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*  Atrasentan
It is an endothelin receptor antagonist selective for subtype A (ETA). While other drugs of this type (sitaxentan, ambrisentan ... atrasentan blocks endothelin induced cell proliferation.[citation needed] In April 2014, de Zeeuw et al. showed that 0.75 mg ... an Endothelin A Receptor Antagonist, in Combination with Paclitaxel and Carboplatin as First-Line Therapy in Advanced Non-Small ... "The endothelin antagonist atrasentan lowers residual albuminuria in patients with type 2 diabetic nephropathy". Journal of the ...
*  Endothelin 3
1991). "Chromosomal assignments of the human endothelin family genes: the endothelin-1 gene (EDN1) to 6p23-p24, the endothelin- ... 1993). "Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a ... The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is ... The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides ...
*  Kell antigen system
Lee S, Lin M, Mele A, Cao Y, Farmar J, Russo D, Redman C (1999). "Proteolytic processing of big endothelin-3 by the kell blood ... a 93-kilodalton transmembrane zinc-dependent endopeptidase which is responsible for cleaving endothelin-3. The KEL gene encodes ... 42 (3): 287-93. doi:10.1046/j.1537-2995.2002.00049.x. Yu LC, Twu YC, Chang CY, Lin M (2001). "Molecular basis of the Kell-null ... 24 (3): 247-52. doi:10.1159/000152657. PMID 4435792. Conneally PM, Dumont-Driscoll M, Huntzinger RS, Nance WE, Jackson CE (1976 ...
*  Endothelin 2
... , also known as ET-2, is a protein that in humans is encoded by the EDN2 gene. Endothelin 2 is a member of the ... Arjomand-Nahad F, Landt O, Stangl K, Diefenbach K, Roots I (2006). "Fifteen polymorphisms in endothelin-1, endothelin-2 and ... endothelin 2". Klipper, E., A. Levit, Y. Mastich, B. Berisha, D. Schams, and R. Meidan. 2010. Induction of Endothelin-2 ... Endothelin-2 in Ovarian Follicular Rupture. Endocrinology. 147:1770-1779. Na, G., P.J. Bridges, Y. Koo, C. Ko. 2008. Role of ...
*  Svarthöna
"A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken". PLoS Genet. 7 ...
*  Ayam Cemani
2011). "A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken". PLoS ... "Gene Duplication of endothelin 3 Is Closely Correlated with the Hyperpigmentation of the Internal Organs (Fibromelanosis) in ... 5 (3): 239-246. European Poultry Society "'Public Radio International's 'The World'". October 14, 2016. Ai Shinomiya; Yasunari ...
*  Endothelin converting enzyme 1
... , also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene. Endothelin- ... 2003). "Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress". Regul. Pept. ... 1996). "Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1". Cytogenet. Cell Genet. 72 (4): 322 ... 1998). "Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations". Biochem. J. 328 ( ...
*  SCN7A
Hiyama TY, Yoshida M, Matsumoto M, Suzuki R, Matsuda T, Watanabe E, Noda M (April 2013). "Endothelin-3 expression in the ... 2 (3): 249-53. PMID 7874451. Han JA, Lu CM, Brown GB, Rado TA (January 1991). "Direct amplification of a single dissected ...
*  Endothelin B receptor
Endothelin receptor type B, also known as ETB is a protein that in humans is encoded by the EDNRB gene. Endothelin receptor ... "Entrez Gene: EDNRB endothelin receptor type B". Sato-Jin K, Nishimura EK, Akasaka E, Huber W, Nakano H, Miller A, Du J, Wu M, ... Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. A splice variant, named ... Endothelin receptor type B has been shown to interact with Caveolin 1. Agonists IRL-1620 Antagonists A-192,621 BQ-788 Bosentan ...
*  Sarafotoxin
... and thus activate endothelin-receptors, endothelin receptor type A (ETA) and endothelin receptor type B (ETB). These receptors ... doi:10.1016/s0041-0101(97)00019-6. Lüscher, Thomas F.; Barton, Matthias (2000-11-07). "Endothelins and Endothelin Receptor ... "Synthesis of endothelin-1 analogues, endothelin-3, and sarafotoxin S6b: Structure - activity relationships". Journal of ... Together with endothelins (ETs), they form a homogenous family of strong vasoconstrictor isopeptides. Among them, few slightly ...
