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*  Moexipril
... hydrochloride is a potent orally active nonsulfhydryl angiotensin converting enzyme inhibitor (ACE inhibitor) which ... Chrysant, S. G. (1998). "Vascular remodeling: The role of angiotensin-converting enzyme inhibitors". American Heart Journal. ... "Synthesis of novel angiotensin converting enzyme inhibitor quinapril and related compounds. A divergence of structure-activity ... AN IMPORTANT INTERMEDIATE IN THE SYNTHESIS OF ANGIOTENSIN CONVERTING ENZYME INHIBITORS". Organic Preparations and Procedures ...
*  Quinapril
... (marketed under the brand name Accupril by Pfizer) is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used ... Quinapril inhibits angiotensin converting enzyme, an enzyme which catalyses the formation of angiotensin II from its precursor ... Impaired renal and liver function Patients with a history of angioedema related to previous treatment with an ACE inhibitor ...
*  Teprotide
It is an angiotensin converting enzyme inhibitor (ACE inhibitor), which inhibits the conversion of angiotensin I to angiotensin ... "Angiotensin-converting enzyme inhibitors from the venom of bothrops jararaca. Isolation, elucidation of structure, and ... "History of the design of captopril and related inhibitors of angiotensin converting enzyme". Hypertension. 17 (4): 589-592. doi ... Many ACE inhibitors have been developed since this time but this was the start of them. Ferreira, Sergio (February 1965). "A ...
*  Angiotensin II receptor blocker
Gales BJ, Bailey EK, Reed AN, Gales MA (February 2010). "Angiotensin-converting enzyme inhibitors and angiotensin receptor ... In addition, there is also a small risk of cross-reactivity in patients having experienced angioedema with ACE inhibitor ... and are thus only rarely associated with the persistent dry cough and/or angioedema that limit ACE inhibitor therapy.[citation ... of the main rationales for the use of this class is the avoidance of dry cough and/or angioedema associated with ACE inhibitor ...
*  Captopril challenge test
... an angiotensin converting enzyme inhibitor. It is used to assist in the diagnosis of renal artery stenosis. It is not generally ...
*  Renin inhibitor
Between the two lobes, deep within the enzyme, resides the active site, and its catalytic activity is due to two aspartic acid ... Consequently, renin inhibitors prevent the formation of Ang I and Ang II. Renin inhibitors may also prevent Ang-(1-7), Ang-(1-9 ... Example of binding to the renin inhibitor: Aliskiren is a peptide-like renin inhibitor and, unlike most, it is rather ... Pepstatin was found to be a potent competitive inhibitor of most aspartic proteases, but a weak inhibitor of renin. Originally ...
*  Enzyme inhibitor
Database of drugs and enzyme inhibitors BRENDA, Database of enzymes giving lists of known inhibitors for each entry Enzymes, ... This new inhibitor is then used to try to obtain a structure of the enzyme in an inhibitor/enzyme complex to show how the ... An enzyme inhibitor is a molecule that binds to an enzyme and decreases its activity. Since blocking an enzyme's activity can ... The most common uses for enzyme inhibitors are as drugs to treat disease. Many of these inhibitors target a human enzyme and ...
*  Captopril
... , sold under the trade name Capoten, is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of ... Brown, NJ; Vaughan, DE (1998). "Angiotensin-converting enzyme inhibitors". Circulation. 97 (14): 1411-20. doi:10.1161/01.cir. ... "collected-product inhibitor" of the converting enzyme. Captopril was developed from this peptide after it was found via QSAR- ... "Design of specific inhibitors of angiotensin-converting enzyme: New class of orally active antihypertensive agents". Science. ...
*  Bioorthogonal chemistry
... enzyme inhibitors, etc. The chemical reporter must not alter the structure of the substrate dramatically to avoid affecting its ... Additionally, it is likely that they are metabolized in vitro by cytochrome P450 enzymes. The kinetics of the reactions are ...
*  Polyestradiol phosphate
"Synthetic high molecular weight enzyme inhibitors. I. Polymeric phosphates of phloretin and related compounds" (PDF). Acta Chem ... Research has found that PEP acts as an inhibitor of alkaline phosphatase in vitro, and it is thought that PEP may inhibit its ... Estradiol is metabolized primarily in the liver by CYP3A4 and other cytochrome P450 enzymes, and is metabolized to a lesser ... 17β-diphosphate acted as an inhibitor of kidney alkaline phosphatase. When the same scientists wanted to synthesize simple ...
