This enzyme catalyses the following chemical reaction Preferentially, release of N-terminal lysine This enzyme requires Co2+. ... Aminopeptidase Y (EC 3.4.11.15, aminopeptidase Co, aminopeptidase (cobalt-activated), lysyl aminopeptidase) is an enzyme. ...
This enzyme catalyses the following chemical reaction geranyl diphosphate ⇌ {\displaystyle \rightleftharpoons } (-)-sabinene + ... Sabinene synthase (EC 4.2.3.109) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase [cyclizing, (-)- ... diphosphate This enzyme requires Mg2+. Savage TJ, Hatch MW, Croteau R (February 1994). "Monoterpene synthases of Pinus contorta ...
... is an enzyme (EC 4.1.1.1) that catalyses the decarboxylation of pyruvic acid to acetaldehyde. It is also ... The enzyme is also means to create ethanol, which is used as an antibiotic to eliminate competing organisms. The enzyme is ... This enzyme should not be mistaken for the unrelated enzyme pyruvate dehydrogenase, an oxidoreductase (EC 1.2.4.1), that ... the enzyme provides the suitable environment for TPP and the alpha-keto acid (pyruvate) to meet. "NiceZyme View of ENZYME: EC ...
... is an enzyme . This enzyme catalyses the following chemical reaction Hydrolysis of proteins, favouring hydrophobic residues at ... Oka T, Ishino K, Tsuzuki H, Morihara K, Arima K (1973). "On the specificity of a rennin-like enzyme from Mucor pusillus". Agric ... Does not accept Lys at P1, and hence does not activate trypsinogen This enzyme is isolated from the zygomycete fungi Mucor ... Arima K, Yu J, Iwasaki S (1970). "Milk-clotting enzyme from Mucor pusillus var. lindt". Methods Enzymol. 19: 446-459. doi: ...
... oxidase (PPO) is an enzyme that catalyses the oxidation of o-diphenols to produce o-quinones. It is the rapid ... are crucial enzymes with subsequent addition of catechin and epicatechin moieties for larger, non-hydrolyzable tannins. The ... which may bind to digestive enzymes and other proteins, particularly in ruminants. In a comparison of cooking methods, phenolic ... which involves inhibition of the liver enzyme, CYP3A4, likely by grapefruit furanocoumarins, a class of polyphenol. The ...
Chorismate lyase is an enzyme that transforms chorismate into 4-hydroxybenzoate and pyruvate. This enzyme catalyses the first ... Chorismate is transformed into para-aminobenzoic acid by the enzymes 4-amino-4-deoxychorismate synthase and 4-amino-4- ... Chorismate synthase is an enzyme that catalyzes the final chemical reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate → ...
Schmidt H, Bode R, Birnbaum D (1988). "A novel enzyme, L-lysine : pyruvate aminotransferase, catalyses the first step of lysine ... doi:10.1111/j.1574-6968.1988.tb02716.x. Portal: Biology v t e (EC 2.6.1, Enzymes of unknown structure, All stub articles, EC ... This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The ... In enzymology, a lysine-pyruvate 6-transaminase (EC 2.6.1.71) is an enzyme that catalyzes the chemical reaction L-lysine + ...
This enzyme catalyses the following chemical reaction uracil + acceptor ⇌ {\displaystyle \rightleftharpoons } barbiturate + ... The enzyme acts on the hydrated derivative of the substrate. Hayaishi O, Kornberg A (May 1952). "Metabolism of cytosine, ... Uracil dehydrogenase (EC 1.1.99.19, uracil oxidase) is an enzyme with systematic name uracil:(acceptor) oxidoreductase. ... thymine, uracil, and barbituric acid by bacterial enzymes". The Journal of Biological Chemistry. 197 (2): 717-32. PMID 12981104 ...
... (EC 3.4.24.78, germination proteinase) is an enzyme. This enzyme catalyses the following chemical reaction: ... Endopeptidase action with P4 Glu or Asp, P1 preferably Glu > Asp, P1' hydrophobic and P2' Ala This enzyme participates in spore ...