*  Neurogenic inflammation
... and endothelin-3 (ET-3). TRPA1 channels stimulated by lipopolysaccharide (LPS) may also cause acute neurogenic inflammation. ... 101 Suppl 3: 2-6. doi:10.1111/j.1464-410X.2008.07493.x. PMID 18307678. Meseguer V, Alpizar YA, Luis E, Tajada S, Denlinger B, ... 3 of article Chiu IM, von Hehn CA, Woolf CJ. "Neurogenic inflammation and the peripheral nervous system in host defense and ... 1992 Sep;263(3 Pt 2):R734-7 Rude, RK; Singer, FR; Gruber, HE (April 2009). "Skeletal and hormonal effects of magnesium ...
*  Chromosome 20 (human)
... endothelin 3 ENTPD6: Ectonucleoside triphosphate diphosphohydrolase 6 ESF1: ESF1 nucleolar pre-rRNA processing protein homolog ... 1 (3): 225-229. doi:10.1089/gte.1997.1.225. PMID 10464650. Genome Decoration Page, NCBI. Ideogram data for Homo sapience (400 ... ISBN 978-3-318-02253-7. Sethakulvichai, W.; Manitpornsut, S.; Wiboonrat, M.; Lilakiatsakun, W.; Assawamakin, A.; Tongsima, S. ( ... encoding protein Zinc finger SWIM-type containing 3 ZMYND8: encoding enzyme Protein kinase C-binding protein 1 ZNF133: encoding ...
*  ET3
Endothelin 3, a protein, member of endothelin family. ... ET3 or ET-3 may refer to: Electronics Technician (US Navy), ... an American football free safety for the Seattle Seahawks Vespa ET-3, model produced between the 1970s and the mid-1990s ...
*  List of MeSH codes (D12.644)
... endothelins MeSH D12.644.276.249.225 --- endothelin-1 MeSH D12.644.276.249.235 --- endothelin-2 MeSH D12.644.276.249.245 --- ... endothelin-3 MeSH D12.644.276.500 --- ephrins MeSH D12.644.276.500.100 --- ephrin-A1 MeSH D12.644.276.500.200 --- ephrin-A2 ... map kinase kinase 3 MeSH D12.644.360.440.400 --- map kinase kinase 4 MeSH D12.644.360.440.500 --- map kinase kinase 5 MeSH ... 14-3-3 proteins MeSH D12.644.360.024.318 --- proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins ...
*  Piperonal
I. Preparation of 3-(3, 4-Methylenedioxyphenyl)-D-, and -L-alanine". Chemical & Pharmaceutical Bulletin. 10 (8): 680. doi: ... 3): 411-412. doi:10.6028/jres.078A.024. Nwaukwa, Stephen; Keehn, Philip (1982). "Oxidative cleavage of α-diols, α-diones, α- ... "An Improved Procedure for Synthesis of DL-4-Hydroxy-3-methoxymandelic Acid (DL-"Vanillyl"-mandelic Acid, VMA)". Journal of ... 4-Diarylpyrrolidine-3-carboxylic AcidsPotent ETASelective Endothelin Receptor Antagonists. 1. Discovery of A-127722". Journal ...
*  Weibel-Palade body
... endothelin-1, angiopoietin-2, osteoprotegerin, the P-selectin cofactor CD63/lamp3, and α-1,3-fucosyltransferase VI. Multimeric ... Additional Weibel-Palade body components are the chemokines Interleukin-8 and eotaxin-3, ...
*  Moexipril
"Interaction between endothelin and angiotensin II." Clinical and Experimental Pharmacology and Physiology. 26.7. (1999): 517- ... Indirectly, angiotensin II stimulates of the production of endothelin 1 and 3 (ET1, ET3) and the transforming growth factor ... Reaction of the product with hydrogen chloride then cleaves the tert-butyl group to give the half acid (3). Coupling of that ... doi:10.1016/s0735-1097(96)00251-3. PMID 8837552. Hartman, J.C. "The role of bradykinin and nitric oxide in the cardioprotective ...
*  Gilead Sciences
... also an endothelin receptor antagonist, for the potential treatment of resistant hypertension. In 2006, the company acquired ... January 3, 2014. "Stocks to Watch". Barrons. January 2, 2014. Sanger-katz, Margot (2014-08-02). "Critics Raise Concerns About ... Additionally, Myogen was developing (in Phase 3 studies) darusentan, ...
