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*  Endothelin 1
... (ET-1), also known as preproendothelin-1 (PPET1), is a potent vasoconstrictor that in humans is encoded by the ... Endothelin-1 receptor antagonists (Bosentan) are used in the treatment of pulmonary hypertension. Inhibition of these receptors ... Davenport AP, Hyndman KA, Dhaun N, Southan C, Kohan DE, Pollock JS, Pollock DM, Webb DJ, Maguire JJ (April 2016). "Endothelin ... Beghetti M, Black SM, Fineman JR (2005). "Endothelin-1 in congenital heart disease". Pediatr. Res. 57 (5 Pt 2): 16R-20R. doi: ...
*  Endothelin-converting enzyme 1
This enzyme catalyses the following chemical reaction Hydrolysis of the -Trp21-Val- bond in big endothelin to form endothelin 1 ... Endothelin-converting enzyme 1 at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Endothelin-converting enzyme 1 (EC 3.4.24.71, endothelin-converting enzyme, ECE-1) is an enzyme. ... Shimada, K.; Takahashi, M.; Tanzawa, K. (1994). "Cloning and functional expression of endothelin-converting enzyme from rat ...
*  Endothelin converting enzyme 1
2003). "Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress". Regul. Pept. ... Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene. Endothelin- ... 1996). "Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1". Cytogenet. Cell Genet. 72 (4): 322 ... 1998). "Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations". Biochem. J. 328 ( ...
*  Bradykinin receptor B2
Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Rev. Invest. Clin. 59 (1): 48- ... 211 (1): 234-40. doi:10.1006/bbrc.1995.1801. PMID 7779090. Ma JX, Wang DZ, Ward DC, et al. (1995). "Structure and chromosomal ... 184 (1): 260-8. doi:10.1016/0006-291X(92)91187-U. PMID 1314587. Eggerickx D, Raspe E, Bertrand D, et al. (1992). "Molecular ... 211 (1): 226-33. doi:10.1006/bbrc.1995.1800. PMID 7779089. Braun A, Kammerer S, Böhme E, et al. (1995). "Identification of ...
*  Angiotensin II receptor type 1
Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Revista De Investigación ... 183 (1): 8-13. doi:10.1016/0006-291X(92)91600-U. PMID 1543512. Takayanagi R, Ohnaka K, Sakai Y, Nakao R, Yanase T, Haji M, ... 47 (1): 17-28. doi:10.1016/S0361-9230(98)00039-2. PMID 9766385. Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG (Dec 2001 ... 186 (1): 277-84. doi:10.1016/S0006-291X(05)80804-6. PMID 1378723. Curnow KM, Pascoe L, White PC (Jul 1992). "Genetic analysis ...
*  Transfection
Mawji IA, Marsden PA (June 2006). "RNA transfection is a versatile tool to investigate endothelin-1 posttranscriptional ... Endothelin-1) with potential applications in gene therapy. Limitation of the silencing approach are the toxicity of the ... 20 (1): 81-9. doi:10.1111/j.1472-8206.2005.00344.x. PMID 16448398. Sharei A, Zoldan J, Adamo A, Sim WY, Cho N, Jackson E, Mao S ... 38 (1): 48, 50, 52. PMID 15679084. Jacobsen LB, Calvin SA, Colvin KE, Wright M (June 2004). "FuGENE 6 Transfection Reagent: the ...
*  GATA2
Lee ME, Temizer DH, Clifford JA, Quertermous T (1991). "Cloning of the GATA-binding protein that regulates endothelin-1 gene ... Yamashita K, Discher DJ, Hu J, Bishopric NH, Webster KA (2001). "Molecular regulation of the endothelin-1 gene by hypoxia. ... "Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells". J. Biol. Chem. 266 (24 ... 273 (1): 239-45. doi:10.1006/bbrc.2000.2947. PMID 10873593. Tsuzuki S, Towatari M, Saito H, Enver T (2000). "Potentiation of ...
*  Pathophysiology of multiple sclerosis
Endothelin-1 shows maybe the most striking discordance between patients and controls, being a 224% higher in patients than ... Haufschild T, Shaw SG, Kesselring J, Flammer J (Mar 2001). "Increased endothelin-1 plasma levels in patients with multiple ... 55 (1): 458-468. doi:10.1002/ana.20016. PMID 15048884. Brück W, Popescu B, Lucchinetti CF, Markovic-Plese S, Gold R, Thal DR, ... 246 (1-2): 85-95. doi:10.1016/j.jneuroim.2012.02.015. PMID 22458983. Ilana Katz Sand et al. CSF from MS Patients Induces ...