This enzyme binds Zn2+. The enzyme catalyses the adenylation of ThiS, a sulfur carrier protein involved in the biosynthesis of ... This enzyme catalyses the following chemical reaction ATP + [ThiS] ⇌ {\displaystyle \rightleftharpoons } diphosphate + adenylyl ... Sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.73, thiF (gene)) is an enzyme with systematic name ATP:(ThiS) ...
Also, in Lechevalieria aerocolonigenes, the enzyme catalyses the initial step in the biosynthesis of antitumor agent ... Following design of a suitable enzyme, a cross-linked enzyme aggregate is used for larger-scale reaction. The enzyme by itself ... This enzyme catalyses the following chemical reaction: tryptophan + FADH2 + Cl− + O2 + H+ ⇌ {\displaystyle \rightleftharpoons ... was able to be halogenated by an evolved enzyme with high selectivity and yield and low enzyme loading. These results suggest ...
White H, Strobl G, Feicht R, Simon H (September 1989). "Carboxylic acid reductase: a new tungsten enzyme catalyses the ... The systematic name of this enzyme class is aldehyde:ferredoxin oxidoreductase. This enzyme is also called AOR. It is a ... AOR has been proposed to be the primary enzyme responsible for oxidising the aldehydes that are produced by the 2-keto acid ... Also, as a result of oxygen sensitivity of AOR, purification of the enzyme is done under anoxic environments. It is proposed ...
... is an enzyme with systematic name terpentedienyl-diphosphate lyase (decyclizing). This enzyme catalyses the following chemical ... reaction geranylgeranyl diphosphate ⇌ {\displaystyle \rightleftharpoons } terpentedienyl diphosphate This enzyme requires Mg2+ ...
Before these discoveries, it was believed that biological catalysis was solely the realm of protein enzymes. The discovery of ... Telomerase is an enzyme that is present in all eukaryotic nuclei which serves to maintain the ends of the linear DNA in the ... Telomerase was shown to be a ribonucleoprotein enzyme that contains an RNA component that serves as a template strand, and a ... In separate work, the RNA component of the bacterial enzyme ribonuclease P (a ribonucleoprotein complex) was shown to catalyze ...
The most common primary function of moonlighting proteins is enzymatic catalysis, but these enzymes have acquired secondary non ... An example of a moonlighting enzyme is pyruvate carboxylase. This enzyme catalyzes the carboxylation of pyruvate into ... the first enzyme of methanol metabolism, is a homo-octameric flavoenzyme. In wild type cells, this enzyme is present as ... also called ancient enzymes. These enzymes are frequently speculated to have evolved moonlighting functions. Since highly ...
Since all microsomal P450 enzymes require POR for catalysis, it is expected that disruption of POR would have devastating ... POR knockout mice are embryonic lethal, probably due to lack of electron transport to extrahepatic P450 enzymes since liver- ... is a membrane-bound enzyme required for electron transfer from NADPH to cytochrome P450 and other heme proteins including heme ... "Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro". Pharmacogenetics and Genomics. 20 ( ...
v t e (Wikipedia articles needing page number citations from January 2022, Enzymes, Catalysis, All stub articles, Molecular ... This is similar to allosteric sites, but differs in the fact that, in order for an enzyme to be active, its exosite typically ... An exosite is a secondary binding site, remote from the active site, on an enzyme or other protein. ...
Hanževački M, Croft AK, Jäger CM (July 2022). "Activation of Glycyl Radical Enzymes─Multiscale Modeling Insights into Catalysis ... Nicolet Y (13 April 2020). "Structure-function relationships of radical SAM enzymes". Nature Catalysis. 3 (4): 337-350. doi: ... may be used to shuttle electrons to the IslB enzyme which is necessary to install the glycyl radical on the IslA enzyme upon ... Hidden within this barrel is the active site of the enzyme. It is believed that the positioning of the active site within the ...
... worked on pepsin catalysis. This began a life long pursuit of work on enzyme catalysis and in later years ... Dixon, H B F; Cornish-Bowden, A (1983). "Revision of Enzyme Nomenclature - Listing Enzymes". Eur. J. Biochem. 133 (3): 479. doi ... Silverberg, Michael (1997). "Review of Fundamentals of Enzyme Kinetics.; Analysis of Enzyme Kinetic Data". The Quarterly Review ... Cornish-Bowden is most well known for his introduction of the direct-linear plot for estimating enzyme parameters, his work on ...