*  Antinutrient
Some proteins can also be antinutrients, such as the trypsin inhibitors and lectins found in legumes. These enzyme inhibitors ... For example, Bowman-Birk trypsin inhibitor is found in soybeans. Lipase inhibitors interfere with enzymes, such as human ... Amylase inhibitors, like lipase inhibitors, have been used as a diet aid and obesity treatment. Amylase inhibitors are present ... Amylase inhibitors prevent the action of enzymes that break the glycosidic bonds of starches and other complex carbohydrates, ...
*  Decoy
... thus blocking the activity of the enzyme. These proteins are therefore enzyme inhibitors. Examples include K3L produced by ... A decoy substrate or pseudosubstrate is a protein that has similar structure to the substrate of an enzyme, in order to make ... August 2007). "Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity ... from binding to the VEGFR-2 The TNF inhibitor etanercept exerts its anti-inflammatory effect by being a decoy receptor that ...
*  Enzyme modulator
An enzyme modulator is a type of drug which modulates enzymes. They include enzyme inhibitors and enzyme inducers. In an ... In the homogeneous assay, an enzyme modulator (antibody, inhibitor or receptor for the enzyme) is covalently linked to the ... Practice and Theory of Enzyme Immunoassays. Elsevier. p. 382. ISBN 9780080858845. Retrieved 22 January 2015. ... homogenous assay, "an enzyme modulator ... is covalently linked to the ligand which competes with free ligand from the test ...
*  Enzyme activator
... s are molecules that bind to enzymes and increase their activity. They are the opposite of enzyme inhibitors. ... In some cases, when a substrate binds to one catalytic subunit of an enzyme, this can trigger an increase in the substrate ... Enzyme inducer Effector (biology) Kurland IJ, Pilkis SJ (1995). "Covalent control of 6-phosphofructo-2-kinase/fructose-2,6- ... These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism. An example of an ...
*  ACE inhibitor
An angiotensin-converting-enzyme inhibitor (ACE inhibitor) is a pharmaceutical drug used primarily for the treatment of ... Previous angioedema associated with ACE inhibitor therapy Hypersensitivity to ACE inhibitors ACE inhibitors should be used with ... Ajayi AA, Campbell BC, Howie CA, Reid JL (1985). "Acute and Chronic Effects of the Converting Enzyme Inhibitors Enalapril and ... van Vark LC, Bertrand M, Akkerhuis KM, Brugts JJ, Fox K, Mourad JJ, Boersma E. "Angiotensin-converting enzyme inhibitors reduce ...
*  Fatty acid amide hydrolase
Minkkilä A, Saario S, Nevalainen T (2010). "Discovery and development of endocannabinoid-hydrolyzing enzyme inhibitors". ... a large number of irreversible and reversible inhibitors of this enzyme have been developed. Some of the more significant ... and include non-covalent inhibitor complexes and covalent adducts. Endocannabinoid enhancer Endocannabinoid reuptake inhibitor ... In vivo, FAAH is the principal catabolic enzyme for a class of bioactive lipids called the fatty acid amides (FAAs). Members of ...
*  Dynamic combinatorial chemistry
"Bivalent enzyme inhibitors discovered using dynamic covalent chemistry". Chem. Eur. J. 18 (34): 10562-10570. doi:10.1002/chem. ... Leung, I. K. H.; Brown Jr, T.; Schofield, C. J.; Claridge, T. D. W. (May 2011). "An approach to enzyme inhibition employing ... Enzyme-catalysed reversible reactions, such as protease-catalysed amide bond formation/hydrolysis reactions and the aldolase- ... Yang, Z.; Fang, Z.; He, W.; Wang, Z.; Gang, H.; Tian, Q.; Guo, K. (Apr 2016). "Identification of inhibitors for vascular ...
*  Β-Lactamase inhibitor
β-lactamase inhibitors expand the useful spectrum of these β-lactam antibiotics by inhibiting the β-lactamase enzymes produced ... Watson ID, Stewart MJ, Platt DJ (1988). "Clinical pharmacokinetics of enzyme inhibitors in antimicrobial chemotherapy". Clin ... Boron based transition state inhibitors or BATSIs are very potent group of beta-lactamase inhibitors. A screen of a series of ... that are more resistant to cleavage and the development of the class of enzyme inhibitors called beta-lactamase inhibitors. ...
