFR/ERBB) family. But contrary to other members of the ... HER2 is so named because it has a similar structure to human epidermal growth factor receptor, or HER1. Neu is so named because ... 2018). "Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of ... The human protein is also frequently referred to as HER2 (human epidermal growth factor receptor 2) or CD340 (cluster of ...

... receptor, epidermal growth factor MeSH D12.776.543.750.060.374 - receptor, erbb-2 MeSH D12.776.543.750.060.437 - receptor, erbb ... receptor, epidermal growth factor MeSH D12.776.543.750.750.400.350 - receptor, erbb-2 MeSH D12.776.543.750.750.400.360 - ... receptor, erbb-3 MeSH D12.776.543.750.750.400.370 - receptors, fibroblast growth factor MeSH D12.776.543.750.750.400.370.500 - ... receptor, cholecystokinin b MeSH D12.776.543.750.750.360.300 - receptor, epidermal growth factor MeSH D12.776.543.750.750.360. ...

Receptor tyrosine-protein kinase erbB-4 is a receptor tyrosine kinase that is a member of the epidermal growth factor receptor ... binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ... a fourth member of the epidermal growth factor receptor family". Proceedings of the National Academy of Sciences of the United ... a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase". Oncogene. 18 (17): 2681-9. doi:10.1038/sj.onc. ...

Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound ... Epidermal growth factor receptor family Epidermal growth factor receptor Receptor tyrosine-kinases GRCh38: Ensembl release 89: ... ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ... "Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/ ...

... has been shown to interact with epidermal growth factor receptors. Recombinant human epidermal growth ... "Role of the N-terminus of epidermal growth factor in ErbB-2/ErbB-3 binding studied by phage display". Biochemistry. 41 (27): ... Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. ... Dreux AC, Lamb DJ, Modjtahedi H, Ferns GA (May 2006). "The epidermal growth factor receptors and their family of ligands: their ...

Hackel PO, Gishizky M, Ullrich A (December 2001). "Mig-6 is a negative regulator of the epidermal growth factor receptor signal ... ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene. MIG6 is a Cytoplasmic protein ... Xu D, Makkinje A, Kyriakis JM (January 2005). "Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor ... "Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like ...

Salomon DS, Brandt R, Ciardiello F, Normanno N (July 1995). "Epidermal growth factor-related peptides and their receptors in ... Recent insights into the activation of EGF/ErbB receptors". Mol. Cell. 12 (3): 541-52. doi:10.1016/S1097-2765(03)00350-2. PMID ... Over-expression or constitutive activation of epidermal growth factor receptor (EGFR) can promote tumor processes. EGF-induced ... "Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation". J. Biol ...

EPH receptor A2, ETV6, Epidermal growth factor receptor, Erythropoietin receptor, FRS2, Fas ligand, GAB1, GAB2, Glycoprotein ... Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Molecular Systems Biology ... The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and ... Grb2 is best known for its ability to link the epidermal growth factor receptor tyrosine kinase to the activation of Ras and ...

The ErbB protein family consists of 4 members ErbB-1, also named epidermal growth factor receptor (EGFR) ErbB-2, also named ... The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor ... There are 11 growth factors that activate ErbB receptors. The ability ('+') or inability ('-') of each growth factor to ... 2002). "Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth ...

"Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis". Cell Growth ... "Expression of the transforming growth factor-alpha/epidermal growth factor receptor pathway in normal human breast epithelial ... epidermal growth factor (EGF), IGF-1, and fibroblast growth factor (FGF), which in turn have specific roles in breast growth ... Based on research with epidermal growth factor receptor (EGFR) knockout mice, the EGFR, which is the molecular target of EGF, ...

Irreversible inhibitors of the epidermal growth factor receptor: 4-(phenylamino)quinazoline- and 4-(phenylamino)pyrido3,2- ... and ErbB-4 (IC50 7 nM). By 2015, Pfizer had discontinued development of the drug. Canertinib has been reported as a substrate ... It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) ...

Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, ... 1998). "A novel brain-derived member of the epidermal growth factor family that interacts with ErbB3 and ErbB4". J. Biochem. ... 1997). "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. Bibcode:1997Natur. ... "Ligands for ErbB-family receptors encoded by a neuregulin-like gene". Nature. 387 (6632): 509-12. Bibcode:1997Natur.387R.509C. ...

... is a part of an Epidermal Growth Factor (EGF) family and functions as a ligand for the epidermal growth factor receptor (EGFR ... July 2004). "Changes in the expression and cytological localization of betacellulin and its receptors (ErbB-1 and ErbB-4) in ... The membrane-anchored form of the betacellulin can activate the epidermal growth factor receptor (EGFR). Betacellulin ... September 2004). "Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by ...

In general, they bind to and activate the erbB family of receptor tyrosine kinases (erbB2 (HER2), erbB3 (HER3), and erbB4 (HER4 ... August 1994). "Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4". EMBO ... Included in the family are heregulin; neu differentiation factor; acetylcholine receptor synthesis stimulator; glial growth ... or acetylcholine receptor inducing activity (ARIA) Type II NRG1; alternative name: Glial Growth Factor-2 (GGF2); Type III NRG1 ...