... explored the mechanisms of enzyme catalysis with Birgit Vennesland and determined the mechanisms of chromic acid oxidations and ... Westheimer joined the project and helped develop an explanation based on the idea of enantiotopicity to explain how the enzyme ... The identification of the "active sites" of an enzyme is difficult in cases where proteins have hydrocarbon-rich sites. In 1962 ... The introduction of an aliphatic diazo group into a bifunctional reagent enabled it to react with the enzyme. The photolabel ...
Hogg has also examined the role of allosteric disulfides in controlling protein-ligand interactions, enzyme catalysis, protein ...
Almost all metabolic processes in the cell need enzyme catalysis in order to occur at rates fast enough to sustain life.: 8.1 ... Both enzymes that have been more or less isolated and enzymes still residing inside living cells are employed for this task. ... Enzyme Enzymes are proteins that act as biological catalysts (biocatalysts). Catalysts accelerate chemical reactions. The ... The modern usage of biotechnologically produced and possibly modified enzymes for organic synthesis is termed chemoenzymatic ...
... prohibiting ATP from entering and decreasing the likelihood of enzyme catalysis. In the active state, D594 chelates the ... Since it is a highly regulated signal transduction kinase, B-Raf must first bind Ras-GTP before becoming active as an enzyme. ... P-Loop The P-loop of B-Raf (residues 464-471) stabilizes the non-transferable phosphate groups of ATP during enzyme ATP-binding ... Bay43-9006 disables the B-Raf kinase domain by locking the enzyme in its inactive form. The inhibitor accomplishes this by ...
... is an enzyme isolated from the myxobacterium Lysobacter enzymogenes. This enzyme is a serine protease that catalyses the ... The nucleotide sequence predicts a large prepro-peptide with homology to pro-peptides of other chymotrypsin-like enzymes". The ... Hydrolytic Enzymes. Vol. 16. Amsterdam: Elsevier. pp. 159-200. Epstein DM, Wensink PC (November 1988). "The alpha-lytic ...
... (EC 3.4.22.24) is an enzyme. This enzyme catalyses the following chemical reaction: Interconversion of the three ... This enzyme degrades azocasein and denatured hemoglobin. Cathepsin Gohda E, Pitot HC (May 1981). "Purification and ...
... is an enzyme with systematic name ethanol:acceptor oxidoreductase. This enzyme catalyses the following chemical reaction ... ethanol + acceptor ⇌ {\displaystyle \rightleftharpoons } acetaldehyde + reduced acceptor This enzyme contains Zn2+. Van Ophem ...
... the protein domain SAICAR synthase is an enzyme which catalyses a reaction to create SAICAR. In enzymology, this enzyme is also ... In bacteria and plants this protein domain only catalyses the synthesis of SAICAR. However, in mammals it also catalyses ... This enzyme belongs to the family of ligases, to be specific those forming carbon-nitrogen bonds as acid-D-amino-acid ligases ( ... It is vital for living organisms since it catalyses a step in the purine biosynthesis pathway which aids energy metabolism and ...
... (EC 3.2.1.177, alpha-xylosidase) is an enzyme. This enzyme catalyses the following chemical ... The enzyme catalyses hydrolysis of a terminal, unsubstituted xyloside at the extreme reducing end of a xylogluco- ... "Mechanistic and structural analysis of a family 31 alpha-glycosidase and its glycosyl-enzyme intermediate". The Journal of ...
Naturally occurring ptyalin enzymes in the maker's saliva catalyses the breakdown of starch in the maize into maltose. This ... Cassava root is very starchy, and therefore the enzymes in the preparer's saliva rapidly convert the starch to simple sugar, ...
This enzyme catalyses the following chemical reaction ATP + propanoate ⇌ {\displaystyle \rightleftharpoons } ADP + propanoyl ... Propionate kinase (EC 2.7.2.15, PduW, TdcD, propionate/acetate kinase) is an enzyme with systematic name ATP:propanoate ... Hesslinger C, Fairhurst SA, Sawers G (January 1998). "Novel keto acid formate-lyase and propionate kinase enzymes are ...