*  Endothelin
Historical background and discovery of endothelin The International Conferences on Endothelin (Est. 1988) Endothelin science ( ... Overproduction of endothelin in the lungs may cause pulmonary hypertension, which can sometimes be treated by the use of an ... Endothelins derived the name from the fact that they were derived and secreted from cultured endothelial cells. There are three ... Endothelins are peptides that constrict blood vessels and raise blood pressure. They are normally kept in balance by other ...
*  Endothelin receptor
Barnes K, Turner AJ; Turner (August 1997). "The endothelin system and endothelin-converting enzyme in the brain: molecular and ... 2016) 'Endothelin' Pharmacol. Rev. 68: 357-418. pmid =26956245 doi =10.1124/pr.115.011833 "Endothelin Receptors". IUPHAR ... There are at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC, all of which are G protein-coupled receptors whose ... Endothelin receptor antagonist Walter F. Boron, Emile L. Boulpaep, eds. (2009). Medical physiology a cellular and molecular ...
*  Endothelin 1
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. Endothelin 1 ... Endothelin 1 (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor that in humans is encoded by the ... Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors ... Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ (April 2016). "Endothelin ...
*  Endothelin A receptor
Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. Endothelin receptor type A has been shown ... EDNRA endothelin receptor type A". Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin ... Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in ... "Endothelin Receptors: ETA". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
*  Macitentan
Endothelin (ET) is an extremely potent blood vessel constricting substance that is secreted by endothelial cells. In the lungs ... Macitentan is a dual ERA, meaning that it acts as an antagonist of two endothelin (ET) receptor subtypes, ETA and ETB. However ... Macitentan (trade name Opsumit) is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial ... a dual endothelin receptor antagonist, in humans. Xenobiotica, 42(9), 901-910. Sidharta, P.N., van Giersbergen, P.L., Halabi, A ...
*  Streptomyces misakiensis
Ihara, M; Fukuroda, T; Saeki, T; Nishikibe, M; Kojiri, K; Suda, H; Yano, M (15 July 1991). "An endothelin receptor (ETA) ... ISBN 90-5702-122-6. CS1 maint: Extra text: authors list (link) Warner, edited by Timothy D. (2001). Endothelin and Its ... Highsmith, edited by Robert F. (1998). Endothelin molecular biology, physiology, and pathology. Totowa, N.J.: Humana Press. ... Streptomyces misakiensis produces tubermycin A, tubermycin B, misakimycin and the endothelin receptor antagonist BE-18257B. ...
*  Benign paroxysmal positional vertigo
"Atrial natriuretic peptides negatively and positively modulate circulating endothelin in humans". Metabolism: clinical and ... This position is maintained for 3 minutes. The purpose is to allow the debris to move to the apex of the ear canal. The patient ... 45 (3): 315-9. doi:10.1016/S0026-0495(96)90284-X. PMID 8606637. Hegemann, Stefan CA; Palla, Antonella (2010). "New methods for ... 256 (3): 333-8. doi:10.1007/s00415-009-0149-2. PMID 19225823. Mayo Clinic Staff (July 10, 2012). "Benign paroxysmal positional ...
*  Tej P. Singh
... endothelin receptor, endothelin converting enzyme, breast cancer regression proteins and matrix metanosomal proteins as well as ... 309 (3): 751-761. doi:10.1006/jmbi.2001.4692. PMID 11397094. Mir, R.; Singh, N.; Vikram, G.; Kumar, R.P.; Sinha, M.; Bhushan, A ... 463 (3): 329-337. doi:10.1042/BJ20140631. ISSN 1470-8728. PMID 25101795. Shukla, Prakash Kumar; Gautam, Lovely; Sinha, Mau; ... 9 (3): e90011. doi:10.1371/journal.pone.0090011. ISSN 1932-6203. PMC 3940724 . PMID 24595088. Rastogi, Nilisha; Singh, Avinash ...
*  RAB14
... response of human lung fibroblast cells to stimulation by endothelin-1". Biochemistry. 41 (3): 1070-8. doi:10.1021/bi0117854. ... 1 (3): 287-92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614. Predic J, Soskic V, Bradley D, Godovac-Zimmermann ... 11 (3): 422-35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166. Simpson JC, Wellenreuther R, Poustka A, et al. (2001). " ...