*  Redback spider
Angiotensin-converting-enzyme inhibitors, or ACE inhibitors, are a class of widely-prescribed medications used in hypertension ... Sweitzer, Nancy K. (2003). "What Is an Angiotensin Converting Enzyme Inhibitor?". Circulation. 108 (3): e16-18. doi:10.1161/01. ... It contains a complex mixture of cellular constituents, enzymes and a number of high-molecular-weight toxins, including insect ... as have small peptides that inhibit angiotensin-1-converting enzyme; the venom of the redback, although little-studied, likely ...
*  Aspergillomarasmine A
Antivirals and Enzyme Inhibitors. Elsevier. p. 499. ISBN 9780080858487. Retrieved 27 June 2014. Matsuura, Akihiro; Hiroshi ... "Pharmacological profiles of aspergillomarasmines as endothelin converting enzyme inhibitors". The Japanese Journal of ... It can inhibit endothelin converting enzymes even in the live rat, probably by chelating metals required by metalloproteases. ...
*  Desorption/ionization on silicon
Reaction monitoring can be used to screen enzyme inhibitors. Atmospheric pressure DIOS was shown to be an effective tool for ...
*  Lisinopril
... is a drug of the angiotensin-converting enzyme (ACE) inhibitor class used primarily in treatment of high blood ... Lisinopril is an ACE Inhibitor, meaning it blocks the actions of angiotensin converting enzyme (ACE) in the renin-angiotensin- ... John Wiley & Sons, Apr 3, 2013 ISBN 9781118354469 Menard J and Patchett A. "Angiotensin-Converting Enzyme Inhibitors". pp. 14- ... 1980). "A new class of angiotensin-converting enzyme inhibitors". Nature. 288 (5788): 280-3. Bibcode:1980Natur.288..280P. doi: ...
*  Nicotinamide adenine dinucleotide
Other drugs are not enzyme inhibitors, but instead activate enzymes involved in NAD+ metabolism. Sirtuins are a particularly ... by designing enzyme inhibitors or activators based on its structure that change the activity of NAD-dependent enzymes, and by ... this can be exploited in enzyme kinetics to give information about the enzyme's mechanism. This is done by mixing an enzyme ... This radical then reacts with NADH, to produce adducts that are very potent inhibitors of the enzymes enoyl-acyl carrier ...
*  Natural product
These include the angiotensin-converting enzyme inhibitor captopril. Captopril is based on the peptidic bradykinin potentiating ... Enzymes in turn are composed of amino acids and often non-peptidic cofactors that are essential for enzyme function. The basic ... they possess enzymes that are functional under quite unusual conditions. These enzymes are of potential use in the food, ... Its mechanism of action is inhibition of the cyclooxygenase (COX) enzyme. Another notable example is opium is extracted from ...
*  Ecallantide
"Ecallantide for the acute treatment of Angiotensin-converting enzyme inhibitor-induced angioedema: a multicenter, randomized, ... HAE is caused by a mutation of the C1-inhibitor gene. Defective or missing C1-inhibitor permits activation of kallikrein, a ... "Pharmacologic management of angioedema induced by angiotensin-converting enzyme inhibitors". American Journal of Health-System ... It is an inhibitor of the protein kallikrein and a 60-amino acid polypeptide which was developed from a Kunitz domain through ...
*  Phage display
It is used for finding new ligands (enzyme inhibitors, receptor agonists and antagonists) to target proteins. The technique is ... Lunder M, Bratkovic T, Kreft S, Strukelj B (July 2005). "Peptide inhibitor of pancreatic lipase selected by phage display using ... "Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K". Biochem. Biophys. Res. Commun. 332 ...
*  Lenvatinib
No relevant interactions with enzyme inhibitors and inducers are expected. Lenvatinib acts as a multiple kinase inhibitor. It ... Non-enzymatic metabolization also occurs, resulting in a low potential for interactions with enzyme inhibitors and inducers. ... and acts as a multiple kinase inhibitor against the VEGFR1, VEGFR2 and VEGFR3 kinases. Lenvatinib is approved (since 2015) for ... Lenvatinib is metabolized by the liver enzyme CYP3A4 to desmethyl-lenvatinib (M2). M2 and lenvatinib itself are oxidized by ...