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*  Protein precursor
Enzyme precursors are called zymogens or proenzymes. Examples are enzymes of the digestive tract in humans. Some protein ... A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an ... Protein precursors are often used by an organism when the subsequent protein is potentially harmful, but needs to be available ... The name of the precursor for a protein is often prefixed by pro-. Examples include proinsulin and proopiomelanocortin, which ...
*  Glucansucrase
... proteins likely evolved from an amylase enzyme precursor. The two enzymes have similar folding patterns and ... For example, both enzymes have three domains in their catalytic core and a (β/α)8 barrel. Glucansucrase has 5 major domains: A ... Bacteria with glucansucrase enzymes are used extensively in industry for a variety of applications. The polymer dextran is one ... Glucansucrase enzymes can synthesize a variety of glucans with differing solubilities, rheology, and other properties by ...
*  Acute pancreatitis
This occurs through inappropriate activation of inactive enzyme precursors called zymogens (or proenzymes) inside the pancreas ... 16 mmol/L E - Enzymes: LDH >600iu/L; AST >200iu/L A - Albumin 10 mmol/L Predicts mortality risk in pancreatitis with fewer ... As the pancreas is stimulated to secrete enzymes by the presence of food in the stomach, having no food pass through the system ... The activation of these digestive enzymes lead to inflammation, edema, vascular injury, and even cellular death. The death of ...
*  ADP-ribosylation
bAREs are produced as enzyme precursors, consisting of a "A" and "B" domains: the "A" domain is responsible for ADP- ... The first mammalian enzyme with poly-ADP-ribose transferase activity was discovered during the late 1980s. For the next 15 ... However, as more enzymes with the ability to ADP-ribosylate proteins were discovered, the multifunctional nature of ADP- ... For over a decade it was thought that PARP1 was the only poly-ADP-ribose polymerase in mammalian cells, therefore this enzyme ...
*  Moses Kunitz
... successfully crystallizing a number of enzymes and enzyme precursor proteins, particularly proteases. Kunitz worked with ... For their role in isolating, purifying, and crystallizing enzymes - a subject underscored by Kunitz' work with Northrop - John ... contributing to the determination that enzymes are proteins. Kunitz was born in Slonim (then part of Russia, now in Belarus) on ... trypsin and chymotrypsin and their precursors, as well as pepsin. He also studied protease inhibitors and devoted particular ...
*  UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase
... lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase, UDP-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1 ... Waheed A, Hasilik A, von Figura K (1982). "UDP-N-acetylglucosamine:lysosomal enzyme precursor N-acetylglucosamine-1- ... Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes". J. Biol. Chem. 256 (9 ... The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase. ...
*  HIKESHI
The ME3 gene stands for mitochondrial malic enzyme 3 precursor. Malic enzyme catalyzes the oxidative decarboxylation of malate ... Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)- ...
*  Gastric chief cell
Chief cells release the zymogen (enzyme precursor) pepsinogen when stimulated by a variety of factors including cholinergic ...
*  Creatorrhea
Where there is a failure to produce, release, or convert trypsinogen-an inactive enzyme precursor or zymogen-muscle fibres are ... Trypsinogen is produced in the pancreas and released into the alimentary canal where it is converted to the active enzyme ... Failure to produce or secrete chemicals known as digestive enzymes can lead to failure digesting or breaking down specific ... as can cystic fibrosis which also affects the production of digestive enzymes. "creatorrhea", The Free Dictionary Brown, Thomas ...
*  Coagulation
The pathways are a series of reactions, in which a zymogen (inactive enzyme precursor) of a serine protease and its ... and labeled the hypothetical enzyme "thrombin" and its precursor "prothrombin". Arthus discovered in 1890 that calcium was ... Another enzyme, Vitamin K epoxide reductase, (VKORC) reduces vitamin K back to its active form. Vitamin K epoxide reductase is ... It is a vitamin K-dependent serine protease enzyme that is activated by thrombin into activated protein C (APC). Protein C is ...
*  Biochemical cascade
The pathways are a series of reactions, in which a zymogen (inactive enzyme precursor) of a serine protease and its ... This receptors may have intrinsic catalytic activity or may be coupled to effector enzymes, or may also be associated to ionic ... The Nrf2/ARE activation leads to a higher expression of enzymes involved in glutathione syntheses and metabolism, that have a ... Besides NUAK1, LKB1 kinase acts under other effectors enzymes as SAD-A/B and MARK, therefore regulating neuronal polarization ...
*  Immunoreactive trypsinogen
Trypsinogen is a pancreatic enzyme precursor found in the blood that is raised in most of those with CF at birth, regardless of ... The concentration of IRT is elevated in babies with CF since pancreatic ducts are partially blocked leading to abnormal enzyme ...
*  Zymogen
The biochemical change usually occurs in Golgi bodies, where a specific part of the precursor enzyme is cleaved in order to ... A zymogen (/ˈzaɪmədʒən, -moʊ-/), also called a proenzyme (/ˌproʊˈɛnzaɪm/), is an inactive precursor of an enzyme. A zymogen ... Although they limit the enzyme's ability, these n-terminal extensions of the enzyme or a "prosegment" often aid in the ... Another way that enzymes can exist in inactive forms and later be converted to active forms is by activating only when a ...