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor ... RTK class I (EGF receptor family) (ErbB family) RTK class II (Insulin receptor family) RTK class III (PDGF receptor family) RTK ... has shown to dephosphorylate the epidermal growth factor receptor and the insulin receptor. Some PTPs, on the other hand, are ... NGF receptor family) RTK class VIII (HGF receptor family) RTK class IX (Eph receptor family) RTK class X (AXL receptor family) ...

The HER (human epidermal growth factor receptor) protein, binds to human epidermal growth factor, and stimulates cell ... an erb-B-related gene encoding a 185,000-Mr tumour antigen". Nature. 312 (5994): 513-516. Bibcode:1984Natur.312..513S. doi: ... The EGF pathway includes the receptors HER1 (EGFR), HER2, HER3, and HER4; the binding of ligands (e.g. EGF etc.) to HER ... It is specifically used for cancer that is HER2 receptor positive. It may be used by itself or together with other chemotherapy ...

Epidermal growth factor receptor, Erk FRS2, GAB1, GAB2, GAB3, Glycoprotein 130, Grb2, Growth hormone receptor, HoxA10, Insulin ... Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 (1): E1 ... "Association of SH2 domain protein tyrosine phosphatases with the epidermal growth factor receptor in human tumor cells. ... Wong L, Johnson GR (August 1996). "Epidermal growth factor induces coupling of protein-tyrosine phosphatase 1D to GRB2 via the ...

CRK (gene) has been shown to interact with: BCAR1, Cbl gene, Dock180, EPS15, Epidermal growth factor receptor, Grb2, IRS4, ... 9614078 Schulze WX, Deng L, Mann M (2005). "Phosphotyrosine interactome of the ErbB-receptor kinase family". Mol. Syst. Biol. 1 ... Karas M, Koval AP, Zick Y, LeRoith D (2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor ... "Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor". J. Biol. Chem. 273 (27): 17186- ...

... receptor, epidermal growth factor MeSH D08.811.913.696.620.682.725.400.150 - receptor, erbb-2 MeSH D08.811.913.696.620.682. ... receptor, fibroblast growth factor, type 1 MeSH D08.811.913.696.620.682.725.400.037 - receptor, fibroblast growth factor, type ... receptor, fibroblast growth factor, type 3 MeSH D08.811.913.696.620.682.725.400.046 - receptor, fibroblast growth factor, type ... receptor, platelet-derived growth factor alpha MeSH D08.811.913.696.620.682.725.400.900.750 - receptor, platelet-derived growth ...

The EGFR is receptor tyrosine kinase which binds multiple growth factors including EGF (epidermal growth factor) and other ... Leahy DJ (April 2008). "A molecular view of anti-ErbB monoclonal antibody therapy". Cancer Cell. 13 (4): 291-3. doi:10.1016/j. ... July 1987). "Tumor growth modulation by a monoclonal antibody to the epidermal growth factor receptor: immunologically mediated ... Matuzumab binds to epidermal growth factor receptor (EGFR) on the outer membrane of normal and tumor cells. The matuzumab ...

It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways. It ... Burris HA (2004). "Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor ... Lapatinib inhibits the tyrosine kinase activity associated with two oncogenes, EGFR (epidermal growth factor receptor) and HER2 ... September 2004). "A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among ...

This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ... "Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3". The Journal ... "Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma". Cancer ... "High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains". ...

Epidermal growth factor receptor, Fanconi anemia, complementation group C, GNB2L1, IFNAR2, IRF1, ISGF3G Interleukin 27 receptor ... Olayioye MA, Beuvink I, Horsch K, Daly JM, Hynes NE (June 1999). "ErbB receptor-induced activation of stat transcription ... "Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for ... Epidermal Growth Factor (EGF), Platelet Derived Growth Factor (PDGF), Interleukin 6 (IL-6), or IL-27. Type I interferons (IFN-α ...

... proximity ligation analyses of protein interactions and post-translational modification of the epidermal growth factor receptor ... "HER-3 targeting alters the dimerization pattern of ErbB protein family members in breast carcinomas". Oncotarget. 7 (5): 5576- ... The two proteins of interest are a B cell receptor and MYD88. The finding of interaction in the cytoplasm was interesting ... because B cell receptors are thought of as being located in the cell membrane. PLA as described above has been used to study ...

September 2001). "The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src ... Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, Hirohashi S (March 1995). "c-erbB-2 gene product directly ... Hazan RB, Norton L (April 1998). "The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin ... "Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate ...

High expression of epidermal growth factor receptor (EGFR) correlates with unfavorable outcome. Over-expression of kinetochore ... 2002). "ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for ... "Identification of gains on 1q and epidermal growth factor receptor overexpression as independent prognostic markers in ... KIT receptor tyrosine kinase and phospho-KIT were found to be present in pediatric ependymomas and may be involved in ...