*  CPA3
"Mast cells promote homeostasis by limiting endothelin-1-induced toxicity". Nature. 432 (7016): 512-6. doi:10.1038/nature03085. ... 89 (1): 273-82. doi:10.1172/JCI115571. PMC 442845 . PMID 1729276. Huang H, Reed CP, Zhang JS, Shridhar V, Wang L, Smith DI ( ... 184 (1): 99-105. doi:10.1016/0022-2836(85)90046-4. PMID 4032478. Kokkonen JO, Vartiainen M, Kovanen PT (December 1986). "Low ... is also reported to have an important role in the protection towards snake venom toxins and vasoconstricting peptide endothelin ...
*  Ambrisentan
... , which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin ... As such, endothelin receptor antagonists such as Ambrisentan are known to be teratogenic. Ambrisentan has a high risk of liver ... Endothelin receptor activation mediates strong pulmonary vasoconstriction and positive inotropic effect on the heart. These ... In addition to this, endothelin receptors are also known to play a role in neural crest cell migration, growth, and ...
*  Theresa A. Jones
She primarily tests rats and uses the Endothelin-1 stroke model. Her most recent work has expanded into the field of ... Jones, TA (1 April 1994). "Use-Dependent Growth Of Pyramidal Neurons After Neocortical Damage" (PDF). The Journal of ... Theresa Jones was born in Pine Bluff, Arkansas on November 1, 1964. Throughout her childhood, her family moved around to Little ... 1): 156-160 May 22, 1992 Times Cited: 148 Jones TA, Chu Cj, Grande La, Et Al. "Motor Skills Training Enhances Lesion-Induced ...
*  Portopulmonary hypertension
Endothelin-1 has two receptors in the pulmonary arterial tree, ET-A which mediates vasoconstriction and ET-B which mediates ... Increase plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med 1991;114:464-9 Luo et al ... 2005;118:93-94 Giaid A. Nitrous oxide and endothelin-1 in pulmonary hypertension. Chest. 1998;114;208-12S Gerbes. ET1 and 3 ... 2005;128:164-8 Wilkins et al.Sildenafil versus Endothelin Receptor Antagonist for Pulmonary Hypertension (SERAPH) study. Am J ...
*  Vasoactivity
Various vasoactive agents, such as prostanoids, phosphodiesterase inhibitors, and endothelin antagonists, are approved for the ... Important vasoactive substances are angiotensin-11, endothelin-1, and alpha-adrenergic agonists. ...
*  Agonist
ISBN 0-07-144343-6 De Mey JGR, Compeer MG, Meens MJ (2009). "Endothelin-1, an Endogenous Irreversible Agonist in Search of an ... 1 (5): 246-257. Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, ... 320 (1): 1-13. doi:10.1124/jpet.106.104463. PMID 16803859. De Min, Anna; Matera, Carlo; Bock, Andreas; Holze, Janine; Kloeckner ...
*  Multiple sclerosis drug pipeline
... endothelin-1 antagonist, has been proposed to lower the ET1 levels, which are involved in brain hypoperfusion Progressive ... "Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1". Proc Natl Acad Sci U S A. 110 (14): ... 286 (1-2): 99-103. doi:10.1016/j.jns.2009.05.028. Voskuhl, Rhonda R; Wang, HeJing; Wu, T C Jackson; Sicotte, Nancy L; Nakamura ... 234 (1-2): 87-91. doi:10.1016/j.jns.2005.03.042. PMID 15935383. Oztaş B, Kiliç S, Dural E, Ispir T (November 2001). "Influence ...
*  Scleroderma
Endothelin signalling is implicated in the pathophysiology of fibrosis. Vitamin D is implicated in the pathophysiology of the ... Leask A (June 2011). "The role of endothelin-1 signaling in the fibrosis observed in systemic sclerosis". Pharmacological ... Experimental therapies under investigation include endothelin receptor antagonsits, tyrosine kinase inhibitors, beta-glycan ... azathioprine with or without corticosteroids Pulmonary arterial hypertension with endothelin receptor antagonists, ...
*  Endothelin A receptor
Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor. Endothelin receptor type A has been shown ... EDNRA endothelin receptor type A". Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin ... Lee HJ, Chun M, Kandror KV (May 2001). "Tip60 and HDAC7 interact with the endothelin receptor a and may be involved in ... "Endothelin Receptors: ETA". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical ...