*  Chemoton
As an autocatalytic but non-genetic entity, it predates the enzyme-dependent precursors of life, such as RNA World. But being ... Unlike cellular metabolic reactions, metabolism of chemoton in autonomous chemical cycle and is not dependent on enzymes. ... most likely before any enzymes or templates existed, chemoton provides a plausible scenario. ...
*  Nardilysin
Gluschankof, P.; Gomez, S.; Morel, A.; Cohen, P. (1987). "Enzymes that process somatostatin precursors. A novel endoprotease ... Nardilysin (EC 3.4.24.61, N-arginine dibasic convertase, NRD-convertase) is an enzyme. This enzyme catalyses the following ... in which Xaa is not Arg or Lys This enzyme is present rat brain and testis. Gomez, S.; Gluschankof, P.; Morel, A.; Cohen, P. ( ... a metalloendopeptidase as a prototype of a class of processing enzymes". Proc. Natl. Acad. Sci. USA. 91: 6078-6082. doi:10.1073 ...
*  Serine protease
Zymogens are the usually inactive precursors of an enzyme. If the digestive enzymes were active when synthesized, they would ... preventing the enzyme from working properly. Trypsin, a powerful digestive enzyme, is generated in the pancreas. Inhibitors ... These enzymes can be further categorised based on their substrate specificity as either trypsin-like, chymotrypsin-like or ... The triad is located in the active site of the enzyme, where catalysis occurs, and is preserved in all superfamilies of serine ...
*  Enzyme inhibitor
This mechanism occurs in the pancreas, which synthesises many digestive precursor enzymes known as zymogens. Many of these are ... An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity. Since blocking an enzyme's activity can ... Not all molecules that bind to enzymes are inhibitors; enzyme activators bind to enzymes and increase their enzymatic activity ... to the enzyme and to the enzyme-substrate complex, respectively. The enzyme-inhibitor constant Ki can be measured directly by ...
*  Product (chemistry)
Chemical reaction Substrate Reagent Precursor Catalyst Enzyme Product Derivative Chemical equilibrium Second law of ... Some enzymes are inhibited by the product of their reaction binds to the enzyme and reduces its activity. This can be important ... S + E → P + E {\displaystyle S+E\rightarrow P+E} Where S is substrate, P is product and E is enzyme. Some enzymes display a ... In biochemistry, enzymes act as biological catalysts to convert substrate to product. For example, the products of the enzyme ...
*  Jasmonate
For example, silencing phenylalanine ammonia lyase (PAL), an enzyme synthesizing precursors to SA, reduces SAR but enhances ... Arachidonic acid (AA), the counterpart of the JA precursor α-LeA occurring in metazoan species but not in plants, is perceived ...
*  Thymidine kinase in clinical chemistry
"Molecular forms in human serum of enzymes synthesizing DNA precursors and DNA". Mol. Cell. Biochem. 92 (1): 23-35. doi:10.1007/ ... Such enzymes are called salvage enzymes. Thymidine kinase 1 is such a salvage enzyme, whereas thymidine kinase 2 is not cell ... Thymidine kinase is a salvage enzyme that is only present in anticipation of cell division. The enzyme is not set free from ... The enzyme suggested as a tumor marker in malignant disease is the cytosolic cell cycle dependent TK1 that is present during ...
*  Thymidine kinase
"Molecular forms in human serum of enzymes synthesizing DNA precursors and DNA". Mol. Cell. Biochem. 92 (1): 23-35. doi:10.1007/ ... Such enzymes are called salvage enzymes. Thymidine kinase 1 is such a salvage enzyme, whereas thymidine kinase 2 and ... Thymidine kinase is a salvage enzyme that is only present in anticipation of cell division. The enzyme is not set free from ... The enzyme form in virus is different from that in other organisms. Thymidine kinase is not present in fungi. The first ...
*  Viral protein
They depend on their host cell's metabolism for energy, enzymes, and precursors, in order to reproduce. As such, viruses do not ... The capsid is a "shield" that protects the viral nucleic acids from getting degraded by host enzymes or other types of ...
*  Human digestive system
Pepsinogen is a precursor enzyme (zymogen) produced by the gastric chief cells, and gastric acid activates this to the enzyme ... The precursor zymogens, are inactive variants of the enzymes; which avoids the onset of pancreatitis caused by autodegradation ... Saliva also contains a catalytic enzyme called amylase which starts to act on food in the mouth. Another digestive enzyme ... The cells are filled with secretory granules containing the precursor digestive enzymes. The major proteases, the pancreatic ...
*  Chymotrypsinogen
... is a proteolytic enzyme and a precursor (zymogen) of the digestive enzyme chymotrypsin. It is a single ... It is activated into its active form by another enzyme called trypsin. This active form is called π-chymotrypsin and is used to ... Schwert G.W, Proteolytic Enzymes. Annual Review of Biochemistry. [online] 1955, 10.1146/annurev.bi.24.070155.000503 http://www. ...
*  Zinc finger nuclease
HIV-2/SIVsmm and Other SIV gene sequence cleavage by various bacteria restriction enzymes: Precursors for a novel HIV ... Each ZFN is made up of multiple zinc fingers and one nuclease enzyme. A recent and unique application of ZFN-technology to ... Both ex-vivo (manipulation of stem or autologous T cell precursors) and in-vivo delivery platforms are being explored. It is ... Zinc-finger nucleases (ZFNs) are artificial restriction enzymes generated by fusing a zinc finger DNA-binding domain to a DNA- ...