*  Gastric inhibitory polypeptide receptor
... role of endothelin-1". Am. J. Physiol. Endocrinol. Metab. 285 (2): E390-6. doi:10.1152/ajpendo.00509.2002. PMID 12721154. ... 373 (1): 23-29. doi:10.1016/0014-5793(95)01006-Z. PMID 7589426. Usdin TB, Mezey E, Button DC, et al. (1994). "Gastric ... 63 (1): 17-22. doi:10.1016/0167-0115(96)00019-5. PMID 8795084. N'Diaye N, Tremblay J, Hamet P, et al. (1998). "Adrenocortical ... 1997). "GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1". ...
*  Flammer syndrome
2015). "Endothelin-1 Plasma Levels in Patients with both Retinitis Pigmentosa and Flammer Syndrome". Klin Monatsbl Augenheilkd ... possible associations with the vascular factor endothelin-1 are under investigation. Flammer syndrome requires no therapy as ... 4 (1): S14. doi:10.1186/1878-5085-4-14. PMC 3693953 . PMID 23742177. Kräuchi, K; Gasio, PF; Vollenweider, S; et al. (Dec 2008 ... 5 (1): 11. doi:10.1186/1878-5085-5-11. PMC 4113774 . PMID 25075228. Flammer, J.; Konieczka, K.; Flammer, A. J. (2013). "The ...
*  Haemodynamic response
The peptides angiotensin II and endothelin-1 (ET-1) bind to pericytes and are vasoactive. Endothelial cells induce expression ... of endothelin-1, which leads to NO production and vasodilation. Experiments have demonstrated that oxygen levels also alter ... 5 (1): 35-44. Bergers Gabriele; Song Steven (2005). "The Role of Pericytes in Blood-vessel Formation and Maintenance" (PDF). ... 66: 1-17. doi:10.1016/j.jinf.2012.09.009. Humbert Marc. "Treatment of Pulmonary Arterial Hypertension". The New England Journal ...
*  Subfornical organ
The subfornical organ also contains endothelin receptors mediating vasoconstriction and high rates of glucose metabolism ... endothelin and relaxin. The role of the SFO in angiotensin regulation is particularly important, as it is involved in ... "Calcium-mediated metabolic stimulation of neuroendocrine structures by intraventricular endothelin-1 in conscious rats". Brain ... 606 (1): 135-42. doi:10.1016/0006-8993(93)91581-c. PMID 8461995. Medeiros, N., Dai, L., and Ferguson, A.V. (2012). Glucose- ...
*  BMP binding endothelial regulator
BMPER is inhibited by endothelin-1, which may be mediated by endothelin inhibition of KLF15. GRCh38: Ensembl release 89: ...
*  KLF15
BMPER is inhibited by endothelin-1, which may be mediated by endothelin inhibition of KLF15. The LRP5 promoter has a KLF15 ... 54 (1): 109-21. doi:10.1002/hep.24362. PMC 3125411 . PMID 21503941. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu ... The enhancement of insulin secretion resulted from down-regulation of stearoyl-CoA desaturase-1 (SCD1) in white adipose tissue ... KLF15 upregulates the expression of the E3 ubiquitin ligases atrogin-1 and SMuRF1 genes and negatively modulates myofiber size ...
*  Øyvind Ellingsen
Regional expression of endothelin-1, ANP, IGF-1, and LV wall stress in the infarcted rat heart. Am J Physiol Heart Circ Physiol ... Attenuated endothelin-1 mRNA expression with endothelin-1 receptor blockade during hypoxaemia and reoxygenation in newborn ... Chronic carbon monoxide exposure in vivo induces myocardial endothelin-1 expression and hypertrophy in rat. Pharmacol Toxicol ... Chronic exposure to carbon monoxide and nicotine: Endothelin ETA receptor antagonism attenuates carbon monoxide-induced ...
*  DLX6
2001). "Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer". Genes Dev. 15 (22): 3039-49. ... 119 (1): 98-101. doi:10.1002/ajmg.b.10012. PMID 12707945. Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and ...
*  Tej P. Singh
... endothelin receptor, endothelin converting enzyme, breast cancer regression proteins and matrix metanosomal proteins as well as ... 529 (1): 1-10. doi:10.1016/j.abb.2012.11.001. ISSN 1096-0384. PMID 23149273. Singh, Avinash; Gautam, Lovely; Sinha, Mau; ... 8 (1): e53756. doi:10.1371/journal.pone.0053756. ISSN 1932-6203. PMC 3541179 . PMID 23326499. Singh, Amit Kumar; Singh, ... www.bio-medicine.org/medicine-news/Five-New-Anti-Inflammatory-Compounds-Produced-By-Indian-Scientists-6838-1/ Sharma, Pradeep; ...